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5,6-dihydroxyindole-2-carboxylic acid oxidase deficiency
Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation.
5,6-dihydroxyindole-2-carboxylic acid oxidase deficiency
Cu,Zn-SOD-mediated Redox Regulation of Jmjd3 Modulates Macrophage Polarization and Pulmonary Fibrosis.
5,6-dihydroxyindole-2-carboxylic acid oxidase deficiency
H3K27 Demethylase, JMJD3, Regulates Fragmentation of Spermatogonial Cysts.
5,6-dihydroxyindole-2-carboxylic acid oxidase deficiency
JMJD3 deficiency alleviates lipopolysaccharide?induced acute lung injury by inhibiting alveolar epithelial ferroptosis in a Nrf2?dependent manner.
5,6-dihydroxyindole-2-carboxylic acid oxidase deficiency
JMJD3 is crucial for female AVPV RIP-Cre neuron controlled kisspeptin-estrogen feedback loop and reproductive function.
5,6-dihydroxyindole-2-carboxylic acid oxidase deficiency
JMJD3 regulates CD4 T cell trafficking by targeting actin cytoskeleton regulatory gene Pdlim4.
5,6-dihydroxyindole-2-carboxylic acid oxidase deficiency
Myeloid Kdm6b deficiency results in advanced atherosclerosis.
5,6-dihydroxyindole-2-carboxylic acid oxidase deficiency
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection.
Acquired Immunodeficiency Syndrome
JMJD3 aids in reprogramming of bone marrow progenitor cells to hepatic phenotype through epigenetic activation of hepatic transcription factors.
Acrocephalosyndactylia
Pharmacological targeting of KDM6A and KDM6B, as a novel therapeutic strategy for treating craniosynostosis in Saethre-Chotzen syndrome.
Acute Lung Injury
JMJD3 deficiency alleviates lipopolysaccharide?induced acute lung injury by inhibiting alveolar epithelial ferroptosis in a Nrf2?dependent manner.
Anthrax
The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
MicroRNA-941 Expression in Polymorphonuclear Granulocytes Is Not Related to Granulomatosis with Polyangiitis.
Aortic Aneurysm, Abdominal
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms.
Arthritis, Rheumatoid
Cystathionine-?-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis.
Arthritis, Rheumatoid
Histone demethylase JMJD3 regulates fibroblast-like synoviocyte-mediated proliferation and joint destruction in rheumatoid arthritis.
Asthma
Inhibition of H3K27me3 demethylases attenuates asthma by reversing the shift in airway smooth muscle phenotype.
Atherosclerosis
Myeloid Ezh2 Deficiency Limits Atherosclerosis Development.
Atherosclerosis
Myeloid Kdm6b deficiency results in advanced atherosclerosis.
Atherosclerosis
The regulation of Jmjd3 upon the expression of NF-?B downstream inflammatory genes in LPS activated vascular endothelial cells.
Bone Diseases, Metabolic
Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.
Brain Injuries
H3K27 demethylase KDM6B aggravates ischemic brain injury through demethylation of IRF4 and Notch2-dependent SOX9 activation.
Brain Ischemia
Inhibiting Jumoji domain containing protein 3 (JMJD3) prevent neuronal apoptosis from stroke.
Brain Neoplasms
JMJD3 promotes the epithelial-mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis.
Brain Neoplasms
The Histone Demethylase Jumonji Coordinates Cellular Senescence Including Secretion of Neural Stem Cell-attracting Cytokines.
Breast Neoplasms
Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B.
Breast Neoplasms
H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ER? ligand dependency.
Breast Neoplasms
Histone demethylase KDM6B inhibits breast cancer metastasis by regulating Wnt/?-catenin signaling.
Breast Neoplasms
Histone demethylase KDM6B promotes epithelial-mesenchymal transition.
Breast Neoplasms
JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity.
Breast Neoplasms
KDM6B Counteracts EZH2-Mediated Suppression of IGFBP5 to Confer Resistance to PI3K/AKT Inhibitor Treatment in Breast Cancer.
