Information on EC 1.14.19.1 - stearoyl-CoA 9-desaturase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
1.14.19.1
-
RECOMMENDED NAME
GeneOntology No.
stearoyl-CoA 9-desaturase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of unsaturated fatty acids
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oleate biosynthesis II (animals and fungi)
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sorgoleone biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)
An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2).
CAS REGISTRY NUMBER
COMMENTARY hide
9014-34-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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-
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Manually annotated by BRENDA team
isoform ADS1, ADS2
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Manually annotated by BRENDA team
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Uniprot
Manually annotated by BRENDA team
milk fish, enzyme activity increases significantly in the beginning of cold acclimation, peaks at day 4 and then decreases constantly. Change of enzyme activity parllels the change of DELTA9 desaturation in the animal
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
grass carp, enzyme activity increases gradually in the first week of cold acclimation, increases dramatically afterward and the maintains a very high level. Change of enzyme activity parllels the change of DELTA9 desaturation in the animal
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Manually annotated by BRENDA team
L.
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Manually annotated by BRENDA team
f. sp. lycopersici
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Manually annotated by BRENDA team
L., sunflower
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Manually annotated by BRENDA team
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Swissprot
Manually annotated by BRENDA team
strain CBS 528.72, ATCC 32222
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-
Manually annotated by BRENDA team
Mortierella alpina CBS 528.72
strain CBS 528.72, ATCC 32222
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Manually annotated by BRENDA team
Mus musculus C57BL/6J
C57BL/6J mice
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Manually annotated by BRENDA team
ATCC 356
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-
Manually annotated by BRENDA team
strain H37Rv, gene rv3229c
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Manually annotated by BRENDA team
strain H37Rv, gene rv3229c
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Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
white pruce
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Manually annotated by BRENDA team
strain 3D7
UniProt
Manually annotated by BRENDA team
strain MLY15
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-
Manually annotated by BRENDA team
strain MLY15
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-
Manually annotated by BRENDA team
ATCC 15174
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Manually annotated by BRENDA team
Rattus norvegicus Long-Evans
Long-Evans
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
-
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-
Manually annotated by BRENDA team
two isozymes
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Trypanosoma brucei Lister 427
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
18-fluoro-10-thiaoctadecanoyl-[acyl-carrier protein] + O2 + ferredoxin
?
show the reaction diagram
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-
-
-
?
ammonium stearate + NADH + O2
?
show the reaction diagram
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-
-
-
?
heptadecanoate + AH2 + O2
?
show the reaction diagram
-
low activity
-
-
?
myristic acid + NADH + O2 + ATP + CoA
myristoleic acid + NAD+ + H2O + ?
show the reaction diagram
-
reaction in presence of fatty acid-binding proteins with mixing at speeds between 250 and 500 rpm
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-
?
myristoyl-CoA + AH2 + O2
?
show the reaction diagram
myristoyl-CoA + NADH + O2
?
show the reaction diagram
-
59% activity of stearoyl-CoA
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-
?
myristoyl-CoA + NADH + O2
myristoleoyl-CoA + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
N-hydroxy-benzenecarboximidamide + NADH + H+ + O2
benzamidine + NAD+ + H2O
show the reaction diagram
nonadecanoate + AH2 + O2
?
show the reaction diagram
-
low activity
-
-
?
nonadecanoyl-CoA + NADH + O2
?
show the reaction diagram
-
-
-
-
?
palmitic acid + AH2 + O2
palmitoleic acid + A + H2O
show the reaction diagram
palmitic acid + reduced acceptor + O2
palmitoleic acid + acceptor + H2O
show the reaction diagram
palmitoyl-CoA + AH2 + O2
palmitoleoyl-CoA + A
show the reaction diagram
palmitoyl-CoA + AH2 + O2
palmitoleoyl-CoA + A + H2O
show the reaction diagram
-
-
-
?
palmitoyl-CoA + ferrocytochrome b5 + O2
palmitoleoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
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-
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-
?
palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + ferricytochrome b5 + 2 H2O
show the reaction diagram
palmitoyl-CoA + NAD(P)H + O2
palmitoleate + NAD(P)+ + H2O
show the reaction diagram
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-
-
?
palmitoyl-CoA + NADH + H+ + O2
palmitoleoyl-CoA + NAD+ + H2O
show the reaction diagram
palmitoyl-CoA + NADH + O2
palmitoleoyl-CoA + NAD+ + H2O
show the reaction diagram
palmitoyl-CoA + NADPH + O2
?
show the reaction diagram
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?
palmitoyl-CoA + NADPH + O2
palmitoleoyl-CoA + NADP+ + H2O
show the reaction diagram
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Angus and American Wagyu steers, corn-fed steers for 8 mo (short-fed) or 16 mo (long-fed), and hay-fed steers fed for 12 mo (short-fed) and 20 mo (long-fed)
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?
palmitoyl-CoA + NADPH + O2 + H+
palmitoleoyl-CoA + NADP+ + H2O
show the reaction diagram
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?
stearate + AH2 + O2
oleate + A + H2O
show the reaction diagram
stearate + AH2 + O2
oleoyl-phospholipid + A + H2O
show the reaction diagram
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-
-
?
stearate + reduced acceptor + O2
oleate + acceptor + H2O
show the reaction diagram
stearic acid + AH2 + O2
oleic acid + A + H2O
show the reaction diagram
stearic acid + reduced acceptor + O2
oleic acid + acceptor + H2O
show the reaction diagram
stearoyl-acyl-carrier protein + AH2 + O2
oleoyl-acyl-carrier protein + A + H2O
show the reaction diagram
stearoyl-CoA + AH2 + H+ + O2
oleoyl-CoA + A + H2O
show the reaction diagram
stearoyl-CoA + AH2 + O2
oleoyl-CoA + A + H2O
show the reaction diagram
stearoyl-CoA + ferrocytochrome b5 + H+ + O2
oleoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
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-
-
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?
stearoyl-CoA + ferrocytochrome b5 + O2
oleoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
?
show the reaction diagram
-
-
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
stearoyl-CoA + NAD(P)H + O2
oleoyl-CoA + NAD(P)+ + H2O
show the reaction diagram
stearoyl-CoA + NADH + H+ + O2
oleoyl-CoA + NAD+ + H2O
show the reaction diagram
stearoyl-CoA + NADH + O2
oleoyl-CoA + NAD+ + H2O
show the reaction diagram
stearoyl-CoA + NADPH + H+ + O2
oleoyl-CoA + NADP+ + H2O
show the reaction diagram
stearoyl-CoA + NADPH + O2
oleoyl-CoA + NADP+ + H2O
show the reaction diagram
trans-2-hexadecenoyl-CoA + ferrocytochrome b5 + O2 + H+
?
