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Information on EC 1.2.4.2 - oxoglutarate dehydrogenase (succinyl-transferring) and Organism(s) Drosophila melanogaster

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EC Tree
IUBMB Comments
Contains thiamine diphosphate. It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex, EC 1.2.1.105, in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, dihydrolipoyllysine-residue succinyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61.
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This record set is specific for:
Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
alpha-ketoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase, kgdhc, alpha-ketoglutarate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex, oxoglutarate dehydrogenase, kgdh, dhtkd1, ogdhl, ogdhc, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-ketoglutarate dehydrogenase
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2-OGDH
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2-oxoglutarate dehydrogenase
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2-oxoglutarate:lipoate oxidoreductase
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AKGDH
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alpha-ketoglutarate dehydrogenase
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alpha-ketoglutaric acid dehydrogenase
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alpha-ketoglutaric dehydrogenase
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alpha-KGD
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alpha-oxoglutarate dehydrogenase
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dehydrogenase, oxoglutarate
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ketoglutaric dehydrogenase
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OGDC
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oxoglutarate decarboxylase
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oxoglutarate dehydrogenase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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oxidative decarboxylation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)
Contains thiamine diphosphate. It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex, EC 1.2.1.105, in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, dihydrolipoyllysine-residue succinyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61.
CAS REGISTRY NUMBER
COMMENTARY hide
9031-02-1
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DHTK1_DROME
919
0
103635
Swiss-Prot
other Location (Reliability: 5)
Q95T35_DROME
1282
0
143010
TrEMBL
Mitochondrion (Reliability: 1)
E1JHW5_DROME
1241
0
138499
TrEMBL
Mitochondrion (Reliability: 1)
A8JNU6_DROME
1105
0
122896
TrEMBL
Mitochondrion (Reliability: 3)
Q0E8J6_DROME
1238
0
138230
TrEMBL
Mitochondrion (Reliability: 1)
Q8IQQ0_DROME
1017
0
113625
TrEMBL
Mitochondrion (Reliability: 3)
Q9VVC5_DROME
1008
0
112586
TrEMBL
Mitochondrion (Reliability: 3)