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Information on EC 1.15.1.1 - superoxide dismutase and Organism(s) Danio rerio

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IUBMB Comments
A metalloprotein; also known as erythrocuprein, hemocuprein or cytocuprein. Enzymes from most eukaryotes contain both copper and zinc; those from mitochondria and most prokaryotes contain manganese or iron.
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This record set is specific for:
Danio rerio
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The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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2
superoxide
+
2
H+
=
O2
+
H2O2
2
+
2
=
+
Synonyms
superoxide dismutase, sod, mnsod, manganese superoxide dismutase, mn-sod, ec-sod, cuznsod, superoxide dismutase 1, cu/zn superoxide dismutase, sod-1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
copper-zinc superoxide dismutase
-
-
-
-
Cu,Zn-SOD
-
-
-
-
Cu-Zn superoxide dismutase
-
-
-
-
cuprein
-
-
-
-
cytocuprein
-
-
-
-
dismutase, superoxide
-
-
-
-
erythrocuprein
-
-
-
-
Fe-SOD
-
-
-
-
ferrisuperoxide dismutase
-
-
-
-
hemocuprein
-
-
-
-
hepatocuprein
-
-
-
-
manganese superoxide dismutase
-
Mn-SOD
SOD
-
-
-
-
SOD-1
-
-
-
-
SOD-2
-
-
-
-
SOD-3
-
-
-
-
SOD-4
-
-
-
-
SODF
-
-
-
-
SODS
-
-
-
-
superoxide dismutase
-
-
-
-
superoxide dismutase I
-
-
-
-
superoxide dismutase II
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
superoxide:superoxide oxidoreductase
A metalloprotein; also known as erythrocuprein, hemocuprein or cytocuprein. Enzymes from most eukaryotes contain both copper and zinc; those from mitochondria and most prokaryotes contain manganese or iron.
CAS REGISTRY NUMBER
COMMENTARY hide
9054-89-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 O2.- + 2 H+
O2 + H2O2
show the reaction diagram
-
-
-
?
O2- + H+
O2 + H2O2
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 O2.- + 2 H+
O2 + H2O2
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
not inhibitory: sodium dodecyl sulfate up to 4%
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2000
-
pH 10.2, 25°C
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2.2 - 11.2
high enzyme activity
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.29
sequence calculation, MnSOD
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SODC_DANRE
154
0
15953
Swiss-Prot
other Location (Reliability: 2)
Q2TV65_DANRE
224
0
24978
TrEMBL
Mitochondrion (Reliability: 1)
E9QIM2_DANRE
192
0
20778
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1NT23_DANRE
664
0
76854
TrEMBL
other Location (Reliability: 2)
H9L6X3_DANRE
213
0
23790
TrEMBL
Secretory Pathway (Reliability: 2)
A5PLA4_DANRE
213
0
23749
TrEMBL
Secretory Pathway (Reliability: 2)
B2GRH9_DANRE
154
0
15953
TrEMBL
other Location (Reliability: 2)
A0A8M1PC95_DANRE
224
0
25008
TrEMBL
Mitochondrion (Reliability: 1)
Q6P980_DANRE
224
0
25008
TrEMBL
Mitochondrion (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
24989
x * 24989, sequence calculation, MnSOD
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 24989, sequence calculation, MnSOD
additional information
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2.3 - 12
-
-
659841
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
80
purified recombinant enzyme, 48% remaining activity after 10 min
90
purified recombinant enzyme, inactivation after 10 min
additional information
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
the enzyme is stable in presence of 4% SDS
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant enzyme from Escherichia coli strain QC779
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, real-time RT-PCR expression analysis, sequence comparisons, expression in Escherichia coli strain QC779
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
agriculture
-
soaking fish larva in enzyme solution protects fish from 100 ppm paraquat-induced oxidative injury
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ken, C.F.; Lin, C.T.; Shaw, J.F.; Wu, J.L.
Characterization of fish Cu/Zn-superoxide dismutase and its protection from oxidative stress
Mar. Biotechnol.
5
167-173
2003
Danio rerio
Manually annotated by BRENDA team
Lin, C.T.; Tseng, W.C.; Hsiao, N.W.; Chang, H.H.; Ken, C.F.
Characterization, molecular modelling and developmental expression of zebrafish manganese superoxide dismutase
Fish Shellfish Immunol.
27
318-324
2009
Danio rerio (Q2TV65), Danio rerio, Danio rerio AB (Q2TV65)
Manually annotated by BRENDA team