Reference on EC 1.16.1.1 - mercury(II) reductase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gachhui, R.; Chaudhuri, J.; Ray, S.; Pahan, K.; Mandal, A.
Studies on mercury-detoxicating enzymes from a broad-spectrum mercury-resistant strain of Flavobacterium rigense
Folia Microbiol. (Praha)
42
337-343
1997
BRENDA: Flavobacterium rigense, Flavobacterium rigense PR2
Textmining: bacterium
Ji, L.; Becana, M.; Sarath, G.; Klucas, R.V.
Cloning and sequence analysis of a cDNA encoding ferric leghemoglobin reductase from soybean nodules
Plant Physiol.
104
453-459
1994
Glycine max
Fox, B.; Walsh, C.T.
Mercuric reductase. Purification and characterization of a transposon-encoded flavoprotein containing an oxidation-reduction-active disulfide
J. Biol. Chem.
257
2498-2503
1982
BRENDA: Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO9501
Textmining: Transposon Tn501, Electron
Rinderle, S.J.; Booth, J.E.; Williams, J.W.
Mercuric reductase from R-plasmid NR1: characterization and mechanistic study
Biochemistry
22
869-876
1983
Escherichia coli
Kusano, T.; Ji, G.; Inoue, C.; Silver, S.
Constitutive synthesis of a transport function encoded by the Thiobacillus ferrooxidans merC gene cloned in Escherichia coli
J. Bacteriol.
172
2688-2692
1990
BRENDA: Acidithiobacillus ferrooxidans
Textmining: Escherichia, Thiobacillus
Barkay, T.; Gillman, M.; Liebert, C.
Genes encoding mercuric reductases from selected gram-negative aquatic bacteria have a low degree of homology with merA of transposon Tn501
Appl. Environ. Microbiol.
56
1695-1701
1990
Burkholderia cepacia, Pseudomonas aeruginosa, Pseudomonas stutzeri
Moore, M.J.; Distefano, M.D.; Walsh, C.T.; Schiering, N.; Pai, E.F.
Purification, crystallization, and preliminary x-ray diffraction studies of the flavoenzyme mercuric ion reductase from Bacillus sp. strain RC607
J. Biol. Chem.
264
14386-14388
1989
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) RC607
Tezuka, T.; Someya, J.
Purification and some properties of mercuric reductase from the organomercury-resistant Penicillium sp. MR-2 strain
Agric. Biol. Chem.
54
1551-1552
1990
Penicillium sp., Penicillium sp. MR-2
-
Olson, G.J.; Porter, F.D.; Rubinstein, J.; Silver, S.
Mercuric reductase enzyme from a mercury-volatilizing strain of Thiobacillus ferrooxidans
J. Bacteriol.
151
1230-1236
1982
Acidithiobacillus ferrooxidans
Sahlman, L.; Lambeir, A.M.; Lindskog, S.; Dunford, H.B.
The reaction between NADPH and mercuric reductase from Pseudomonas aeruginosa
J. Biol. Chem.
259
12403-12408
1984
Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO9501 (pVS1)
Sahlman, L.; Lindskog, S.
A stopped-flow study of the reaction between mercuric reductase and NADPH
Biochem. Biophys. Res. Commun.
117
231-237
1983
Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO9501
Bogdanova, E.S.; Mindlin, S.Z.
Two structural types of mercury reductases and possible ways of their evolution
FEBS Lett.
247
333-336
1989
Arthrobacter sp., Priestia megaterium, Bacillus licheniformis, Paenibacillus polymyxa, Bacillus sp. (in: Bacteria), Lysinibacillus sphaericus, Citrobacter sp., Escherichia coli, Micrococcus luteus, Staphylococcus aureus, Kocuria rosea, Mycobacterium sp., Oerskovia sp., Rhodococcus sp., Staphylococcus saprophyticus
Sandstroem, A.; Lindskog, S.
Activation of mercuric reductase by the substrate NADPH
Eur. J. Biochem.
164
243-249
1987
Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO 9501
Miller, S.M.; Ballou, D.P.; Massey, V.; Williams, C.H.; Walsh, C.T.
Two-electron reduced mercuric reductase binds Hg(II) to the active site dithiol but does not catalyze Hg(II) reduction
J. Biol. Chem.
261
8081-8084
1986
Escherichia coli
Nakahara, H.; Schottel, J.L.; Yamada, T.; Miyakawa, Y.; Asakawa, M.; Harville, J.; Silver, S.
Mercuric reductase enzymes from Streptomyces species and group B Streptococcus
J. Gen. Microbiol.
131
1053-1059
1985
BRENDA: Streptococcus agalactiae, Streptomyces coelicolor, Streptomyces espinosus, Streptomyces lividans, Streptomyces lividans 1326, Streptomyces coelicolor M130, Streptomyces espinosus 5, Streptomyces lividans 8
Textmining: Streptococcus sp. 'group B', Streptomyces
Booth, J.E.; Williams, J.W.
The isolation of a mercuric ion-reducing flavoprotein from Thiobacillus ferrooxidans
J. Gen. Microbiol.
130
725-730
1984
BRENDA: Acidithiobacillus ferrooxidans, Acidithiobacillus ferrooxidans TFI 29
Textmining: Streptococcus sp. 'group B', Streptomyces
Meissner, P.S.; Falkinham, J.O.
Plasmid-encoded mercuric reductase in Mycobacterium scrofulaceum
J. Bacteriol.
157
669-672
1984
Mycobacterium scrofulaceum
Blaghen, M.; Lett, M.C.; Vidon, D.J.M.
