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1,2-naphthoquinone + O2 + NADH + H+
?
-
-
-
-
?
1,4-naphthoquinone + O2 + NADH + H+
?
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
2 ferricytochrome b5 + NADPH + H+
2 ferrocytochrome b5 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome c + NADH + H+
2 ferrocytochrome c + NAD+
-
-
-
-
?
2-hydroxyestradiol + O2 + NADH + H+
?
-
-
-
-
?
2-methyl-1,4-naphthoquinone + O2 + NADH + H+
?
-
-
-
-
?
2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt + NADH
?
-
-
-
?
9,10-phenanthrenequinone + O2 + NADH + H+
?
-
-
-
-
?
benzamidoxime + NADH
?
-
in the presence of cytochrome b5
-
-
?
dapsone hydroxylamine + NADH
?
-
in the presence of cytochrome b5
-
-
?
ferricytochrome b5 + 4-(5-(4-[amino(hydroxyamino)methyl]phenyl)-2-furyl)-N'-hydroxybenzenecarboximidamide
ferrocytochrome b5 + ?
-
metabolite of DB289, an antimicrobial prodrug of furamidine
-
-
?
ferricytochrome b5 + 4-(5-(4-[amino(hydroxyamino)methyl]phenyl)-2-furyl)-N'-methoxybenzenecarboximidamide
ferrocytochrome b5 + ?
-
metabolite of DB289, an antimicrobial prodrug of furamidine
-
-
?
ferricytochrome b5 + N-hydroxy-2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine
ferrocytochrome b5 + ?
-
arylhydroxylamine carcinogen found in grilled meat
-
-
?
ferricytochrome b5 + N-hydroxy-4-aminobiphenyl
ferrocytochrome b5 + ?
-
arylhydroxylamine carcinogen found in cigarette smoke
-
-
?
lucigenin + NADH
?
-
-
-
?
methemoglobin + NADH
hemoglobin + NAD+
-
provides functional hemoglobin
-
-
?
NADH + ferricyanide
NAD+ + H+ + ferrocyanide
NADH + ferricytochrome b5
NAD+ + H+ + 2 ferrocytochrome b5
-
-
-
-
r
NADH + ferricytochrome b5
NAD+ + H+ + ferrocytochrome b5
NADH + H+ + 2 O2
?
-
-
-
-
?
NADH + oxidized 2,6-dichlorophenolindophenol
NAD+ + H+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
NADPH + ferricytochrome b5
NADP+ + H+ + ferrocytochrome b5
-
-
-
-
r
nitrofurantoin + O2 + NADH + H+
?
-
-
-
-
?
sulfamethoxazole hydroxylamine + NADH
?
-
in the presence of cytochrome b5
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
-
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
specific for NADH as electron donor, artificial acceptors: ferricyanide, 2,6-dichlorphenolindophenol
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
specific for NADH as electron donor, artificial acceptors: ferricyanide, 2,6-dichlorphenolindophenol
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
specific for NADH as electron donor, artificial acceptors: ferricyanide, 2,6-dichlorphenolindophenol
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
specific for NADH as electron donor, artificial acceptors: ferricyanide, 2,6-dichlorphenolindophenol
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
poor electron acceptors: methylene blue, ferricytochrome c, O2, oxidized glutathione, methemoglobin
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
artificial electron acceptor in the presence of menadione: cytochrome c
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
additional electron donors: deamino-NADH, 3-acetylpyridine-NADH
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
artificial acceptors: p-benzoquinone, 5-hydroxy-1,4-naphthoquinone, nitroblue-tetrazolium
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
additional acceptor: methemoglobin-ferrocyanide complex
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
involved in metabolism of endogenous compounds such as steroids, drugs, carcinogens, environmental pollutants
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
enzyme participates in methemoglobin reduction in erythrocytes, in other tissues it plays a role in elongation and desaturation of fatty acids, P-450 mediated drug metabolism and cholesterol biosynthesis as part of the microsomal electron transfer system
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
soluble form of erythrocytes: reduction of methemoglobin
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
soluble form of erythrocytes: reduction of methemoglobin
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
involved in the synthesis of fatty acids and cholesterol, and in the oxidation of xenobiotics
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
involved in the synthesis of fatty acids and cholesterol, and in the oxidation of xenobiotics
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
involved in the synthesis of fatty acids and cholesterol, and in the oxidation of xenobiotics, enzyme in presence of cytochrome b5 supports activity of CYP2E1
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
involved in the synthesis of fatty acids and cholesterol, and in the oxidation of xenobiotics, participates in the regeneration of vitamin E and of ascorbate, maintains antioxidant levels and is therefore involved in the protection of membrane lipids from peroxidation, considered as a constitutive housekeeping enzyme
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
recessive congenital methaemoglobinaemia, is caused by NADH-cytochrome b5 reductase deficiency. Two distinct clinical forms, types I and II, are recognized, both characterized by cyanosis from birth. In type II, the cyanosis is accompanied by neurological impairment and reduced life expectancy
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
the electrostatic interactions between the lysyl residues (K42, K126, K163, and K164) in the enzyme and the carboxyl groups (E47, E48, E52, E60, and D64) of cytochrome b5 keep the proteins tightly complexed and are suitable for electron transfer, reaction mechanism, overview
-
-
?
2 ferricytochrome b5 + NADH
2 ferrocytochrome b5 + NAD+ + H+
-
potassium ferricyanide, cytochrome b5, or NADH-2,6-dichlorophenol-indophenol can act as electron acceptors
-
-
?
NADH + ferricyanide
NAD+ + H+ + ferrocyanide
-
-
-
-
?
NADH + ferricyanide
NAD+ + H+ + ferrocyanide
-
-
-
?
NADH + ferricytochrome b5
NAD+ + H+ + ferrocytochrome b5
-
-
-
-
?
NADH + ferricytochrome b5
NAD+ + H+ + ferrocytochrome b5
-
-
-
-
r
NADH + ferricytochrome b5
NAD+ + H+ + ferrocytochrome b5
-
-
-
?
NADH + ferricytochrome b5
NAD+ + H+ + ferrocytochrome b5
-
-
-
-
?
NADH + ferricytochrome b5
NAD+ + H+ + ferrocytochrome b5
-
-
-
?
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Abortion, Habitual
Recessive congenital methemoglobinemia due to NADH-cytochrome b5 reductase deficiency associated with recurrent early pregnancy loss (REPL) in an Indian family.
Brain Diseases
Alteration of NADH-diaphorase and cytochrome b5 reductase activities of erythrocytes, platelets, and leucocytes in hereditary methaemoglobinaemia with and without mental retardation.
Brain Diseases
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Breast Neoplasms
DT-diaphorase and cytochrome B5 reductase in human lung and breast tumours.
Breast Neoplasms
Microsomal reductase activity in patients with thyroid neoplasms.
Breast Neoplasms
NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer.
Breast Neoplasms
Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women.
Carcinogenesis
Monooxygenase system in Guerins carcinoma of rats under conditions of ?-3 polyunsaturated fatty acids administration.
Carcinogenesis
[Functional activity of NADH-dependent reductase system in the liver microsomal fraction and Guerin's carcinoma in rats exposed to preliminary irradiation].
Carcinoma
Monooxygenase system in Guerins carcinoma of rats under conditions of ?-3 polyunsaturated fatty acids administration.
Carcinoma
[Functional activity of NADH-dependent reductase system in the liver microsomal fraction and Guerin's carcinoma in rats exposed to preliminary irradiation].
