Information on EC 1.2.3.1 - aldehyde oxidase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
1.2.3.1
-
RECOMMENDED NAME
GeneOntology No.
aldehyde oxidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an aldehyde + H2O + O2 = a carboxylate + H2O2
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Drug metabolism - cytochrome P450
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Metabolic pathways
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Microbial metabolism in diverse environments
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Nicotinate and nicotinamide metabolism
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Retinol metabolism
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Tryptophan metabolism
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Tyrosine metabolism
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Valine, leucine and isoleucine degradation
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Vitamin B6 metabolism
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SYSTEMATIC NAME
IUBMB Comments
aldehyde:oxygen oxidoreductase
Contains molybdenum, [2Fe-2S] centres and FAD. The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides [4,6]. The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11, retinal oxidase) [5,7].
CAS REGISTRY NUMBER
COMMENTARY hide
9029-07-6
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9033-52-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
navel orangeworm
UniProt
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
Nistari strain
UniProt
Manually annotated by BRENDA team
Bombyx mori Nistari
Nistari strain
UniProt
Manually annotated by BRENDA team
house mosquito, organophosphorus insecticide-resistant strain PelRR, aldehyde oxidase may play a role in insecticide resistance
SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain DSM 12254, aminolytic strain performing thiosulfate dismutation
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Manually annotated by BRENDA team
ATCC 27774
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Manually annotated by BRENDA team
lacks FAD
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
DBA/2 mouse
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Manually annotated by BRENDA team
no activity in Aspergillus nidulans
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Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
Hass avocado
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain AIU 362
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Manually annotated by BRENDA team
KY 4690
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Manually annotated by BRENDA team
12695
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Manually annotated by BRENDA team
12695
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Manually annotated by BRENDA team
Rattus norvegicus Sprague–Dawley
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Manually annotated by BRENDA team
strain ATCC10970, enzyme belongs to xanthine oxidase family
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Manually annotated by BRENDA team
strain ATCC10970, enzyme belongs to xanthine oxidase family
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Manually annotated by BRENDA team
synthetic construct
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
aldehyde oxidase catalyzes the final step in the synthesis of abscisic acid and possibly of indole-3-acetic acid; aldehyde oxidase catalyzes the final step in the synthesis of abscisic acid and possibly of indole-3-acetic acid; aldehyde oxidase catalyzes the final step in the synthesis of abscisic acid and possibly of indole-3-acetic acid; aldehyde oxidase catalyzes the final step in the synthesis of abscisic acid and possibly of indole-3-acetic acid
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine + H2O + O2
?
show the reaction diagram
-
i.e. (S)-RS-8359
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-
?
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
?
show the reaction diagram
-
i.e. (S)-RS-8359
-
-
?
(+)-biotin (+)-sulfoxide methyl ester + acetaldehyde + H2O
?
show the reaction diagram
-
under anaerobic conditions
-
-
?
(+/-)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine + H2O + O2
?
show the reaction diagram
-
i.e. RS-8359
-
-
?
(1S)-camphor oxime + H2O + 2-hydroxypyrimidine
(1S)-camphor + (1S)-camphor imine + NH3
show the reaction diagram
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
the corresponding ketimine is an intermediate
?
(2E)-hex-2-enal + H2O + O2
(2E)-hex-2-enoic acid + H2O2
show the reaction diagram
-
-
-
?
(2E)-non-2-enal + H2O + O2
(2E)-non-2-enoic acid + H2O2
show the reaction diagram
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-
-
?
(S)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. S-8359
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?
(S)-RS-8359
?
show the reaction diagram
(S)-RS-8359 + H2O + O2
2-keto-(S)-RS-8359 + H2O2
show the reaction diagram
(Z)-11-hexadecenal + H2O + O2
(Z)-11-hexadecenoic acid + H2O2
show the reaction diagram
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-
-
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?
(Z)-7-dodecenal + H2O + O2
(Z)-7-dodecenoic acid + H2O2
show the reaction diagram
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-
-
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?