Mercuric reductase activity in a mercury-resistant strain of Yersinia enterolytica
FEMS Microbiol. Lett.
19
93-96
1983
Yersinia enterolytica, Yersinia enterolytica 138A14
-
Carlberg, I.C.; Sahlman, L.; Mannervik, B.
The effect of 2,4,6-trinitrobenzenesulfonate on mercuric reductase, glutathione reductase and lipoamide dehydrogenase
FEBS Lett.
180
102-106
1985
Escherichia coli, Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO9501, Pseudomonas aeruginosa PAO 9501
Bogdanova, E.S.; Mindlin, S.Z.; Kalyaeva, E.S.; Nikiforov, V.G.
The diversity of mercury reductases among mercury-resistant bacteria
FEBS Lett.
234
280-282
1988
Acinetobacter calcoaceticus, Acinetobacter lwoffii, Aeromonas sp., Geobacillus stearothermophilus, Bacillus licheniformis, Paenibacillus polymyxa, Bacillus sp. (in: Bacteria), Lysinibacillus sphaericus, Escherichia coli, Erwinia sp., Staphylococcus aureus, Kocuria rosea, Oerskovia sp., Pseudomonas sp., Pseudomonas aeruginosa, Pseudomonas alcaligenes, Pseudomonas fluorescens, Pseudomonas mendocina, Rhodococcus sp., Staphylococcus saprophyticus, Xanthomonas campestris, Xanthomonas sp.
Fox, B.S.; Walsh, C.T.
Mercuric reductase: homology to glutathione reductase and lipoamide dehydrogenase. Iodoacetamide alkylation and sequence of the active site peptide
Biochemistry
22
4082-4088
1983
Pseudomonas aeruginosa
Sahlman, L.; Lambeir, A.M.; Lindskog, S.
Rapid-scan stopped-flow studies of the pH dependence of the reaction between mercuric reductase and NADPH
Eur. J. Biochem.
156
479-488
1986
Pseudomonas aeruginosa
Inoue, C.; Sugawara, K.; Shiratori, T.; Kusano, T.; Kitagawa, Y.
Nucleotide sequence of the Thiobacillus ferrooxidans chromosomal gene encoding mercuric reductase
Gene
84
47-54
1989
Acidithiobacillus ferrooxidans
Rennex, D.; Pickett, M.; Bradley, M.
In vivo and in vitro effects of mutagenesis of active site tyrosine residues of mercuric reductase
FEBS Lett.
355
220-222
1994
Escherichia coli
Anspach, F.B.; Hueckel, M.; Brunke, M.; Schuette, H.; Deckwer, W.D.
Immobilization of mercuric reductase from a Pseudomonas putida strain on different activated carriers
Appl. Biochem. Biotechnol.
44
135-150
1994
Pseudomonas putida, Pseudomonas putida KT2442::mer-73
-
Blaghen, M.; Vidon, D.J.M.; El Kebbaj, M.S.
Purification and properties of mercuric reductase from Yersinia enterocolitica 138A14
Can. J. Microbiol.
39
193-200
1993
BRENDA: Yersinia enterolytica, Yersinia enterolytica 138A14
Textmining: Yersinia enterocolitica
Ghosh, S.; Sadhukhan, P.C.; Chaudhuri, J.; Ghosh, D.K.; Mandal, A.
Purification and properties of mercuric reductase from Azotobacter chroococcum
J. Appl. Microbiol.
86
7-12
1999
Azotobacter chroococcum, Azotobacter chroococcum SS2
-
Moore, M.J.; Miller, S.M.; Walsh, C.T.
C-Terminal cysteines of Tn501 mercuric ion reductase
Biochemistry
31
1677-1685
1992
Escherichia coli
Engst, S.; Miller, S.M.
Alternative Routes for Entry of HgX2 into the Active Site of Mercuric Ion Reductase Depend on the Nature of the X Ligands
Biochemistry
38
3519-3529
1999
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) RC607
Chang, J.S.; Hwang, Y.P.; Fong, Y.M.; Lin, P.J.
Detoxification of mercury by immobilized mercuric reductase
J. Chem. Technol. Biotechnol.
74
965-973
1999
Escherichia coli, Escherichia coli PWS1
-
Rennex, D.; Cummings, R.T.; Pickett, M.; Walsh, C.T.; Bradley, M.
Role of tyrosine residues in Hg(II) detoxification by mercuric reductase from Bacillus sp. strain RC607
Biochemistry
32
7475-7478
1993
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) RC607
Bizily, S.P.; Rugh, C.L.; Meagher, R.B.
Phytodetoxification of hazardous organomercurials by genetically engineered plants
Nat. Biotechnol.
18
213-217
2000
plant
Zeroual, Y.; Moutaouakkil, A.; Dzairi, F.Z.; Talbi, M.; Chung, P.U.; Lee, K.; Blaghen, M.
Purification and characterization of cytosolic mercuric reductase from Klebsiella pneumoniae
Ann. Microbiol.
53
149-160
2003
Klebsiella pneumoniae
-
Vetriani, C.; Chew, Y.S.; Miller, S.M.; Yagi, J.; Coombs, J.; Lutz, R.A.; Barkay, T.
Mercury adaptation among bacteria from a deep-sea hydrothermal vent
Appl. Environ. Microbiol.