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
palmitoyl-CoA + AH2 + O2
palmitoleoyl-CoA + A + H2O
show the reaction diagram
-
-
-
?
palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + ferricytochrome b5 + 2 H2O
show the reaction diagram
-
a key step in triglyceride synthesis in the fatty acid metabolic network
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-
?
stearate + AH2 + O2
oleate + A + H2O
show the reaction diagram
stearoyl-acyl-carrier protein + AH2 + O2
oleoyl-acyl-carrier protein + A + H2O
show the reaction diagram
stearoyl-CoA + AH2 + O2
oleoyl-CoA + A + H2O
show the reaction diagram
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ascorbate
cytochrome b5
FAD
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required
ferrocytochrome b5
flavin
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flavin-containing NADH-cytochrome b5 reductase (EC 1.6.2.2.)
FMN
-
required, almost as active as FAD
NAD+
-
supports desaturation
NADP+
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supports desaturation
additional information
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
superoxid dismutase
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8% stimulation
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1-[6-[3-(3-hydroxybenzyl)-1,2,4-oxadiazol-5-yl]pyridazin-3-yl]piperidin-4-yl)[2-(trifluoromethyl)phenyl]methanone
(1-[6-[4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidin-1-yl]pyridazin-3-yl]-1H-imidazol-4-yl)methanol
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(1-[6-[4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidin-1-yl]pyridazin-3-yl]-1H-pyrazol-4-yl)methanol
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(2-[[(5-[[(4-fluoro-2-heptylphenyl)amino]methyl]thiophen-2-yl)carbonyl]amino]-1,3-thiazol-4-yl)acetic acid
(2E)-3-(4-methoxyphenyl)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]prop-2-enamide
(2R)-2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]propanamide
(2R)-N-[3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]-2-hydroxypropanamide
(2S)-2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]propanamide
(2S)-N-[3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]-2-hydroxypropanamide
(3-[5-[(3S)-3-(2-bromo-5-fluorophenoxy)pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]-1,2,4-oxadiazol-5-yl)methanol
(4-[6-[4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidin-1-yl]pyridazin-3-yl]phenyl)methanol
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(5-[6-[3-(2-bromo-5-fluorophenoxy)azetidin-1-yl]pyridazin-3-yl]-1,3,4-oxadiazol-2-yl)methanol
(5-[6-[3-(2-bromophenoxy)azetidin-1-yl]pyridazin-3-yl]-1,3,4-oxadiazol-2-yl)methanol
(5-[6-[4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyridin-2-yl)methanol
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(5R)-5-(hydroxymethyl)-3-(6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridin-3-yl)-1,3-oxazolidin-2-one
(E)-N-(2-cyclopropylethyl)-N2-(pyridin-2-yl[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]methylidene)glycinamide
([5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[5,4-d]pyrimidin-2-yl]amino)acetic acid
([5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[5,4-d]pyrimidin-2-yl]oxy)acetic acid
1'-[6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]-2,3-dihydrospiro[indene-1,4'-piperidine]
1,2 diglycerides
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only slight depression
1-(1,3-thiazol-2-yl)-4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazine
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1-(1-[6-[1-(2-ethoxyethyl)-1H-pyrazol-4-yl]pyridazin-3-yl]piperidin-4-yl)-6-fluoro-2,3-dihydro-1H-indole
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1-(1-[6-[4-(ethoxymethyl)-1H-pyrazol-1-yl]pyridazin-3-yl]piperidin-4-yl)-6-fluoro-2,3-dihydro-1H-indole
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1-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)pyrrolidin-2-one
1-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)urea
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1-hydroxy-3-[5-(6-[3-[2-(trifluoromethyl)benzyl]azetidin-1-yl]pyridazin-3-yl)-1,3,4-oxadiazol-2-yl]propan-2-one
1-[1-[6-(1-ethyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-6-fluoro-2,3-dihydro-1H-indole
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-
1-[1-[6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-1H-indole
-
-
1-[1-[6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
1-[1-[6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-6-(trifluoromethyl)-2,3-dihydro-1H-indole
-
-
1-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]urea
1-[5-(1,2,4-oxadiazol-3-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine
1-[5-(1,3,4-oxadiazol-2-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine
1-[5-(1,3-oxazol-2-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine
1-[5-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine
1-[5-(5-methyl-1,3,4-thiadiazol-2-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine
-
-
1-[5-(benzylcarbamoyl)-4-methyl-1,3-thiazol-2-yl]-N-(4-fluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
2,3-Butanedione
-
reversible
2,3-dihydroxy-N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]propanamide
2-(1-[6-[4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidin-1-yl]pyridazin-3-yl]-1H-pyrazol-4-yl)ethanol
-
-
2-(2'-chlorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole
2-(2'-fluorobiphenyl-4-yl)-1-methyl-5-(methylsulfonyl)-2,3-dihydro-1H-benzimidazole
-
-
2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole-6-sulfonamide
2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfanyl)-1H-benzimidazole
-
-
2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfinyl)-1H-benzimidazole
2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole
2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-imidazo[4,5-b]pyridine
2-(2'-fluorobiphenyl-4-yl)-N,N-dimethyl-1H-benzimidazole-6-sulfonamide
-
-
2-(2'-methylbiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole
-
-
2-(2-cyclopropylethyl)-5-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1H-isoindole-1,3(2H)-dione
2-(3'-chloro-2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole
-
-
2-(3'-chlorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole
2-(3'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole
2-(3'-methylbiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole
-
-
2-(4'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole
-
-
2-(4-phenoxyphenyl)-N-(1,3-thiazol-2-ylmethyl)-1H-benzimidazole-5-carboxamide
-
-
2-(4-phenoxyphenyl)-N-(2-phenylethyl)-1H-benzimidazole-5-carboxamide
-
-
2-(4-[6-[4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidin-1-yl]pyridazin-3-yl]-1H-pyrazol-1-yl)-N-methylacetamide
-
-
2-(4-[6-[4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidin-1-yl]pyridazin-3-yl]-1H-pyrazol-1-yl)ethanol
-
-
2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxamide
2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxylic acid
-
-
2-(4-[[2-(trifluoromethyl)phenyl]sulfanyl]piperidin-1-yl)-1,3-thiazole-5-carboxamide
2-(4-[[5-(hexylamino)-2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-N-pentylpyridine-4-carboxamide
2-(5'-chloro-2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole
-
-
2-(5-[1-[(2,5-dichlorophenyl)carbonyl]piperidin-4-ylidene]-2,4-dioxo-1,3-thiazolidin-3-yl)-N-pentylacetamide
