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Acatalasia
Glutathione oxidation in response to intracellular H2O2: Key but overlapping roles for dehydroascorbate reductases.
Acidosis
Acidosis-induced metallothionein (MT) mRNA expression in neonatal rat primary astrocyte cultures.
Acidosis
Dimethyl sulfoxide, but not acidosis-induced metallothionein mRNA expression in neonatal rat primary astrocyte cultures is inhibited by the bioflavonoid, quercetin.
Adenocarcinoma
Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo.
Alzheimer Disease
Influence of Transgenic Metallothionein-1 on Gliosis, CA1 Neuronal Loss, and Brain Metal Levels of the Tg2576 Mouse Model of Alzheimer's Disease.
Alzheimer Disease
Overexpression of Metallothionein-1 Modulates the Phenotype of the Tg2576 Mouse Model of Alzheimer's Disease.
Alzheimer Disease
Structure, function and disease relevance of Omega-class glutathione transferases.
Amyotrophic Lateral Sclerosis
Structure, function and disease relevance of Omega-class glutathione transferases.
Arthritis
Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A
Arthritis, Rheumatoid
Metallothionein-1 suppresses rheumatoid arthritis pathogenesis by shifting the Th17/Treg balance.
Asthma
GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1?-induced eosinophilic airway inflammation.
Asthma
Sanfu herbal patch applied at acupoints in patients with bronchial asthma: study protocol for a randomized controlled trial.
Bone Resorption
Systemic over-secretion of growth hormone in transgenic mice results in a specific pattern of skeletal modeling and adaptation.
Brain Diseases
Metallothioneins are multipurpose neuroprotectants during brain pathology.
Brain Injuries
Differential regulation of metallothionein-I and metallothionein-II mRNA expression in the rat brain following traumatic brain injury.
Brain Injuries
Metallothionein (MT) -I and MT-II Expression Are Induced and Cause Zinc Sequestration in the Liver after Brain Injury.
Brain Injuries, Traumatic
Differential regulation of metallothionein-I and metallothionein-II mRNA expression in the rat brain following traumatic brain injury.
Brain Injuries, Traumatic
The comparison of mouse full metallothionein-1 versus alpha and beta domains and metallothionein-1-to-3 mutation following traumatic brain injury reveals different biological motifs.
Brain Ischemia
Evidence for a protective role of metallothionein-1 in focal cerebral ischemia.
Brain Ischemia
Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion.
Brain Ischemia
Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia.
Breast Neoplasms
A case-control study of Metallothionein-1 expression in breast cancer and breast fibroadenoma.
Breast Neoplasms
A Role for Glutathione Transferase Omega 1 (GSTO1-1) in the Glutathionylation Cycle.
Breast Neoplasms
Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs.
Breast Neoplasms
Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer.
Breast Neoplasms
S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1.
Breast Neoplasms
Structure, function and disease relevance of Omega-class glutathione transferases.
Breast Neoplasms
Thioltransferase overexpression increases resistance of MCF-7 cells to adriamycin.
Carcinogenesis
Increased susceptibility of estrogen-induced bladder outlet obstruction in a novel mouse model.
Carcinogenesis
Metallothionein deficiency promotes mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene.
Carcinoma
Expression of metallothionein in lung carcinoma: correlation with histological type and grade.
Carcinoma
Metallothionein-1 Genotypes in the Risk of Oral Squamous Cell Carcinoma.
Carcinoma
Peculiarities of antioxidant system and iron metabolism in organism during development of tumor resistance to cisplatin.
Carcinoma
The upregulation of metallothionein-1 expression in areca quid chewing-associated oral squamous cell carcinomas.
Carcinoma
Upregulated glutathione transferase omega-1 correlates with progression of urinary bladder carcinoma.
Carcinoma, Hepatocellular
Amplification of the metallothionein-1 and metallothionein-2 genes in copper-resistant hepatoma cells.
Carcinoma, Hepatocellular
Effects of Metallothionein-1 Genetic Polymorphism and Cigarette Smoking on the Development of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Expression of metallothionein-1 and metallothionein-2 as a prognostic marker in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Metallothionein mRNA stability in chicken and mouse cells.
Carcinoma, Hepatocellular
Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib.
Carcinoma, Hepatocellular
Prognostic Significance of 14-3-3?, Aldo-keto Reductase Family 1 B10 and Metallothionein-1 in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
[Glutathione: dehydroascorbate-oxidoreductase activity in rat tissues]
Carcinoma, Transitional Cell
Upregulated glutathione transferase omega-1 correlates with progression of urinary bladder carcinoma.
catalase deficiency
Glutathione oxidation in response to intracellular H2O2: Key but overlapping roles for dehydroascorbate reductases.
