Information on EC 1.2.1.3 - aldehyde dehydrogenase (NAD+)

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
1.2.1.3
-
RECOMMENDED NAME
GeneOntology No.
aldehyde dehydrogenase (NAD+)
PATHWAY
KEGG Link
MetaCyc Link
alkane oxidation
-
Arginine and proline metabolism
-
aromatic biogenic amine degradation (bacteria)
-
Ascorbate and aldarate metabolism
-
beta-Alanine metabolism
-
Biosynthesis of secondary metabolites
-
Chloroalkane and chloroalkene degradation
-
dimethylsulfoniopropionate biosynthesis I (Wollastonia)
-
dimethylsulfoniopropionate biosynthesis II (Spartina)
-
dopamine degradation
-
Entner-Doudoroff pathway III (semi-phosphorylative)
-
ethanol degradation II
-
ethanol degradation III (oxidative)
-
ethanol degradation IV
-
fatty acid alpha-oxidation I
-
fatty acid alpha-oxidation II
-
fatty acid alpha-oxidation III
-
Fatty acid degradation
-
Glycerolipid metabolism
-
Glycolysis / Gluconeogenesis
-
histamine degradation
-
Histidine metabolism
-
hypotaurine degradation
-
juvenile hormone III biosynthesis I
-
juvenile hormone III biosynthesis II
-
Limonene and pinene degradation
-
Lysine degradation
-
Metabolic pathways
-
Microbial metabolism in diverse environments
-
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)
-
noradrenaline and adrenaline degradation
-
octane oxidation
-
Pentose and glucuronate interconversions
-
phytol degradation
-
Propanoate metabolism
-
putrescine degradation III
-
Pyruvate metabolism
-
serotonin degradation
-
tryptophan degradation X (mammalian, via tryptamine)
-
Tryptophan metabolism
-
Valine, leucine and isoleucine degradation
-
SYSTEMATIC NAME
IUBMB Comments
aldehyde:NAD+ oxidoreductase
Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
AHD-M1
-
-
-
-
ALD1A1
-
isoform
ALDDH
-
-
-
-
aldehyde dehydrogenase
-
-
aldehyde dehydrogenase
-
-
aldehyde dehydrogenase
-
-
aldehyde dehydrogenase
-
-
aldehyde dehydrogenase
-
-
aldehyde dehydrogenase
Q4F895
-
aldehyde dehydrogenase
Rhodococcus erythropolis UPV-1
Q4F895
-
-
aldehyde dehydrogenase
-
-
aldehyde dehydrogenase
Q402C7
-
aldehyde dehydrogenase
Sphingomonas sp. 14DN61
Q402C7
-
-
aldehyde dehydrogenase (NAD)
-
-
aldehyde dehydrogenase 1
-
-
aldehyde dehydrogenase 1A1
-
-
aldehyde dehydrogenase 1A1
-
isoform
aldehyde dehydrogenase 1A1
-
-
aldehyde dehydrogenase 1B1
-
isoform
aldehyde dehydrogenase 2
-
-
aldehyde dehydrogenase 2
P47738
-
aldehyde dehydrogenase 2
-
-
aldehyde dehydrogenase 3A1
-
-
aldehyde dehydrogenase 7A1
-
-
aldehyde dehydrogenase class 1
-
-
aldehyde dehydrogenase type 2
-
-
Aldehyde dehydrogenase [NAD+]
-
-
-
-
Aldehyde dehydrogenase, cytosolic
-
-
-
-
Aldehyde dehydrogenase, microsomal
-
-
-
-
aldehyde dehydrogenase-2
-
-
aldehyde dehydrogenase-2
-
-
aldehyde dehydrogenase7
Q9FPK6
-
aldehyde:NAD+ oxidoreductase
-
-
-
-
ALDH
Klebsiella pneumoniae DSM 2026
A6T782
-
-
ALDH
-
-
ALDH
Rhodococcus erythropolis UPV-1
Q4F895
-
-
ALDH
Sulfolobus tokodaii 7
-
-
-
ALDH 2
-
-
ALDH I
-
-
ALDH II
-
-
ALDH-2
-
-
ALDH-2
P05091
-
ALDH-E1
-
-
-
-
ALDH-E2
-
-
-
-
ALDH1
-
-
-
-
ALDH1
-
isozyme
ALDH1
-
-
ALDH1
Phanerochaete chrysosporium ATCC 34541
-
isoform
-
ALDH1-NL
-
-
-
-
ALDH1A1
-
-
ALDH1A1
-
isoform
ALDH1A1
-
isozyme
ALDH1A1
O35945
isozyme
Aldh1a2
-