2-(biphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole
2-(biphenyl-4-yl)-7-(methylsulfonyl)imidazo[1,2-a]pyridine
2-(thiophen-2-yl)-N-(2-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-1H-benzimidazol-5-yl)acetamide
-
-
2-([2-[4-(2-chloro-3,5-difluorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-methylbenzamide
2-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-phenylbenzamide
-
-
2-acetyl-N-[1-(3,4-dichlorobenzyl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroisoquinoline-6-carboxamide
2-hydroxy-N-[2-[2-oxo-3-(trifluoromethyl)-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]acetamide
2-hydroxy-N-[2-[3-(1-methylethyl)-2-oxo-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]acetamide
2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]acetamide
2-hydroxy-N-[4-oxo-3-[3-(trifluoromethyl)benzyl]-3,4-dihydroquinazolin-6-yl]acetamide
2-hydroxy-N-[4-oxo-3-[4-(trifluoromethyl)benzyl]-3,4-dihydroquinazolin-6-yl]acetamide
2-mercaptoethanol
-
-
2-[(2,5-dichlorophenoxy)methyl]-N-[4-(1H-pyrazol-1-ylmethyl)phenyl]pyridine-4-carboxamide
2-[(2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl)amino]benzamide
2-[(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl]-1,3-thiazole-5-carboxamide
2-[1-[2-(4-fluorophenyl)ethyl]-1H-1,2,3-triazol-4-yl]-4-methyl-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
2-[3-(4-fluorobenzyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-N-(pyridin-3-ylmethyl)-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide
2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3-benzothiazole
2-[4-(2-chlorophenoxy)phenyl]-N-(1,3-thiazol-2-ylmethyl)-1H-benzimidazole-5-carboxamide
-
-
2-[4-(2-chlorophenoxy)phenyl]-N-(2-cyclopropylethyl)-1H-benzimidazole-5-carboxamide
-
-
2-[4-(2-chlorophenoxy)phenyl]-N-(3-methylbutyl)-1H-benzimidazole-5-carboxamide
-
-
2-[4-(2-chlorophenoxy)phenyl]-N-[(5-chlorothiophen-2-yl)methyl]-1H-benzimidazole-5-carboxamide
-
-
2-[4-(furan-3-yl)phenyl]-6-(methylsulfonyl)-1H-benzimidazole
2-[4-(phenylcarbonyl)piperazin-1-yl]-1,3-thiazole-5-carboxamide
-
-
2-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide
2-[4-[2-(trifluoromethyl)benzyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-4-carboxamide
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-5-carboxamide
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-5-sulfonamide
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,4,5,9-tetrahydro-6H-purin-6-one
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purin-8-ol
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purine
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-b]pyridine
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7-amine
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[5,4-c]pyridin-4(5H)-one
2-[5-(2-fluorophenyl)pyridin-2-yl]-6-(methylsulfonyl)-1H-benzimidazole
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2-[6-(2-fluorophenyl)pyridin-3-yl]-6-(methylsulfonyl)-1H-benzimidazole
3,4-bis(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3,4-dimethoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3,4-dimethyl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3-(2,2-dihydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3-(2,3-dihydroxypropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3-(2-hydroxy-2-methylpropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3-(2-hydroxyethoxy)-4-(2-methoxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3-(2-hydroxyethoxy)-4-methoxy-N-(5-[[3-(trifluoromethyl)phenyl]carbonyl]-1,3-thiazol-2-yl)benzamide
3-(2-hydroxyethoxy)-4-methoxy-N-methyl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethoxy)benzyl]-1,3-thiazol-2-yl]benzamide
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3,4-thiadiazol-2-yl]benzamide
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]thiophen-2-yl]benzamide
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)phenoxy]-1,3-thiazol-2-yl]benzamide
3-(2-hydroxyethoxy)-4-methoxy-N-{5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl}benzamide
3-(2-hydroxyethoxy)-4-morpholin-4-yl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3-(2-hydroxyethoxy)-4-[(methylsulfonyl)amino]-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3-(2-hydroxyethoxy)-N-(5-[hydroxy[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl)-4-methoxybenzamide
3-(3-benzyl-1,2,4-oxadiazol-5-yl)-6-(4-phenoxypiperidin-1-yl)pyridazine
3-(3-benzyl-1,2,4-oxadiazol-5-yl)-6-[4-(2-chlorophenoxy)piperidin-1-yl]pyridazine
3-(3-benzyl-1,2,4-oxadiazol-5-yl)-6-[4-(2-fluorophenoxy)piperidin-1-yl]pyridazine
3-(3-hydroxypropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3-(3-methyl-1,2,4-oxadiazol-5-yl)-6-[4-[2-(phenoxymethyl)phenoxy]piperidin-1-yl]pyridazine
3-(4-phenoxypiperidin-1-yl)-6-(5-propyl-1,2,4-oxadiazol-3-yl)pyridazine
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3-(4-phenoxypiperidin-1-yl)-6-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]pyridazine
3-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazino[3,4-b][1,5]benzoxazepin-5(6H)-one
3-(5-benzyl-1,2,4-oxadiazol-3-yl)-6-(4-phenoxypiperidin-1-yl)pyridazine
3-(5-benzyl-1,3,4-oxadiazol-2-yl)-6-[4-(2-chlorophenoxy)piperidin-1-yl]pyridazine
3-(5-methyl-1,2,4-oxadiazol-3-yl)-6-(4-phenoxypiperidin-1-yl)pyridazine
3-(5-methyl-1,3,4-oxadiazol-2-yl)-6-[3-[2-(trifluoromethyl)phenoxy]azetidin-1-yl]pyridazine
3-(5-methyl-1,3,4-oxadiazol-2-yl)-6-[3-[3-(trifluoromethyl)phenoxy]azetidin-1-yl]pyridazine
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3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazine
3-(5-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-1H-benzimidazol-2-yl)-N-(1,3-thiazol-2-ylmethyl)benzamide
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3-([2-[4-(2,3-difluorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-methylpyrazine-2-carboxamide
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3-([2-[4-(2,5-dichlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-methylpyrazine-2-carboxamide
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3-([2-[4-(2-bromophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-methylpyrazine-2-carboxamide
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3-([2-[4-(2-chloro-3,5-difluorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-methylpyrazine-2-carboxamide
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3-([2-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-methylpyrazine-2-carboxamide
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3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-(2-hydroxyethyl)pyrazine-2-carboxamide
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3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-(pyridin-2-ylmethyl)pyrazine-2-carboxamide
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3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-(pyridin-3-ylmethyl)pyrazine-2-carboxamide
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3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-(pyridin-4-ylmethyl)pyrazine-2-carboxamide
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3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-ethylpyrazine-2-carboxamide
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3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-methylpyrazine-2-carboxamide
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3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)-N-phenylpyrazine-2-carboxamide