(Z)-7-tetradecenal + H2O + O2
(Z)-7-tetradecenoic acid + H2O2
show the reaction diagram
-
-
-
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?
(Z)-9-hexadecenal + H2O + O2
(Z)-9-hexadecenoic acid + H2O2
show the reaction diagram
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-
-
-
?
(Z)-9-tetradecenal + H2O + O2
(Z)-9-tetradecenoic acid + H2O2
show the reaction diagram
-
-
-
-
?
1-methoxy-2-naphthaldehyde + H2O + O2
1-methoxy-2-naphthoic acid + H2O2
show the reaction diagram
-
-
-
-
?
1-methyl-acetylpyridine + H2O + ferricyanide
?
show the reaction diagram
-
-
-
-
?
1-naphthaldehyde + H2O + O2
1-naphthoic acid + H2O2
show the reaction diagram
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-
-
-
?
1-nitropyrene + H2O + O2
?
show the reaction diagram
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-
-
?
13-cis-retinal + O2 + H2O
13-cis-retinoate + H2O2
show the reaction diagram
-
-
-
?
2,3-diazanaphthalene + O2
1-phthalazinone
show the reaction diagram
-
-
-
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?
2-ethylbutylaldehyde + H2O + O2
2-ethylbutanoate + H2O2
show the reaction diagram
2-hydroxybenzaldehyde + H2O + O2
2-hydroxybenzoate + H2O2
show the reaction diagram
-
-
-
-
?
2-hydroxypyrimidine + ferricyanide
?
show the reaction diagram
2-hydroxypyrimidine + H2O + ferricyanide + O2
?
show the reaction diagram
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-
-
-
?
2-hydroxypyrimidine + H2O + O2
uracil + H2O2
show the reaction diagram
2-hydroxypyrimidine + O2 + H2O
?
show the reaction diagram
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?
2-hydroxypyrimidine + O2 + H2O
? + H2O2
show the reaction diagram
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?
2-methoxybenzaldehyde + H2O + O2
2-methoxybenzoate + H2O2
show the reaction diagram
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?
2-methylbenzaldehyde + H2O + O2
2-methylbenzoate + H2O2
show the reaction diagram
2-naphthaldehyde + H2O + O2
2-naphthoic acid + H2O2
show the reaction diagram
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-
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?
2-pyrimidone + H2O + O2
? + H2O2
show the reaction diagram
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?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
show the reaction diagram
3,4-dihydroxybenzaldehyde + H2O + O2
3,4-dihydroxybenzoate + H2O2
show the reaction diagram
-
38.2% of the rate with benzaldehyde
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?
3,4-dimethoxybenzaldehyde + H2O + O2
3,4-dimethoxybenzoate + H2O2
show the reaction diagram
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?
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine N-oxide + electron donor
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine + an electron acceptor
show the reaction diagram
-
electron donors are 2-hydroxypyrimidine, N1-methylnicotinamide, benzaldehyde or butyraldehyde under anaerobic conditions
-
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?
3-aminocarbonyl-1-methylpyridinium chloride + H2O + O2
?
show the reaction diagram
-
-
-
-
?
3-hydroxybenzaldehyde + H2O + O2
3-hydroxybenzoate + H2O2
show the reaction diagram
-
-
-
-
?
3-methoxy-2-naphthaldehyde + H2O + O2
3-methoxy-2-naphthoic acid + H2O2
show the reaction diagram
-
-
-
-
?
3-methoxy-4-hydroxybenzaldehyde + H2O + O2
3-methoxy-4-hydroxybenzoate + H2O2
show the reaction diagram
-
-
-
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?
3-methoxybenzaldehyde + H2O + O2
3-methoxybenzoate + H2O2
show the reaction diagram
-
-
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?
3-methylbenzaldehyde + H2O + O2
3-methylbenzoate + H2O2
show the reaction diagram
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
? + H2O2
show the reaction diagram
4-(dimethylamino)-cinnamaldehyde + H2O + O2
?
show the reaction diagram
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?
4-(dimethylamino)cinnamaldehyde + H2O + O2
?
show the reaction diagram
-
-
-
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?
