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10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
additional information
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10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
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10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
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10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
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10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
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10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
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Cys-707 is involved in enzyme activity
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10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
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enzyme is an important factor in regulation of formate oxidation and is related with methanol poisoning
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10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
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folate-dependent metabolism of formate to carbon dioxide
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10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
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regulation of the ratio of 10-formyltetrahydrofolate to tetrahydrofolate and of the purine biosynthesis through control of the level of 10-formyltetrahydrofolate, down-regulation of FDH in tumors is one of the cellular mechanisms that enhance proliferation, FDH possesses tumor specific suppressor effects
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10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
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folate-dependent pathway is the exclusive route of formate metabolism in primates, plays major role in disposition of formate generated from one-carbon moieties of environmental chemicals, drugs, and foods, importance in the toxicity of methanol
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additional information
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FDH-expressing cells show accumulation of cells in G0-G1 phase and a sharp decrease of cells in S phase. Accumulation of the tumor suppressor protein p53 and its downstream target p21. FDH antiproliferative effects on A549 cells include both G1 cell cycle arrest and caspase-dependent apoptosis
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additional information
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activation of p53 tumor suppressor protein-dependent pathways is a general downstream mechanism in response to induction of enzyme expression in p53 functional cancer cells
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10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
additional information
?
-
10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
-
-
-
-
?
10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
-
enzyme is an important factor in regulation of formate oxidation and is related with methanol poisoning
-
?
10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
-
folate-dependent metabolism of formate to carbon dioxide
-
?
10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
-
regulation of the ratio of 10-formyltetrahydrofolate to tetrahydrofolate and of the purine biosynthesis through control of the level of 10-formyltetrahydrofolate, down-regulation of FDH in tumors is one of the cellular mechanisms that enhance proliferation, FDH possesses tumor specific suppressor effects
-
?
10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
-
folate-dependent pathway is the exclusive route of formate metabolism in primates, plays major role in disposition of formate generated from one-carbon moieties of environmental chemicals, drugs, and foods, importance in the toxicity of methanol
-
?
additional information
?
-
-
FDH-expressing cells show accumulation of cells in G0-G1 phase and a sharp decrease of cells in S phase. Accumulation of the tumor suppressor protein p53 and its downstream target p21. FDH antiproliferative effects on A549 cells include both G1 cell cycle arrest and caspase-dependent apoptosis
-
-
?
additional information
?
-
-
activation of p53 tumor suppressor protein-dependent pathways is a general downstream mechanism in response to induction of enzyme expression in p53 functional cancer cells
-
-
?
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Acute Kidney Injury
Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2.
Adenocarcinoma of Lung
Epigenetic Silencing of ALDH1L1, a Metabolic Regulator of Cellular Proliferation, in Cancers.
Adenocarcinoma of Lung
The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer.
Astrocytoma
Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes.
Breast Neoplasms
Deep Sequencing Revealed a CpG Methylation Pattern Associated With ALDH1L1 Suppression in Breast Cancer.
Breast Neoplasms
Regional methylome profiling reveals dynamic epigenetic heterogeneity and convergent hypomethylation of stem cell quiescence-associated genes in breast cancer following neoadjuvant chemotherapy.
Carcinogenesis
ALDH1L1 and ALDH1L2 Folate Regulatory Enzymes in Cancer.
Carcinogenesis
Decreased expression of ALDH1L1 is associated with a poor prognosis in hepatocellular carcinoma.
Carcinogenesis
Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis.
Carcinogenesis
Reply to Krupenko et al. Comment on "Lee et al. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer Cancers 2020, 12, 1382".
Carcinoma, Hepatocellular
ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma.
Carcinoma, Hepatocellular
Decreased expression of ALDH1L1 is associated with a poor prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis.
Carcinoma, Non-Small-Cell Lung
Reply to Krupenko et al. Comment on "Lee et al. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer Cancers 2020, 12, 1382".
Carcinoma, Non-Small-Cell Lung
The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer.
Colonic Neoplasms
Investigation of Schwann cells at neoplastic cell sites before the onset of cancer invasion.
Colonic Neoplasms
[Functional Hypermethylation of ALDH1L1, PLCL2, and PPP2R3A in Colon Cancer].
Dementia
The Therapeutic Targets of Fingolimod (FTY720) Are Involved in Pathological Processes in the Frontal Cortex of Alzheimer's Disease Patients: A Network Pharmacology Study.
dna (cytosine-5-)-methyltransferase deficiency
A necessary role of DNMT3A in endurance exercise by suppressing ALDH1L1-mediated oxidative stress.
