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alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
additional information
?
-
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
preferred substrate
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
additional information
?
-
-
DELTA6-desaturation appears to occur both in glycerolipids and the acyl-CoA pool
-
-
?
additional information
?
-
the protein product of the cDNA efficiently converts fatty acids 18:3n-3 and 18:2n-6 to 18:4n-3 and 18:3n-6, respectively, indicating DELTA6 desaturation activity
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
preferred substrate
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
highest DELTA6fad mRNA expression is detected in liver followed by brain, with lower expression in other tissues including intestine, eye, muscle, adipose, heart kidney and gill, and lowest expression in stomach and spleen
brenda
highest DELTA6fad mRNA expression is detected in liver followed by brain, with lower expression in other tissues including intestine, eye, muscle, adipose, heart kidney and gill, and lowest expression in stomach and spleen
brenda
-
-
brenda
-
-
brenda
DELTA6fad is constitutively expressed
brenda
highest DELTA6fad mRNA expression is detected in liver followed by brain, with lower expression in other tissues including intestine, eye, muscle, adipose, heart kidney and gill, and lowest expression in stomach and spleen
brenda
highest DELTA6fad mRNA expression is detected in liver followed by brain, with lower expression in other tissues including intestine, eye, muscle, adipose, heart kidney and gill, and lowest expression in stomach and spleen
brenda
-
-
brenda
DELTA6fad is constitutively expressed
brenda
highest DELTA6fad mRNA expression is detected in liver followed by brain, with lower expression in other tissues including intestine, eye, muscle, adipose, heart kidney and gill, and lowest expression in stomach and spleen
brenda
DELTA6fad is constitutively expressed
brenda
highest DELTA6fad mRNA expression is detected in liver followed by brain, with lower expression in other tissues including intestine, eye, muscle, adipose, heart kidney and gill, and lowest expression in stomach and spleen
brenda
DELTA6fad is constitutively expressed
brenda
highest DELTA6fad mRNA expression is detected in liver followed by brain, with lower expression in other tissues including intestine, eye, muscle, adipose, heart kidney and gill, and lowest expression in stomach and spleen
brenda
DELTA6fad is constitutively expressed
brenda
highest DELTA6fad mRNA expression is detected in liver followed by brain, with lower expression in other tissues including intestine, eye, muscle, adipose, heart kidney and gill, and lowest expression in stomach and spleen
brenda
DELTA6fad is constitutively expressed
brenda
highest DELTA6fad mRNA expression is detected in liver followed by brain, with lower expression in other tissues including intestine, eye, muscle, adipose, heart kidney and gill, and lowest expression in stomach and spleen
brenda
DELTA6fad is constitutively expressed
brenda
FADS2 transcript levels in liver of fish fed N-3 long-chain-polyunsaturated fatty acids and fish oil are significantly lower than those in fish fed other diets except alpha-linolenic acid
brenda
-
-
brenda
highest DELTA6fad mRNA expression is detected in liver followed by brain, with lower expression in other tissues including intestine, eye, muscle, adipose, heart kidney and gill, and lowest expression in stomach and spleen
brenda
DELTA6fad is constitutively expressed
brenda
highest DELTA6fad mRNA expression is detected in liver followed by brain, with lower expression in other tissues including intestine, eye, muscle, adipose, heart kidney and gill, and lowest expression in stomach and spleen
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Chen, Q.; Nimal, J.; Li, W.; Liu, X.; Cao, W.
Delta-6 desaturase from borage converts linoleic acid to gamma-linolenic acid in HEK293 cells
Biochem. Biophys. Res. Commun.
410
484-488
2011
Borago officinalis
brenda
Laoteng, K.; Mannontarat, R.; Tanticharoen, M.; Cheevadhanarak, S.
DELTA6-Desaturase of Mucor rouxii with high similarity to plant DELTA6-desaturase and its heterologous expression in Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
279
17-22
2000
Amylomyces rouxii (Q9HDG8), Amylomyces rouxii ATCC 24905 (Q9HDG8)
brenda
Marzo, I.; Alava, M.A.; Pineiro, A.; Naval, J.
Biosynthesis of docosahexaenoic acid in human cells: Evidence that two different DELTA 6-desaturase activities may exist
Biochim. Biophys. Acta
1301
263-272
1996
Homo sapiens
brenda
Sakuradani, E.; Kobayashi, M.; Shimizu, S.
DELTA6-fatty acid desaturase from an arachidonic acid-producing Mortierella fungus. Gene cloning and its heterologous expression in a fungus, Aspergillus
Gene
238
445-453
1999
Mortierella alpina (Q9UVY3), Mortierella alpina 1S-4 (Q9UVY3)
brenda
Biagi, P.L.; Bordoni, A.; Hrelia, S.; Celadon, M.; Turchetto, E.