71
220-226
2005
Halomonas sp., Pseudomonas sp., Pseudoalteromonas sp., Pseudoalteromonas sp. (Q5ILH6), Alcanivorax sp., Alcanivorax sp. (Q5ILH3), Alcanivorax sp. (Q5ILH4), Alcanivorax sp. (Q5ILH5), Marinobacter sp., Alcanivorax sp. EPR 10, Alcanivorax sp. EPR 5, Alcanivorax sp. EPR 7 (Q5ILH4), Alcanivorax sp. EPR 6 (Q5ILH5), Alcanivorax sp. EPR 8 (Q5ILH3)
Kholodii, G.; Bogdanova, E.
Tn5044-conferred mercury resistance depends on temperature: the complexity of the character of thermosensitivity
Genetica
115
233-241
2002
Escherichia coli
Simbahan, J.; Kurth, E.; Schelert, J.; Dillman, A.; Moriyama, E.; Jovanovich, S.; Blum, P.
Community analysis of a mercury hot spring supports occurrence of domain-specific forms of mercuric reductase
Appl. Environ. Microbiol.
71
8836-8845
2005
BRENDA: uncultured bacterium
Textmining: Bacteria
Ledwidge, R.; Patel, B.; Dong, A.; Fiedler, D.; Falkowski, M.; Zelikova, J.; Summers, A.O.; Pai, E.F.; Miller, S.M.
NmerA, the metal binding domain of mercuric ion reductase, removes Hg2+ from proteins, delivers it to the catalytic core, and protects cells under glutathione-depleted conditions
Biochemistry
44
11402-11416
2005
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) RC607
Schneider, M.; Deckwer, W.
Kinetics of mercury reduction by Serratia marcescens mercuric reductase expressed by Pseudomonas putida strains
Eng. Life Sci.
5
415-424
2005
Serratia marcescens
-
Schelert, J.; Dixit, V.; Hoang, V.; Simbahan, J.; Drozda, M.; Blum, P.
Occurrence and characterization of mercury resistance in the hyperthermophilic archaeon Sulfolobus solfataricus by use of gene disruption.
J. Bacteriol.
186
427-437
2004
BRENDA: Saccharolobus solfataricus (Q97VD9), Saccharolobus solfataricus
Textmining: Bacteria
Schue, M.; Glendinning, K.J.; Hobman, J.L.; Brown, N.L.
Evidence for direct interactions between the mercuric ion transporter (MerT) and mercuric reductase (MerA) from the Tn501 mer operon
Biometals
21
107-116
2008
BRENDA: Escherichia coli K-12
Textmining: Bacteria
Oregaard, G.; S?rensen, S.J.
High diversity of bacterial mercuric reductase genes from surface and sub-surface floodplain soil (Oak Ridge, USA)
ISME J.
1
453-467
2007
BRENDA: uncultured Gammaproteobacteria bacterium, Actinobacteria, uncultured beta proteobacterium
Textmining: Bacteria, Firmicutes
Park, S.; Ely, R.L.
Candidate stress genes of Nitrosomonas europaea for monitoring inhibition of nitrification by heavy metals
Appl. Environ. Microbiol.
74
5475-5482
2008
Nitrosomonas europaea
Radniecki, T.S.; Semprini, L.; Dolan, M.E.
Expression of merA, amoA and hao in continuously cultured Nitrosomonas europaea cells exposed to zinc chloride additions
Biotechnol. Bioeng.
102
546-553
2009
Nitrosomonas europaea
Radniecki, T.S.; Semprini, L.; Dolan, M.E.
Expression of merA, trxA, amoA, and hao in continuously cultured Nitrosomonas europaea cells exposed to cadmium sulfate additions
Biotechnol. Bioeng.
104
1004-1011
2009
Nitrosomonas europaea
Zeyaullah, M.; Haque, S.; Nabi, G.; Nand, K.; Ali, A.
Molecular cloning and expression of bacterial mercuric reductase gene
Afr. J. Biotechnol.
9
3714-3718
2010
plasmid R100
-
Hong, B.; Nauss, R.; Harwood, I.M.; Miller, S.M.
Direct measurement of mercury(II) removal from organomercurial lyase (MerB) by tryptophan fluorescence: NmerA domain of coevolved gamma-proteobacterial mercuric ion reductase (MerA) is more efficient than MerA catalytic core or glutathione
Biochemistry
49
8187-8196
2010
Serratia marcescens (E0XF09)
Ledwidge, R.; Hong, B.; Doetsch, V.; Miller, S.M.
NmerA of Tn501 mercuric ion reductase: structural modulation of the pKa values of the metal binding cysteine thiols
Biochemistry
49
8988-8998
2010
Pseudomonas aeruginosa
Haque, S.; Zeyaullah, M.; Nabi, G.; Srivastava, P.S.; Ali, A.
Transgenic tobacco plant expressing environmental E. coli merA gene for enhanced volatilization of ionic mercury
J. Microbiol. Biotechnol.
20
917-924
2010
BRENDA: Escherichia coli (Q93UN8), Escherichia coli
Textmining: Nicotiana tabacum, Electron
Kim, J.; Copley, S.D.
The orphan protein bis-?-glutamylcystine reductase joins the pyridine nucleotide disulfide reductase family
Biochemistry
52
2905-2913
2013
Escherichia coli
Freedman, Z.; Zhu, C.; Barkay, T.
Mercury resistance and mercuric reductase activities and expression among chemotrophic thermophilic Aquificae
Appl. Environ. Microbiol.
78
6568-6575
2012
BRENDA: Hydrogenivirga sp. 128-5-R1-1 (A8UT36), Hydrogenobaculum sp. Y04AAS1 (B4U9T7)
Textmining: Aquificae
Zhang, W.; Chen, L.; Liu, D.
Characterization of a marine-isolated mercury-resistant Pseudomonas putida strain SP1 and its potential application in marine mercury reduction
Appl. Microbiol. Biotechnol.