Cataract
Structure, function and disease relevance of Omega-class glutathione transferases.
Cerebral Infarction
Role of Metallothionein-1 and Metallothionein-2 in the Neuroprotective Mechanism of Sevoflurane Preconditioning in Mice.
Chagas Disease
Metallothionein-1 and nitric oxide expression are inversely correlated in a murine model of Chagas disease.
Colitis
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
Colonic Neoplasms
Glutathione transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation.
Colorectal Neoplasms
Glutathione transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation.
Cystic Fibrosis
Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
Dehydration
Antioxidant response of wheat roots to drought acclimation.
Dehydration
Ascorbic acid mitigation of water stress-inhibition of root growth in association with oxidative defense in tall fescue (Festuca arundinacea Schreb.).
Dehydration
Cytological and physiological changes in orthodox maize embryos during cryopreservation.
Dehydration
Cytological and physiological changes in recalcitrant Chinese fan palm (Livistona chinensis) embryos during cryopreservation.
Dehydration
Dioscorin, the major tuber storage protein of yam (Dioscorea batatas decne) with carbonic anhydrase and trypsin inhibitor activities.
Dehydration
Drought-responsive mechanisms in rice genotypes with contrasting drought tolerance during reproductive stage.
Dehydration
Effect of short-term water deficit stress on antioxidative systems in cucumber seedling roots.
Dehydration
Effect of water stress on antioxidant systems and oxidative parameters in fruits of tomato (Solanum lycopersicon L, cv. Micro-tom).
Dehydration
Jasmonic acid regulates ascorbate and glutathione metabolism in Agropyron cristatum leaves under water stress
Dehydration
Nitric Oxide Signal, Nitrogen Metabolism, and Water Balance Affected by ?-Aminobutyric Acid (GABA) in Relation to Enhanced Tolerance to Water Stress in Creeping Bentgrass.
Dehydration
Possible Involvement of Reactive Oxygen Species Scavenging Enzymes in Desiccation Sensitivity of Antiaris toxicaria Seeds and Axes.
Dehydration
Pretreatment with NaCl Promotes the Seed Germination of White Clover by Affecting Endogenous Phytohormones, Metabolic Regulation, and Dehydrin-Encoded Genes Expression under Water Stress.
Dengue
Potent virucidal activity against Flaviviridae of a group IIA phospholipase A2 isolated from the venom of Bothrops asper.
Dental Caries
Status of dental caries and treatment needs in tribal children of Mandu (Central India).
Dermatitis, Atopic
Commentary on Nagaraja, Kanwar, Dhar, and Singh: frequency and significance of minor clinical features in various age-related subgroups of atopic dermatitis in children.
Diabetes Mellitus
Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.
Diabetes Mellitus, Type 2
Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.
Encephalitis
Specificity and divergence in the neurobiologic effects of different metallothioneins after brain injury.
Eosinophilia
GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1?-induced eosinophilic airway inflammation.
Esophageal Neoplasms
[Expression of metallothionein-3 in esophageal cancer and its correlations to expression of metallothionein-1 and -2.]
Fibroadenoma
A case-control study of Metallothionein-1 expression in breast cancer and breast fibroadenoma.
Fluorosis, Dental
Dental fluorosis and associated risk factors in early adolescents in India.
Gastrointestinal Stromal Tumors
Expression of Metallothionein and Ki-67 Antigen in GISTs of Different Grade of Malignancy.
Glioblastoma
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones.
Glioma
Regulated expression of the diphtheria toxin A gene in human glioma cells using prokaryotic transcriptional control elements.
Glucose Intolerance
135-Day Interventions of Yam Dioscorin and the Dipeptide Asn-Trp (NW) To Reduce Weight Gains and Improve Impaired Glucose Tolerances in High-Fat Diet-Induced C57BL/6 Mice.
Glucose Intolerance
Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats.
glutathione dehydrogenase (ascorbate) deficiency
Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs.
glutathione dehydrogenase (ascorbate) deficiency
GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1?-induced eosinophilic airway inflammation.
glutathione dehydrogenase (ascorbate) deficiency
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
glutathione dehydrogenase (ascorbate) deficiency
Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1.
Hyperalgesia
Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A
Hypersensitivity
Overexpression of metallothionein-II sensitizes rodent cells to apoptosis induced by DNA cross-linking agent through inhibition of NF-kappa B activation.
Hypertension
Both dioscorin, the tuber storage protein of yam (Dioscorea alata cv. Tainong No. 1), and its peptic hydrolysates exhibited angiotensin converting enzyme inhibitory activities.