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3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)pyrazine-2-carbaldehyde
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3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)pyrazine-2-carbonitrile
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3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)pyrazine-2-carboxamide
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3-chloro-N-[2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]pyrazin-2-amine
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3-hydroxy-N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]propanamide
3-methoxy-4-(2-morpholin-4-ylethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3-[(2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl)amino]-N-(2-phenylethyl)pyridine-2-carboxamide
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3-[(2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl)amino]-N-(pyridin-3-ylmethyl)pyridine-2-carboxamide
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3-[(2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl)amino]-N-(pyridin-4-ylmethyl)pyridine-2-carboxamide
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3-[(2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl)amino]-N-pentylpyridine-2-carboxamide
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3-[(2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl)amino]-N-propylpyridine-2-carboxamide
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3-[(2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl)amino]pyridine-2-carboxamide
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3-[([4-[2-(acetylamino)ethyl]-2-(4-methoxyphenyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-6-yl]amino)methyl]benzoic acid
3-[2-(4-methoxyphenyl)-3-oxo-6-[[3-(trifluoromethyl)benzyl]amino]pyrido[2,3-b]pyrazin-4(3H)-yl]-N-methylpropanamide
3-[2-(4-methoxyphenyl)-3-oxo-6-[[3-(trifluoromethyl)benzyl]amino]pyrido[2,3-b]pyrazin-4(3H)-yl]propanamide
3-[2-[(3,4-dichlorophenyl)amino]-6-(4-methoxyphenyl)-7-oxopteridin-8(7H)-yl]propanamide
3-[2-[(3,4-dichlorophenyl)amino]-7-oxo-6-(4-pyridin-3-ylphenyl)pteridin-8(7H)-yl]propanamide
3-[2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-7-oxo-6,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl]propanoic acid
3-[3-(2,6-dichloro-4-fluorophenoxy)azetidin-1-yl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridazine
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3-[3-(2-bromo-4-fluorophenoxy)azetidin-1-yl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridazine
3-[3-(2-bromo-5-fluorophenoxy)azetidin-1-yl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridazine
3-[3-(2-bromophenoxy)azetidin-1-yl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridazine
3-[3-(2-chloro-5-fluorophenoxy)azetidin-1-yl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridazine
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3-[3-(2-iodophenoxy)azetidin-1-yl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridazine
3-[3-oxo-2-pyridin-3-yl-6-[[3-(trifluoromethyl)benzyl]amino]pyrido[2,3-b]pyrazin-4(3H)-yl]propanamide
3-[3-[2-chloro-3-(trifluoromethyl)phenoxy]azetidin-1-yl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridazine
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3-[4-(2-benzylphenoxy)piperidin-1-yl]-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine
3-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-6-(1H-imidazol-1-yl)pyridazine
3-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-6-(2-methyl-1H-imidazol-1-yl)pyridazine
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3-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridazine
3-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-6-(5-methyl-4H-1,2,4-triazol-3-yl)pyridazine
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(1H-pyrrol-1-yl)pyridazine
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(1H-tetrazol-5-yl)pyridazine
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3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(2-methyl-1H-imidazol-1-yl)pyridazine
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(5-methyl-1,2,4-oxadiazol-3-yl)pyridazine
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridazine
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3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-furan-3-ylpyridazine
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-pyridin-3-ylpyridazine
3-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,2,4-oxadiazole-5-carboxamide
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3-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,2-oxazole-5-carboxamide
3-[6-(4'-chlorobiphenyl-4-yl)-7-oxo-2-[[3-(trifluoromethyl)phenyl]amino]pteridin-8(7H)-yl]propanamide
3-[6-(4'-methylbiphenyl-4-yl)-7-oxo-2-[[3-(trifluoromethyl)phenyl]amino]pteridin-8(7H)-yl]propanamide
3-[6-(4-methoxyphenyl)-7-oxo-2-[[3-(trifluoromethyl)phenyl]amino]pteridin-8(7H)-yl]propanamide
3-[6-[(3,4-dichlorobenzyl)amino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]propanamide
3-[7-oxo-6-(4-pyridin-3-ylphenyl)-2-[[3-(trifluoromethyl)phenyl]amino]pteridin-8(7H)-yl]propanamide
4'-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]biphenyl-2-ol
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4'-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]biphenyl-3-ol
4'-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]biphenyl-4-ol
4-(1,2-benzoxazol-3-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide
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4-(1H-indol-1-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide
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4-(1H-indol-1-yl)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
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4-(1H-indol-3-yl)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
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15% inhibition at 0.001 mM
4-(2,3-dihydro-1H-indol-1-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide
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4-(2,3-dihydro-1H-indol-1-yl)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
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4-(2-bromo-5-fluorophenoxy)-1-[5-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3,4-thiadiazol-2-yl]piperidine
4-(2-bromophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
4-(2-chloro-4-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
4-(2-chloro-5-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
4-(2-chloro-6-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
4-(2-chlorophenoxy)-N-phenylpiperidine-1-carboxamide
4-(2-chlorophenoxy)-N-[3-(1H-imidazol-2-yl)phenyl]piperidine-1-carboxamide
4-(2-chlorophenoxy)-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]piperidine-1-carboxamide
4-(2-chlorophenoxy)-N-[3-(ethylcarbamoyl)phenyl]piperidine-1-carboxamide
4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
4-(2-chlorophenoxy)-N-[3-[(1-methylethyl)carbamoyl]phenyl]piperidine-1-carboxamide
4-(2-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
4-(2-hydroxyethoxy)-3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
4-(2-methoxyphenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
4-(3,4-dihydroquinolin-1(2H)-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide
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4-(3-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
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4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)piperidine-1-carboxamide
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4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide
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4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)piperidine-1-carboxamide
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4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(5-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide
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4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(6-hydroxy-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)piperidine-1-carboxamide
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4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[4-(2-hydroxyethyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide
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4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[4-(hydroxymethyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide
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4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[4-(methylcarbamoyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide
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20% inhibition at 0.001 mM
4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[5-(2-hydroxyethyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide
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4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[5-(hydroxyacetyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl]piperidine-1-carboxamide
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4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[5-(hydroxymethyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide
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4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[5-(methylcarbamoyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide
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4-(acetylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
4-(diethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
4-(dimethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
4-(ethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
4-([6-[4-(2-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl]ethynyl)phenol
4-ethoxy-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide
4-fluoro-1-[1-[6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
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4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
4-methyl-2-[2-oxo-3-[4-(trifluoromethyl)benzyl]-2,3-dihydro-1H-imidazol-1-yl]-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
4-[(7-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-5,6,7,7a-tetrahydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl)methoxy]benzoic acid
4-[2-(dimethylamino)ethoxy]-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
4-[6-[4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidin-1-yl]pyridazin-3-yl]benzoic acid
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5,5-dimethyl-1-pyrroline-N-oxide
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5-(hydroxymethyl)-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one
5-chloro-1-[1-[6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
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5-fluoro-1-[1-[6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
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5-fluoro-3-[1-[6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-1,2-benzoxazole
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5-methyl-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one
5-methyl-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidine
5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1H-imidazo[4,5-b]pyrazine
5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[4,5-b]pyrazin-2-amine
5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-oxadiazole-2-carboxamide
5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-thiadiazole-2-carboxamide
5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1H-1,2,4-triazole-3-carboxamide
5-[6-[4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidin-1-yl]pyridazin-3-yl]-N,N-dimethylpyridin-2-amine
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5-[6-[4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidin-1-yl]pyridazin-3-yl]-N-methylpyridine-2-carboxamide
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6'-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-2,3'-bipyridine-5-carboxylic acid
6-(3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide
6-(3-bromobenzyl)-5,7-dimethyl-N-(tetrahydrofuran-2-ylmethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
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6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxylic acid
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6-(5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-thiadiazol-2-yl)pyridine-3-carboxylic acid
6-(cyclopropylsulfonyl)-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole
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6-(ethylsulfonyl)-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole
6-(methylsulfonyl)-2-(2-phenylpyrimidin-5-yl)-1H-benzimidazole
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6-(methylsulfonyl)-2-[4-(3-methylthiophen-2-yl)phenyl]-1H-benzimidazole
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6-(methylsulfonyl)-2-[4-(pyridin-2-yl)phenyl]-1H-benzimidazole
6-(methylsulfonyl)-2-[4-(pyridin-3-yl)phenyl]-1H-benzimidazole
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6-(methylsulfonyl)-2-[4-(pyridin-4-yl)phenyl]-1H-benzimidazole
6-(methylsulfonyl)-2-[4-(thiophen-2-yl)phenyl]-1H-benzimidazole
6-(methylsulfonyl)-2-[4-(thiophen-3-yl)phenyl]-1H-benzimidazole
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6-chloro-1-[1-[6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
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6-fluoro-1-(1-[6-[4-(trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-4-yl)-2,3-dihydro-1H-indole
-
-
6-fluoro-1-(1-[6-[6-(trifluoromethyl)pyridin-3-yl]pyridazin-3-yl]piperidin-4-yl)-2,3-dihydro-1H-indole
-
-
6-fluoro-1-[1-[6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-1H-indazole
-
-
6-fluoro-1-[1-[6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-1H-indole
-
-
6-fluoro-1-[1-[6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-fluoro-1-[1-[6-(1-propyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-fluoro-1-[1-[6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-fluoro-1-[1-[6-(4-fluorophenyl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-fluoro-1-[1-[6-(4-methyl-1,3-thiazol-2-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-fluoro-1-[1-[6-(4-methyl-1H-imidazol-1-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-fluoro-1-[1-[6-(4-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-fluoro-1-[1-[6-(4-methylphenyl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-fluoro-1-[1-[6-(5-methyl-1,3-thiazol-2-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-fluoro-1-[1-[6-(5-methylthiophen-2-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-fluoro-1-[1-[6-(6-methoxypyridin-3-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-fluoro-1-[1-[6-(6-methylpyridin-3-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-methoxy-1-[1-[6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]naphthalene-2-carboxamide
