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Information on EC 1.2.1.12 - glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) and Organism(s) Pseudomonas aeruginosa

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EC Tree
IUBMB Comments
Also acts very slowly on D-glyceraldehyde and some other aldehydes; thiols can replace phosphate.
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This record set is specific for:
Pseudomonas aeruginosa
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The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
gapdhs, d-glyceraldehyde-3-phosphate dehydrogenase, gapds, gadph, glyceraldehyde-3-phosphate dehydrogenases, plasmin receptor, gapc1, plasminogen-binding protein, gapcp, glyceraldehyde-3 phosphate dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-phosphoglyceraldehyde dehydrogenase
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-
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BARS-38
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-
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CP 17/CP 18
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-
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dehydrogenase, glyceraldehyde phosphate
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-
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dihydrogenase, glyceraldehyde phosphate
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-
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G3PD
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-
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GAPDH
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-
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GAPDH1
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-
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GAPDH2
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-
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glyceraldehyde phosphate dehydrogenase (NAD)
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-
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glyceraldehyde-3-P-dehydrogenase
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-
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glyceraldehyde-3-phosphate dehydrogenase (NAD)
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-
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GPD
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-
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Gra3PDH
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-
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GraP-DH
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-
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Larval antigen OVB95
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-
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Major larval surface antigen
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-
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NAD+-G-3-P dehydrogenase
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-
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NAD-dependent glyceraldehyde phosphate dehydrogenase
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NAD-dependent glyceraldehyde-3-phosphate dehydrogenase
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NAD-G3PDH
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NADH-glyceraldehyde phosphate dehydrogenase
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-
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P-37
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phosphoglyceraldehyde dehydrogenase
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Plasmin receptor
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Plasminogen-binding protein
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-
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TLAb
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-
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triose phosphate dehydrogenase
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)
Also acts very slowly on D-glyceraldehyde and some other aldehydes; thiols can replace phosphate.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-50-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glyceraldehyde 3-phosphate + phosphate + NAD+
3-phospho-D-glyceroyl phosphate + NADH
show the reaction diagram
-
-
-
?
additional information
?
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importance of the enzyme in glucose catabolism. Activity is reduced severalfold after growth on gluconeogenic substrates such as citrate compared to growth on glucose
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
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importance of the enzyme in glucose catabolism. Activity is reduced severalfold after growth on gluconeogenic substrates such as citrate compared to growth on glucose
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-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6-phosphogluconate
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-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
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slight activation
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A485FCX3_PSEAI
514
0
56219
TrEMBL
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A0A8G7C2Q9_PSEAI
488
0
53203
TrEMBL
-
A0A367M7I3_PSEAI
328
0
35515
TrEMBL
-
A0A8G3JQ76_PSEAI
488
0
53233
TrEMBL
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
315000
-
non-denaturing PAGE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
15
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5 min, stable
55
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5 min, complete loss of activity
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, 1 mM EDTA, 75% glycerol, stable
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rivers, D.B.; Blevins, W.T.
Multiple enzyme forms of glyceraldehyde-3-phosphate dehydrogenase in Pseudomonas aeruginosa PAO
J. Gen. Microbiol.
133
3159-3164
1987
Pseudomonas aeruginosa
Manually annotated by BRENDA team