93
1305-1314
2012
Pseudomonas putida, Pseudomonas putida SP1
Bafana, A.; Chakrabarti, T.; Krishnamurthi, K.
Mercuric reductase activity of multiple heavy metal-resistant Lysinibacillus sphaericus G1
J. Basic Microbiol.
55
285-992
2015
Lysinibacillus sphaericus (D9J041), Lysinibacillus sphaericus, Lysinibacillus sphaericus G1 (D9J041)
Sayed, A.; Ghazy, M.A.; Ferreira, A.J.; Setubal, J.C.; Chambergo, F.S.; Ouf, A.; Adel, M.; Dawe, A.S.; Archer, J.A.; Bajic, V.B.; Siam, R.; El-Dorry, H.
A novel mercuric reductase from the unique deep brine environment of Atlantis II in the Red Sea
J. Biol. Chem.
289
1675-1687
2014
uncultured prokaryote (V5TDP2)
Johs, A.; Harwood, I.M.; Parks, J.M.; Nauss, R.E.; Smith, J.C.; Liang, L.; Miller, S.M.
Structural characterization of intramolecular Hg2+ transfer between flexibly linked domains of mercuric ion reductase
J. Mol. Biol.
413
639-656
2011
Shigella flexneri
Lian, P.; Guo, H.B.; Riccardi, D.; Dong, A.; Parks, J.M.; Xu, Q.; Pai, E.F.; Miller, S.M.; Wei, D.Q.; Smith, J.C.; Guo, H.
X-ray structure of a Hg2+ complex of mercuric reductase (MerA) and quantum mechanical/molecular mechanical study of Hg2+ transfer between the C-terminal and buried catalytic site cysteine pairs
Biochemistry
53
7211-7222
2014
Pseudomonas aeruginosa
Bafana, A.; Khan, F.; Suguna, K.
Structural and functional characterization of mercuric reductase from Lysinibacillus sphaericus strain G1
Biometals
30
809-819
2017
BRENDA: Lysinibacillus sphaericus (D9J041), Lysinibacillus sphaericus, Lysinibacillus sphaericus G1 (D9J041)
Textmining: Bacteria
Hong, L.; Sharp, M.A.; Poblete, S.; Biehl, R.; Zamponi, M.; Szekely, N.; Appavou, M.S.; Winkler, R.G.; Nauss, R.E.; Johs, A.; Parks, J.M.; Yi, Z.; Cheng, X.; Liang, L.; Ohl, M.; Miller, S.M.; Richter, D.; Gompper, G.; Smith, J.C.
Structure and dynamics of a compact state of a multidomain protein, the mercuric ion reductase
Biophys. J.
107
393-400
2014
Pseudomonas aeruginosa
Keirsse-Haquin, J.; Picaud, T.; Bordes, L.; de Gracia, A.G.; Desbois, A.
Modulation of the flavin-protein interactions in NADH peroxidase and mercuric ion reductase a resonance Raman study
Eur. Biophys. J.
47
205-223
2018
Enterococcus faecalis, Cupriavidus metallidurans
Moller, A.K.; Barkay, T.; Hansen, M.; Norman, A.; Hansen, L.; Soslas, S.; rensen, S.; Boyd, E.; Kroer, N.
Mercuric reductase genes (merA) and mercury resistance plasmids in high arctic snow, freshwater and sea-ice brine
FEMS Microbiol. Ecol.
87
52-63
2014
Variovorax sp. SOK15 (T1RLC6), Pseudomonas sp. SOK70 (T1RLC7), Arthrobacter sp. 8D5s (T1RLC8), Bacillus sp. SOK1b (T1RLH1), Flavobacterium sp. SOK62 (T1RLH3), Pseudomonas sp. SOK89 (T1RLH7), Pseudomonas sp. SOK44 (T1RLH8), Pseudomonas sp. SOK13 (T1RLH9), Pseudomonas sp. SOK52 (T1RR73), Pseudomonas sp. SOK32 (T1RR74), Pseudomonas sp. SOK80 (T1RR75), Pseudomonas sp. SOK65 (T1RR77), Pseudomonas sp. SOK54 (T1RRJ1), Sphingomonas sp. SOK19y (T1RRJ3), Pseudomonas sp. SOK75 (T1RRJ7), Pseudomonas sp. SOK59 (T1RRJ9), Sphingomonas sp. SOK19 (T1RRK0), Pseudomonas sp. SOK73 (T1RRK2), Pseudomonas sp. SOK43 (T1RRL9), Pseudomonas sp. SOK41 (T1RRM0), Sphingomonas sp. SOK5 (T1RRM1), Pseudomonas sp. SOK85 (T1RRM2), Pseudomonas sp. SOK50 (T1RRS1), Pseudomonas sp. SOK33 (T1RRS2), Pseudomonas sp. SOK84 (T1RRS3), Pseudomonas sp. SOK68 (T1RRS4)
Artz, J.H.; White, S.N.; Zadvornyy, O.A.; Fugate, C.J.; Hicks, D.; Gauss, G.H.; Posewitz, M.C.; Boyd, E.S.; Peters, J.W.
Biochemical and structural properties of a thermostable mercuric ion reductase from Metallosphaera sedula
Front. Bioeng. Biotechnol.
3
97
2015
Metallosphaera sedula (A4YG49), Metallosphaera sedula, Metallosphaera sedula ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2 (A4YG49)
Giovanella, P.; Cabral, L.; Bento, F.M.; Gianello, C.; Camargo, F.A.
