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Information on EC 1.2.1.27 - methylmalonate-semialdehyde dehydrogenase (CoA-acylating) and Organism(s) Drosophila melanogaster

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EC Tree
IUBMB Comments
Also converts 3-oxopropanoate into acetyl-CoA . The reaction occurs in two steps with the decarboxylation process preceding CoA-binding . Bicarbonate rather than CO2 is released as a final product .
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This record set is specific for:
Drosophila melanogaster
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
msdh, mmsdh, methylmalonate semialdehyde dehydrogenase, methylmalonic acid semialdehyde dehydrogenase, odommsdh, momsdh, methylmalonate semialdehyde dehydrogenase protein, mmsadh, sso1218, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MMSDH
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
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reduction
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-
-
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SYSTEMATIC NAME
IUBMB Comments
2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
Also converts 3-oxopropanoate into acetyl-CoA [3]. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding [3]. Bicarbonate rather than CO2 is released as a final product [3].
CAS REGISTRY NUMBER
COMMENTARY hide
37205-49-5
-
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MMSA_DROME
520
0
55972
Swiss-Prot
Mitochondrion (Reliability: 3)
A9UN30_DROME
379
1
40322
TrEMBL
Secretory Pathway (Reliability: 5)
I0B1N8_DROME
535
0
57665
TrEMBL
Mitochondrion (Reliability: 4)