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Information on EC 1.3.3.3 - coproporphyrinogen oxidase and Organism(s) Arabidopsis thaliana

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EC Tree
     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.3 With oxygen as acceptor
                1.3.3.3 coproporphyrinogen oxidase
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This record set is specific for:
Arabidopsis thaliana
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
coproporphyrinogen oxidase, coproporphyrinogen iii oxidase, hem13, cpox4, copro'gen oxidase, coprogen oxidase, klhem13, oxygen-dependent coproporphyrinogen iii oxidase, hemn1, coproporphyrinogen-iii oxidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Coprogen oxidase
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coproporphyrinogen III oxidase
coproporphyrinogenase
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COX
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-
-
-
CPO III oxidase
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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oxidative decarboxylation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
coproporphyrinogen:oxygen oxidoreductase (decarboxylating)
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CAS REGISTRY NUMBER
COMMENTARY hide
9076-84-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
show the reaction diagram
-
-
-
-
?
coproporphyrinogen III + O2 + H+
protoporphyrinogen IX + CO2 + H2O
show the reaction diagram
-
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
show the reaction diagram
-
-
-
-
?
coproporphyrinogen III + O2 + H+
protoporphyrinogen IX + CO2 + H2O
show the reaction diagram
-
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
show the reaction diagram
enzyme is involved in heme and chlorophyll biosynthesis
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-
?
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
LIN2 encodes coproporphyrinogen III oxidase, CPO, a key enzyme of the tetrapyrrole biosynthesis pathway
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HEM61_ARATH
386
0
43796
Swiss-Prot
Chloroplast (Reliability: 2)
HEM62_ARATH
233
0
26134
Swiss-Prot
Chloroplast (Reliability: 2)
A0A5S9XPI8_ARATH
240
0
26945
TrEMBL
Chloroplast (Reliability: 2)
A0A178WIW9_ARATH
386
0
43796
TrEMBL
Chloroplast (Reliability: 2)
A0A654FLF8_ARATH
240
0
26931
TrEMBL
Chloroplast (Reliability: 2)
A0A7G2EVW0_ARATH
233
0
26122
TrEMBL
Chloroplast (Reliability: 2)
A0A7G2DRL1_ARATH
300
0
34173
TrEMBL
other Location (Reliability: 2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
spontaneous lesion formation mutant lin2-2
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene AtCPO-1, chromosome I, DNA and amino acid sequence determination and analysis, complementation of an enzyme-deletion Saccharomyces cerevisiae hem13 mutant, expression as GFP-fusion protein in transgenic Arabidopsis thaliana plants via Agrobacterium tumefaciens tranbsformation
gene AtCPO-2, DNA sequence determination and analysis, no complementation of an enzyme-deletion Saccharomyces cerevisiae hem13 mutant, possibly a pseudogene
gene LIN2, construction of transgenic plants expressing the mutant LIN2 gene using Agrobacterium tumefaciens strain GV3101 transfection
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Santana, M.A.; Tan, F.C.; Smith, A.G.
Molecular characterization of coproporphyrinogen oxidase from Glycine max and Arabidopsis thaliana
Plant Physiol. Biochem.
40
289-298
2002
Glycine max, Lotus japonicus, Vigna radiata var. radiata, Arabidopsis thaliana (Q93Z96), Arabidopsis thaliana (Q9LR75)
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Manually annotated by BRENDA team
Guo, C.Y.; Wu, G.H.; Xing, J.; Li, W.Q.; Tang, D.Z.; Cui, B.M.
A mutation in a coproporphyrinogen III oxidase gene confers growth inhibition, enhanced powdery mildew resistance and powdery mildew-induced cell death in Arabidopsis
Plant Cell Rep.
32
687-702
2013
Arabidopsis thaliana (Q9LR75), Arabidopsis thaliana Col-0 (Q9LR75)
Manually annotated by BRENDA team
Pratibha, P.; Singh, S.K.; Srinivasan, R.; Bhat, S.R.; Sreenivasulu, Y.
Gametophyte development needs mitochondrial coproporphyrinogen III oxidase function
Plant Physiol.
174
258-275
2017
Arabidopsis thaliana
Manually annotated by BRENDA team