Epilepsy
Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy.
Hallucinations
Identification of blood biomarkers for psychosis using convergent functional genomics.
Hepatitis
ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma.
Hydrocephalus
Neonatal hydrocephalus is a result of a block in folate handling and metabolism involving 10-formyltetrahydrofolate dehydrogenase.
Hyperthyroidism
Quantification of the carbon flow through the folate-dependent one-carbon pool using radiolabeled histidine: effect of altered thyroid and folate status.
Ischemic Stroke
Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke.
Lung Neoplasms
Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion.
Lung Neoplasms
Reply to Krupenko et al. Comment on "Lee et al. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer Cancers 2020, 12, 1382".
Lung Neoplasms
The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer.
Lymphoma, T-Cell
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential.
Neoplasm Metastasis
ALDH1L1 and ALDH1L2 Folate Regulatory Enzymes in Cancer.
Neoplasm Metastasis
Oxidative stress inhibits distant metastasis by human melanoma cells.
Neoplasms
10-formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells.
Neoplasms
10-formyltetrahydrofolate dehydrogenase-induced c-Jun-NH2-kinase pathways diverge at the c-Jun-NH2-kinase substrate level in cells with different p53 status.
Neoplasms
Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.
Neoplasms
ALDH1L1 and ALDH1L2 Folate Regulatory Enzymes in Cancer.
Neoplasms
ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A.
Neoplasms
ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma.
Neoplasms
ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase.
Neoplasms
Cancer cells activate p53 in response to 10-formyltetrahydrofolate dehydrogenase expression.
Neoplasms
CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase.
Neoplasms
Decreased expression of ALDH1L1 is associated with a poor prognosis in hepatocellular carcinoma.
Neoplasms
Ectopic expression of 10-formyltetrahydrofolate dehydrogenase in A549 cells induces G1 cell cycle arrest and apoptosis.
Neoplasms
Epigenetic alterations of chromosome 3 revealed by NotI-microarrays in clear cell renal cell carcinoma.
Neoplasms
Epigenetic Silencing of ALDH1L1, a Metabolic Regulator of Cellular Proliferation, in Cancers.
Neoplasms
Folate Stress Induces Apoptosis via p53-Dependent de novo Ceramide Synthesis and Up-Regulation of Ceramide Synthase 6.
Neoplasms
Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes.
Neoplasms
Investigation of Schwann cells at neoplastic cell sites before the onset of cancer invasion.
Neoplasms
Is ALDH1L1 Elevated in Lung Cancer? Comment on: Lee, S.-H.; et al. "The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer" Cancers 2020, 12, 1382.
Neoplasms
JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1.
Neoplasms
Knocking down 10-Formyltetrahydrofolate dehydrogenase increased oxidative stress and impeded zebrafish embryogenesis by obstructing morphogenetic movement.
Neoplasms
Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis.
Neoplasms
Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression.
Neoplasms
Novel tumor suppressor candidates on chromosome 3 revealed by NotI-microarrays in cervical cancer.
Neoplasms
Oxidative stress inhibits distant metastasis by human melanoma cells.
Neoplasms
Reply to Krupenko et al. Comment on "Lee et al. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer Cancers 2020, 12, 1382".
Neoplasms
The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer.
Neoplasms
The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review).
Neoplasms
The Role of Single-Nucleotide Polymorphisms in the Function of Candidate Tumor Suppressor ALDH1L1.
Neoplasms
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential.
Neural Tube Defects
Association between ALDH1L1 gene polymorphism and neural tube defects in the Chinese Han population.
Neural Tube Defects
The folate metabolic enzyme ALDH1L1 is restricted to the midline of the early CNS, suggesting a role in human neural tube defects.
Neuroblastoma
Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma.
Ovarian Neoplasms
Prognostic values of aldehyde dehydrogenase 1 isoenzymes in ovarian cancer.
Prostatic Neoplasms
JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1.
Protein Deficiency
Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice.
Spinal Dysraphism
An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).
