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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
additional information
?
-
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
cholesterol 25-hydroxylase has the capacity to play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of gene transcription
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
genetic variability in the set of cholesterol metabolism genes: cholesterol 25-hydroxylase, cholesterol 24-hydroxylase and ATP-binding cassette transporter A1 does not influence the development of Alzheimers disease
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the enzyme has the capacity to synthesize an active and potent regulator of the sterol response element binding protein pathway within the cell
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
lower 25-hydroxylation enzyme activity by CYP1A2 compared to marker enzyme CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
lower 25-hydroxylation enzyme activity by CYP2C9 compared to marker enzyme CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
lower 25-hydroxylation enzyme activity by CYP2D6 compared to marker enzyme CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
production of 25-hydroxycholesterol by intact CYP3A4, most significant activity is 25-hydroxylation, which is higher than that of 4beta-hydroxylation, a marker activity of CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the reaction might be catalyzed by CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
cholesterol 25-hydroxylase has the capacity to play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of gene transcription
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the enzyme has the capacity to synthesize an active and potent regulator of the sterol response element binding protein pathway within the cell
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the reaction might be catalyzed by CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
testicular macrophagers play an important role in the differentiation of Leydig cells through the secretion of 25-hydroxycholesterol
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
expression of 25-hydroxylase mRNA and production of 25-hydroxycholesterol by cultured testicular macrophages is significantly inhibited by testosterone at 0.01 mg/ml
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
additional information
?
-
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
-
-
?
additional information
?
-
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
-
-
?
additional information
?
-
-
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
-
-
?
additional information
?
-
-
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
additional information
?
-
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
cholesterol 25-hydroxylase has the capacity to play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of gene transcription
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
genetic variability in the set of cholesterol metabolism genes: cholesterol 25-hydroxylase, cholesterol 24-hydroxylase and ATP-binding cassette transporter A1 does not influence the development of Alzheimers disease
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the enzyme has the capacity to synthesize an active and potent regulator of the sterol response element binding protein pathway within the cell
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
lower 25-hydroxylation enzyme activity by CYP1A2 compared to marker enzyme CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
lower 25-hydroxylation enzyme activity by CYP2C9 compared to marker enzyme CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
lower 25-hydroxylation enzyme activity by CYP2D6 compared to marker enzyme CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
production of 25-hydroxycholesterol by intact CYP3A4, most significant activity is 25-hydroxylation, which is higher than that of 4beta-hydroxylation, a marker activity of CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the reaction might be catalyzed by CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
cholesterol 25-hydroxylase has the capacity to play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of gene transcription
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the enzyme has the capacity to synthesize an active and potent regulator of the sterol response element binding protein pathway within the cell
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the reaction might be catalyzed by CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
testicular macrophagers play an important role in the differentiation of Leydig cells through the secretion of 25-hydroxycholesterol
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
additional information
?
-
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
-
-
?
additional information
?
-
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
-
-
?
additional information
?
-
-
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
-
-
?
additional information
?
-
-
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
-
-
?
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malfunction
loss of function of Ch25h leads to susceptibility to viral infections in vitro
malfunction
mice with a disruption in the cholesterol 25-hydroxylase gene regulate cholesterol metabolism normally. Ch25h-/- mice have higher levels of mRNAs coding for immunoglobulin A and immunoglobulin J. Disruption in the Cyp7b1 gene leads to significantly increased levels of 25-hydroxycholesterol in the circulation, and to significantly lower levels of IgA compared to wild-type mice
malfunction
patients with hereditary spastic paresis, a rare inherited disease with mutations in the CYP7B1 gene, have highly elevated levels of 25- and 27-hydroxycholesterol but normal levels of cholesterol and bile acids
malfunction
decitabine-induced hypomethylation of the cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells
physiological function
-
cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis
physiological function
-
cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis
physiological function
cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis
physiological function
cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis
physiological function
-
cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis
physiological function
cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis
physiological function
cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis
physiological function
cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis
physiological function
cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis
physiological function
cholesterol-25-hydroxylase acts as a broadly antiviral interferon-stimulated gene. CH25H converts cholesterol to a soluble antiviral factor, 25-hydroxycholesterol. 25-Hydroxycholesterol treatment in cultured cells broadly inhibits growth of enveloped viruses including VSV, HSV, HIV, and MHV68 and acutely pathogenic EBOV, RVFV, RSSEV, and Nipah viruses. The compound inhibits cell entry of viruses HIV and VSV, and inhibits viral protein-mediated cell-cell membrane fusion of virus NIV. 25-Hydroxycholesterol directly modifies membranes
physiological function
-
formation of 25-hydroxycholesterol in liver mitochondria is dependent on CYP27A1, and the 25-hydroxycholesterol formed is subsequently sulfated by the insulin-regulated cytosolic sulfotransferase 2B1b. 25-Hydroxycholesterol decreases the level of cytoplasmic IkBa and increases the nuclear NFkB level, its sulfated form has the opposite effects
physiological function
formation of 25-hydroxycholesterol in liver mitochondria is dependent on CYP27A1, and the 25-hydroxycholesterol formed is subsequently sulfated by the insulin-regulated cytosolic sulfotransferase 2B1b. 25-Hydroxycholesterol is, however, a weak activator of the liver X receptors. 25-Hydroxycholesterol is of great importance for maintaining cholesterol homeostasis. 25-Hydroxycholesterol induces the secretion of the proinflammatory cytokine IL-8
physiological function
important role for 25-hydroxycholesterol in the immune system. High concentrations of 25-hydroxycholesterol induce apoptosis in a mouse oligodendrocyte cell line 158N in an liver X receptor-independent manner. Treatment of these cells with 25-hydroxycholesterol results in enhanced secreted phospholipase A2 activity
physiological function
-
adenovirus-mediated enzyme overexpression in mice improves glucose tolerance and insulin sensitivity and lowers the homeostatic model assessment for insulin resistance score
physiological function
-
cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication
physiological function
-
cholesterol 25-hydroxylase inhibits porcine reproductive and respiratory syndrome virus replication
physiological function
enzyme expression in human hepatoma cells restricts hepatitis C virus infection in a genotype-independent manner
physiological function
-
the enzyme is a host restriction factor and part of the primary innate immune responses against hepatitis C virus infection. The enzyme inhibits hepatitis C virus infection by suppressing the maturation of sterol regulatory element-binding proteins, critical transcription factors for host lipid biosynthesis
physiological function
the enzyme restricts hepatitis C virus replication not only through its enzyme activity to produce 25-hydroxycholesterol but also by targeting the NS5A protein leading to the selective inhibition of NS5A dimer formation
additional information
-
Ch25h expression is controlled primarily by type I IFN signaling, type1 IFN-mediated Ch25h expression is IFNR-dependent, overview
additional information
25-hydroxycholesterol does not stimulate the sPLA2-IIA promoter in the mouse Schwann cell line MSC80
additional information
the high concentrations of vitamin D3 metabolites required for upregulation of the cholesterol 25-hydroxylase gene makes it unlikely that these metabolites are important regulators of cholesterol 25-hydroxylase in vivo
additional information
-
Ch25h expression is controlled primarily by type I IFN signaling, type1 IFN-mediated Ch25h expression is IFNR-dependent, overview
-
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expressed in Huh-7.5.1 cells
expressed in MARC-145 cells
-
expression in COS cells, expression of cholesterol 25-hydroxylase in transfected cells reduces the biosynthesis of cholesterol from acetate and suppresses the cleavage of sterol regulatory element binding protein-1 and -2
gene CH25H, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10
-
gene CH25H, overexpression in HEK-293T cells
gene Ch25h, quantitative real-time RT-PCR expression analysis
-
intronless gene CH25H is located on chromosome 1, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10
intronless gene CH25H is located on chromosome 10, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10
intronless gene CH25H is located on chromosome 19, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10
intronless gene CH25H is located on chromosome 26, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10
intronless gene CH25H is located on chromosome 6, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10
-
intronless gene CH25H is located on chromosome 9, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10
recombinant expression in insect cell microsomes via baculovirus transfection
the gene encoding the enzyme is located on chromosome 10
-
expression in COS cells, expression of cholesterol 25-hydroxylase in transfected cells reduces the biosynthesis of cholesterol from acetate and suppresses the cleavage of sterol regulatory element binding protein-1 and -2
expression in COS cells, expression of cholesterol 25-hydroxylase in transfected cells reduces the biosynthesis of cholesterol from acetate and suppresses the cleavage of sterol regulatory element binding protein-1 and -2
intronless gene CH25H is located on chromosome 1, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10
intronless gene CH25H is located on chromosome 1, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10
intronless gene CH25H is located on chromosome 26, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10
-
intronless gene CH25H is located on chromosome 26, DNA and amino acid sequence deterination and analysis, sequence comparisons, gene structures and tandem locations for the human CH25H and LIPA, EC 3.1.1.13, genes on chromosome 10
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Russell, D.W.
