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Information on EC 1.3.5.1 - succinate dehydrogenase and Organism(s) Xenopus tropicalis

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EC Tree
IUBMB Comments
A complex generally comprising an FAD-containing component that also binds the carboxylate substrate (A subunit), a component that contains three different iron-sulfur centers [2Fe-2S], [4Fe-4S], and [3Fe-4S] (B subunit), and a hydrophobic membrane-anchor component (C, or C and D subunits) that is also the site of the interaction with quinones. The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of bacteria and archaea, with the hydrophilic domain extending into the mitochondrial matrix and the cytoplasm, respectively. Under aerobic conditions the enzyme catalyses succinate oxidation, a key step in the citric acid (TCA) cycle, transferring the electrons to quinones in the membrane, thus linking the TCA cycle with the aerobic respiratory chain (where it is known as complex II). Under anaerobic conditions the enzyme functions as a fumarate reductase, transferring electrons from the quinol pool to fumarate, and participating in anaerobic respiration with fumarate as the terminal electron acceptor. The enzyme interacts with the quinone produced by the organism, such as ubiquinone, menaquinone, caldariellaquinone, thermoplasmaquinone, rhodoquinone etc. Some of the enzymes contain two heme subunits in their membrane anchor subunit. These enzymes catalyse an electrogenic reaction and are thus classified as EC 7.1.1.12, succinate dehydrogenase (electrogenic, proton-motive force generating).
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Xenopus tropicalis
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The taxonomic range for the selected organisms is: Xenopus tropicalis
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
succinate dehydrogenase, complex ii, succinic dehydrogenase, mitochondrial complex ii, succinate dehydrogenase complex, mitochondrial succinate dehydrogenase, succinate dehydrogenase subunit b, succinate dehydrogenase b, sdhcdab, succinate-ubiquinone oxidoreductase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
complex II
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-
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dehydrogenase, succinate
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-
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Fcc3
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-
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FL cyt
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-
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Flavocytochrome c3
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-
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FRD
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-
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fumarate reductase
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-
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fumarate reductase complex
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fumaric hydrogenase
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-
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Ifc3
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Iron(III)-induced flavocytochrome C3
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-
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menaquinol-fumarate oxidoreductase
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-
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menaquinol:fumarate oxidoreductase
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succinate dehydrogenase (quinone)
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succinate dehydrogenase complex
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succinate oxidoreductase
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succinate-coenzyme Q reductase
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succinic acid dehydrogenase
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succinic dehydrogenase
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succinodehydrogenase
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succinyl dehydrogenase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
succinate:quinone oxidoreductase
A complex generally comprising an FAD-containing component that also binds the carboxylate substrate (A subunit), a component that contains three different iron-sulfur centers [2Fe-2S], [4Fe-4S], and [3Fe-4S] (B subunit), and a hydrophobic membrane-anchor component (C, or C and D subunits) that is also the site of the interaction with quinones. The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of bacteria and archaea, with the hydrophilic domain extending into the mitochondrial matrix and the cytoplasm, respectively. Under aerobic conditions the enzyme catalyses succinate oxidation, a key step in the citric acid (TCA) cycle, transferring the electrons to quinones in the membrane, thus linking the TCA cycle with the aerobic respiratory chain (where it is known as complex II). Under anaerobic conditions the enzyme functions as a fumarate reductase, transferring electrons from the quinol pool to fumarate, and participating in anaerobic respiration with fumarate as the terminal electron acceptor. The enzyme interacts with the quinone produced by the organism, such as ubiquinone, menaquinone, caldariellaquinone, thermoplasmaquinone, rhodoquinone etc. Some of the enzymes contain two heme subunits in their membrane anchor subunit. These enzymes catalyse an electrogenic reaction and are thus classified as EC 7.1.1.12, succinate dehydrogenase (electrogenic, proton-motive force generating).
CAS REGISTRY NUMBER
COMMENTARY hide
9002-02-2
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9028-11-9
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9076-99-7
cf EC 1.3.1.6
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SDHA_XENTR
665
0
72706
Swiss-Prot
Mitochondrion (Reliability: 2)
SDHB_XENTR
284
0
32087
Swiss-Prot
Mitochondrion (Reliability: 1)
A0A6I8RHW9_XENTR
622
0
67914
TrEMBL
other Location (Reliability: 2)
A0A803J5T7_XENTR
283
0
32142
TrEMBL
Mitochondrion (Reliability: 2)
A0A803JEC7_XENTR
284
0
32259
TrEMBL
Mitochondrion (Reliability: 2)
F6V2C7_XENTR
617
0
67297
TrEMBL
Mitochondrion (Reliability: 2)
A0A6I8QLC5_XENTR
616
0
67441
TrEMBL
other Location (Reliability: 2)
A0A803KFL7_XENTR
280
0
32070
TrEMBL
Mitochondrion (Reliability: 1)
A0A6I8S8T0_XENTR
615
0
67334
TrEMBL
other Location (Reliability: 2)
A0A803K313_XENTR
278
0
31473
TrEMBL
Mitochondrion (Reliability: 4)
A0A803JK12_XENTR
272
0
30960
TrEMBL
Mitochondrion (Reliability: 2)
A0A6I8R432_XENTR
668
0
73362
TrEMBL
other Location (Reliability: 3)
A0A7D9NLH8_XENTR
665
0
73008
TrEMBL
Mitochondrion (Reliability: 4)
A0A6I8SZP0_XENTR
628
0
68338
TrEMBL
Mitochondrion (Reliability: 2)