Breast Neoplasms
Lysyl oxidase expression is regulated by the H3K27 demethylase Jmjd3 in tumor-associated M2-like macrophages.
Breast Neoplasms
The histone methyltransferase EZH2 promotes mammary stem and luminal progenitor cell expansion, metastasis and inhibits estrogen receptor-positive cellular differentiation in a model of basal breast cancer.
Breast Neoplasms
[Association of JMJD3, MMP-2 and VEGF expressions with clinicopathological features of invasive ductal breast carcinoma].
Carcinogenesis
Decreased expression of JMJD3 predicts poor prognosis of patients with clear cell renal cell carcinoma.
Carcinogenesis
Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid ?-oxidation.
Carcinogenesis
KDM6B induces epithelial-mesenchymal transition and enhances clear cell renal cell carcinoma metastasis through the activation of SLUG.
Carcinogenesis
Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B.
Carcinogenesis
The Roles of Histone Demethylase Jmjd3 in Osteoblast Differentiation and Apoptosis.
Carcinoma
Decreased expression of JMJD3 predicts poor prognosis of patients with clear cell renal cell carcinoma.
Carcinoma
Different expression patterns of histone H3K27 demethylases in renal cell carcinoma and bladder cancer.
Carcinoma
Expression and significance of histone H3K27 demethylases in renal cell carcinoma.
Carcinoma
EZH2 and KDM6B Expressions Are Associated with Specific Epigenetic Signatures during EMT in Non Small Cell Lung Carcinomas.
Carcinoma
JmjC-KDMs KDM3A and KDM6B modulate radioresistance under hypoxic conditions in esophageal squamous cell carcinoma.
Carcinoma
JMJD3 expression is an independent prognosticator in patients with esophageal squamous cell carcinoma.
Carcinoma
JMJD3 promotes esophageal squamous cell carcinoma pathogenesis through epigenetic regulation of MYC.
Carcinoma
KDM6B induces epithelial-mesenchymal transition and enhances clear cell renal cell carcinoma metastasis through the activation of SLUG.
Carcinoma
Long noncoding RNA HOTAIR promotes metastasis of renal cell carcinoma by up-regulating histone H3K27 demethylase JMJD3.
Carcinoma
Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B.
Carcinoma
The Prognostic Significance Of JMJD3 In Primary Sarcomatoid Carcinoma Of The Lung, A Rare Subtype Of Lung Cancer.
Carcinoma
Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1.
Carcinoma
Transcriptomic Profiling and H3K27me3 Distribution Reveal Both Demethylase-Dependent and Independent Regulation of Developmental Gene Transcription in Cell Differentiation.
Carcinoma, Hepatocellular
Aberrant JMJD3 Expression Upregulates Slug to Promote Migration, Invasion, and Stem Cell-Like Behaviors in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
H3K27 Demethylase JMJD3 Employs the NF-?B and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis.
Carcinoma, Hepatocellular
MicroRNA-941 Expression in Polymorphonuclear Granulocytes Is Not Related to Granulomatosis with Polyangiitis.
Carcinoma, Non-Small-Cell Lung
JMJD3 enhances invasiveness and migratory capacity of non-small cell lung cancer cell via activating EMT signaling pathway.
Carcinoma, Non-Small-Cell Lung
KDM6B Elicits Cell Apoptosis by Promoting Nuclear Translocation of FOXO1 in Non-Small Cell Lung Cancer.
Carcinoma, Ovarian Epithelial
KDM6B promotes ovarian cancer cell migration and invasion by induced transforming growth factor-?1 expression.
Carcinoma, Renal Cell
Decreased expression of JMJD3 predicts poor prognosis of patients with clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Different expression patterns of histone H3K27 demethylases in renal cell carcinoma and bladder cancer.
Carcinoma, Renal Cell
Expression and significance of histone H3K27 demethylases in renal cell carcinoma.