6-methyl-1-[1-[6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydro-1H-indole
-
-
6-tert-butyl-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole
6-[(3,4-dichlorobenzyl)amino]-4-(4-oxopentyl)-2-pyridin-3-ylpyrido[2,3-b]pyrazin-3(4H)-one
6-[(3-chloro-4-fluorobenzyl)amino]-4-(4-oxopentyl)-2-pyridin-3-ylpyrido[2,3-b]pyrazin-3(4H)-one
6-[3-[2-(trifluoromethyl)phenoxy]azetidin-1-yl]pyridazine-3-carbohydrazide
6-[3-[2-(trifluoromethyl)phenoxy]azetidin-1-yl]pyridazine-3-carboxamide
6-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-9H-purine
6-[4-[(2-bromo-5-methoxyphenyl)carbonyl]piperazin-1-yl]-N-(3-phenylpropyl)pyridine-3-carboxamide
6-[4-[(4-fluorophenyl)carbonyl]piperidin-1-yl]-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide
6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purin-2-amine
6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purine
6-[5-chloro-2-(trifluoromethyl)benzyl]-N-hexyl-5,6,7,8-tetrahydro-1,6-naphthyridine-2-carboxamide
7-[(3-chlorobenzyl)amino]-1-(4-oxopentyl)-3-(3-pyridin-4-ylphenyl)pyrido[3,4-b]pyrazin-2(1H)-one
7-[(3-chlorobenzyl)amino]-3-(4-methoxyphenyl)-1-(4-oxopentyl)pyrido[3,4-b]pyrazin-2(1H)-one
7-[(3-chlorobenzyl)amino]-3-(4-methylphenyl)-1-(4-oxopentyl)pyrido[3,4-b]pyrazin-2(1H)-one
8-(2-octylcyclopropenyl)octanoic acid
-
-
8-(trifluoromethyl)-2,5,21,24,25-pentaazatetracyclo[21.2.2.2-2,5.1-7,11]triaconta-1(25),7(28),8,10,23,26-hexaene-6,22-dione
8-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purin-6-amine
A939572
-
i.e. 4-(2-chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide
-
adrenaline
-
-
benzyl [3-(2,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]carbamate
benzyl [3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]carbamate
benzyl [3-(3,4-dimethylbenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]carbamate
benzyl [3-(3-chloro-4-fluorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]carbamate
benzyl [3-(4-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]carbamate
benzyl [3-[(3,4-dichlorobenzyl)carbamoyl]-4-(pyridin-3-yloxy)phenyl]carbamate
bis(salicylidene)-1,3-propanediamine
-
-
-
BVT168149
-
a property compound of Biovitrum
-
CGX0168
-
-
-
CGX0290
-
-
-
cis-10,trans-12-conjugated linoleic acid
-
-
cis-9,trans-11 conjugated linoleic acid
-
-
CP-24879
-
9% inhibition at 0.01 mM
Cu+
-
strong, complete inhibition at 0.1 mM
CVT-11,563
CVT-11127
-
specific small molecule inhibitor
-
cycloheximide
-
-
cyclosporin A
-
-
cytochrome c
decanoyl-CoA
Dihydrolipoic acid
-
-
Dodecanoyl-CoA
ethanol
-
depression
ethyl 2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxylate
-
-
ethyl linoleate
-
-
ethyl palmitate
-
-
ethyl [5-(4-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]phenyl)-1,3,4-oxadiazol-2-yl]acetate
Fe2+
-
76% inhibition at 10 mM
glutathione
-
reduced, not marked
GSK-993
L-cysteine
-
not marked
linoleic acid
-
-
lysophosphatidylcholine
-
-
menadione
methyl (2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)carbamate
methyl 3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)pyrazine-2-carboxylate
-
-
methyl 8-methoxy-8-(2-octylcycloprop-1-en-1-yl)octanoate
-
methyl 9-(2-octylcycloprop-1-en-1-yl)nonanoate
-
methyl malvalate
-
methyl sterculate
inhibits the synthesis of oleic acid both with parasite lysates and infected erythrocytes, most likely by targeting SCD
methyl [5-(4-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]phenyl)-1,3,4-thiadiazol-2-yl]acetate
methylene blue
-
-
MF-152
myristoyl-CoA
-
inhibitory above 0.266 mM
N,N-dimethyl-3-[(2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl)amino]pyridine-2-carboxamide
-
-
N-(1,3-thiazol-2-yl)-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide
-
-
N-(1,3-thiazol-2-ylmethyl)-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide
-
-
N-(2-amino-2-oxoethyl)-6-(2,3-dichlorobenzyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
N-(2-cyclopropyl-2-hydroxyethyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
-
-
N-(2-cyclopropylethyl)-2-(4-phenoxyphenyl)-1H-benzimidazole-5-carboxamide
-
-
N-(2-cyclopropylethyl)-2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-4-carboxamide
-
-
N-(2-cyclopropylethyl)-2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxamide
N-(2-cyclopropylethyl)-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide
-
-
N-(2-cyclopropylethyl)-3-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1H-pyrazole-5-carboxamide
N-(2-cyclopropylethyl)-5-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3,4-thiadiazole-2-carboxamide
N-(2-cyclopropylethyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
N-(2-cyclopropylethyl)-6-(4-[[5-fluoro-2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
N-(2-cyclopropylethyl)-6-[(1-[[2-(trifluoromethyl)phenyl]carbonyl]azetidin-3-yl)amino]pyridazine-3-carboxamide
N-(2-cyclopropylethyl)-6-[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]pyridazine-3-carboxamide
N-(2-hydroxy-2-phenylethyl)-6-(4-[[2-(trifluoromethoxy)phenyl]carbonyl]piperidin-1-yl)pyridazine-3-carboxamide
N-(2-hydroxy-2-phenylethyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperidin-1-yl)pyridazine-3-carboxamide
N-(2-hydroxy-2-phenylethyl)-6-[4-(phenylcarbonyl)piperidin-1-yl]pyridazine-3-carboxamide
N-(2-hydroxy-2-phenylethyl)-6-[4-[(2-methoxyphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
N-(2-hydroxy-2-phenylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
N-(2-hydroxy-2-pyridin-2-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
N-(2-hydroxy-2-pyridin-3-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
N-(2-hydroxy-2-pyridin-4-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
N-(2-hydroxy-2-thiophen-2-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
N-(2-hydroxy-2-thiophen-3-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
N-(2-hydroxyethyl)-3-[(2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl)amino]pyridine-2-carboxamide
-
-
N-(2-phenylethyl)-4-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)benzamide
N-(2-phenylethyl)-5-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridine-2-carboxamide
N-(2-phenylethyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
N-(2-phenylethyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridine-3-carboxamide
N-(2-[2-[(3,4-dichlorobenzyl)amino]-6-(4-methoxyphenyl)-7-oxopteridin-8(7H)-yl]ethyl)acetamide
N-(2-[2-[(3,4-dichlorophenyl)amino]-6-(4-methoxyphenyl)-7-oxopteridin-8(7H)-yl]ethyl)acetamide
N-(2-[2-[(3,4-dichlorophenyl)amino]-6-(4-methoxyphenyl)-7-oxopteridin-8(7H)-yl]ethyl)benzamide
N-(2-[2-[(3,4-dichlorophenyl)amino]-6-(4-methoxyphenyl)-7-oxopteridin-8(7H)-yl]ethyl)methanesulfonamide
N-(2-[2-[(3,4-dichlorophenyl)amino]-6-(4-methoxyphenyl)-7-oxopteridin-8(7H)-yl]ethyl)propanamide
N-(2-[2-[(3,4-dichlorophenyl)amino]-6-(4-methoxyphenyl)-7-oxopteridin-8(7H)-yl]ethyl)thiophene-3-carboxamide
N-(2-[2-[(3,4-dichlorophenyl)amino]-7-oxo-6-(4-pyridin-3-ylphenyl)pteridin-8(7H)-yl]ethyl)acetamide
N-(2-[2-[(3-chloro-4-fluorophenyl)amino]-6-(4-methoxyphenyl)-7-oxopteridin-8(7H)-yl]ethyl)acetamide
N-(2-[2-[(3-chlorophenyl)amino]-6-(4-methoxyphenyl)-7-oxopteridin-8(7H)-yl]ethyl)acetamide