4-(dimethylamino)cinnamaldehyde + nitrite + H2O + O2
? + nitric oxide
show the reaction diagram
-
in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide
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-
?
4-(dimethylamino)cinnamaldehyde + O2 + H2O
4-(dimethylamine)cinnamate + H2O2
show the reaction diagram
4-hydroxybenzaldehyde + H2O + O2
4-hydroxybenzoate + H2O2
show the reaction diagram
-
-
-
-
?
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
show the reaction diagram
4-hydroxypyrimidine + H2O + O2
?
show the reaction diagram
-
ferricyanide as electron acceptor under aerobic conditions
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?
4-methoxybenzaldehyde + H2O + O2
4-methoxybenzoate + H2O2
show the reaction diagram
-
-
-
-
?
4-methylbenzaldehyde + H2O + O2
4-methylbenzoate + H2O2
show the reaction diagram
4-nitrobenzaldehyde + H2O + O2
4-nitrobenzoic acid + H2O2
show the reaction diagram
-
-
-
-
?
5-fluoropyrimidine + H2O + O2
5-fluorouracil + H2O2
show the reaction diagram
-
-
-
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?
6-benzylguanine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
6-chloroquinazolin-4(3H)-one + H2O + O2
6-chloroquinazoline-2,4(1H,3H)-dione + H2O2
show the reaction diagram
-
-
-
-
?
6-deoxypenciclovir
penciclovir
show the reaction diagram
-
is catalyzed by AOX1
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-
?
6-deoxypenciclovir + H2O + O2
?
show the reaction diagram
-
-
-
-
?
6-dimethyloamino-2-naphthaldehyde + H2O + O2
6-dimethylamino-2-naphthoic acid + H2O2
show the reaction diagram
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-
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?
6-ethyl-5H-dibenz(c,e)azepine + H2O + O2
?
show the reaction diagram
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
6-mercaptopurine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
6-methoxy-2-naphthaldehyde + H2O + O2
6-methoxy-2-naphthoic acid + H2O2
show the reaction diagram
-
-
-
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?
6-methoxyquinazolin-4(3H)-one + H2O + O2
6-methoxyquinazoline-2,4(1H,3H)-dione + H2O2
show the reaction diagram
-
-
-
-
?
6-methylpurine + H2O + chromate
?
show the reaction diagram
-
-
-
-
?
6-methylquinazolin-4(3H)-one + H2O + O2
6-methylquinazoline-2,4(1H,3H)-dione + H2O2
show the reaction diagram
-
-
-
-
?
6-methylthiopurine + H2O + O2
6-methylthio-8-hydroxypurine + H2O2
show the reaction diagram
-
2,6-dichlorophenol indophenol can also act as electron acceptor
-
-
?
6-thioxanthine + H2O + O2
6-thiouric acid + H2O2
show the reaction diagram
-
-
-
-
?
7-methoxy-1-naphthaldehyde + H2O + O2
7-methoxy-2-naphthoic acid + H2O2
show the reaction diagram
-
-
-
-
?
9-cis-retinal + O2 + H2O
9-cis-retinoate + H2O2
show the reaction diagram
-
-
-
?
abscisic aldehyde + H2O + O2
abscisic acid + H2O2
show the reaction diagram
abscisic aldehyde + O2 + H2O
abscisic acid + H2O2
show the reaction diagram
-
-
-
-
?
acetaldehyde + 2 ferricyanide + H2O
acetate + 2 ferrocyanide + 2 H+
show the reaction diagram
acetaldehyde + H2O + O2
acetate + H2O2
show the reaction diagram
acetaldehyde + H2O + O2
acetic acid + H2O2
show the reaction diagram
acetaldehyde + O2 + H2O
acetate + H2O2
show the reaction diagram
acetamiprid + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (1E)-N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, little inactivation of neonicotinoid insecticide substrate
-
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?
