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Information on EC 1.3.8.8 - long-chain acyl-CoA dehydrogenase and Organism(s) Sus scrofa

for references in articles please use BRENDA:EC1.3.8.8

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1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.8 With a flavin as acceptor

1.3.8.8 long-chain acyl-CoA dehydrogenase

IUBMB Comments

Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 6 to at least 16 carbon atoms. The highest activity was found with C12, and the rates with C8 and C16 were 80 and 70%, respectively . The enzyme from rat can accept substrates with C8-C22. It is most active with C14 and C16, and has no activity with C4, C6 or C24 . cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.

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Word Map

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1.3.8.8
medium-chain
beta-oxidation
carnitine
acylcarnitine
cardiomyopathy
cardiac
peroxisome
triglyceride
rhabdomyolysis
hypoglycemia
acadvl
palmitoyltransferase
proliferator-activated
inborn
trifunctional
nbs
3-hydroxyacyl-coa
acidurias
myopathic
hypoketotic
glutaric
myoglobinuria
dehydrogenase-deficient
isovaleryl-coa
bezafibrate
lchad
faods
medicine
mcadd

The taxonomic range for the selected organisms is: Sus scrofa
The enzyme appears in selected viruses and cellular organisms

Reaction Schemes

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a long-chain acyl-CoA

electron-transfer flavoprotein

a long-chain trans-2,3-dehydroacyl-CoA

reduced electron-transfer flavoprotein

Synonyms

vlcad, very long-chain acyl-coa dehydrogenase, long-chain acyl-coa dehydrogenase, very long chain acyl-coa dehydrogenase, long-chain acyl-coa hydrolase, long chain acyl-coa dehydrogenase, long-chain acyl-coenzyme a dehydrogenase, palmitoyl-coa dehydrogenase, acyl-coa dehydrogenase 9, very-long-chain acyl-coenzyme a dehydrogenase, show all synonyms

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LCAD

long-chain acyl-coenzyme A dehydrogenase

palmitoyl-CoA dehydrogenase

palmitoyl-coenzyme A dehydrogenase

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dehydrogenation

oxidation

redox reaction

reduction

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BRENDA

lipid metabolism

KEGG

Fatty acid degradation

-, -, -

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long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 6 to at least 16 carbon atoms. The highest activity was found with C12, and the rates with C8 and C16 were 80 and 70%, respectively [2]. The enzyme from rat can accept substrates with C8-C22. It is most active with C14 and C16, and has no activity with C4, C6 or C24 [4]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.

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59536-74-2

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decanoyl-CoA + electron-transfer flavoprotein

2-decenoyl-CoA + reduced electron-transfer flavoprotein

2 entries

dodecanoyl-CoA + electron-transfer flavoprotein

2-dodecenoyl-CoA + reduced electron-transfer flavoprotein

2 entries

eicosanoyl-CoA + electron-transfer flavoprotein

trans-2-eicosenoyl-CoA + reduced electron-transfer flavoprotein