Mercury (II) removal by resistant bacterial isolates and mercuric (II) reductase activity in a new strain of Pseudomonas sp. B50A
New Biotechnol.
33
216-223
2016
BRENDA: Pseudomonas putida, Pseudomonas entomophila, Enterobacter sp. B50C, Enterobacter sp. A25B, Pseudomonas sp. B50A, Pseudomonas sp. B50B, Pseudomonas sp. B50D, Pseudomonas entomophila A50A, Pseudomonas putida V1, Pseudomonas entomophila B100A
Textmining: Pseudomonas sp., Bacteria
Otulakowski, G; Robinson, BH
Isolation and sequence determination of cDNA clones for porcine and human lipoamide dehydrogenase. Homology to other disulfide oxidoreductases.
J Biol Chem
262
17313-8
1987
Homo sapiens
Stephens, PE; Lewis, HM; Darlison, MG; Guest, JR
Nucleotide sequence of the lipoamide dehydrogenase gene of Escherichia coli K12.
Eur J Biochem
135
519-27
1983
Homo sapiens, Sus scrofa
Jang, YJ; Chung, KS; Park, C; Yoo, HS
Fission yeast dihydrolipoamide dehydrogenase gene is involved in G1/S cell cycle progression.
Biochim Biophys Acta
1358
229-39
1997
Schizosaccharomyces pombe, Bacteria
Perry, AC; Ni Bhriain, N; Brown, NL; Rouch, DA
Molecular characterization of the gor gene encoding glutathione reductase from Pseudomonas aeruginosa: determinants of substrate specificity among pyridine nucleotide-disulphide oxidoreductases.
Mol Microbiol
5
163-71
1991
Pseudomonas aeruginosa, Transposon Tn501
Perr, ACF; Bhriain, NN; Brown, NL; Rouch, DA
Molecular characterization of the gor gene encoding glutathione reductase from Pseudomonas aeruginosa: determinants of substrate specificity among pyridine nucleotide-disulphide oxidoreductases.
Mol Microbiol
5
163-171
1991
Pseudomonas aeruginosa, Transposon Tn501
Russel, M; Model, P
Sequence of thioredoxin reductase from Escherichia coli. Relationship to other flavoprotein disulfide oxidoreductases.
J Biol Chem
263
9015-9
1988
Escherichia coli
Poole, LB; Claiborne, A
The non-flavin redox center of the streptococcal NADH peroxidase. I. Thiol reactivity and redox behavior in the presence of urea.
J Biol Chem
264
12322-9
1989
Streptococcus
Bogdanova, ES; Mindlin, SZ; Pakrová, E; Kocur, M; Rouch, DA
Mercuric reductase in environmental gram-positive bacteria sensitive to mercury.
FEMS Microbiol Lett
76
95-100
1992
Firmicutes
Blaghen, M; el Kebbaj, MS; Vidon, DJ; Tritsch, D
Essential arginines in mercuric reductase isolated from Yersinia enterocolitica 138A14.
Biochimie
74
557-60
1992
Yersinia enterocolitica
Rensing, C; Kües, U; Stahl, U; Nies, DH; Friedrich, B
Expression of bacterial mercuric ion reductase in Saccharomyces cerevisiae.
J Bacteriol
174
1288-92
1992
Saccharomyces cerevisiae, Saccharomyces cerevisiae AH22
Steingrube, VA; Wallace, RJ; Steele, LC; Pang, YJ
Mercuric reductase activity and evidence of broad-spectrum mercury resistance among clinical isolates of rapidly growing mycobacteria.
Antimicrob Agents Chemother
35
819-23
1991
Corynebacteriales
Schiering, N; Kabsch, W; Moore, MJ; Distefano, MD; Walsh, CT; Pai, EF
Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607.
Nature
352
168-72
1991
Bacillus sp. (in: Bacteria)
Misra, TK; Brown, NL; Haberstroh, L; Schmidt, A; Goddette, D; Silver, S
Mercuric reductase structural genes from plasmid R100 and transposon Tn501: functional domains of the enzyme.
Gene
34
253-62
1985
Transposon Tn501, plasmid R100, Homo sapiens
Walsh, C; Distefano, M; Moore, M
Mutagenesis of paired cysteine residues in the disulphide-containing flavoprotein mercuric ion reductase from mercury-resistant bacteria.
Biochem Soc Trans
16
90-1
1988
Bacteria
Trevors, JT
Mercury-resistance and mercuric reductase activity in Chromobacterium, Erwinia, and Bacillus species.
Bull Environ Contam Toxicol
38
1070-5
1987
Chromobacterium, Erwinia, Bacillus
Summers, AO; Kight-Olliff, L
Tn1 generated mutants in the mercuric ion reductase of the Inc P plasmid, R702.
Mol Gen Genet
180
91-7
1980
Plasmid R702, insertion sequences
Brown, NL; Ford, SJ; Pridmore, RD; Fritzinger, DC
Nucleotide sequence of a gene from the Pseudomonas transposon Tn501 encoding mercuric reductase.
Biochemistry
22
4089-95
1983
Pseudomonas, Transposon Tn501
Chen, J; Carey, K; Godowski, PJ
Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation.
Oncogene
14
2033-9
1997
Transformation
Vallverdú, A; Asturias, JA; Arilla, MC; Gómez-Bayón, N; MartÃnez, A; MartÃnez, J; Palacios, R
Characterization of recombinant Mercurialis annua major allergen Mer a 1 (profilin).
