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Information on EC 1.5.3.7 - L-pipecolate oxidase and Organism(s) Homo sapiens

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EC Tree
     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
                1.5.3.7 L-pipecolate oxidase
IUBMB Comments
The product reacts with water to form (S)-2-amino-6-oxohexanoate.
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
pipox, l-pipecolate oxidase, pipecolate oxidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L-pipecolate oxidase
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L-pipecolic acid oxidase
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-
-
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pipecolate oxidase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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-
-
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redox reaction
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-
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reduction
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-
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-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
L-pipecolate:oxygen 1,6-oxidoreductase
The product reacts with water to form (S)-2-amino-6-oxohexanoate.
CAS REGISTRY NUMBER
COMMENTARY hide
81669-65-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-pipecolate + O2
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
show the reaction diagram
L-pipecolate + O2
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
show the reaction diagram
L-pipecolate + O2
DELTA1-piperideine-6-carboxylate + H2O2
show the reaction diagram
-
-
-
?
L-proline + O2
?
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-pipecolate + O2
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
show the reaction diagram
pipecolate metabolism leads to protection against H2O2 stress in mammalian cells. The enzyme is necessary for pipecolate protection
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-
?
L-pipecolate + O2
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
show the reaction diagram
L-pipecolate + O2
DELTA1-piperideine-6-carboxylate + H2O2
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.7
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
knockdown of the enzyme by small interference RNA abolishes pipecolate protection against hydrogen peroxide-induced cell death in HEK293 cells suggesting a critical role for this enzyme
physiological function
pipecolate metabolism leads to protection against H2O2 stress in mammalian cells. The enzyme is necessary for pipecolate protection
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SOX_HUMAN
390
1
44066
Swiss-Prot
other Location (Reliability: 2)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 44000, calculated from amino acid sequence
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed as a chimera between maltose-binding protein and L-pipecolic acid oxidase
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expressed in Escherichia coli BL21
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dodt, G.; Kim, D.; Reimann, S.; McCabe, K.; Gould, S.J.; Mihalik, S.J.
The human L-pipecolic acid oxidase is similar to bacterial monomeric sarcosine oxidases rather than D-amino acid oxidases
Cell Biochem. Biophys.
32
313-316
2000
Homo sapiens
Manually annotated by BRENDA team
Ijlst, L.; de Kromme, I.; Oostheim, W.; Wanders, R.J.A.
Molecular cloning and expression of human L-pipecolate oxidase
Biochem. Biophys. Res. Commun.
270
1101-1105
2000
Homo sapiens
Manually annotated by BRENDA team
Rao, V.V.; Chang, Y.F.
L-Pipecolic acid metabolism in human liver: detection of L-pipecolate oxidase and identification of its reaction product
Biochim. Biophys. Acta
1038
295-299
1990
Homo sapiens
Manually annotated by BRENDA team
Wanders, R.J.A.; Romeyn, G.J.; Schutgens, R.B.H.; Tager, J.M.
L-pipecolate oxidase: a distinct peroxisomal enzyme in man
Biochem. Biophys. Res. Commun.
164
550-555
1989
Homo sapiens
Manually annotated by BRENDA team
Natarajan, S.K.; Muthukrishnan, E.; Khalimonchuk, O.; Mott, J.L.; Becker, D.F.
Evidence for pipecolate oxidase in mediating protection against hydrogen peroxide stress
J. Cell. Biochem.
118
1678-1688
2017
Homo sapiens, Homo sapiens (Q9P0Z9)
Manually annotated by BRENDA team