Cholestasis, Intrahepatic
Selective reduction of hepatic cytochrome P450 content in patients with intrahepatic cholestasis. A mechanism for impairment of microsomal drug oxidation.
Colonic Neoplasms
Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women.
Colorectal Neoplasms
Intratumoral Heterogeneity for Inactivating Frameshift Mutation of CYB5R2 Gene in Colorectal Cancers.
cytochrome-b5 reductase deficiency
A 5-hour-old male neonate with cyanosis.
cytochrome-b5 reductase deficiency
A case of methemoglobinemia type II due to NADH-cytochrome b5 reductase deficiency: determination of the molecular basis.
cytochrome-b5 reductase deficiency
A Thai boy with hereditary enzymopenic methemoglobinemia type II.
cytochrome-b5 reductase deficiency
Alteration of NADH-diaphorase and cytochrome b5 reductase activities of erythrocytes, platelets, and leucocytes in hereditary methaemoglobinaemia with and without mental retardation.
cytochrome-b5 reductase deficiency
Analysis of mutant NADH-cytochrome b5 reductase: apparent "type III" methemoglobinemia can be explained as type I with an unstable reductase.
cytochrome-b5 reductase deficiency
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
cytochrome-b5 reductase deficiency
Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in cats.
cytochrome-b5 reductase deficiency
Clinical, metabolic, and molecular genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in 30 dogs.
cytochrome-b5 reductase deficiency
Congenital cyanosis due to methemoglobin reductase deficiency: first reported Tunisian case.
cytochrome-b5 reductase deficiency
Congenital methemoglobin-reductase (cytochrome b5 reductase) deficiency associated with mental retardation in a Spanish girl.
cytochrome-b5 reductase deficiency
Congenital methemoglobinemia due to methemoglobin reductase deficiency in two unrelated American black families.
cytochrome-b5 reductase deficiency
Congenital Methemoglobinemia Identified by Pulse Oximetry Screening.
cytochrome-b5 reductase deficiency
Congenital methemoglobinemia methemoglobin reductase deficiency.
cytochrome-b5 reductase deficiency
Congenital Recessive Methemoglobinemia Revealed in Adulthood: Description of a New Mutation in Cytochrome b5 Reductase Gene.
cytochrome-b5 reductase deficiency
Cytochrome B5 reductase deficiency and mental retardation.
cytochrome-b5 reductase deficiency
Cytochrome b5 reductase deficiency, an uncommon cause of cyanosis.
cytochrome-b5 reductase deficiency
Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency.
cytochrome-b5 reductase deficiency
Deficient cytochrome b5 reductase activity in nontoxic goiter with iodide organification defect.
cytochrome-b5 reductase deficiency
Enzymopenic hereditary methemoglobinemia: a clinical/biochemical classification.
cytochrome-b5 reductase deficiency
Erratum for Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in cats.
cytochrome-b5 reductase deficiency
Evaluation of the methemoglobinemia associated with sulofenur.
cytochrome-b5 reductase deficiency
Hb Chile [beta28(B10)Leu-->Met]: an unstable hemoglobin associated with chronic methemoglobinemia and sulfonamide or methylene blue-induced hemolytic anemia.
cytochrome-b5 reductase deficiency
Hereditary methemoglobinemia due to cytochrome b5 reductase deficiency in blood cells without associated neurologic and mental disorders.
cytochrome-b5 reductase deficiency
Long-term Treatment with Methylene Blue in a Dog with Hereditary Methemoglobinemia Caused by Cytochrome b5 Reductase Deficiency.
cytochrome-b5 reductase deficiency
Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice.
cytochrome-b5 reductase deficiency
Membrane-Bound CYB5R3 Is a Common Effector of Nutritional and Oxidative Stress Response Through FOXO3a and Nrf2.
cytochrome-b5 reductase deficiency
Methemoglobin reductase deficiency in a cat.
cytochrome-b5 reductase deficiency
Methemoglobin reductase deficiency in a dog.
cytochrome-b5 reductase deficiency
Methemoglobin reductase deficiency: novel mutation is associated with a disease phenotype of intermediate severity.
cytochrome-b5 reductase deficiency
Methemoglobinemia as a complication of 20% benzocaine spray for endoscopy.
cytochrome-b5 reductase deficiency
Methemoglobinemia: Living with Dormant Devil.
cytochrome-b5 reductase deficiency
Molecular basis of two novel mutations found in type I methemoglobinemia.
cytochrome-b5 reductase deficiency
Mutation update: Variants of the CYB5R3 gene in recessive congenital methemoglobinemia.
cytochrome-b5 reductase deficiency
NADH cytochrome b5 reductase activity in lymphoid cell lines. Expression of the defect in epstein Barr virus transformed lymphoblastoid cell lines from patients with recessive congenital methemoglobinemia.
cytochrome-b5 reductase deficiency
NCB5OR Deficiency in the Cerebellum and Midbrain Leads to Dehydration and Alterations in Thirst Response, Fasted Feeding Behavior, and Voluntary Exercise in Mice.
cytochrome-b5 reductase deficiency
Ncb5or deficiency increases Fatty Acid catabolism and oxidative stress.
cytochrome-b5 reductase deficiency
New variant of cytochrome b5 reductase deficiency (b5RKurashiki) in red cells, platelets, lymphocytes, and cultured fibroblasts with congenital methemoglobinemia, mental and neurological retardation, and skeletal anomalies.
cytochrome-b5 reductase deficiency
Novel mutation (R192C) in CYB5R3 gene causing NADH-cytochrome b5 reductase deficiency in eight Indian patients associated with autosomal recessive congenital methemoglobinemia type-I.
cytochrome-b5 reductase deficiency
Prenatal diagnosis of congenital enzymopenic methaemoglobinaemia with mental retardation due to generalized cytochrome b5 reductase deficiency: first report of two cases.
cytochrome-b5 reductase deficiency
Quantitative variations of red-cell cytochrome b5 reductase (NADH-methemoglobin-reductase) in the Algerian population: evidence for defective alleles.
cytochrome-b5 reductase deficiency
Recessive congenital methemoglobinemia due to NADH-cytochrome b5 reductase deficiency associated with recurrent early pregnancy loss (REPL) in an Indian family.
cytochrome-b5 reductase deficiency
Recessive congenital methemoglobinemia type II: Hypoplastic basal ganglia in two siblings with a novel mutation of the cytochrome b5 reductase gene.
cytochrome-b5 reductase deficiency
Recessive hereditary methemoglobinemia: two novel mutations in the NADH-cytochrome b5 reductase gene.
cytochrome-b5 reductase deficiency
Red cell enzymes.
cytochrome-b5 reductase deficiency
Smooth muscle cell CYB5R3 preserves cardiac and vascular function under chronic hypoxic stress.
cytochrome-b5 reductase deficiency
Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice.
cytochrome-b5 reductase deficiency
The Acute Treatment of Methemoglobinemia in Pregnancy.
cytochrome-b5 reductase deficiency
The laboratory use of butylnitrite for the production of methemoglobin.
cytochrome-b5 reductase deficiency
Transient Neonatal Cyanosis Associated With a New Hb F Variant: Hb F Viseu.
cytochrome-b5 reductase deficiency
[A NEW CASE OF RECESSIVE CONGENITAL METHEMOGLOBINEMIA LINKED WITH A DIAPHORASE I DEFICIENCY.]