previously known as retinaldehyde dehydrogenase 2
Aldh1a3
-
isozyme
Aldh1a7
O35945
isozyme
Aldh1b1
-
isoform
Aldh1b1
P30837
-
Aldh1b1
Q9CZS1
isoform, formerly known as ALDHx or ALDH5
Aldh1b1
Q9CZS1
isozyme
ALDH2
-
-
ALDH2
P05091
isoform
ALDH2
P47738
-
ALDH2
P47738
isoform
ALDH2
P47738
isozyme
ALDH2
Phanerochaete chrysosporium ATCC 34541
-
isoform
-
ALDH2
P11884
-
ALDH2
P11884
isoform
ALDH2(1)
-
-
ALDH2(2)
-
mutant enzyme
ALDH2(2)
-
-
ALDH2(3)
-
-
ALDH22A1
-
isoform
ALDH2C4
-
isoform
ALDH3A1
-
isoform
ALDH3A1
-
-
ALDH3A1
Q3UNF5
isoform
ALDH3A1
-
isoform
ALDH3A2
-
isozyme
ALDH3A2
P47740
isozyme
Aldh3b1
-
isozyme
ALDH3H1
-
cytosolic isoform
ALDH5A
P51650
-
ALDH7
Q9FPK6
-
Aldh7a1
-
-
Aldh7a1
-
isozyme
Aldh7a1
-
-
Aldh7a1
Q9DBF1
isoform
Aldh8a1
Q9H2A2
-
Aldh8a1
Q8BH00
isozyme
ALDHI
-
-
-
-
ALDHX
-
-
-
-
ALHDII
-
-
-
-
Allergen Alt a 10
-
-
-
-
aryl-aldehyde dehydrogenases
-
-
benzaldehyde dehydrogenase
-
-
Brassica turgor-responsive/drought-induced gene 26 protein
-
-
-
-
Btg-26
-
-
-
-
class 1 aldehyde dehydrogenase
-
-
class 2 aldehyde dehydrogenase
-
-
CoA-independent aldehyde dehydrogenase
-
-
-
-
coniferyl-aldehyde dehydrogenase
-
-
ETA-crystallin
-
-
-
-
gamma-aminobutyraldehyde dehydrogenase
-
-
-
-
hALDH2
-
-
irreversible NAD+-dependent aldehyde dehydrogenase
-
-
irreversible NAD+-dependent aldehyde dehydrogenase
-
-
-
K(+)-ACDH
-
-
-
-
K(+)-activated acetaldehyde dehydrogenase
-
-
-
-
m-methylbenzaldehyde dehydrogenase
-
-
-
-
Matured fruit 60 kDa protein
-
-
-
-
MF-60
-
-
-
-
Mg(2+)-ACDH
-
-
-
-
Mg(2+)-activated acetaldehyde dehydrogenase
-
-
-
-
mitochondrial aldehyde dehydrogenase
-
-
mitochondrial aldehyde dehydrogenase
P47738
-
NAD+-dependent aldehyde dehydrogenase
A6T782
-
NAD+-dependent aldehyde dehydrogenase
Klebsiella pneumoniae DSM 2026
A6T782
-
-
NAD+-linked aldehyde dehydrogenase
-
-
-
-
NAD+-pimelic semialdehyde-dependent aldehyde dehydrogenase
-
-
NAD+-pimelic semialdehyde-dependent aldehyde dehydrogenase
Sphingopyxis macrogoltabida TFA
-
-
-
NAD+-specific ALDH
A6T782
-
NAD+-specific ALDH
Klebsiella pneumoniae DSM 2026
A6T782
-
-
NAD-aldehyde dehydrogenase
-
-
-
-
NAD-aldehyde dehydrogenase
-
-
NAD-dependent 4-hydroxynonenal dehydrogenase
-
-
-
-
NAD-dependent aldehyde dehydrogenase
-
-
-
-
NAD-linked aldehyde dehydrogenase
-
-
-
-
Non-lens ALDH1
-
-
-
-
P51
-
-
-
-
PhnN
Q402C7
-
PhnN
Sphingomonas sp. 14DN61
Q402C7
-
-
PM-ALDH9
-
-
-
-
propionaldehyde dehydrogenase
-
-
-
-
PuuC
Klebsiella pneumoniae DSM 2026
A6T782
-
-
R-aminobutyraldehyde dehydrogenase
-
-
-
-
RALDH
-
-
-
-
RALDH(II)
-
-
-
-
RalDH1
-
-
-
-
RalDH1
-
-
Retinal dehydrogenase
-
-
-
-
retinal dehydrogenase type I
-
-
sALDH
-
-
salvery aldehyde dehydrogenase
-
-
ThnG
Sphingopyxis macrogoltabida TFA
-
-
-
Turgor-responsive protein 26G
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9028-86-8
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
strain K-12
-
-
Manually annotated by BRENDA team
isoenzyme E1, E2, and E3
-
-
Manually annotated by BRENDA team
isoenzyme E3
-
-
Manually annotated by BRENDA team
usual livers contains cytosolic ALDH1 and ALDH2, the atypical phenotype contains only the ALDH1 isoenzyme and immunologically cross-reactive material resulting from a mutation of the ALDH2 locus. 50% of orientals are atypical in respect to ALDH isoenzymes