Infarction, Middle Cerebral Artery
Assessment of the Therapeutic Potential of Metallothionein-II Application in Focal Cerebral Ischemia In Vitro and In Vivo.
Infections
Ascorbate, glutathione and related enzymes in chloroplasts of tomato leaves infected by Botrytis cinerea.
Infections
Identification of proteins induced or upregulated by Fusarium head blight infection in the spikes of hexaploid wheat (Triticum aestivum).
Infections
Interferon-alpha-induced changes in metallothionein expression in liver biopsies from patients with chronic hepatitis C.
Infections
The effect of Botrytis cinerea infection on the antioxidant profile of mitochondria from tomato leaves.
Infections
Up-regulation of the ascorbate-dependent antioxidative system in barley leaves during powdery mildew infection.
Inflammatory Bowel Diseases
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
Influenza, Human
Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms.
Insulin Resistance
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
Ischemic Stroke
Assessment of the Therapeutic Potential of Metallothionein-II Application in Focal Cerebral Ischemia In Vitro and In Vivo.
Leprosy, Paucibacillary
Thalidomide does not modify the ability of cells in leprosy patients to incorporate [3H]-thymidine when incubated with M. leprae antigens.
Leukemia
Association of glutathione S-transferase ? 1-1 polymorphisms (A140D and E208K) with the expression of interleukin-8 (IL-8), transforming growth factor beta (TGF-?), and apoptotic protease-activating factor 1 (Apaf-1) in humans chronically exposed to arsenic in drinking water.
Leukemia
Metallothionein-1 isoforms and vimentin are direct PU.1 downstream target genes in leukemia cells.
Liver Neoplasms
MDM2-TP53 Crossregulation: An Underestimated Target to Promote Loss of TP53 Function and Cell Survival.
Lordosis
The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat.
Lung Diseases
Association of glutathione S-transferase ? 1-1 polymorphisms (A140D and E208K) with the expression of interleukin-8 (IL-8), transforming growth factor beta (TGF-?), and apoptotic protease-activating factor 1 (Apaf-1) in humans chronically exposed to arsenic in drinking water.
Lung Injury
Molecular signatures of trauma-hemorrhagic shock-induced lung injury: hemorrhage- and injury-associated genes.
Lung Neoplasms
Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure.
Lymphoma
Different types of hypersensitive sites in the mouse metallothionein gene region.
Lymphoma, Non-Hodgkin
Long-term cadmium exposure enhances metallothionein-1 induction after subsequent exposure to high concentrations of cadmium in P1798 mouse lymphosarcoma cells.
Medulloblastoma
MDM2-TP53 Crossregulation: An Underestimated Target to Promote Loss of TP53 Function and Cell Survival.
Melanoma
Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor.
Melanoma
Melanoma associated with the use of melanotan-II.
Metabolic Syndrome
Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats.
Motor Neuron Disease
Effect of Neuroprotective Drugs on Gene Expression in G93A/SOD1 Mice.
Multiple Sclerosis
Mouse metallothionein-1 and metallothionein-2 are not biologically interchangeable in an animal model of multiple sclerosis, EAE.
Neoplasms
Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R.
Neoplasms
Covalent sequestration of melphalan by metallothionein and selective alkylation of cysteines.
Neoplasms
Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs.
Neoplasms
Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor.
Neoplasms
Differential Expression of Inflammatory Cytokines and Stress Genes in Male and Female Mice in Response to a Lipopolysaccharide Challenge.
Neoplasms
Ectopic expression of rhombotin-2 causes selective expansion of CD4-CD8- lymphocytes in the thymus and T-cell tumors in transgenic mice.
Neoplasms
Effects of environmental lead contamination on cattle in a lead/zinc mining area: Changes in cattle immune systems on exposure to lead in vivo and in vitro.
Neoplasms
Enhancement of immunogenicity of tumor cells by cotransfection with genes encoding antisense insulin-like growth factor-1 and B7.1 molecules.
Neoplasms
Expression of Metallothionein and Ki-67 Antigen in GISTs of Different Grade of Malignancy.
Neoplasms
Expression of metallothionein in lung carcinoma: correlation with histological type and grade.
Neoplasms
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones.
Neoplasms
GSTO1*CC Genotype (rs4925) Predicts Shorter Survival in Clear Cell Renal Cell Carcinoma Male Patients.
Neoplasms
Immunohistochemically detectable metallothionein expression in malignant pleural mesotheliomas is strongly associated with early failure to platin-based chemotherapy.
Neoplasms
Isolation and characterization of complementary DNA clones corresponding to genes induced in mouse epidermis in vivo by tumor promoters.