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
show the reaction diagram
acrolein + H2O + O2
?
show the reaction diagram
results indicate that AtraAOX2 also functions as a xenobiotic-degrading enzyme
-
-
?
acrolein + H2O + O2
acrylic acid + H2O2
show the reaction diagram
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
show the reaction diagram
all-trans-retinal + O2 + H2O
all-trans-retinoate + H2O2
show the reaction diagram
anthracene-9-carboxaldehyde + H2O + O2
anthracene-9-carboxylate + H2O2
show the reaction diagram
-
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
show the reaction diagram
benzaldehyde + 2,6-dichlorophenol indophenol
?
show the reaction diagram
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
show the reaction diagram
benzaldehyde + H2O + O2
benzoic acid + H2O2
show the reaction diagram
benzaldehyde + O2 + H2O
benzoate + H2O2
show the reaction diagram
benzamidoxime + H2O + 2-hydroxypyrimidine
benzamidine + ?
show the reaction diagram
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
-
-
?
BIBX1382 + H2O + O2
BIBU1476 + ?
show the reaction diagram
-
high hepatic clearance of 17 to 18 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
bombykal + H2O + O2
?
show the reaction diagram
butanal + 2 ferricyanide + H2O
butanoate + 2 ferrocyanide + 2 H+
show the reaction diagram
butanal + H2O + O2
butyric acid + H2O2
show the reaction diagram
butylaldehyde + H2O + O2
butanoate + H2O2
show the reaction diagram
butyraldehyde + H2O + O2
butanoate + H2O2
show the reaction diagram
-
-
-
-
?
carbazeran + H2O + O2
?
show the reaction diagram
-
-
-
-
?
carbazeran + H2O + O2
carbazeran phthalazinone + ?
show the reaction diagram
-
high hepatic clearance of 17 to 18 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
chloroacetaldehyde + H2O + O2
chloroacetic acid + H2O2
show the reaction diagram
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
cinchonidine + H2O + O2
?
show the reaction diagram
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
show the reaction diagram
cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylindenyl]indene-3-acetic acid + electron acceptor + H2O
5-fluoro-2-methyl-1-[p-(methylthio)benzylindenyl]indene-3-acetic acid + ?
show the reaction diagram
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
show the reaction diagram
citral + H2O + O2
citrate + H2O2
show the reaction diagram
-
13% of activity with n-hexylaldehyde
-
-
?
clothianidin + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (2E)-2-[([(2-chloro-1,3-thiazol-5-yl)methyl]amino)(methylamino)methylene]-1-hydroxy-1-oxodiazanium, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
clothianidin + NMNH
nitroso-clothianidin + amino-clothianidin + ?
show the reaction diagram
-
-
-
-
?
crotonaldehyde + H2O + O2
crotonate + H2O2
show the reaction diagram
-
32% of activity with n-hexylaldehyde
-
-
?
crotonaldehyde + H2O + O2
crotonic acid + H2O2
show the reaction diagram
decylaldehyde + H2O + O2
decanoate + H2O2
show the reaction diagram
desmethyl-thiamethoxam + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (4E)-3-[(2-chloro-1,3-thiazol-5-yl)methyl]-N-nitro-1,3,5-oxadiazinan-4-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
dibenzyl sulfoxide + acetaldehyde + H2O
?
show the reaction diagram
-
under anaerobic conditions
-
-
?
dinotefuran + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. 1-methyl-2-nitro-3-(tetrahydrofuran-3-ylmethyl)guanidine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
diphenyl sulfoxide + acetaldehyde + H2O
?
show the reaction diagram
DL-glyceraldehyde + H2O + O2
DL-glycerate + H2O2
show the reaction diagram
DL-glyceraldehyde + O2 + H2O
glycerate + H2O2
show the reaction diagram
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
show the reaction diagram
formaldehyde + H2O + O2
formate + H2O2
show the reaction diagram
formaldehyde + H2O + O2
formic acid + H2O2
show the reaction diagram
formaldehyde + O2 + H2O
formate + H2O2
show the reaction diagram
formate + O2
CO2 + H2O2
show the reaction diagram
-
-
-
-
?
furfural + H2O + O2
2-furoic acid + H2O2
show the reaction diagram
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
glutaraldehyde + H2O + O2
? + H2O2
show the reaction diagram
-
-
-
-
?