J Allergy Clin Immunol
101
363-70
1998
Mercurialis annua, Escherichia coli, Ricinus communis, Olea europaea, Helianthus, Homo sapiens
Yang, H; Nairn, J; Ozias-Akins, P
Transformation of peanut using a modified bacterial mercuric ion reductase gene driven by an actin promoter from Arabidopsis thaliana.
J Plant Physiol
160
945-52
2003
Arabidopsis thaliana, Arachis hypogaea, Transformation
Rossy, E; Champier, L; Bersch, B; Brutscher, B; Blackledge, M; Covès, J
Biophysical characterization of the MerP-like amino-terminal extension of the mercuric reductase from Ralstonia metallidurans CH34.
J Biol Inorg Chem
9
49-58
2004
Cupriavidus metallidurans CH34
Huang, CC; Chen, MW; Hsieh, JL; Lin, WH; Chen, PC; Chien, LF
Expression of mercuric reductase from Bacillus megaterium MB1 in eukaryotic microalga Chlorella sp. DT: an approach for mercury phytoremediation.
Appl Microbiol Biotechnol
72
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Bacillus megaterium MB1, Chlorella, Priestia megaterium
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Folia Microbiol (Praha)
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Bacteria
Zeyaullah, M; Nabi, G; Malla, R; Ali, A
Molecular studies of E. coli mercuric reductase gene (merA) and its impact on human health.
Nepal Med Coll J
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Escherichia coli, Homo sapiens, Bacteria
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Mercuric reductase genes (merA) and mercury resistance plasmids in High Arctic snow, freshwater and sea-ice brine.
FEMS Microbiol Ecol
2013
plasmids
Mathew, DC; Mathew, GM; Gicana, RG; Huang, CC
Genome Sequence of Photobacterium halotolerans MELD1, with Mercury Reductase (merA), Isolated from Phragmites australis.
Genome Announc
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Phragmites australis, Photobacterium halotolerans
Dash, HR; Sahu, M; Mallick, B; Das, S
Functional efficiency of MerA protein among diverse mercury resistant bacteria for efficient use in bioremediation of inorganic mercury.
Biochimie
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Bacteria, Transformation
Arregui, G; Hipólito, P; Pallol, B; Lara-Dampier, V; García-Rodríguez, D; Varela, HP; Tavakoli Zaniani, P; Balomenos, D; Paape, T; Coba de la Peña, T; Lucas, MM; Pueyo, JJ
Mercury-Tolerant Ensifer medicae Strains Display High Mercuric Reductase Activity and a Protective Effect on Nitrogen Fixation in Medicago truncatula Nodules Under Mercury Stress.
Front Plant Sci
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Medicago truncatula, Sinorhizobium medicae, Bradyrhizobium canariense
Hart MC;Elliott GN;Osborn AM;Ritchie DA;Strike P
Diversity amongst Bacillus mer A genes amplified from mercury resistant isolates and directly from mercury polluted soil
FEMS microbiology ecology
27
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1998
Bacillus
Huang, ZM; Mi, ZH; Chu, QJ; Shan, H; Xiong, CL; Zou, YX; Xia, SH; Qin, L
[Emergence of 16S rRNA methylase gene rmtB in Klebsiella pneumoniae isolates from the inpatients in Zhejiang Province, China]
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transposons, Transposon Tn21
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Appl Environ Microbiol
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Electron
Kiyono, M; Omura, T; Fujimori, H; Pan-Hou, H
Lack of involvement of merT and merP in methylmercury transport in mercury resistant Pseudomonas K-62.
FEMS Microbiol Lett
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Pseudomonas
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FEMS Microbiol Lett
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Streptomyces lividans 1326
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Conjugal Gene Transfer to Aquatic Bacteria Detected by the Generation of a New Phenotype.
Appl Environ Microbiol
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plasmids
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Environ Geochem Health
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Appl Environ Microbiol
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Alphaproteobacteria
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Anaerobic Mercury Methylation and Demethylation by Geobacter bemidjiensis Bem.
Environ Sci Technol
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Geobacter bemidjiensis
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Expanded Diversity and Phylogeny of mer Genes Broadens Mercury Resistance Paradigms and Reveals an Origin for MerA Among Thermophilic Archaea.
Front Microbiol
12
682605
2021
Bacteria
Belliveau, BH; Trevors, JT
Mercury resistance determined by a self-transmissible plasmid in Bacillus cereus 5.
Biol Met
3
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Bacillus cereus
Bogdanova, ES; Mindlin, SZ
Occurrence of two structural types of mercury reductases among gram-positive bacteria.
FEMS Microbiol Lett
62
277-80
1991
Firmicutes, plasmids, Staphylococcus
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Hypersensitivity to Hg2+ and hyperbinding activity associated with cloned fragments of the mercurial resistance operon of plasmid NR1.
J Bacteriol
140
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Plasmid NR1, Plasmid ColE1
Foster, TJ; Nakahara, H
Deletions in the r-determinant mer region of plasmid R100-1 selected for loss of mercury hypersensitivy.
J Bacteriol
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Plasmid R100-1, insertion sequences
Wang, Y; Moore, M; Levinson, HS; Silver, S; Walsh, C; Mahler, I
Nucleotide sequence of a chromosomal mercury resistance determinant from a Bacillus sp. with broad-spectrum mercury resistance.
J Bacteriol
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Bacillus sp. (in: Bacteria), Bacillus subtilis, Bacteria, Escherichia coli, Plasmid pI258, Staphylococcus aureus
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Pathol Biol (Paris)
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plasmids
Lenartova V;Holovska K;Javorsky P
The influence of mercury on the antioxidant enzyme activity of rumen bacteria Streptococcus bovis and Selenomonas ruminantium
FEMS microbiology ecology
27
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Bacteria, Selenomonas ruminantium, Streptococcus equinus
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Gene copy number effects in the mer operon of plasmid NR1.