N-(2-[2-[(4-chloro-3-fluorophenyl)amino]-6-(4-methoxyphenyl)-7-oxopteridin-8(7H)-yl]ethyl)acetamide
N-(2-[6-[(2-chlorobenzyl)amino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl)acetamide
N-(2-[6-[(3,4-dichlorobenzyl)amino]-2,2-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethyl)-2-hydroxyacetamide
N-(2-[6-[(3,4-dichlorobenzyl)amino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl)acetamide
N-(2-[6-[(3,4-dichlorobenzyl)amino]-2-methyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethyl)-2-hydroxyacetamide
N-(2-[6-[(3,4-dichlorobenzyl)amino]-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethyl)-2-hydroxyacetamide
N-(2-[6-[(3-chloro-4-fluorobenzyl)amino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl)acetamide
N-(2-[6-[(3-chlorobenzyl)amino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl)acetamide
N-(2-[6-[(3-fluorobenzyl)amino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl)acetamide
N-(2-[6-[(3-methoxybenzyl)amino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl)acetamide
N-(2-[6-[(4-chlorobenzyl)amino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl)acetamide
N-(2-[7-[(3,4-dichlorobenzyl)amino]-3-(4-methoxyphenyl)-2-oxopyrido[3,4-b]pyrazin-1(2H)-yl]ethyl)acetamide
N-(2-[7-[(3,4-dichlorobenzyl)amino]-3-(4-methoxyphenyl)-2-oxoquinoxalin-1(2H)-yl]ethyl)acetamide
N-(2-[7-[(3,4-dimethylbenzyl)amino]-3-(4-methoxyphenyl)-2-oxoquinoxalin-1(2H)-yl]ethyl)acetamide
N-(2-[7-[(4-fluoro-3-methylbenzyl)amino]-3-(4-methoxyphenyl)-2-oxoquinoxalin-1(2H)-yl]ethyl)acetamide
N-(3-carbamoylphenyl)-4-(2-chlorophenoxy)piperidine-1-carboxamide
N-(3-methylbutyl)-2-(4-phenoxyphenyl)-1H-benzimidazole-5-carboxamide
-
-
N-(3-methylbutyl)-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide
-
-
N-(3-methylbutyl)-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide
-
-
N-(3-methylbutyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
N-(3-methylbutyl)-6-oxo-8-[[2-(trifluoromethyl)phenyl]carbonyl]-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1',2':1,6]pyrazino[2,3-c]pyridazine-3-carboxamide
N-(3-methylbutyl)-6-[[2-(trifluoromethyl)phenyl]carbonyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridine-2-carboxamide
N-(3-phenylpropyl)-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide
-
-
N-(4-carbamoyl-1,3-thiazol-2-yl)-4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxamide
-
-
N-(5-acetyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)-4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxamide
-
46% inhibition at 0.001 mM
N-(5-carbamoyl-1,3-thiazol-2-yl)-4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxamide
-
-
N-(6,7-dihydro-4H-pyrano[4,3-d][1,3]thiazol-2-yl)-4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxamide
-
-
N-(cyclopentylmethyl)-6-[5-[[2-(trifluoromethyl)phenyl]carbonyl]-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]pyridine-3-carboxamide
N-(cyclopropylmethyl)-2-(4-phenoxyphenyl)-1H-benzimidazole-5-carboxamide
-
-
N-(thiophen-2-ylmethyl)-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide
-
-
N-benzyl-2-(5-hydroxy-1-oxoisoquinolin-2(1H)-yl)-4-methyl-1,3-thiazole-5-carboxamide
N-benzyl-2-[3-(4-fluorobenzyl)-2-oxopyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxamide
N-benzyl-2-[3-(4-fluorophenoxy)-2-oxopiperidin-1-yl]-4-methyl-1,3-thiazole-5-carboxamide
N-benzyl-3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)pyrazine-2-carboxamide
-
-
N-benzyl-3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)pyridine-2-carboxamide
-
-
N-benzyl-4-(morpholin-4-ylmethyl)-2-[(3-phenylpropanoyl)amino]-1,3-thiazole-5-carboxamide
N-benzyl-4-methyl-2-(1-[2-[methyl(phenyl)amino]ethyl]-1H-pyrazol-3-yl)-1,3-thiazole-5-carboxamide
N-benzyl-4-methyl-2-[6-(2-phenylethyl)pyrazin-2-yl]-1,3-thiazole-5-carboxamide
N-benzyl-6-[(2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl)amino]pyridine-2-carboxamide
-
-
N-ethyl-3-[(2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl)amino]pyridine-2-carboxamide
-
-
N-methoxy-3-[2-(4-methoxyphenyl)-3-oxo-6-[[3-(trifluoromethyl)benzyl]amino]pyrido[2,3-b]pyrazin-4(3H)-yl]propanamide
N-methyl-2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxamide
-
-
N-methyl-2-[(2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl)amino]pyridine-3-carboxamide
-
-
N-methyl-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide
-
-
N-methyl-3-[(2-oxo-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]ethyl)amino]pyridine-2-carboxamide
-
-
N-methyl-3-[[2-oxo-2-(4-phenoxypiperidin-1-yl)ethyl]amino]pyrazine-2-carboxamide
-
-
N-methyl-3-[[2-oxo-2-(4-phenylpiperidin-1-yl)ethyl]amino]pyrazine-2-carboxamide
-
-
N-methyl-3-[[2-oxo-2-(4-[[2-(trifluoromethyl)phenyl]amino]piperidin-1-yl)ethyl]amino]pyrazine-2-carboxamide
-
-
N-methyl-6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1H-imidazo[4,5-c]pyridin-4-amine
N-tert-butyl-3-([2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino)pyrazine-2-carboxamide
-
-
N-[(2R)-2-hydroxy-2-phenylethyl]-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
N-[(2S)-2-hydroxy-2-phenylethyl]-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
N-[(5-chlorothiophen-2-yl)methyl]-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide
-
-
N-[(5-chlorothiophen-2-yl)methyl]-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide
-
-
N-[(5-chlorothiophen-2-yl)methyl]-3-(5-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-1H-benzimidazol-2-yl)benzamide
-
-
N-[(6-chloropyridin-3-yl)methyl]-2-[4-[(4-fluorobenzyl)oxy]-2-oxopyridin-1(2H)-yl]-4-methyl-1,3-thiazole-5-carboxamide
N-[1-[5-chloro-2-(cyclopropylmethoxy)benzyl]-5-methyl-1H-pyrazol-3-yl]-1,2,3,4-tetrahydroisoquinoline-6-carboxamide
N-[2-(2-fluorophenyl)-2-hydroxyethyl]-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
N-[2-(3-fluorophenyl)-2-hydroxyethyl]-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
N-[2-(4-fluorophenyl)-2-hydroxyethyl]-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
N-[2-(4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-2-oxoethyl]-5-(2-methoxyphenyl)-1H-pyrazole-3-carboxamide
N-[2-(4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-2-oxoethyl]biphenyl-4-carboxamide
N-[2-(5-chlorothiophen-2-yl)ethyl]-2-(4-phenoxyphenyl)-1H-benzimidazole-5-carboxamide
-
-
N-[2-[2-(4-methoxyphenyl)-3-oxo-6-([[4-(trifluoromethyl)pyridin-2-yl]methyl]amino)pyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]acetamide
N-[2-[2-(4-methoxyphenyl)-3-oxo-6-([[6-(trifluoromethyl)pyridin-2-yl]methyl]amino)pyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]acetamide
N-[2-[2-(4-methoxyphenyl)-3-oxo-6-[[3-(2,2,2-trifluoroethoxy)benzyl]amino]pyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]acetamide
N-[2-[2-(4-methoxyphenyl)-3-oxo-6-[[3-(trifluoromethyl)benzyl]amino]pyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]acetamide
N-[2-[2-(4-methoxyphenyl)-3-oxo-6-[[4-(2,2,2-trifluoroethyl)benzyl]amino]pyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]acetamide
N-[2-[2-(4-methoxyphenyl)-6-[(3-methylbenzyl)amino]-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]acetamide
N-[2-[2-(4-methoxyphenyl)-6-[[(5-methylisoxazol-3-yl)methyl]amino]-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]acetamide
N-[2-[2-oxo-3-pyridin-3-yl-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]acetamide
N-[2-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-5-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
N-[2-[3-(4-ethylphenyl)-2-oxo-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]acetamide