glutaraldehyde + H2O + O2
glutarate + H2O2
show the reaction diagram
glutaraldehyde + O2 + H2O
glutarate + H2O2
show the reaction diagram
-
-
-
-
?
glyceraldehyde + H2O + O2
2,3-dihydroxypropanoic acid + H2O2
show the reaction diagram
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
glycoaldehyde + H2O + O2
hydroxyacetic acid + H2O2
show the reaction diagram
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
glyoxal + H2O + O2
? + H2O2
show the reaction diagram
-
-
-
-
?
glyoxal + H2O + O2
glyoxylate + H2O2
show the reaction diagram
-
-
-
-
?
heptaldehyde + H2O + O2
heptanoic acid + H2O2
show the reaction diagram
-
-
-
-
?
heptanal + H2O + O2
heptanoic acid + H2O2
show the reaction diagram
heptylaldehyde + H2O + O2
heptanoate + H2O2
show the reaction diagram
hexanal + H2O + O2
hexanoic acid + H2O2
show the reaction diagram
hexylaldehyde + H2O + O2
hexanoate + H2O2
show the reaction diagram
hypoxanthine + O2 + H2O
xanthine + H2O2
show the reaction diagram
-
22-26% of the activity compared to purine
-
?
imidacloprid + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
imidacloprid + H2O + O2
nitroso-imidacloprid
show the reaction diagram
-
-
without addition of an electron donor, product is nitroso-imidacloprid
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
show the reaction diagram
imidacloprid + NMNH
nitroso-imidacloprid + amino-imidacloprid + ?
show the reaction diagram
-
-
-
-
?
imipramine N-oxide + electron donor
imipramine + electron acceptor
show the reaction diagram
-
electron donors are 2-hydroxypyrimidine, N1-methylnicotinamide, benzaldehyde or butyraldehyde under anaerobic conditions
-
-
?
indol-3-carboxyaldehyde + H2O + O2
indol-3-carboxylic acid + H2O2
show the reaction diagram
indole 3-acetaldehyde + H2O + O2
indole 3-acetic acid + H2O2
show the reaction diagram
indole 3-carbaldehyde + H2O + O2
indole 3-carboxylate + H2O2
show the reaction diagram
indole-3-aldehyde + H2O + O2
indole-3-carboxylate + H2O2
show the reaction diagram
indole-3-aldehyde + H2O + O2
indole-3-carboxylic acid + H2O2
show the reaction diagram
indole-3-aldehyde + O2 + H2O
indole-3-carboxylate + H2O2
show the reaction diagram
isobutyraldehyde + H2O + O2
isobutyric acid + H2O2
show the reaction diagram
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
isovaleraldehyde + H2O + O2
isovaleric acid + H2O2
show the reaction diagram
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
L-methionine sulfoxide + acetaldehyde + H2O
?
show the reaction diagram
-
under anaerobic conditions
-
-
?
m-tolualdehyde + H2O + O2
m-methylbenzoic acid + H2O2
show the reaction diagram
-
-
-
-
?
methotrexate + H2O + O2
7-hydroxymethotrexate + H2O2
show the reaction diagram
-
-
-
-
?
methotrexate + H2O + O2
?
show the reaction diagram
n-alkanal + H2O + O2
n-alkanoic acid + H2O2
show the reaction diagram
-
C5-C10, C12, C14 with decreasing activities
-
-
?
n-heptanal + H2O + O2
n-heptanoic acid + H2O2
show the reaction diagram
-
-
-
-
?
n-heptylaldehyde + H2O + O2
heptanoate + H2O2
show the reaction diagram
-
78% of activity with n-hexylaldehyde
-
-
?
n-heptylaldehyde + O2 + H2O
heptanoate + H2O2
show the reaction diagram
-
-
-
-
?
n-hexanal + H2O + O2
n-hexanoic acid + H2O2
show the reaction diagram
-
-
-
-
?
n-hexylaldehyde + H2O + O2
hexanoate + H2O2
show the reaction diagram
-
-
-
-
?