The effect of dietary polyenylphosphatidylcholine on microsomal delta-6-desaturase activity, fatty acid composition, and microviscosity in rat liver under oxidative stress
J. Nutr. Biochem.
4
690-694
1993
Rattus norvegicus
brenda
Huang, Y.S.; Chaudhary, S.; Thurmond, J.M.; Bobik, E.G.; Yuan, L.; Chan, G.M.; Kirchner, S.J.; Mukerji, P.; Knutzon, D.S.
Cloning of DELAT12- and DELTA6-desaturases from Mortierella alpina and recombinant production of gamma-linolenic acid in Saccharomyces cerevisiae
Lipids
34
649-659
1999
Mortierella alpina (Q9UVV3)
brenda
Cook, D.; Grierson, D.; Jones, C.; Wallace, A.; West, G.; Tucker, G.
Modification of fatty acid composition in tomato (Lycopersicon esculentum) by expression of a borage DELTA6-desaturase
Mol. Biotechnol.
21
123-128
2002
Borago officinalis (O04353)
brenda
Reddy, A.S.; Nuccio, M.L.; Gross, L.M.; Thomas, T.L.
Isolation of a DELTA6-desaturase gene from the cyanobacterium Synechocystis sp. strain PCC 6803 by gain-of-function expression in Anabaena sp.strain PCC 7120
Plant Mol. Biol.
22
293-300
1993
Synechocystis sp.
brenda
Kajikawa, M.; Yamato, K.T.; Kohzu, Y.; Nojiri, M.; Sakuradani, E.; Shimizu, S.; Sakai, Y.; Fukuzawa, H.; Ohyama, K.
Isolation and characterization of DELTA6-desaturase, an ELO-like enzyme and DELTA5-desaturase from the liverwort Marchantia polymorpha and production of arachidonic and eicosapentaenoic acids in the methylotrophic yeast Pichia pastoris
Plant Mol. Biol.
54
335-352
2004
Marchantia polymorpha
brenda
Sayanova, O.; Shewry, P.R.; Napier, J.A.
Histidine-41 of the cytochrome b5 domain of the borage delta6 fatty acid desaturase is essential for enzyme activity
Plant Physiol.
121
641-646
1999
Borago officinalis (O04353)
brenda
Zhou, X.-R.; Robert S.; Singh, S.; Green, A.
Heterologous production of GLA and SDA by expression of an Echium plantagineum DELTA6-desaturase gene
Plant Sci.
172
421-422
2007
Echium plantagineum (Q2M488)
-
brenda
Whitney, H.M.; Michaelson, L.V.; Sayanova, O.; Pickett, J.A.; Napier, J.A.
Functional characterisation of two cytochrome b5-fusion desaturases from Anemone leveillei: the unexpected identification of a fatty acid DELTA6-desaturase
Planta
217
983-992
2003
Anemone leveillei (Q71BG5)
brenda
Jeennor, S.; Cheawchanlertfa, P.; Suttiwattanakul, S.; Panchanawaporn, S.; Chutrakul, C.; Laoteng, K.
The codon-optimized {increment}6-desaturase gene of Pythium sp. as an empowering tool for engineering n3/n6 polyunsaturated fatty acid biosynthesis
BMC Biotechnol.
15
82
2015
Pythium sp. (A0A0F6TLZ2), Pythium sp., Pythium sp. BCC53698 (A0A0F6TLZ2)
brenda
Nayak, M.; Saha, A.; Pradhan, A.; Samanta, M.; Giri, S.S.
Dietary fish oil replacement by linseed oil Effect on growth, nutrient utilization, tissue fatty acid composition and desaturase gene expression in silver barb (Puntius gonionotus) fingerlings
Comp. Biochem. Physiol. B
205
1-12
2017
Barbonymus gonionotus (T1RQF8)
brenda
Wang, Y.D.; Peng, K.C.; Wu, J.L.; Chen, J.Y.
Transgenic expression of salmon DELTA-5 and DELTA-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity
Fish Shellfish Immunol.
39
223-230
2014
Salmo salar (Q6SES0)
brenda
Xu, H.; Dong, X.; Ai, Q.; Mai, K.; Xu, W.; Zhang, Y.; Zuo, R.
Regulation of tissue LC-PUFA contents, DELTA6 fatty acyl desaturase (FADS2) gene expression and the methylation of the putative FADS2 gene promoter by different dietary fatty acid profiles in Japanese seabass (Lateolabrax japonicus)
PLoS ONE
9
e87726
2014
Lateolabrax japonicus (T1QEU2)
brenda
Xie, D.; Chen, F.; Lin, S.; Wang, S.; You, C.; Monroig, O.; Tocher, D.R.; Li, Y.
Cloning, functional characterization and nutritional regulation of DELTA6 fatty acyl desaturase in the herbivorous euryhaline teleost Scatophagus argus
PLoS ONE
9
e90200
2014
Scatophagus argus (V9PQI1)
brenda