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Information on EC 1.5.5.1 - electron-transferring-flavoprotein dehydrogenase and Organism(s) Caenorhabditis elegans

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IUBMB Comments
An iron-sulfur flavoprotein, forming part of the mitochondrial electron-transfer system.
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Caenorhabditis elegans
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Word Map
The taxonomic range for the selected organisms is: Caenorhabditis elegans
The enzyme appears in selected viruses and cellular organisms
Synonyms
electron transfer flavoprotein, etfdh, etf-qo, etf:qo, electron transfer flavoprotein dehydrogenase, electron transfer flavoprotein-ubiquinone oxidoreductase, etf dehydrogenase, etf-ubiquinone oxidoreductase, electron transfer flavoprotein:ubiquinone oxidoreductase, electron-transferring-flavoprotein dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
electron flavoprotein reductase
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electron transfer flavoprotein dehydrogenase
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electron transfer flavoprotein Q oxidoreductase
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electron transfer flavoprotein-ubiquinone oxidoreductase
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electron-transferring flavoprotein dehydrogenase
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Electron-transferring-flavoprotein dehydrogenase
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ETF dehydrogenase
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ETF-QO
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ETF-ubiquinone oxidoreductase
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ETF:ubiquinone oxidoreductase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
electron-transferring-flavoprotein:ubiquinone oxidoreductase
An iron-sulfur flavoprotein, forming part of the mitochondrial electron-transfer system.
CAS REGISTRY NUMBER
COMMENTARY hide
86551-03-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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RNA transcribed in somatic gonads
Manually annotated by BRENDA team
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RNA transcribed
Manually annotated by BRENDA team
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RNA transcribed
Manually annotated by BRENDA team
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RNA transcribed in body wall muscle
Manually annotated by BRENDA team
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RNA transcribed
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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ETFDH is an inner mitochondrial membrane localized enzyme
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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three cis-regulatory sequences (pha-site, rep-site, and act-site) are identified. Phylogenetic footprinting of each site indicates that they are conserved between four Caenorhabditis species. Results show that let-721 is under complex transcriptional control
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ETFD_CAEEL
597
0
65335
Swiss-Prot
Mitochondrion (Reliability: 2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G362E
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mutation occurs in one of two beta-sheets that form the structure of the FAD binding domain likely disrupting the secondary structur. Phenotype of homozygous let-721 mutant is maternal effects lethality. F1 homozygotes have no gross morphological or developmental defects. The maternal effect lethal manifests as the self-fertilized offspring arrest as unhatched embryos. F1 worms are also self semi-sterile, as unmated homozygous mutants produce significantly fewer embryos than wild-type worms
S61F
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affected residue lies within a conserved domain that interacts with the adenine monophosphate moiety of the FAD prosthetic group. Phenotype of homozygous let-721 mutant is maternal effects lethality. F1 homozygotes have no gross morphological or developmental defects. The maternal effect lethal manifests as the self-fertilized offspring arrest as unhatched embryos. F1 worms are also self semi-sterile, as unmated homozygous mutants produce significantly fewer embryos than wild-type worms
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chew, D.S.; Mah, A.K.; Baillie, D.L.
Characterizing the transcriptional regulation of let-721, a Caenorhabditis elegans homolog of human electron flavoprotein dehydrogenase
Mol. Genet. Genomics
282
555-570
2009
Caenorhabditis elegans
Manually annotated by BRENDA team