N-methyl-5,6-benzoquinolinium + H2O + ferricyanide
?
show the reaction diagram
-
-
-
-
?
N-methylimidacloprid + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (2E)-1-[(6-chloropyridin-3-yl)methyl]-3-methyl-N-nitroimidazolidin-2-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, little inactivation of neonicotinoid insecticide substrate
-
-
?
N-methylnicotinamide + electron acceptor + H2O
?
show the reaction diagram
-
electron acceptors i.e.: dichlorophenolindophenol, nitro blue tetrazolium, ferricyanide, diaphorase activity
-
-
?
N-methylphenanthridinium + H2O + ferricyanide
N-methyl-6-phenanthridone + ferrocyanide
show the reaction diagram
-
-
-
-
?
N-methylphthalazinium + O2 + H2O
?
show the reaction diagram
-
-
-
-
?
N-methylquinolinium + H2O + electron donor
N-methyl-4-quinolone and N-methyl-2-quinolone + electron acceptor
show the reaction diagram
n-pentanal + H2O + O2
n-pentanoic acid + H2O2
show the reaction diagram
-
-
-
-
?
N-phenylquinolinium + H2O + electron donor
N-phenyl-4-quinolone and N-phenyl-2-quinolone + electron acceptor
show the reaction diagram
n-valeraldehyde + O2 + H2O
valerate + H2O2
show the reaction diagram
-
-
-
-
?
N-[(2'-dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
?
show the reaction diagram
-
-
-
-
?
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide + H2O + O2
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
show the reaction diagram
N-[(2-dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
DACA-9(10H)-acridone + ?
show the reaction diagram
-
N-[(2-dimethylamino)ethyl]acridine-4-carboxamide i.e. DACA, an experimental antitumor agent
-
-
?
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide-9-(10H)-acridone + H2O2
show the reaction diagram
-
antitumor drug
-
-
?
N1-methylnicotinamide + 2,6-dichlorophenol indophenol
?
show the reaction diagram
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + ?
show the reaction diagram
-
variations in the ratio of the amount of pyridones to the total amount of NMN and pyridones in urine are closely related to the enzyme activity
-
-
-
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
show the reaction diagram
N1-propylnicotinamide + H2O + O2
N1-propyl-2-pyridone-5-carboxamide + N1-propyl-4-pyridone-3-carboxamide + H2O2
show the reaction diagram
NADH + nitrite + H2O + O2
? + nitric oxide
show the reaction diagram
-
in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide. NADH reacts with aldehyde oxidase at the FAD site of the enzyme
-
-
?
nitenpyram + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (E)-N-[(6-chloropyridin-3-yl)methyl]-N-ethyl-N'-methyl-2-nitroethylene-1,1-diamine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, partial inactivation of neonicotinoid insecticide substrate
-
-
?
nitenpyram + NMNH
nitroso-nitenpyram + amino-nitenpyram + ?
show the reaction diagram
-
-
-
-
?
nithiazine + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (2Z)-2-(nitromethylene)-1,3-thiazinane, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, partial inactivation of neonicotinoid insecticide substrate
-
-
?
nonanal + H2O + O2
nonanoic acid + H2O2
show the reaction diagram
-
-
-
?
o-tolualdehyde + H2O + O2
o-methylbenzoic acid + H2O2
show the reaction diagram
-
-
-
-
?
O6-benzylguanine + H2O + O2
O6-benzyl-8-oxoguanine benzylguanine + ?
show the reaction diagram
-
hepatic clearance of 11.2 to 12.8 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
octylaldehyde + H2O + O2
octanoate + H2O2
show the reaction diagram
octylaldehyde + O2 + H2O
octanoate + H2O2
show the reaction diagram
-
-
-
-
?
p-aminobenzamidine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
p-anisaldehyde + H2O + O2
p-anisic acid + H2O2
show the reaction diagram
p-dimethyl aminocinnamaldehyde + H2O + O2
? + H2O2
show the reaction diagram
-
-
-
-
?
p-hydroxybenzaldehyde + H2O + O2
p-hydroxybenzoate + H2O2
show the reaction diagram
p-methoxybenzaldehyde + H2O + O2
p-methoxybenzoate + H2O2
show the reaction diagram
-
-
-
-
?
p-tolualdehyde + H2O + O2
p-methylbenzoic acid + H2O2
show the reaction diagram
-
-
-
-
?