Oxysterol biosynthetic enzymes
Biochim. Biophys. Acta
1529
126-135
2000
Homo sapiens (O95992), Mus musculus (Q9Z0F5)
brenda
Lukyanenko, Y.O.; Chen, J.J.; Hutson, J.C.
Production of 25-hydroxycholesterol by testicular macrophages and its effects on Leydig cells
Biol. Reprod.
64
790-796
2001
Rattus norvegicus
brenda
Chen, J.J.; Lukyanenko, Y.; Hutson, J.C.
25-hydroxycholesterol is produced by testicular macrophages during the early postnatal period and influences differentiation of Leydig cells in vitro
Biol. Reprod.
66
1336-1341
2002
Rattus norvegicus
brenda
Lukyanenko, Y.; Chen, J.J.; Hutson, J.C.
Testosterone regulates 25-hydroxycholesterol production in testicular macrophages
Biol. Reprod.
67
1435-1438
2002
Rattus norvegicus
brenda
Lund, E.G.; Kerr, T.A.; Sakai, J.; Li, W.P.; Russell, D.W.
cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
J. Biol. Chem.
273
34316-34327
1998
Homo sapiens (O95992), Mus musculus (Q9Z0F5)
brenda
Shibata, N.; Kawarai, T.; Lee, J.H.; Lee, H.S.; Shibata, E.; Sato, C.; Liang, Y.; Duara, R.; Mayeux, R.P.; St George-Hyslop, P.H.; Rogaeva, E.
Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease
Neurosci. Lett.
391
142-146
2006
Homo sapiens
brenda
Papassotiropoulos, A.; Lambert, J.C.; Wavrant-De Vrieze, F.; Wollmer, M.A.; von der Kammer, H.; Streffer, J.R.; Maddalena, A.; Huynh, K.D.; Wolleb, S.; Lutjohann, D.; Schneider, B.; Thal, D.R.; Grimaldi, L.M.; Tsolaki, M.; Kapaki, E.; Ravid, R.; Konietzko, U.; Hegi, T.; Pasch, T.; Jung, H.; Braak, H.
Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimers disease
Neurodegener. Dis.
2
233-241
2005
Homo sapiens
brenda
Diczfalusy, U.; Olofsson, K.; Carlsson, A.; Gong, M.; Golenbock, D.; Rooyackers, O.; Flring, U.; Bjrkbacka, H.
Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
J. Lipid Res.
50
2258-2264
2009
Homo sapiens, Mus musculus
brenda
Bauman, D.R.; Bitmansour, A.D.; McDonald, J.G.; Thompson, B.M.; Liang, G.; Russell, D.W.
25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
Proc. Natl. Acad. Sci. USA
106
16764-16769
2009
Mus musculus
brenda
Park, K.; Scott, A.L.
Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons
J. Leukoc. Biol.
88
1081-1087
2010
Mus musculus, Mus musculus BALB/cJ
brenda
Holmes, R.S.; Vandeberg, J.L.; Cox, L.A.
Genomics and proteomics of vertebrate cholesterol ester lipase (LIPA) and cholesterol 25-hydroxylase (CH25H)
3 Biotech
1
99-109
2011
Canis lupus familiaris, Gallus gallus, Xenopus tropicalis, Equus caballus (F6T000), Macaca mulatta (F7EC50), Homo sapiens (O95992), Homo sapiens, Bos taurus (Q0P599), Rattus norvegicus (Q4QQV7), Mus musculus (Q9Z0F5)
brenda
Diczfalusy, U.
On the formation and possible biological role of 25-hydroxycholesterol
Biochimie
95
455-460
2013
Rattus norvegicus, Sus scrofa, Homo sapiens (Q02318), Mus musculus (Q64459)
brenda
Liu, S.Y.; Aliyari, R.; Chikere, K.; Li, G.; Marsden, M.D.; Smith, J.K.; Pernet, O.; Guo, H.; Nusbaum, R.; Zack, J.A.; Freiberg, A.N.; Su, L.; Lee, B.; Cheng, G.
Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol
Immunity
38
92-105
2013
Mus musculus (Q9Z0F5)
brenda
Honda, A.; Miyazaki, T.; Ikegami, T.; Iwamoto, J.; Maeda, T.; Hirayama, T.; Saito, Y.; Teramoto, T.; Matsuzaki, Y.
Cholesterol 25-hydroxylation activity of CYP3A
J. Lipid Res.
52
1509-1516
2011
Homo sapiens (P05177), Homo sapiens (P08684), Homo sapiens (P10635), Homo sapiens (P11712), Mus musculus (Q9Z0F5)
brenda
Li, Z.; Martin, M.; Zhang, J.; Huang, H.Y.; Bai, L.; Zhang, J.; Kang, J.; He, M.; Li, J.; Maurya, M.R.; Gupta, S.; Zhou, G.; Sangwung, P.; Xu, Y.J.; Lei, T.; Huang, H.D.; Jain, M.; Jain, M.K.; Subramaniam, S.; Shyy, J.Y.
Krueppel-like factor 4 regulation of cholesterol-25-hydroxylase and liver X receptor mitigates atherosclerosis susceptibility
Circulation
136
1315-1330
2017
Mus musculus (Q9Z0F5)
brenda
Anggakusuma, G.; Romero-Brey, I.; Berger, C.; Colpitts, C.C.; Boldanova, T.; Engelmann, M.; Todt, D.; Perin, P.M.; Behrendt, P.; Vondran, F.W.; Xu, S.; Goffinet, C.; Schang, L.M.; Heim, M.H.; Bartenschlager, R.; Pietschmann, T.; Steinmann, E.
Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation
Hepatology
62
702-714
2015
Homo sapiens (Q95992), Homo sapiens
brenda
Noebauer, B.; Jais, A.; Todoric, J.; Gossens, K.; Sutterluety-Fall, H.; Einwallner, E.
Hepatic cholesterol-25-hydroxylase overexpression improves systemic insulin sensitivity in mice
J. Diabetes Res.
2017
4108768
2017
Mus musculus
brenda
Wang, J.; Zeng, L.; Zhang, L.; Guo, Z.Z.; Lu, S.F.; Ming, S.L.; Li, G.L.; Wan, B.; Tian, K.G.; Yang, G.Y.; Chu, B.B.
Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication
J. Gen. Virol.
98
1467-1476
2017
Sus scrofa
brenda
Mukherjee, P.; Hough, G.; Chattopadhyay, A.; Navab, M.; Fogelman, H.R.; Meriwether, D.; Williams, K.; Bensinger, S.; Moller, T.; Faull, K.F.; Lusis, A.J.; Iruela-Arispe, M.L.; Bostrom, K.I.; Tontonoz, P.; Reddy, S.T.; Fogelman, A.M.
Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-beta and cholesterol 25-hydroxylase in jejunum
J. Lipid Res.
58
1636-1647
2017
Mus musculus
brenda
Xiang, Y.; Tang, J.J.; Tao, W.; Cao, X.; Song, B.L.; Zhong, J.
Identification of cholesterol 25-hydroxylase as a novel host restriction factor and a part of the primary innate immune responses against hepatitis C virus infection
J. Virol.
89
6805-6816
2015
Homo sapiens
brenda
Ke, W.; Fang, L.; Jing, H.; Tao, R.; Wang, T.; Li, Y.; Long, S.; Wang, D.; Xiao, S.
Cholesterol 25-hydroxylase inhibits porcine reproductive and respiratory syndrome virus replication through enzyme activity-dependent and -independent mechanisms
J. Virol.
91
e00827-17
2017
Sus scrofa
brenda
Chen, Y.; Wang, S.; Yi, Z.; Tian, H.; Aliyari, R.; Li, Y.; Chen, G.; Liu, P.; Zhong, J.; Chen, X.; Du, P.; Su, L.; Qin, F.X.; Deng, H.; Cheng, G.
Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms
Sci. Rep.
4
7242
2014
Homo sapiens (Q95992)
brenda
Tsujioka, T.; Yokoi, A.; Itano, Y.; Takahashi, K.; Ouchida, M.; Okamoto, S.; Kondo, T.; Suemori, S.; Tohyama, Y.; Tohyama, K.
Five-aza-2-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells
Sci. Rep.
5
16709
2015
Homo sapiens (Q95992)
brenda