J Bacteriol
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Escherichia coli, Proteus mirabilis
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J Bacteriol
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Transposon Tn21
Karunakaran, T; Gunasekaran, P
Cloning and expression in Escherichia coli of mercuric ion resistance coding genes from Zymomonas mobilis.
J Biotechnol
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Escherichia coli
Ji, GY; Salzberg, SP; Silver, S
Cell-free mercury volatilization activity from three marine caulobacter strains.
Appl Environ Microbiol
55
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Caulobacter
Wang, Y; Mahler, I; Levinson, HS; Halvorson, HO
Cloning and expression in Escherichia coli of chromosomal mercury resistance genes from a Bacillus sp.
J Bacteriol
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Bacillus subtilis
Gilbert, MP; Summers, AO
The distribution and divergence of DNA sequences related to the Tn21 and Tn501 mer operons.
Plasmid
20
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1988
Transposon Tn21
Brown, NL; Misra, TK; Winnie, JN; Schmidt, A; Seiff, M; Silver, S
The nucleotide sequence of the mercuric resistance operons of plasmid R100 and transposon Tn501: further evidence for mer genes which enhance the activity of the mercuric ion detoxification system.
Mol Gen Genet
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Transposon Tn501, plasmid R100
Izaki, K
Enzymatic reduction of mercurous and mercuric ions in Bacillus cereus.
Can J Microbiol
27
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1981
Escherichia coli
Muss, HB; Richards, F; Cooper, MR; White, DR; Jackson, DV; Stuart, JJ; Howard, V; Shore, A; Rhyne, AL; Spurr, CL
Chemotherapy vs. chemoimmunotherapy with methanol extraction residue of Bacillus Calmette-Guerin (MER) in advanced breast cancer: a randomized trial by the Piedmont Oncology Association.
Cancer
47
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Homo sapiens
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Development of transgenic yellow poplar for mercury phytoremediation.
Nat Biotechnol
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Populus
Velasco, A; Acebo, P; Flores, N; Perera, J
The mer operon of the acidophilic bacterium Thiobacillus T3.2 diverges from its Thiobacillus ferrooxidans counterpart.
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3
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Thiobacillus
Bass, L; Liebert, CA; Lee, MD; Summers, AO; White, DG; Thayer, SG; Maurer, JJ
Incidence and characterization of integrons, genetic elements mediating multiple-drug resistance, in avian Escherichia coli.
Antimicrob Agents Chemother
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integrons
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Differential mercury volatilization by tobacco organs expressing a modified bacterial merA gene.
Cell Res
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Escherichia coli
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Diversity of mercury resistance determinants among Bacillus strains isolated from sediment of Minamata Bay.
FEMS Microbiol Lett
223
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2003
Bacillus
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Toward detoxifying mercury-polluted aquatic sediments with rice genetically engineered for mercury resistance.
Environ Toxicol Chem
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plant
Ojo, KK; Tung, D; Luis, H; Bernardo, M; Leitao, J; Roberts, MC
Gram-positive merA gene in gram-negative oral and urine bacteria.
FEMS Microbiol Lett
238
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2004
Bacteria, Enterobacter cloacae, Escherichia coli, Staphylococcus aureus, Streptococcus oralis, Acinetobacter junii
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Functional dissection of a mercuric ion transporter, MerC, from Acidithiobacillus ferrooxidans.
Biosci Biotechnol Biochem
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Acidithiobacillus ferrooxidans, Escherichia coli
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Novel reduction of mercury (II) by mercury-sensitive dissimilatory metal reducing bacteria.
Environ Sci Technol
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Shewanella oneidensis MR-1, bacterium
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Escherichia coli
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An initial characterization of the mercury resistance (mer) system of the thermophilic bacterium Thermus thermophilus HB27.
FEMS Microbiol Ecol
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Thermus thermophilus HB27
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Response to mercury (II) ions in Methylococcus capsulatus (Bath).
FEMS Microbiol Lett
324
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2011
Methylococcus capsulatus, Bacteria, gammaproteobacteria, Betaproteobacteria
Allen, RC; Tu, YK; Nevarez, MJ; Bobbs, AS; Friesen, JW; Lorsch, JR; McCauley, JA; Voet, JG; Hamlett, NV
The mercury resistance (mer) operon in a marine gliding flavobacterium, Tenacibaculum discolor 9A5.
FEMS Microbiol Ecol
2012
Flavobacterium johnsoniae
Battistel, D; Baldi, F; Marchetto, D; Gallo, M; Daniele, S
A Rapid Electrochemical Procedure for the Detection of Hg(0) Produced by Mercuric-Reductase: Application for Monitoring Hg-resistant Bacteria Activity.
Environ Sci Technol
2012
Pseudomonas putida, Marinobacter vinifirmus
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A rhizosphere-associated symbiont, Photobacterium spp. strain MELD1, and its targeted synergistic activity for phytoprotection against mercury.
PLoS One
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Vibrio
Mahbub, KR; Krishnan, K; Megharaj, M; Naidu, R
Bioremediation potential of a highly mercury resistant bacterial strain Sphingobium SA2 isolated from contaminated soil.
Chemosphere
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Vibrio algivorus
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Methylmercury degradation by Pseudomonas putida V1.
Ecotoxicol Environ Saf
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Pseudomonas
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Co-selection of Mercury and Multiple Antibiotic Resistances in Bacteria Exposed to Mercury in the Fundulus heteroclitus Gut Microbiome.
