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Information on EC 1.3.8.7 - medium-chain acyl-CoA dehydrogenase and Organism(s) Mus musculus

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IUBMB Comments
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C8 to C12 compounds . The enzyme from rat does not accept C16 at all and is most active with C6-C8 compounds . cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.
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Mus musculus
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
medium-chain acyl-coa dehydrogenase, acadm, medium chain acyl-coa dehydrogenase, acyl coa dehydrogenase, medium-chain acyl-coenzyme a dehydrogenase, acyl coenzyme a dehydrogenase, mcadh, medium-chain acyl coa dehydrogenase, acyl dehydrogenase, pmcad, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acyl CoA dehydrogenase
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acyl coenzyme A dehydrogenase
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acyl dehydrogenase
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dehydrogenase, acyl coenzyme A
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fatty acyl coenzyme A dehydrogenase
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fatty-acyl-CoA dehydrogenase
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general acyl CoA dehydrogenase
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LCAD
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medium-chain acyl-CoA dehydrogenase
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medium-chain acyl-coenzyme A dehydrogenase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dehydrogenation
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oxidation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
medium-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C8 to C12 compounds [2]. The enzyme from rat does not accept C16 at all and is most active with C6-C8 compounds [4]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-65-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
show the reaction diagram
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?
hexanoyl-CoA + acceptor
2-hexenoyl-CoA + reduced acceptor
show the reaction diagram
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100% activity
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?
phenylpropionyl-CoA + acceptor
? + reduced acceptor
show the reaction diagram
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110% activity
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?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
rosiglitazone
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treatment with 10 mg per kg and day increases acyl-CoA dehydrogenase expression and activity in both epididymal and inguinal white adipose tissue but not in brown adipose tissue, liver or muscle. The effect is the same in wild-type and PPAR-alpha knock-out mice
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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3T3-L1 fibroblast
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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localized on GLU4-containing vesicles via association with insulin-regulated aminopeptidase in a manner dependent on its dileucine motif and plays a role in retention of GLUT4-containing vesicles to an intracellular compartment
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ACADM_MOUSE
421
0
46481
Swiss-Prot
Mitochondrion (Reliability: 2)
Q91WS8_MOUSE
421
0
46437
TrEMBL
Mitochondrion (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Katagiri, H.; Asano, T.; Yamada, T.; Aoyama, T.; Fukushima, Y.; Kikuchi, M.; Kodama, T.; Oka, Y.
Acyl-coenzyme A dehydrogenases are localized on GLUT4-containing vesicles via association with insulin-regulated aminopeptidase in a manner dependent on its dileucine motif
Mol. Endocrinol.
16
1049-1059
2002
Mus musculus
Manually annotated by BRENDA team
Herrema, H.; Derks, T.G.; van Dijk, T.H.; Bloks, V.W.; Gerding, A.; Havinga, R.; Tietge, U.J.; Mueller, M.; Smit, G.P.; Kuipers, F.; Reijngoud, D.J.
Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl-CoA dehydrogenase (MCAD)-deficient mice
Hepatology
47
1894-1904
2008
Mus musculus
Manually annotated by BRENDA team
Goetzman, E.S.
The regulation of acyl-CoA dehydrogenases in adipose tissue by rosiglitazone
Obesity (Silver Spring)
17
196-198
2009
Mus musculus
Manually annotated by BRENDA team