cytochrome-b5 reductase deficiency
[Clinical and biological forms of cytochrome b5 reductase deficiency]
cytochrome-b5 reductase deficiency
[Congenital methemoglobinemia due to NADH (DPNH) dependent methemoglobin reductase deficiency]
cytochrome-b5 reductase deficiency
[Erythrocyte metabolism in congenital methemoglobin reductase deficiency]
cytochrome-b5 reductase deficiency
[Establishment of a cellular model with human NADH-cytochrome b5 reductase deficiency via RNA interference]
cytochrome-b5 reductase deficiency
[Gene analysis and genetic diagnosis of hereditary erythrocyte abnormalities. Cytochrome b5 reductase deficiency]
cytochrome-b5 reductase deficiency
[Genetic injuries in 2 families with congenital methemoglobinemia caused by diaphorase I deficiency]
cytochrome-b5 reductase deficiency
[Genetics and biochemistry of NADH-cytochrome b5 reductase deficiency]
cytochrome-b5 reductase deficiency
[Hereditary methemoglobinemia caused by NADH methemoglobin reductase deficiency]
cytochrome-b5 reductase deficiency
[On the mechanism of ascorbic acid induced methemoglobin reduction of human erythrocytes (author's transl)]
cytochrome-b5 reductase deficiency
[Prenatal diagnosis of generalized cytochrome b5 reductase deficiency (congenital methemoglobinemia with mental retardation, type II) (author's transl)]
Dehydration
NCB5OR Deficiency in the Cerebellum and Midbrain Leads to Dehydration and Alterations in Thirst Response, Fasted Feeding Behavior, and Voluntary Exercise in Mice.
Diabetes Mellitus, Type 2
Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus.
Diabetes, Gestational
Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus.
Down Syndrome
Oxidative stress in Portuguese children with Down syndrome.
Drug Hypersensitivity
Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity.
Dyskinesias
Alteration of NADH-diaphorase and cytochrome b5 reductase activities of erythrocytes, platelets, and leucocytes in hereditary methaemoglobinaemia with and without mental retardation.
Dystonia
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Exanthema
Evaluation of sulfonamide detoxification pathways in haematologic malignancy patients prior to intermittent trimethoprim-sulfamethoxazole prophylaxis.
Genetic Diseases, Inborn
Amino acid sequence of NADH-cytochrome b5 reductase of human erythrocytes.
Genetic Diseases, Inborn
[Molecular analysis of the structure of the mutant NADH-cytochrome b5 reductase gene causing methemoglobinemia]
Glioblastoma
Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells.
Glucose Intolerance
Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with ?-cell failure.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Molecular Characterization of Glucose-6-Phosphate Dehydrogenase: Do Single Nucleotide Polymorphisms Affect Hematological Parameters in HIV-Positive Patients?
glucose-6-phosphate dehydrogenase (nadp+) deficiency
The laboratory use of butylnitrite for the production of methemoglobin.
Glucosephosphate Dehydrogenase Deficiency
Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue treatment.
Glucosephosphate Dehydrogenase Deficiency
Molecular Characterization of Glucose-6-Phosphate Dehydrogenase: Do Single Nucleotide Polymorphisms Affect Hematological Parameters in HIV-Positive Patients?
Glucosephosphate Dehydrogenase Deficiency
The laboratory use of butylnitrite for the production of methemoglobin.
Goiter
Deficient cytochrome b5 reductase activity in nontoxic goiter with iodide organification defect.
Goiter
Microsomal reductase activity in patients with thyroid neoplasms.
Goiter, Nodular
Microsomal reductase activity in patients with thyroid neoplasms.
Granulomatous Disease, Chronic
Subcellular localization of the human neutrophil NADPH oxidase. b-Cytochrome and associated flavoprotein.
Hemoglobinopathies
Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency.
Herpes Zoster
Zonal distribution of cytochromes P-450 and related enzymes of bovine adrenal cortex--quantitative assay of concentrations and total contents.
Hyperglycemia
Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with ?-cell failure.
Hyperglycemia
[Adaptation of rats following sodium-nitrite-induced methemoglobinemia]
Hypersensitivity
Cytochrome b5 and NADH cytochrome b5 reductase: genotype-phenotype correlations for hydroxylamine reduction.
Hypersensitivity
Evaluation of Polymorphisms in the Sulfonamide Detoxification Genes CYB5A and CYB5R3 in Dogs with Sulfonamide Hypersensitivity.
Hypersensitivity
Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity.
Hypertension
Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation.
Hypertension
Smooth muscle cell CYB5R3 preserves cardiac and vascular function under chronic hypoxic stress.
Hypertension, Pulmonary
Smooth muscle cell CYB5R3 preserves cardiac and vascular function under chronic hypoxic stress.
Hypertension, Pulmonary
Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice.
Hyperthyroidism
Microsomal reductase activity in patients with thyroid neoplasms.
Infections
Changes in rodent-erythrocyte methemoglobin reductase system produced by two malaria parasites, viz. Plasmodium yoelii nigeriensis and Plasmodium berghei.
Infections
Effect of beta-arteether treatment on erythrocytic methemoglobin reductase system in Plasmodium yoelii nigeriensis infected mice.
Infections
Primaquine-induced severe methemoglobinemia developed during treatment of Plasmodium vivax malarial infection in an Indian family associated with a novel mutation (p.Agr57Trp) in the CYB5R3 gene.
Infections
Studies on erythrocytic methemoglobin reductase systems in Plasmodium yoelii nigeriensis infected mice.
Intellectual Disability
Adipose fatty acid composition in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation.
Intellectual Disability
Alteration of NADH-diaphorase and cytochrome b5 reductase activities of erythrocytes, platelets, and leucocytes in hereditary methaemoglobinaemia with and without mental retardation.
Intellectual Disability
Analysis of mutant NADH-cytochrome b5 reductase: apparent "type III" methemoglobinemia can be explained as type I with an unstable reductase.
Intellectual Disability
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Intellectual Disability
Cytochrome B5 reductase deficiency and mental retardation.
Intellectual Disability
Decrease of palmitoyl-CoA elongation in platelets and leukocytes in the patient of hereditary methemoglobinemia associated with mental retardation.
Intellectual Disability
Generalised deficiency of cytochrome b5 reductase in congenital methaemoglobinaemia with mental retardation.
Intellectual Disability
Heterogeneity of the rat NADH-cytochrome-b5-reductase transcripts resulting from multiple alternative first exons.
Intellectual Disability
Lipids of liver, kidney, spleen and muscle in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation.
Intellectual Disability
Lipids of myelin, white matter and gray matter in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation.
Intellectual Disability
Prenatal diagnosis of congenital enzymopenic methaemoglobinaemia with mental retardation due to generalized cytochrome b5 reductase deficiency: first report of two cases.
Intellectual Disability
Severe mental retardation and recessive congenital methemoglobinemia in three Indian patients: compound heterozygous for NADH-cytochrome b5 reductase gene mutations.
Intellectual Disability
Soluble and microsomal forms of NADH-cytochrome beta 5 reductase from human placenta. Similarity with NADH-methemoglobin reductase from human erythrocytes.
Intellectual Disability
[An infant with hereditary methemoglobinemia]
Intellectual Disability
[Prenatal diagnosis of generalized cytochrome b5 reductase deficiency (congenital methemoglobinemia with mental retardation, type II) (author's transl)]
Iron Deficiencies
Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice.
Kidney Failure, Chronic
[Effect of methylguanidine and guanidine succinic acid on methemoglobin reductase activity in human red cells]
Leishmaniasis
Changes in hepatic xenobiotic-metabolising enzymes in mouse liver following infection with Leishmania donovani.