N-[2-[3-(4-methoxyphenyl)-2-oxo-7-([[4-(trifluoromethyl)pyridin-2-yl]methyl]amino)quinoxalin-1(2H)-yl]ethyl]acetamide
N-[2-[3-(4-methoxyphenyl)-2-oxo-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]acetamide
N-[2-[3-(4-methoxyphenyl)-7-[(3-methylbenzyl)amino]-2-oxoquinoxalin-1(2H)-yl]ethyl]acetamide
N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]acetamide
N-[2-[3-oxo-2-pyridin-3-yl-6-[[3-(trifluoromethyl)benzyl]amino]pyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]acetamide
N-[2-[3-tert-butyl-2-oxo-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]-2-hydroxyacetamide
N-[2-[6-(benzylamino)-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]acetamide
N-[2-[6-[[2-fluoro-5-(trifluoromethyl)benzyl]amino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]acetamide
N-[2-[6-[[3,5-bis(trifluoromethyl)benzyl]amino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]acetamide
N-[2-[6-[[4-fluoro-3-(trifluoromethyl)benzyl]amino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]acetamide
N-[2-[7-[[4-chloro-3-(trifluoromethyl)benzyl]amino]-3-(4-methoxyphenyl)-2-oxoquinoxalin-1(2H)-yl]ethyl]acetamide
N-[3-(2-hydroxyethoxy)-4-methoxyphenyl]-5-[3-(trifluoromethyl)benzyl]-1,3-thiazole-2-carboxamide
N-[3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl]-2-hydroxyacetamide
N-[3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]-2-hydroxyacetamide
N-[3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]-2-phenoxyacetamide
N-[3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]-3-hydroxypropanamide
N-[3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]acetamide
N-[3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-2-hydroxyacetamide
N-[3-(3-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-2-hydroxyacetamide
N-[3-(4-chlorobenzyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl]-2-hydroxyacetamide
N-[3-(4-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]-2-hydroxyacetamide
N-[3-(4-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]-2-phenoxyacetamide
N-[3-(4-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-2-hydroxyacetamide
N-[3-(biphenyl-3-ylmethyl)-4-oxo-3,4-dihydroquinazolin-6-yl]-2-hydroxyacetamide
N-[3-(methylcarbamoyl)phenyl]-4-(2-methylphenoxy)piperidine-1-carboxamide
N-[3-(methylcarbamoyl)phenyl]-4-(2-oxo-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxamide
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7% inhibition at 0.001 mM
N-[3-(methylcarbamoyl)phenyl]-4-phenoxypiperidine-1-carboxamide
N-[3-(tert-butylcarbamoyl)phenyl]-4-(2-chlorophenoxy)piperidine-1-carboxamide
N-[3-[4-chloro-3-(trifluoromethyl)benzyl]-4-oxo-3,4-dihydroquinazolin-6-yl]-2-hydroxyacetamide
N-[5-(2,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
N-[5-(3,4-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
N-[5-(3,4-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
N-[5-(3,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
N-[5-(3,5-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
N-[5-(3-chloro-4-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
N-[5-(3-chlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
N-[5-(3-fluoro-4-methylbenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
N-[5-(3-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
N-[5-(3-tert-butylbenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
N-[5-methyl-1-[3-(trifluoromethyl)benzyl]-1H-pyrazol-3-yl]-1,2,3,4-tetrahydroisoquinoline-6-carboxamide
N-[5-[(2-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-1,2,3,4-tetrahydroisoquinoline-6-carboxamide
N-[5-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]naphthalene-2-carboxamide
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N-[5-[4-fluoro-3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
N-{5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl}naphthalene-2-carboxamide
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o-phenanthroline
oleoyl-CoA
oleyl-CoA
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competitive, up to 50% decrease in reaction rate
p-chloromercuribenzoate
p-hydroxymercuribenzoate
palmitoyl-CoA
phenazine methosulfate
Phenyllactate
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partial inhibition, maximal at 0.08 mM
phenylpyruvate
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partial inhibition
potassium cyanide
potassium hexacyanoferrate
Rapamycin
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riboflavin
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25-30% inhibition at 0.04 mM
SAR707
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-
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stearoyl-CoA
Sterculic acid
sterculic oil
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in vivo enzyme inhibition by feeding sterculic oil
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Tetranitromethane
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Thenoyltrifluoroacetone
trans-10,cis-12 conjugated linoleic acid
Trifluoperazine
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[(5-methyl-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-5,7a-dihydro[1,3]thiazolo[4,5-d]pyrimidin-7-yl)oxy]acetic acid
[2-(biphenyl-4-yl)-1H-benzimidazol-5-yl](phenyl)methanone
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[2-([[4-([[2-(2-cyclopentylethyl)phenyl]amino]methyl)phenyl]carbonyl]amino)-1,3-thiazol-4-yl]acetic acid
[2-([[4-([[2-(trifluoromethyl)phenyl]amino]methyl)piperidin-1-yl]carbonyl]amino)-1,3-thiazol-4-yl]acetic acid
[2-methoxy-4-([5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]carbamoyl)phenoxy]acetic acid
[2-methoxy-5-([5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]carbamoyl)phenoxy]acetic acid
[2-[4-(benzyloxy)phenyl]-1H-benzimidazol-5-yl](phenyl)methanone
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[2-[4-(benzyloxy)phenyl]-1H-benzimidazol-5-yl][2-(trifluoromethyl)phenyl]methanol
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[2-[4-(benzyloxy)phenyl]-1H-benzimidazol-5-yl][2-(trifluoromethyl)phenyl]methanone
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[3-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)-1,2,4-oxadiazol-5-yl]methanol
[3-(5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-thiadiazol-2-yl)-1H-1,2,4-triazol-1-yl]acetic acid
[4-(5-benzoyl-1H-benzimidazol-2-yl)phenyl][2-(trifluoromethyl)phenyl]methanone
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[5-(2-[3-[2-bromo-5-(trifluoromethyl)phenoxy]propoxy]-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetic acid
[5-(4-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]phenyl)-1,3,4-oxadiazol-2-yl]methanol
[5-(5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-thiadiazol-2-yl)-1H-tetrazol-1-yl]acetic acid
[5-(6-[3-[2-(trifluoromethyl)phenoxy]azetidin-1-yl]pyridazin-3-yl)-1,3,4-oxadiazol-2-yl]methanol
[5-(6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl)-1,3,4-oxadiazol-2-yl]methanol
[5-(6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl)-1,3,4-thiadiazol-2-yl]acetic acid
[5-[2-([(2S)-3-[2-bromo-5-(trifluoromethoxy)phenoxy]-2-methylpropyl]oxy)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl]acetic acid
[5-[6-(benzyloxy)pyridazin-3-yl]-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-(trifluoromethyl)phenyl]methanone
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[[3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]amino](oxo)acetic acid
additional information