PF-4217903 + H2O + O2
?
show the reaction diagram
-
-
-
-
?
PF-945863 + H2O + O2
?
show the reaction diagram
-
-
-
-
?
phenanthrene-9-carboxaldehyde + H2O + O2
phenanthrene-9-carboxylate + H2O2
show the reaction diagram
-
-
-
-
?
phenanthridine + H2O + O2
6-phenanthridone + H2O2
show the reaction diagram
-
-
-
?
phenanthridine + H2O + O2
6-phenantridone + H2O2
show the reaction diagram
phenanthridine + H2O + O2
?
show the reaction diagram
phenanthridine + H2O + O2
phenanthridinone + H2O2
show the reaction diagram
-
-
-
-
?
phenanthridine + O2 + H2O
?
show the reaction diagram
-
-
-
-
?
phenothiazine sulfoxide + acetaldehyde + H2O
?
show the reaction diagram
-
under anaerobic conditions
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetate + H2O2
show the reaction diagram
phenylacetaldehyde + H2O + O2
phenylacetic acid + H2O2
show the reaction diagram
phthalaldehyde + H2O + O2
phthalic acid + H2O2
show the reaction diagram
-
13% of activity with n-hexylaldehyde
-
-
?
phthalazine + 2,6-dichlorophenol indophenol
?
show the reaction diagram
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
phthalazine + ferricyanide
1-phthalazinone + ferrocyanide
show the reaction diagram
-
-
-
-
?
phthalazine + ferricyanide
?
show the reaction diagram
-
-
-
-
?
phthalazine + H2O + O2
1-phthalazinone + H2O2
show the reaction diagram
phthalazine + H2O + O2
? + H2O2
show the reaction diagram
phthalazine + O2 + H2O
1-phthalazinone + H2O2
show the reaction diagram
propanal + H2O + O2
propanoic acid + H2O2
show the reaction diagram
highest AtraAOX2 activity
-
-
?
propionaldehyde + H2O + O2
propionate + H2O2
show the reaction diagram
propionaldehyde + H2O + O2
propionic acid + H2O2
show the reaction diagram
protocatechualdehyde + H2O + O2
protocatechuic acid + H2O2
show the reaction diagram
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
purine + O2 + H2O
? + H2O2
show the reaction diagram
-
best substrate tested
-
?
purine derivative + H2O + ferricyanide
oxidized purine derivative + ?
show the reaction diagram
-
various purine derivatives are listed, this enzyme catalyzes usually a ring methine group vicinal to a ring nitrogen
-
-
?
pyrazolo[3,4-d]pyrimidine + H2O + ferricyanide
oxidized pyrazolo[3,4-d]pyrimidine + ?
show the reaction diagram
-
various pyrazolo[3,4-d]pyrimidines are listed, this enzyme catalyzes usually a ring methine group vicinal to a ring nitrogen
-
-
?
pyridoxal + H2O + O2
4-pyridoxic acid + H2O2
show the reaction diagram
quinazolin-4(3H)-one + H2O + O2
quinazoline-2,4(1H,3H)-dione + H2O2
show the reaction diagram
-
-
-
-
?
quinine + H2O + O2
?
show the reaction diagram
-
-
-
?
quinoline + H2O + electron donor
?
show the reaction diagram
retinal + O2 + H2O
retinoate + H2O2
show the reaction diagram
retinal + O2 + H2O
retinoic acid + H2O2
show the reaction diagram
retinalaldehyde + O2 + H2O
retinoic acid + H2O2
show the reaction diagram
-
-
-
-
?
retinaldehyde + H2O + O2
retinoic acid + H2O2
show the reaction diagram
-
-
-
?