Leukemia, Erythroblastic, Acute
Expression of NADH-cytochrome b5 reductase during dimethyl sulfoxide-induced differentiation of Friend erythroleukemia cells.
Lipid Metabolism Disorders
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Lymphatic Metastasis
Cytochrome b5 reductase 2 is a novel candidate tumor suppressor gene frequently inactivated by promoter hypermethylation in human nasopharyngeal carcinoma.
Lymphatic Metastasis
Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis.
Lymphoma
MicroRNA library screening identifies growth-suppressive microRNAs that regulate genes involved in cell cycle progression and apoptosis.
Lymphoma
NADH cytochrome b5 reductase activity in lymphoid cell lines. Expression of the defect in epstein Barr virus transformed lymphoblastoid cell lines from patients with recessive congenital methemoglobinemia.
Lymphoma, B-Cell
MicroRNA library screening identifies growth-suppressive microRNAs that regulate genes involved in cell cycle progression and apoptosis.
Malaria
Changes in rodent-erythrocyte methemoglobin reductase system produced by two malaria parasites, viz. Plasmodium yoelii nigeriensis and Plasmodium berghei.
Metabolic Diseases
NADH cytochrome b5 reductase activity in lymphoid cell lines. Expression of the defect in epstein Barr virus transformed lymphoblastoid cell lines from patients with recessive congenital methemoglobinemia.
Methemoglobinemia
A case of methemoglobinemia type II due to NADH-cytochrome b5 reductase deficiency: determination of the molecular basis.
Methemoglobinemia
A compound heterozygote in the NADH-cytochrome b5 reductase gene from a Chinese patient with hereditary methemoglobinemia type I.
Methemoglobinemia
A linkage and physical map of chromosome 22, and some applications to gene mapping.
Methemoglobinemia
A microplate reader-based method to quantify NADH-cytochrome b5 reductase activity for diagnosis of recessive congenital methaemoglobinemia.
Methemoglobinemia
A novel G143D mutation in the NADH-cytochrome b5 reductase gene in an Indian patient with type I recessive hereditary methemoglobinemia.
Methemoglobinemia
A novel L218P mutation in NADH-cytochrome b5 reductase associated with type I recessive congenital methemoglobinemia.
Methemoglobinemia
A novel mutation found in the 3' domain of NADH-cytochrome B5 reductase in an African-American family with type I congenital methemoglobinemia.
Methemoglobinemia
A novel mutation in the NADH-cytochrome b5 reductase gene of a Chinese patient with recessive congenital methemoglobinemia.
Methemoglobinemia
A Novel Mutation in Type II Methemoglobinemia.
Methemoglobinemia
A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia.
Methemoglobinemia
A novel nine base deletion mutation in NADH-cytochrome b5 reductase gene in an Indian family with recessive congenital methemoglobinemia-type-II.
Methemoglobinemia
A novel point mutation in a 3' splice site of the NADH-cytochrome b5 reductase gene results in immunologically undetectable enzyme and impaired NADH-dependent ascorbate regeneration in cultured fibroblasts of a patient with type II hereditary methemoglobinemia.
Methemoglobinemia
A rare cause of mental motor retardation: recessive congenital methemoglobinemia type II.
Methemoglobinemia
A Thai boy with hereditary enzymopenic methemoglobinemia type II.
Methemoglobinemia
Acquired methemoglobinemia from multiple oxidants.
Methemoglobinemia
Adipose fatty acid composition in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation.
Methemoglobinemia
An in-frame deletion of codon 298 of the NADH-cytochrome b5 reductase gene results in hereditary methemoglobinemia type II (generalized type). A functional implication for the role of the COOH-terminal region of the enzyme.
Methemoglobinemia
Analysis of mutant NADH-cytochrome b5 reductase: apparent "type III" methemoglobinemia can be explained as type I with an unstable reductase.
Methemoglobinemia
Antibody-based spot test for NADH-cytochrome b5 reductase activity for the laboratory diagnosis of congenital methemoglobinemia.
Methemoglobinemia
Blue cures blue but be cautious.
Methemoglobinemia
Characterization of a novel nicotinamide adenine dinucleotide-cytochrome b5 reductase mutation associated with canine hereditary methemoglobinemia.
Methemoglobinemia
Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in cats.
Methemoglobinemia
Clinical, metabolic, and molecular genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in 30 dogs.
Methemoglobinemia
Concentration of NADH-cytochrome b5 reductase in erythrocytes of normal and methemoglobinemic individuals measured with a quantitative radioimmunoblotting assay.
Methemoglobinemia
Congenital erythrocyte enzyme deficiencies.
Methemoglobinemia
Congenital methemoglobinemia due to methemoglobin reductase deficiency in two unrelated American black families.
Methemoglobinemia
Congenital methemoglobinemia due to NADH-methemoglobin reductase deficiency in three Indian families.
Methemoglobinemia
Congenital Methemoglobinemia Identified by Pulse Oximetry Screening.
Methemoglobinemia
Congenital methemoglobinemia methemoglobin reductase deficiency.
Methemoglobinemia
Congenital methemoglobinemia misdiagnosed as polycythemia vera: Case report and review of literature.
Methemoglobinemia
Congenital methemoglobinemia: the result of age-dependent decay of methemoglobin reductase.
Methemoglobinemia
Congenital Recessive Methemoglobinemia Revealed in Adulthood: Description of a New Mutation in Cytochrome b5 Reductase Gene.
Methemoglobinemia
Cyanosis and congenital methemoglobinemia in a puppy.
Methemoglobinemia
Cytochrome b5 reductase: the roles of the recessive congenital methemoglobinemia mutants P144L, L148P, and R159*.
Methemoglobinemia
Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency.
Methemoglobinemia
Dapsone-induced methemoglobinemia: A dose-related occurrence?
Methemoglobinemia
Decrease of palmitoyl-CoA elongation in platelets and leukocytes in the patient of hereditary methemoglobinemia associated with mental retardation.
Methemoglobinemia
Delayed Diagnosis in Army Ranger Postdeployment Primaquine-Induced Methemoglobinemia.
Methemoglobinemia
Determination of concentration of cytosolic NADH-cytochrome b5 reductase in erythrocytes from normal Chinese adults, neonates and patients with hereditary methemoglobinemia by double-antibody sandwich ELISA.
Methemoglobinemia
Enzymatic instability of NADH-cytochrome b5 reductase as a cause of hereditary methemoglobinemia type I (red cell type).
Methemoglobinemia
Enzymopenic hereditary methemoglobinemia.
Methemoglobinemia
Erratum for Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in cats.
Methemoglobinemia
Establishment of monoclonal antibodies against human erythrocyte NADH-cytochrome b5 reductase.
Methemoglobinemia
Evaluation of the methemoglobinemia associated with sulofenur.
Methemoglobinemia
Exonic point mutations in NADH-cytochrome B5 reductase genes of homozygotes for hereditary methemoglobinemia, types I and III: putative mechanisms of tissue-dependent enzyme deficiency.
Methemoglobinemia
Expression of a novel P275L variant of NADH:cytochrome b5 reductase gives functional insight into the conserved motif important for pyridine nucleotide binding.
Methemoglobinemia
Familial Congenital Methemoglobinemia in Pomeranian Dogs Caused by a Missense Variant in the NADH-Cytochrome B5 Reductase Gene.
Methemoglobinemia
Familial idiopathic methemoglobinemia revisited: original cases reveal 2 novel mutations in NADH-cytochrome b5 reductase.