-
-
Manually annotated by BRENDA team
Klebsiella pneumoniae DSM 2026
-
UniProt
Manually annotated by BRENDA team
isoform ALDH1B1
UniProt
Manually annotated by BRENDA team
isoform ALDH2
SwissProt
Manually annotated by BRENDA team
isoform ALDH3A1
UniProt
Manually annotated by BRENDA team
isoform ALDH7A1
UniProt
Manually annotated by BRENDA team
Nocardia sp. 239
239
-
-
Manually annotated by BRENDA team
cultivar Dongjin
UniProt
Manually annotated by BRENDA team
Japanese medaka
-
-
Manually annotated by BRENDA team
Phanerochaete chrysosporium ATCC 34541
-
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa IH 35342
IH 35342
-
-
Manually annotated by BRENDA team
strain ATCC 12633
-
-
Manually annotated by BRENDA team
enzyme from the promotion phase of hepatocarcinogenesis and phenobabital-inducible enzyme
-
-
Manually annotated by BRENDA team
enzyme I
-
-
Manually annotated by BRENDA team
membrane-bound ALDH, ALDH-I: soluble high Km ALDH, and ALDH-II: low Km ALDH
-
-
Manually annotated by BRENDA team
strain UPV-1
SwissProt
Manually annotated by BRENDA team
Rhodococcus erythropolis UPV-1
strain UPV-1
SwissProt
Manually annotated by BRENDA team
strain 14DN61
SwissProt
Manually annotated by BRENDA team
Sphingomonas sp. 14DN61
strain 14DN61
SwissProt
Manually annotated by BRENDA team
Sphingopyxis macrogoltabida TFA
-
-
-
Manually annotated by BRENDA team
Sulfolobus tokodaii 7
-
-
-
Manually annotated by BRENDA team
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
70
90
-
about 50% activity at 70°C, 100% activity at 80°C, about 80% activity at 90°C
PDB
SCOP
CATH
ORGANISM
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)
Gadus morhua subsp. callarias
Gadus morhua subsp. callarias
Pseudomonas sp. (strain WBC-3)
Pseudomonas sp. (strain WBC-3)
Rhizobium meliloti (strain 1021)
Rhizobium meliloti (strain 1021)
Rhizobium meliloti (strain 1021)
Rhizobium meliloti (strain 1021)
Rhizobium meliloti (strain 1021)
Staphylococcus aureus (strain Mu50 / ATCC 700699)
ORGANIC SOLVENT
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
dithiothreitol
-
the enzyme is stable in dithiothreitol (90% of the original activity remaining)
dithiothreitol
Sulfolobus tokodaii 7
-
the enzyme is stable in dithiothreitol (90% of the original activity remaining)
-
Ethanol
-
the enzyme is stable in ethanol (90% of the original activity remaining)
Ethanol
Sulfolobus tokodaii 7
-
the enzyme is stable in ethanol (90% of the original activity remaining)
-
isopropanol
-
the enzyme is stable in isopropanol (90% of the original activity remaining)
isopropanol
Sulfolobus tokodaii 7
-
the enzyme is stable in isopropanol (90% of the original activity remaining)
-
Methanol
-
the enzyme is stable in methanol (90% of the original activity remaining)
Methanol
Sulfolobus tokodaii 7
-
the enzyme is stable in methanol (90% of the original activity remaining)
-
phenylmethylsulfonyl fluoride
-
the enzyme is stable in phenylmethylsulfonyl fluoride (90% of the original activity remaining)
SDS
-
the enzyme is stable in SDS (90% of the original activity remaining)
SDS
Sulfolobus tokodaii 7
-
the enzyme is stable in SDS (90% of the original activity remaining)
-