Carcinoma, Renal Cell
KDM6B induces epithelial-mesenchymal transition and enhances clear cell renal cell carcinoma metastasis through the activation of SLUG.
Carcinoma, Renal Cell
Long noncoding RNA HOTAIR promotes metastasis of renal cell carcinoma by up-regulating histone H3K27 demethylase JMJD3.
Carcinoma, Squamous Cell
Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B.
Carcinoma, Squamous Cell
Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1.
Cardiomegaly
JMJD3 inhibition protects against isoproterenol-induced cardiac hypertrophy by suppressing ?-MHC expression.
Cardiomyopathies
Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression.
Cardiomyopathy, Dilated
Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression.
Cerebral Infarction
H3K27 demethylase KDM6B aggravates ischemic brain injury through demethylation of IRF4 and Notch2-dependent SOX9 activation.
Chordoma
Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death.
Colitis
Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation.
Colitis
Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice.
Colitis, Ulcerative
Colonic vitamin D receptor expression is inversely associated with disease activity and jumonji domain-containing 3 in active ulcerative colitis.
Colonic Neoplasms
KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells.
Craniosynostoses
Pharmacological targeting of KDM6A and KDM6B, as a novel therapeutic strategy for treating craniosynostosis in Saethre-Chotzen syndrome.
Cystitis
Activation of NFKB-JMJD3 signaling promotes bladder fibrosis via boosting bladder smooth muscle cell proliferation and collagen accumulation.
Cysts
H3K27 Demethylase, JMJD3, Regulates Fragmentation of Spermatogonial Cysts.
Diabetes Mellitus, Type 2
Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid ?-oxidation.
Diabetes Mellitus, Type 2
Histone demethylase UTX is a therapeutic target for diabetic kidney disease.
Diffuse Intrinsic Pontine Glioma
An epigenetic therapy for diffuse intrinsic pontine gliomas.
Encephalomyelitis
The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs.
Encephalomyelitis, Autoimmune, Experimental
The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs.
Endometrial Neoplasms
Targeting P16INK4A in uterine serous carcinoma through inhibition of histone demethylation.
Esophageal Squamous Cell Carcinoma
JmjC-KDMs KDM3A and KDM6B modulate radioresistance under hypoxic conditions in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
JMJD3 expression is an independent prognosticator in patients with esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
JMJD3 promotes esophageal squamous cell carcinoma pathogenesis through epigenetic regulation of MYC.
Fatty Liver
Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase.
Glioblastoma
Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.
Glioblastoma
Increased expression of the histone H3 lysine 4 methyltransferase MLL4 and the histone H3 lysine 27 demethylase UTX prolonging the overall survival of patients with glioblastoma and a methylated MGMT promoter.
Glioblastoma
Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3.
Glioblastoma
Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells.
Glioblastoma
The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1.
Glioblastoma
The pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells.
Glioma
An epigenetic therapy for diffuse intrinsic pontine gliomas.
Glioma
Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells.
Glioma
JMJD3 promotes the epithelial-mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis.
Glioma
The Histone Demethylase Jumonji Coordinates Cellular Senescence Including Secretion of Neural Stem Cell-attracting Cytokines.
Glioma
The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1.
Glioma
The pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells.
Gout
Genetic Correlation Analysis and Transcriptome-wide Association Study Suggest the Overlapped Genetic Mechanism between Gout and Attention-deficit Hyperactivity Disorder: L'analyse de corrélation génétique et l'étude d'association à l'échelle du transcriptome suggèrent un mécanisme génétique superposé entre la goutte et le trouble de déficit de l'attention avec hyperactivité.
Granulomatosis with Polyangiitis
MicroRNA-941 Expression in Polymorphonuclear Granulocytes Is Not Related to Granulomatosis with Polyangiitis.
Hearing Loss
Inhibition of H3K27me3 Histone Demethylase Activity Prevents the Proliferative Regeneration of Zebrafish Lateral Line Neuromasts.