Methemoglobinemia
Four new mutations in the NADH-cytochrome b5 reductase gene from patients with recessive congenital methemoglobinemia type II.
Methemoglobinemia
Hb Chile [beta28(B10)Leu-->Met]: an unstable hemoglobin associated with chronic methemoglobinemia and sulfonamide or methylene blue-induced hemolytic anemia.
Methemoglobinemia
Hereditary methemoglobinemia due to cytochrome b5 reductase deficiency in blood cells without associated neurologic and mental disorders.
Methemoglobinemia
Heterogeneity of the rat NADH-cytochrome-b5-reductase transcripts resulting from multiple alternative first exons.
Methemoglobinemia
Heterologous expression of enzymopenic methemoglobinemia variants using a novel NADH:cytochrome c reductase fusion protein.
Methemoglobinemia
Human cytochrome b5 reductase: structure, function, and potential applications.
Methemoglobinemia
Lipids of liver, kidney, spleen and muscle in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation.
Methemoglobinemia
Lipids of myelin, white matter and gray matter in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation.
Methemoglobinemia
Long-term Treatment with Methylene Blue in a Dog with Hereditary Methemoglobinemia Caused by Cytochrome b5 Reductase Deficiency.
Methemoglobinemia
Methemoglobin reductase (cytochrome b5 reductase) deficiency in congenital methemoglobinemia.
Methemoglobinemia
Methemoglobin reductase activity and in vitro sensitivity towards oxidant induced methemoglobinemia in swiss mice and beagle dogs erythrocytes.
Methemoglobinemia
Methemoglobinemia and eccentrocytosis in equine erythrocyte flavin adenine dinucleotide deficiency.
Methemoglobinemia
Methemoglobinemia as a complication of 20% benzocaine spray for endoscopy.
Methemoglobinemia
Methemoglobinemia in a young man.
Methemoglobinemia
Methemoglobinemia in bronchoscopy: a case series and a review of the literature.
Methemoglobinemia
Methemoglobinemia in children with acute lymphoblastic leukemia (ALL) receiving dapsone for pneumocystis carinii pneumonia (PCP) prophylaxis: a correlation with cytochrome b5 reductase (Cb5R) enzyme levels.
Methemoglobinemia
Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue treatment.
Methemoglobinemia
Metoclopramide-induced methemoglobinemia in an adult.
Methemoglobinemia
Molecular basis of recessive congenital methemoglobinemia, types I and II: Exon skipping and three novel missense mutations in the NADH-cytochrome b5 reductase (diaphorase 1) gene.
Methemoglobinemia
Molecular basis of two novel mutations found in type I methemoglobinemia.
Methemoglobinemia
Mutation update: Variants of the CYB5R3 gene in recessive congenital methemoglobinemia.
Methemoglobinemia
NADH cytochrome b5 reductase activity in lymphoid cell lines. Expression of the defect in epstein Barr virus transformed lymphoblastoid cell lines from patients with recessive congenital methemoglobinemia.
Methemoglobinemia
NADH-cytochrome b5 reductase in platelets and leukocytes with special reference to normal levels and to levels in carriers of hereditary methemoglobinemia with or without neurological symptoms.
Methemoglobinemia
New variant of cytochrome b5 reductase deficiency (b5RKurashiki) in red cells, platelets, lymphocytes, and cultured fibroblasts with congenital methemoglobinemia, mental and neurological retardation, and skeletal anomalies.
Methemoglobinemia
Novel mutation (R192C) in CYB5R3 gene causing NADH-cytochrome b5 reductase deficiency in eight Indian patients associated with autosomal recessive congenital methemoglobinemia type-I.
Methemoglobinemia
Pathogenesis, laboratory diagnosis, and clinical implications of erythrocyte enzyme deficiencies in dogs, cats, and horses.
Methemoglobinemia
Pharmacokinetics of sodium nitrite-induced methemoglobinemia in the rat.
Methemoglobinemia
Primaquine-induced severe methemoglobinemia developed during treatment of Plasmodium vivax malarial infection in an Indian family associated with a novel mutation (p.Agr57Trp) in the CYB5R3 gene.
Methemoglobinemia
Profiling the erythrocyte membrane proteome isolated from patients diagnosed with chronic obstructive pulmonary disease.
Methemoglobinemia
Quantitative variations of red-cell cytochrome b5 reductase (NADH-methemoglobin-reductase) in the Algerian population: evidence for defective alleles.
Methemoglobinemia
Recessive congenital methemoglobinemia caused by a rare mechanism: maternal uniparental heterodisomy with segmental isodisomy of a chromosome 22.
Methemoglobinemia
Recessive congenital methemoglobinemia due to NADH-cytochrome b5 reductase deficiency associated with recurrent early pregnancy loss (REPL) in an Indian family.
Methemoglobinemia
Recessive congenital methemoglobinemia type II: Hypoplastic basal ganglia in two siblings with a novel mutation of the cytochrome b5 reductase gene.
Methemoglobinemia
Recessive hereditary methemoglobinemia: two novel mutations in the NADH-cytochrome b5 reductase gene.
Methemoglobinemia
Reexamining the risks of drinking-water nitrates on public health.
Methemoglobinemia
Serine-proline replacement at residue 127 of NADH-cytochrome b5 reductase causes hereditary methemoglobinemia, generalized type.
Methemoglobinemia
Severe mental retardation and recessive congenital methemoglobinemia in three Indian patients: compound heterozygous for NADH-cytochrome b5 reductase gene mutations.
Methemoglobinemia
Severe Methemoglobinemia Secondary to Ferula asafoetida Ingestion in an Infant: A Case Report.
Methemoglobinemia
Soluble and microsomal forms of NADH-cytochrome beta 5 reductase from human placenta. Similarity with NADH-methemoglobin reductase from human erythrocytes.
Methemoglobinemia
Structural analysis of NADH-cytochrome b5 reductase in relation to hereditary methemoglobinemia.
Methemoglobinemia
The Acute Treatment of Methemoglobinemia in Pregnancy.
Methemoglobinemia
The structure of the S127P mutant of cytochrome b5 reductase that causes methemoglobinemia shows the AMP moiety of the flavin occupying the substrate binding site.
Methemoglobinemia
Two novel mutations in the reduced nicotinamide adenine dinucleotide (NADH)-cytochrome b5 reductase gene of a patient with generalized type, hereditary methemoglobinemia.
Methemoglobinemia
Unstable variant of NADH methemoglobin reductase in Puerto Ricans with hereditary methemoglobinemia.
Methemoglobinemia
[A NEW CASE OF RECESSIVE CONGENITAL METHEMOGLOBINEMIA LINKED WITH A DIAPHORASE I DEFICIENCY.]