retinaldehyde + O2 + H2O
retinoic acid + H2O2
show the reaction diagram
-
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
show the reaction diagram
salicylaldoxime + H2O + 2-hydroxypyrimidine
salicylaldehyde + NH3
show the reaction diagram
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
the corresponding ketimine is an intermediate
?
terephthalaldehyde + H2O + O2
terephthalic acid + H2O2
show the reaction diagram
-
45% of activity with n-hexylaldehyde
-
-
?
thiacloprid + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. ((2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene)cyanamide, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, little inactivation of neonicotinoid insecticide substrate
-
-
?
thiamethoxam + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (4E)-3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
tropylium tetrafluoroborate + H2O + ferricyanide
tropone + ?
show the reaction diagram
-
other electron acceptors as dichloroindophenol and chromate
-
-
?
valeraldehyde + H2O + O2
valerate + H2O2
show the reaction diagram
valeraldehyde + H2O + O2
valeric acid + H2O2
show the reaction diagram
vanillin + H2O + O2
vanillic acid + H2O2
show the reaction diagram
vanillin + O2 + H2O
vanillic acid + H2O2
show the reaction diagram
veratraldehyde + H2O + O2
veratranoate + H2O2
show the reaction diagram
veratraldehyde + H2O + O2
veratric acid + H2O2
show the reaction diagram
-
18% of activity with n-hexylaldehyde
-
-
?
xanthine + H2O + O2
? + H2O2
show the reaction diagram
xanthine + O2 + H2O
urate + H2O2
show the reaction diagram
-
low activity
-
?
XK-469 + H2O + O2
3-oxo-XK-469 + ?
show the reaction diagram
-
hepatic clearance less than 4.3 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
XK-469 + H2O + O2
?
show the reaction diagram
-
-
-
-
?
Z11Z13-16Ald + H2O + O2
? + H2O2
show the reaction diagram
low AtraAOX2 activity
-
-
?
zaleplon + H2O + O2
5-oxozaleplon + ?
show the reaction diagram
-
hepatic clearance less than 4.3 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
zaleplon + H2O + O2
?
show the reaction diagram
-
-
-
-
?
zebularine + H2O + O2
uridine + H2O2
show the reaction diagram
zoniporide + H2O + O2
2-oxozoniporide + H2O2
show the reaction diagram
-
i.e. 1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl guanidine
-
-
?
zoniporide + H2O + O2
?
show the reaction diagram
-
-
-
-
?
zonisamide + H2O + O2
?
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
13-cis-retinal + O2 + H2O
13-cis-retinoate + H2O2
show the reaction diagram
-
-
-
?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
show the reaction diagram
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
show the reaction diagram
9-cis-retinal + O2 + H2O
9-cis-retinoate + H2O2
show the reaction diagram
-
-
-
?
abscisic aldehyde + H2O + O2
abscisic acid + H2O2
show the reaction diagram
-
four aldehyde oxidases are known that have varying affinities to abscisic aldehyde. AOdelta, endcoded by AAO3 specifically catalyses this step in rosette leaves
-
-
?
all-trans-retinal + O2 + H2O
all-trans-retinoate + H2O2
show the reaction diagram
hypoxanthine + O2 + H2O
xanthine + H2O2
show the reaction diagram
-
22-26% of the activity compared to purine
-
?
purine + O2 + H2O
? + H2O2
show the reaction diagram
-
best substrate tested
-
?
retinal + O2 + H2O
retinoate + H2O2
show the reaction diagram
xanthine + O2 + H2O
urate + H2O2
show the reaction diagram
-
low activity
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
iron-sulfur centre
two centers, FeSI and FeSII
molybdenum cofactor
molybdopterin
molybdopterin cytosine dinucleotide
-
-
NAD+
-
enzyme is able to oxidize benzaldehyde without NAD+, but its activity increases by 50% when the cofactor is added. Km value 0.0581 mM
[2Fe-2S]-center
-
two distinct ones
additional information
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CuCl2
-
1 mM, 123% of initial activity
Fe
-
8.24 mol per mol enzyme
Mo
-
2.01 mol per mol enzyme
Molybdenum
additional information