Neoplasms
MDM2-TP53 Crossregulation: An Underestimated Target to Promote Loss of TP53 Function and Cell Survival.
Neoplasms
Metallothionein-1 and -2 expression in cadmium- or arsenic-derived human malignant urothelial cells and tumor heterotransplants and as a prognostic indicator in human bladder cancer.
Neoplasms
Metallothioneins, longevity and cancer: Comment on "Deficiency of metallothionein-1 and -2 genes shortens the lifespan of the 129/Sv mouse strain".
Neoplasms
Peculiarities of antioxidant system and iron metabolism in organism during development of tumor resistance to cisplatin.
Neoplasms
Polymorphism of glutathione transferase Omega 1 in a population exposed to a high environmental arsenic burden.
Neoplasms
Polyomavirus large T-antigen expression in heart of transgenic mice causes cardiomyopathy.
Neoplasms
Prognostic Significance of 14-3-3?, Aldo-keto Reductase Family 1 B10 and Metallothionein-1 in Hepatocellular Carcinoma.
Neoplasms
Regulation of metallothionein gene expression.
Neoplasms
Structure-Based Design of N-(5-Phenylthiazol-2-yl)acrylamides as Novel and Potent Glutathione S-Transferase Omega 1 Inhibitors.
Neoplasms
Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat.
Neoplasms
Upregulated glutathione transferase omega-1 correlates with progression of urinary bladder carcinoma.
Nervous System Diseases
Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating Retina.
Neuralgia
Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain.
Neuroblastoma
Ascorbic acid recycling in N-myc amplified human neuroblastoma cells.
Neurodegenerative Diseases
The role of metallothionein II in neuronal differentiation and survival.
Neuroinflammatory Diseases
Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain.
Neuroinflammatory Diseases
Expression of metallothionein-I, -II, and -III in Alzheimer disease and animal models of neuroinflammation.
Obesity
Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats.
Obesity
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
Obesity
Obesity and hyperleptinemia in metallothionein (-I and -II) null mice.
Obesity
The effect of the melanocortin agonist, MT-II, on the defended level of body adiposity.
Osteoarthritis
Metallothionein-1 is associated with osteoarthritis disease activity and suppresses proinflammatory cytokines production in synovial cells.
Ototoxicity
Co-treatment with melanotan-II, a potent melanocortin, does not protect against cisplatin ototoxicity.
Paralysis
Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis.
Parkinson Disease
Structure, function and disease relevance of Omega-class glutathione transferases.
Pulmonary Disease, Chronic Obstructive
Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
Pulmonary Disease, Chronic Obstructive
Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients.
Pulmonary Disease, Chronic Obstructive
Structure, function and disease relevance of Omega-class glutathione transferases.
Retinal Degeneration
Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating Retina.
Shock, Septic
Structure, function and disease relevance of Omega-class glutathione transferases.
Squamous Cell Carcinoma of Head and Neck
Metallothionein-1 Genotypes in the Risk of Oral Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
The upregulation of metallothionein-1 expression in areca quid chewing-associated oral squamous cell carcinomas.
Starvation
Potassium starvation induces oxidative stress inSolanum lycopersicumL. roots.
Stomach Neoplasms
Inducible Expression of bcl-2 Antisense RNA Promotes Apoptosis of Human Gastric Cancer Cell Line.
Stroke
Assessment of the Therapeutic Potential of Metallothionein-II Application in Focal Cerebral Ischemia In Vitro and In Vivo.
Sunburn
Photoprotection mechanism in the 'Fuji' apple peel at different levels of photooxidative sunburn.
Sunburn
Photoprotection mechanism in the Fuji apple peel at different levels of photooxidative sunburn
Testicular Neoplasms
Decreased Fas antigen receptor expression in testicular tumor cell lines derived from polyomavirus large T-antigen transgenic mice.
Testicular Neoplasms
The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue.
Tics
Metallothionein gene expression in testicular interstitial cells and liver of rats treated with cadmium.
Tuberculosis
Caught between two proteins: a mycobacterial inhibitor challenges the mold.
Urinary Bladder Neoplasms
Metallothionein-1 and -2 expression in cadmium- or arsenic-derived human malignant urothelial cells and tumor heterotransplants and as a prognostic indicator in human bladder cancer.
Vaccinia
A glutaredoxin, encoded by the G4L gene of vaccinia virus, is essential for virion morphogenesis.
Vaccinia
Glutaredoxin homolog encoded by vaccinia virus is a virion-associated enzyme with thioltransferase and dehydroascorbate reductase activities.
Virus Diseases
Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms.
Wilms Tumor
Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells.
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1.8.5.1 glutathione dehydrogenase (ascorbate)
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