Methemoglobinemia
[A search for mutations in the DIA1 gene in case of hereditary methemoglobinemia type I in the iakut population]
Methemoglobinemia
[Adaptation of rats following sodium-nitrite-induced methemoglobinemia]
Methemoglobinemia
[An infant with hereditary methemoglobinemia]
Methemoglobinemia
[Arginine-glutamine replacement at residue 57 of NADH-cytochrome b5 reductase in Chinese hereditary methemoglobinemia]
Methemoglobinemia
[Clinical and biological forms of cytochrome b5 reductase deficiency]
Methemoglobinemia
[Congenital deficiency of NADH dependent methemoglobin reductase in erythrocytes of two children with methemoglobinemia]
Methemoglobinemia
[Congenital methemoglobinemia caused by the absence of NADH-dependent methemoglobin reductase in the red blood cells]
Methemoglobinemia
[Congenital methemoglobinemia due to NADH (DPNH) dependent methemoglobin reductase deficiency]
Methemoglobinemia
[Congenital methemoglobinemia with central nervous system damage caused by generalized deficiency of NADH-dependent methemoglobin reductase in a 2-year-old Polish girl]
Methemoglobinemia
[Congenital methemoglobinemia with cytochrome-b5-reductase deficiency: 4th Swiss family]
Methemoglobinemia
[Cyanosis in children caused by inherited methemoglobinemia due to deficiency of NADH-dependent methemoglobin reductase in erythrocytes]
Methemoglobinemia
[Familial case of methemoglobinemia associated with glucose-4-phosphate dehydrogenase deficiency]
Methemoglobinemia
[Genetic injuries in 2 families with congenital methemoglobinemia caused by diaphorase I deficiency]
Methemoglobinemia
[Hereditary methemoglobinemia caused by NADH methemoglobin reductase deficiency]
Methemoglobinemia
[Hereditary methemoglobinemias]
Methemoglobinemia
[Leu 72 Pro mutation in the NADH-cytochrome b5 reductase gene found in a Chinese hereditary methemoglobinemia patient]
Methemoglobinemia
[Methemoglobinemia in an infant due to the transient deficiency of NADH-dependent methemoglobin reductase in erythrocytes]
Methemoglobinemia
[Molecular analysis of the structure of the mutant NADH-cytochrome b5 reductase gene causing methemoglobinemia]
Methemoglobinemia
[Novel large deletion c.22-1320_633+1224del in the CYB5R3 gene from patients with hereditary methemoglobinemia].
Methemoglobinemia
[Population frequency and age of c.806C > T mutation in CYB5R3 gene as cause of recessive congenital methemoglobinemia in Yakutia].
Methemoglobinemia
[Prenatal diagnosis of generalized cytochrome b5 reductase deficiency (congenital methemoglobinemia with mental retardation, type II) (author's transl)]
Methemoglobinemia
[Studies on congenital methemoglobinemia due to a dificiency of methemoglobin reductase in the red blood cells]
Microcephaly
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Movement Disorders
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Nasopharyngeal Carcinoma
Cytochrome b5 reductase 2 is a novel candidate tumor suppressor gene frequently inactivated by promoter hypermethylation in human nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis.
Neoplasm Metastasis
Cytochrome b5 reductase 2 is a novel candidate tumor suppressor gene frequently inactivated by promoter hypermethylation in human nasopharyngeal carcinoma.
Neoplasm Metastasis
Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis.
Neoplasm Metastasis
Microsomal reductase activity in patients with thyroid neoplasms.
Neoplasm Metastasis
NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer.
Neoplasms
Capsaicin alleviates the imbalance in xenobiotic metabolizing enzymes and tumor markers during experimental lung tumorigenesis.
Neoplasms
Cytochrome b5 reductase 2 is a novel candidate tumor suppressor gene frequently inactivated by promoter hypermethylation in human nasopharyngeal carcinoma.
Neoplasms
Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis.
Neoplasms
Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells.
Neoplasms
Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors.
Neoplasms
DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?
Neoplasms
Enhancement of the antineoplastic effect of mitomycin C by dietary fat.
Neoplasms
Evaluation of sulfonamide detoxification pathways in haematologic malignancy patients prior to intermittent trimethoprim-sulfamethoxazole prophylaxis.
Neoplasms
Microsomal reductase activity in patients with thyroid neoplasms.
Neoplasms
Monooxygenase system in Guerins carcinoma of rats under conditions of ?-3 polyunsaturated fatty acids administration.
Neoplasms
NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer.
Neoplasms
Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women.
Neoplasms
Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) in tumor cells.
Neoplasms
[Functional activity of NADH-dependent reductase system in the liver microsomal fraction and Guerin's carcinoma in rats exposed to preliminary irradiation].
Nervous System Diseases
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Nervous System Diseases
Membrane-Bound CYB5R3 Is a Common Effector of Nutritional and Oxidative Stress Response Through FOXO3a and Nrf2.
Neuroblastoma
Cytochrome b5 reductase, a plasma membrane redox enzyme, protects neuronal cells against metabolic and oxidative stress through maintaining redox state and bioenergetics.
Neurologic Manifestations
Hereditary methemoglobinemia due to cytochrome b5 reductase deficiency in blood cells without associated neurologic and mental disorders.
Ovarian Neoplasms
Genome-wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma.
Parasitemia
Effect of beta-arteether treatment on erythrocytic methemoglobin reductase system in Plasmodium yoelii nigeriensis infected mice.
Pneumonia
Methemoglobinemia in children with acute lymphoblastic leukemia (ALL) receiving dapsone for pneumocystis carinii pneumonia (PCP) prophylaxis: a correlation with cytochrome b5 reductase (Cb5R) enzyme levels.
Pneumonia, Pneumocystis
Methemoglobinemia in children with acute lymphoblastic leukemia (ALL) receiving dapsone for pneumocystis carinii pneumonia (PCP) prophylaxis: a correlation with cytochrome b5 reductase (Cb5R) enzyme levels.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Methemoglobinemia in children with acute lymphoblastic leukemia (ALL) receiving dapsone for pneumocystis carinii pneumonia (PCP) prophylaxis: a correlation with cytochrome b5 reductase (Cb5R) enzyme levels.
Protein Deficiency
Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice.
Pulmonary Disease, Chronic Obstructive
Profiling the erythrocyte membrane proteome isolated from patients diagnosed with chronic obstructive pulmonary disease.
Riboflavin Deficiency
Lipid metabolism in riboflavin-deficient rats. 2. Mitochondrial fatty acid oxidation and the microsomal desaturation pathway.
Sarcoma
Effect of extra-hepatic Walker sarcoma 256 on the synthesis and degradation of liver cytochromes P-450 and b5.
Spondylosis
New variant of cytochrome b5 reductase deficiency (b5RKurashiki) in red cells, platelets, lymphocytes, and cultured fibroblasts with congenital methemoglobinemia, mental and neurological retardation, and skeletal anomalies.
Starvation
NCB5OR Deficiency in the Cerebellum and Midbrain Leads to Dehydration and Alterations in Thirst Response, Fasted Feeding Behavior, and Voluntary Exercise in Mice.
Stomatitis
Epidemiological evaluation of recurrent stomatitis, nitrates in drinking water, and cytochrome b5 reductase activity.
Sulfhemoglobinemia
Evaluation of the methemoglobinemia associated with sulofenur.
Thyroid Cancer, Papillary
Microsomal reductase activity in patients with thyroid neoplasms.
Thyroid Neoplasms
Microsomal reductase activity in patients with thyroid neoplasms.
Tremor
Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice.
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Kitajima, S.; Yasukochi, Y.; Minakami, S.
Purification and properties of human erythrocyte membrane NADH-cytochrome b5 reductase
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210
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1981
Homo sapiens
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Rigby, J.S.; Bull, P.C.; Ashworth, A.; Shephard, E.A.; Santisteban, I.; Phillips, I.R.
Isolation and characterization of genes coding for cytochrome b5 and cytochrome-b5 reductase
Biochem. Soc. Trans.
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1989
Homo sapiens
-
brenda
Palmieri, D.A.; Rangachari, A.; Butterfield, D.A.
Effects of domain-specific erythrocyte membrane modulators on acetylcholinesterase and NADH:cytochrome b5 reductase activities
Arch. Biochem. Biophys.
280
224-228
1990
Homo sapiens
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Shirabe, K.; Yubisui, T.; Takeshita, M.