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transformed embryonic kidney cell line HEK-293A
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moderate FDH mRNA level
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moderate FDH mRNA level
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moderate FDH mRNA level
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much lower levels than in liver, preferentially localized in Müller cells, FDH levels in human retina are higher than in rat retina, folate levels in human retina are 14% of those in rat retina
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moderate FDH mRNA level
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moderate FDH mRNA level
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significantly decreased levels of FDH and its mRNA in 15 tested tumors compared with normal tissues, strong down-regulation of FDH on both the mRNA and protein level in tumors
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inducible expression of 10-formyltetrahydrofolate dehydrogenase
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moderate FDH mRNA level
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most highly expressed in pancreas, heart and brain
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moderate FDH mRNA level
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most highly expressed in pancreas, heart and brain
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mainly expressed in
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high FDH mRNA level, specialized organ of folate metabolism
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most highly expressed in pancreas, liver and kidney
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activity in human liver is 26% of that in rat liver, reduced amount of enzyme in human liver
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specialized organ of folate metabolism
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high FDH mRNA level
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mainly expressed in fetal liver
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most highly expressed in pancreas, liver and kidney
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mainly expressed in skeletal muscle
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moderate FDH mRNA level in skeletal muscle
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high FDH mRNA level
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most highly expressed in pancreas, heart and brain
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most highly expressed in pancreas, liver and kidney
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additional information
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FDH expression is highly tissue specific, very low or nondetectable levels of FDH mRNA in placenta, spleen, colon, small intestine, and leukocytes
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additional information
cytosolic FDH mRNa is not detectable in cancer cells
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additional information
cytosolic FDH mRNa is not detectable in cancer cells
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additional information
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cytosolic FDH mRNa is not detectable in cancer cells
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additional information
In contrast to the cytosolic enzyme, mtFDH mRNA and protein are clearly present in cancer cell lines
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additional information
In contrast to the cytosolic enzyme, mtFDH mRNA and protein are clearly present in cancer cell lines
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additional information
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In contrast to the cytosolic enzyme, mtFDH mRNA and protein are clearly present in cancer cell lines
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Johlin, F.C.; Swain, E.; Smith, C.; Tephly, T.R.
Studies on the mechanism of methanol poisoning: purification and comparison of rat and human liver 10-formyltetrahydrofolate dehydrogenase
Mol. Pharmacol.
35
745-750
1989
Homo sapiens, Rattus norvegicus
brenda
Hong, M.; Lee, Y.; Kim, J.W.; Lim, J.S.; Chang, S.Y.; Lee, K.S.; Paik, S.G.; Choe, I.S.
Isolation and characterization of cDNA clone for human liver 10-formyltetrahydrofolate dehydrogenase
Biochem. Mol. Biol. Int.
47
407-415
1999
Homo sapiens
brenda
Krupenko, S.A.; Oleinik, N.V.
10-Formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells
Cell Growth Differ.
13
227-236
2002
Homo sapiens, Rattus norvegicus
brenda
Martinasevic, M.K.; Green, M.D.; Baron, J.; Tephly, T.R.
Folate and 10-formyltetrahydrofolate dehydrogenase in human and rat retina: Relation to methanol toxicity
Toxicol. Appl. Pharmacol.
141
373-381
1996
Homo sapiens, Rattus norvegicus
brenda
Oleinik, N.V.; Krupenko, S.A.
Ectopic expression of 10-formyltetrahydrofolate dehydrogenase in A549 cells induces G1 cell cycle arrest and apoptosis
Mol. Cancer Res.
1
577-588
2003
Homo sapiens
brenda
Oleinik, N.V.; Krupenko, N.I.; Priest, D.G.; Krupenko, S.A.
Cancer cells activate p53 in response to 10-formyltetrahydrofolate dehydrogenase expression
Biochem. J.
391
503-511
2005
Homo sapiens
brenda
Strickland, K.C.; Hoeferlin, L.A.; Oleinik, N.V.; Krupenko, N.I.; Krupenko, S.A.
Acyl carrier protein-specific 4-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase
J. Biol. Chem.
285
1627-1633
2010
Homo sapiens
brenda
Krupenko, N.I.; Dubard, M.E.; Strickland, K.C.; Moxley, K.M.; Oleinik, N.V.; Krupenko, S.A.
ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase
J. Biol. Chem.
285
23056-23063
2010
Homo sapiens (O75891), Homo sapiens (Q3SY69), Homo sapiens
brenda
Ghose, S.; Oleinik, N.V.; Krupenko, N.I.; Krupenko, S.A.
10-formyltetrahydrofolate dehydrogenase-induced c-Jun-NH2-kinase pathways diverge at the c-Jun-NH2-kinase substrate level in cells with different p53 status
Mol. Cancer Res.
7
99-107
2009
Homo sapiens
brenda
Strickland, K.C.; Krupenko, N.I.; Dubard, M.E.; Hu, C.J.; Tsybovsky, Y.; Krupenko, S.A.
Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase
Chem. Biol. Interact.
191
129-136
2011
Homo sapiens
brenda