Curr Microbiol
2016
Chondrichthyes
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Mercury remediation potential of a mercury resistant strain Sphingopyxis sp. SE2 isolated from contaminated soil.
J Environ Sci (China)
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Ascomycota
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Metagenomic Evidence for a Methylocystis Species Capable of Bioremediation of Diverse Heavy Metals.
Front Microbiol
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Bacteria, Bradyrhizobium sp., Paracoccus halophilus
Singh, DK; Lingaswamy, B; Koduru, TN; Nagu, PP; Jogadhenu, PSS
A putative merR family transcription factor Slr0701 regulates mercury inducible expression of MerA in the cyanobacterium Synechocystis sp. PCC6803.
Microbiologyopen
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Synechocystis
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Expression and regulation of the mer operon in Thermus thermophilus.
Environ Microbiol
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Thermus thermophilus HB27
Chang, J; Si, G; Dong, J; Yang, Q; Shi, Y; Chen, Y; Zhou, K; Chen, J
Transcriptomic analyses reveal the pathways associated with the volatilization and resistance of mercury(II) in the fungus Lecythophora sp. DC-F1.
Sci Total Environ
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Fungi
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Development of transgenic hybrid sweetgum (Liquidambar styraciflua x L. formosana) expressing ?-glutamylcysteine synthetase or mercuric reductase for phytoremediation of mercury pollution
New forests.
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plant
Distefano, MD; Moore, MJ; Walsh, CT
Active site of mercuric reductase resides at the subunit interface and requires Cys135 and Cys140 from one subunit and Cys558 and Cys559 from the adjacent subunit: evidence from in vivo and in vitro heterodimer formation.
Biochemistry
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Bacteria
Ogunseitan, OA
Protein method for investigating mercuric reductase gene expression in aquatic environments.
Appl Environ Microbiol
64
695-702
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Pseudomonas aeruginosa
Che, D; Meagher, RB; Heaton, AC; Lima, A; Rugh, CL; Merkle, SA
Expression of mercuric ion reductase in Eastern cottonwood (Populus deltoides) confers mercuric ion reduction and resistance.
Plant Biotechnol J
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Bacteria
Liu, YR; He, JZ; Zhang, LM; Zheng, YM
Effects of long-term fertilization on the diversity of bacterial mercuric reductase gene in a Chinese upland soil.
J Basic Microbiol
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Transformation
Kim, T; Balish, RS; Heaton, AC; McKinney, EC; Dhankher, OP; Meagher, RB
Engineering a root-specific, repressor-operator gene complex.
Plant Biotechnol J
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Arabidopsis
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Bacterial resistances to inorganic mercury salts and organomercurials.
Plasmid
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Bacteria
Ruiz, ON; Hussein, HS; Terry, N; Daniell, H
Phytoremediation of organomercurial compounds via chloroplast genetic engineering.
Plant Physiol
132
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Transformation
Czakó, M; Feng, X; He, Y; Liang, D; Márton, L
Genetic modification of wetland grasses for phytoremediation.
Z Naturforsch [C]
60
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0
Agrobacterium, Spartina
Arenas-Salinas, M; Vargas-Pérez, JI; Morales, W; Pinto, C; Muñoz-Díaz, P; Cornejo, FA; Pugin, B; Sandoval, JM; Díaz-Vásquez, WA; Muñoz-Villagrán, C; Rodríguez-Rojas, F; Morales, EH; Vásquez, CC; Arenas, FA
Flavoprotein-Mediated Tellurite Reduction: Structural Basis and Applications to the Synthesis of Tellurium-Containing Nanostructures.
Front Microbiol
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1160
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Bacteria, Escherichia coli
Voith, MA; Lichtenfeld, KM; Schimpff, SC; Wiernik, PH
Systemic complications of MER immunotherapy of cancer: pulmonary granulomatosis and rash.
Cancer
43
500-4
1979
Mycobacterium tuberculosis variant bovis BCG
Barkay, T; Fouts, DL; Olson, BH
Preparation of a DNA gene probe for detection of mercury resistance genes in gram-negative bacterial communities.
Appl Environ Microbiol
49
686-92
1985
Bacteria
Scott, RS; McMahon, EJ; Pop, SM; Reap, EA; Caricchio, R; Cohen, PL; Earp, HS; Matsushima, GK
Phagocytosis and clearance of apoptotic cells is mediated by MER.
Nature
411
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Mus sp.
Brown, NL; Shih, YC; Leang, C; Glendinning, KJ; Hobman, JL; Wilson, JR
Mercury transport and resistance.
Biochem Soc Trans
30
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2002
Bacteria
Barkay, T; Miller, SM; Summers, AO
Bacterial mercury resistance from atoms to ecosystems.
FEMS Microbiol Rev
27
355-84
2003
Bacteria
Anast, N; Smit, J
Isolation and Characterization of Marine Caulobacters and Assessment of Their Potential for Genetic Experimentation.
Appl Environ Microbiol
54
809-817
1988
plasmids
Kritee, K; Blum, JD; Johnson, MW; Bergquist, BA; Barkay, T
Mercury stable isotope fractionation during reduction of Hg(II) to Hg(0) by mercury resistant microorganisms.
Environ Sci Technol
41
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2007
Bacteria
Wang, Y; Boyd, E; Crane, S; Lu-Irving, P; Krabbenhoft, D; King, S; Dighton, J; Geesey, G; Barkay, T
Environmental Conditions Constrain the Distribution and Diversity of Archaeal merA in Yellowstone National Park, Wyoming, U.S.A.
Microb Ecol
2011
Transformation
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