Expression of human erythrocyte NADH-cytochrome b5 reductase as an alpha-thrombin-cleavable fused protein in Escherichia coli
Biochim. Biophys. Acta
1008
189-192
1989
Homo sapiens
brenda
Murakami, K.; Yubisui, T.; Takeshita, M.; Miyata, T.
The NH2-terminal structures of human and rat liver microsomal NADH-cytochrome b5 reductases
J. Biochem.
105
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1989
Homo sapiens
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Takano, T.; Ogawa, K.; Sato, M.; Bando, S.; Yubisui, T.
Preliminary X-ray data of NADH-cytochrome b5 reductase from human erythrocytes
J. Mol. Biol.
195
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1987
Oryctolagus cuniculus, Homo sapiens
brenda
Tauber, A.I.; Wright, J.; Higson, F.K.; Edelman, S.A.; Waxman, D.J.
Purification and characterization of the human neutrophil NADH-cytochrome b5 reductase
Blood
66
673-678
1985
Homo sapiens
brenda
Kitajima, S.; Minakami, S.
Human NADH-cytochrome b5 reductases: comparison among those of erythrocyte membrane, erythrocyte cytosol, and liver microsomes
J. Biochem.
93
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1983
Homo sapiens
brenda
Badwey, J.A.; Tauber, A.I.; Karnovsky, M.L.
Properties of NADH-cytochrome-b5 reductase from human neutrophils
Blood
62
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1983
Homo sapiens
brenda
Yubisui, T.; Takeshita, M.
Characterization of the purified NADH-cytochrome b5 reductase of human erythrocytes as a FAD-containing enzyme
J. Biol. Chem.
255
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1980
Homo sapiens
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Hultquist, D.E.
Methemoglobin reduction system of erythrocytes
Methods Enzymol.
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463-473
1978
Homo sapiens
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Ortiz de Montellano, P.R.
Cytochrome P450-Structure, Mechanism and Biochemistry
Cytochrome P450. Structure, Mechanism Biochem. (Ortiz de Montellano, P. R. ed. ) Plenum Press, New York
1986
Homo sapiens
-
brenda
Hultquist, D.E.; Passon, P.G.
Catalysis of methaemoglobin reduction by erythrocyte cytochrome b5 and cytochrome b5 reductase
Nat. New Biol.
229
252-254
1971
Homo sapiens
brenda
Yubisui, T.; Naitoh, Y.; Zenno, S.; Tamura, M.; Takeshita, M.; Sakaki, Y.
Molecular cloning of cDNAs of human liver and placenta NADH-cytochrome b5 reductase
Proc. Natl. Acad. Sci. USA
84
3609-3613
1987
Homo sapiens
brenda
Fujimoto, Y.; Shirabe, K.; Nagai, T.; Yubisui, T.; Takeshita, M.
Role of Lys-110 of human NADH-cytochrome b5 reductase in NADH binding as probed by site-directed mutagenesis
FEBS Lett.
322
30-32
1993
Homo sapiens
brenda
Mota Vieira, L.; Kaplan, J.C.; Kahn, A.; Leroux, A.
Heterogeneity of the rat NADH-cytochrome-b5-reductase transcripts resulting from multiple alternative first exons
Eur. J. Biochem.
220
729-737
1994
Homo sapiens, Rattus norvegicus
brenda
Barham, H.M.; Inglis, R.; Chinje, E.C.; Stratford, I.J.
Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells
Br. J. Cancer
74
1188-1193
1996
Homo sapiens
brenda
Kawano, M.; Shirabe, K.; Nagai, T.; Takeshita, M.
Role of carboxyl residues surrounding heme of human cytochrome b5 in the electrostatic interaction with NADH-cytochrome b5 reductase
Biochem. Biophys. Res. Commun.
245
666-669
1998
Homo sapiens
brenda
Bando, S.; Takano, T.; Yubisui, T.; Shirabe, K.; Takeshita, M.; Nakagawa, A.
Structure of human erythrocyte NADH-cytochrome b5 reductase
Acta Crystallogr. Sect. D
60
1929-1934
2004
Homo sapiens
brenda
Mokashi, V.; Li, L.; Porter, T.D.
Cytochrome b5 reductase and cytochrome b5 support the CYP2E1-mediated activation of nitrosamines in a recombinant Ames test
Arch. Biochem. Biophys.
412
147-152
2003
Homo sapiens
brenda
Baker, M.A.; Krutskikh, A.; Curry, B.J.; Hetherington, L.; Aitken, R.J.
Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa
Biol. Reprod.
73
334-42
2005
Homo sapiens (Q6BCY4), Homo sapiens
brenda
Bello, R.I.; Alcain, F.J.; Gomez-Diaz, C.; Lopez-Lluch, G.; Navas, P.; Villalba, J.M.
Hydrogen peroxide- and cell-density-regulated expression of NADH-cytochrome b5 reductase in HeLa cells
J. Bioenerg. Biomembr.
35
169-179
2003
Homo sapiens
brenda
Kurian, J.R.; Bajad, S.U.; Miller, J.L.; Chin, N.A.; Trepanier, L.A.
NADH cytochrome b5 reductase and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans
J. Pharmacol. Exp. Ther.
311
1171-1178
2004
Homo sapiens
brenda
Percy, M.J.; Crowley, L.J.; Boudreaux, J.; Barber, M.J.
Expression of a novel P275L variant of NADH:cytochrome b5 reductase gives functional insight into the conserved motif important for pyridine nucleotide binding
Arch. Biochem. Biophys.
447
59-67
2006
Homo sapiens (P00387), Homo sapiens
brenda
Percy, M.J.; Crowley, L.J.; Roper, D.; Vulliamy, T.J.; Layton, D.M.; Barber, M.J.
Identification and characterization of the novel FAD-binding lobe G75S mutation in cytochrome b(5) reductase: an aid to determine recessive congenital methemoglobinemia status in an infant
Blood Cells Mol. Dis.
36
81-90
2006
Homo sapiens
brenda
Percy, M.J.; Crowley, L.J.; Davis, C.A.; McMullin, M.F.; Savage, G.; Hughes, J.; McMahon, C.; Quinn, R.J.; Smith, O.; Barber, M.J.; Lappin, T.R.
Recessive congenital methaemoglobinaemia: functional characterization of the novel D239G mutation in the NADH-binding lobe of cytochrome b5 reductase
Br. J. Haematol.
129
847-853
2005
Homo sapiens
brenda
Kurian, J.R.; Chin, N.A.; Longlais, B.J.; Hayes, K.L.; Trepanier, L.A.
Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5
Chem. Res. Toxicol.
19
1366-1373
2006
Homo sapiens
brenda
Saulter, J.Y.; Kurian, J.R.; Trepanier, L.A.; Tidwell, R.R.; Bridges, A.S.; Boykin, D.W.; Stephens, C.E.; Anbazhagan, M.; Hall, J.E.
Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase
Drug Metab. Dispos.
33
1886-1893
2005
Homo sapiens
brenda
Kedar, P.S.; Warang, P.; Nadkarni, A.H.; Colah, R.B.; Ghosh, K.
A novel G143D mutation in the NADH-cytochrome b5 reductase gene in an Indian patient with type I recessive hereditary methemoglobinemia
Blood Cells Mol. Dis.
40
323-327
2008
Homo sapiens (P00387)
brenda
Fermo, E.; Bianchi, P.; Vercellati, C.; Marcello, A.P.; Garatti, M.; Marangoni, O.; Barcellini, W.; Zanella, A.