Heart Defects, Congenital
Suppression of canonical TGF-? signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis.
Hematologic Neoplasms
Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis.
Herpes Simplex
Inhibition of H3K27me3-Specific Histone Demethylases JMJD3 and UTX Blocks Reactivation of Herpes Simplex Virus 1 in Trigeminal Ganglion Neurons.
Hodgkin Disease
The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma.
Hyperalgesia
Histone modification of pain-related gene expression in spinal cord neurons under a persistent postsurgical pain-like state by electrocautery.
Hyperalgesia
KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats.
Hypersensitivity
Oncogenic KRAS sensitizes lung adenocarcinoma to GSK-J4-induced metabolic and oxidative stress.
Hypertension
Lysine demethylase KDM6B regulates HIF-1?-mediated systemic and cellular responses to intermittent hypoxia.
Immune System Diseases
JMJD3: a critical epigenetic regulator in stem cell fate.
Infections
Kdm6b Regulates the Generation of Effector CD8+ T Cells by Inducing Chromatin Accessibility in Effector-Associated Genes.
Infections
MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection.
Infections
Role of Serum Amyloid A, Granulocyte-Macrophage Colony-Stimulating Factor, and Bone Marrow Granulocyte-Monocyte Precursor Expansion in Segmented Filamentous Bacterium-Mediated Protection from Entamoeba histolytica.
Infections
The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae.
Infections
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection.
Inflammatory Bowel Diseases
Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice.
Insulin Resistance
Metabolic and energetic benefits of microRNA-22 inhibition.
Intellectual Disability
Genetic variants in the KDM6B gene are associated with neurodevelopmental delays and dysmorphic features.
Ischemic Stroke
H3K27 demethylase KDM6B aggravates ischemic brain injury through demethylation of IRF4 and Notch2-dependent SOX9 activation.
Ischemic Stroke
Inhibiting Jumoji domain containing protein 3 (JMJD3) prevent neuronal apoptosis from stroke.
Kidney Neoplasms
Calcitriol induces cell senescence of kidney cancer through JMJD3 mediated histone demethylation.
Kidney Neoplasms
Nicotine induces alteration of H3K27 demethylase UTX in kidney cancer cell.
Kidney Neoplasms
The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells.
Leukemia
Histone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX.
Leukemia
Increased expression of the histone H3 lysine 4 methyltransferase MLL4 and the histone H3 lysine 27 demethylase UTX prolonging the overall survival of patients with glioblastoma and a methylated MGMT promoter.
Leukemia
JMJD3 facilitates C/EBP?-centered transcriptional program to exert oncorepressor activity in AML.
Leukemia
KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice.
Leukemia
Low HOX gene expression in PML-RAR?-positive leukemia results from suppressed histone demethylation.
Leukemia
Proteomic changes induced by histone demethylase JMJD3 in TNF alpha-treated human monocytic (THP-1) cells.
Leukemia
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
Leukemia
USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.
Leukemia
UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia.
Leukemia, Myeloid
Low HOX gene expression in PML-RAR?-positive leukemia results from suppressed histone demethylation.
Leukemia, Myeloid, Acute
JMJD3 facilitates C/EBP?-centered transcriptional program to exert oncorepressor activity in AML.
Leukemia, Myeloid, Acute
Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis.
Leukemia, Myelomonocytic, Chronic
KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice.
Liver Cirrhosis
Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis.
Liver Diseases
Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase.
Lung Injury
Dexmedetomidine preconditioning ameliorates lung injury induced by pulmonary ischemia/reperfusion by upregulating promoter histone H3K4me3 modification of KGF-2.
Lung Neoplasms
Epigenetic regulation of TGF-?-induced EMT by JMJD3/KDM6B histone H3K27 demethylase.
Lung Neoplasms
JMJD3 enhances invasiveness and migratory capacity of non-small cell lung cancer cell via activating EMT signaling pathway.