Recessive hereditary methemoglobinemia: two novel mutations in the NADH-cytochrome b5 reductase gene
Blood Cells Mol. Dis.
41
50-55
2008
Homo sapiens (P00387), Homo sapiens
brenda
Percy, M.J.; Lappin, T.R.
Recessive congenital methaemoglobinaemia: cytochrome b(5) reductase deficiency
Br. J. Haematol.
141
298-308
2008
Homo sapiens (P00387), Homo sapiens, Rattus norvegicus (P20070)
brenda
Percy, M.J.; Aslan, D.
NADH-cytochrome b5 reductase in a Turkish family with recessive congenital methaemoglobinaemia type I
J. Clin. Pathol.
61
1122-1123
2008
Homo sapiens
brenda
Deng, B.; Parthasarathy, S.; Wang, W.; Gibney, B.R.; Battaile, K.P.; Lovell, S.; Benson, D.R.; Zhu, H.
Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain
J. Biol. Chem.
285
30181-30191
2010
Homo sapiens (Q7L1T6), Homo sapiens
brenda
Arikoglu, T.; Yarali, N.; Kara, A.; Bay, A.; Bozkaya, I.O.; Tunc, B.; Percy, M.J.
A novel L218P mutation in NADH-cytochrome b5 reductase associated with type I recessive congenital methemoglobinemia
Pediatr. Hematol. Oncol.
26
381-385
2009
Homo sapiens
brenda
Elahian, F.; Sepehrizadeh, Z.; Moghimi, B.; Mirzaei, S.A.
Human cytochrome b5 reductase: structure, function, and potential applications
Crit. Rev. Biotechnol.
2012
1-11
2012
Homo sapiens
brenda
Rawa, K.; Chelmecka-Hanusiewicz, L.; Plochocka, D.; Pawinska-Wasikowska, K.; Balwierz, W.; Burzynska, B.
Characterization of a novel mutation in the NADH-cytochrome b5 reductase gene responsible for rare hereditary methaemoglobinaemia type I
Acta Haematol.
130
122-125
2013
Homo sapiens
brenda
Hyun, D.; Lee, G.
Cytochrome b5 reductase, a plasma membrane redox enzyme, protects neuronal cells against metabolic and oxidative stress through maintaining redox state and bioenergetics
Age (Dordr)
37
122
2015
Homo sapiens
brenda
Amdahl, M.B.; Sparacino-Watkins, C.E.; Corti, P.; Gladwin, M.T.; Tejero, J.
Efficient reduction of vertebrate cytoglobins by the cytochrome b5/cytochrome b5 reductase/NADH system
Biochemistry
56
3993-4004
2017
Homo sapiens (P00387), Homo sapiens
brenda
Ming, H.; Lan, Y.; He, F.; Xiao, X.; Zhou, X.; Zhang, Z.; Li, P.; Huang, G.
Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis
Chin. J. Cancer
34
459-467
2015
Homo sapiens
brenda
Elahian, F.; Sepehrizadeh, Z.; Moghimi, B.; Mirzaei, S.
Human cytochrome b5 reductase Structure, function, and potential applications
Crit. Rev. Biotechnol.
34
134-143
2014
Homo sapiens, Arabidopsis thaliana (A0A178US77), Bos taurus (P07514)
-
brenda
Plitzko, B.; Havemeyer, A.; Bork, B.; Bittner, F.; Mendel, R.; Clement, B.
Defining the role of the NADH-cytochrome-b5 reductase 3 in the mitochondrial amidoxime reducing component enzyme system
Drug Metab. Dispos.
44
1617-1621
2016
Homo sapiens
brenda
Zambo, V.; Toth, M.; Schlachter, K.; Szelenyi, P.; Sarnyai, F.; Lotz, G.; Csala, M.; Kereszturi, E.
Cytosolic localization of NADH cytochrome b5 oxidoreductase (Ncb5or)
FEBS Lett.
590
661-671
2016
Homo sapiens (Q7L1T6)
brenda
Rahaman, M.M.; Reinders, F.G.; Koes, D.; Nguyen, A.T.; Mutchler, S.M.; Sparacino-Watkins, C.; Alvarez, R.A.; Miller, M.P.; Cheng, D.; Chen, B.B.; Jackson, E.K.; Camacho, C.J.; Straub, A.C.
Structure guided chemical modifications of propylthiouracil reveal novel small molecule inhibitors of cytochrome b5 reductase 3 that increase nitric oxide bioavailability
J. Biol. Chem.
290
16861-16872
2015
Homo sapiens (P00387)
brenda
Lund, R.R.; Leth-Larsen, R.; Caterino, T.D.; Terp, M.G.; Nissen, J.; Laenkholm, A.V.; Jensen, O.N.; Ditzel, H.J.
NADH-cytochrome b5 reductase 3 promotes colonization and metastasis formation and is a prognostic marker of disease-free and overall survival in estrogen receptor-negative breast cancer
Mol. Cell. Proteomics
14
2988-2999
2015
Homo sapiens (P00387), Homo sapiens
brenda
Xiao, X.; Zhao, W.; Tian, F.; Zhou, X.; Zhang, J.; Huang, T.; Hou, B.; Du, C.; Wang, S.; Mo, Y.; Yu, N.; Zhou, S.; You, J.; Zhang, Z.; Huang, G.; Zeng, X.
Cytochrome b5 reductase 2 is a novel candidate tumor suppressor gene frequently inactivated by promoter hypermethylation in human nasopharyngeal carcinoma
Tumour Biol.
35
3755-3763
2014
Homo sapiens
brenda
Benson, D.; Lovell, S.; Mehzabeen, N.; Galeva, N.; Cooper, A.; Gao, P.; Battaile, K.; Zhu, H.
Crystal structures of the naturally fused CS and cytochrome b5 reductase (b5R) domains of Ncb5or reveal an expanded CS fold, extensive CS-b5R interactions and productive binding of the NAD(P)+ nicotinamide ring
Acta Crystallogr. Sect. D
75
628-638
2019
Homo sapiens (Q7L1T6)
brenda
Samhan-Arias, A.K.; Almeida, R.M.; Ramos, S.; Cordas, C.M.; Moura, I.; Gutierrez-Merino, C.; Moura, J.J.G.
Topography of human cytochrome b5/cytochrome b5 reductase interacting domain and redox alterations upon complex formation
Biochim. Biophys. Acta Bioenerg.
1859
78-87
2018
Homo sapiens (P00387)
brenda
Kedar, P.; Desai, A.; Warang, P.; Colah, R.
A microplate reader-based method to quantify NADH-cytochrome b5 reductase activity for diagnosis of recessive congenital methaemoglobinemia
Hematology
22
252-257
2017
Homo sapiens (P00387)
brenda
Samhan-Arias, A.K.; Fortalezas, S.; Cordas, C.M.; Moura, I.; Moura, J.J.G.; Gutierrez-Merino, C.
Cytochrome b5 reductase is the component from neuronal synaptic plasma membrane vesicles that generates superoxide anion upon stimulation by cytochrome c
Redox Biol.
15
109-114
2018
Homo sapiens, Rattus norvegicus
brenda
Szilagyi, J.T.; Fussell, K.C.; Wang, Y.; Jan, Y.H.; Mishin, V.; Richardson, J.R.; Heck, D.E.; Yang, S.; Aleksunes, L.M.; Laskin, D.L.; Laskin, J.D.
Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase
Toxicol. Appl. Pharmacol.
359
102-107
2018
Homo sapiens
brenda