Lung Neoplasms
KDM6B Elicits Cell Apoptosis by Promoting Nuclear Translocation of FOXO1 in Non-Small Cell Lung Cancer.
Lung Neoplasms
The Prognostic Significance Of JMJD3 In Primary Sarcomatoid Carcinoma Of The Lung, A Rare Subtype Of Lung Cancer.
Lung Neoplasms
[Effect of Jumonji domain-containing protein-3 on the proliferation and migration of lung cancer cell line].
Lupus Erythematosus, Systemic
Histone demethylase JMJD3 regulates CD11a expression through changes in histone H3K27 tri-methylation levels in CD4+ T cells of patients with systemic lupus erythematosus.
Lupus Nephritis
The occurrence of lupus nephritis is regulated by USP7-mediated JMJD3 stabilization.
Lymphatic Metastasis
JMJD3 enhances invasiveness and migratory capacity of non-small cell lung cancer cell via activating EMT signaling pathway.
Lymphatic Metastasis
KDM6B induces epithelial-mesenchymal transition and enhances clear cell renal cell carcinoma metastasis through the activation of SLUG.
Lymphatic Metastasis
KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBP? transcription.
Lymphatic Metastasis
The diagnostic performance of lysine(K)-specific demethylase 6B (KDM6B) in non-small cell lung cancer.
Lymphatic Metastasis
[Association of JMJD3, MMP-2 and VEGF expressions with clinicopathological features of invasive ductal breast carcinoma].
Lymphoma, B-Cell
Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs.
Lymphoma, B-Cell
JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms.
Lymphoma, Large B-Cell, Diffuse
Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs.
Lymphoma, Large B-Cell, Diffuse
JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms.
Medulloblastoma
Immunohistochemical investigation of topoII?, H3K27me3 and JMJD3 expressions in medulloblastoma.
Medulloblastoma
OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels.
Melanoma
H3K27 Demethylase JMJD3 Employs the NF-?B and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis.
Melanoma
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.
Meningomyelocele
Amniotic fluid and serum biomarkers from women with neural tube defect-affected pregnancies: a case study for myelomeningocele and anencephaly.
Mesothelioma
Kdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma.
Mesothelioma
KDM6B histone demethylase is an epigenetic regulator of estrogen receptor ? expression in human pleural mesothelioma.
Mesothelioma, Malignant
Kdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma.
Mesothelioma, Malignant
KDM6B histone demethylase is an epigenetic regulator of estrogen receptor ? expression in human pleural mesothelioma.
mrna m6a methyltransferase deficiency
Interplay of m6A and H3K27 trimethylation restrains inflammation during bacterial infection.
Multiple Myeloma
KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival.
Multiple Myeloma
UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.
Muscular Dystrophy, Duchenne
KDM6A and KDM6B play contrasting roles in nuclear transfer embryos revealed by MERVL reporter system.
Myelodysplastic Syndromes
Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells.
Myelodysplastic Syndromes
KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice.
Myocardial Infarction
Human umbilical cord mesenchymal stem cells ameliorate depression by regulating Jmjd3 and microglia polarization in myocardial infarction mice.
Myocardial Infarction
Targeting JMJD3 histone demethylase mediates cardiac fibrosis and cardiac function following myocardial infarction.
Neoplasm Metastasis
Correction to: KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBP? transcription.
Neoplasm Metastasis
H3K27 Demethylase JMJD3 Employs the NF-?B and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis.
Neoplasm Metastasis
Histone demethylase KDM6B inhibits breast cancer metastasis by regulating Wnt/?-catenin signaling.
Neoplasm Metastasis
JMJD3 enhances invasiveness and migratory capacity of non-small cell lung cancer cell via activating EMT signaling pathway.
Neoplasm Metastasis
KDM6B Elicits Cell Apoptosis by Promoting Nuclear Translocation of FOXO1 in Non-Small Cell Lung Cancer.
Neoplasm Metastasis
KDM6B induces epithelial-mesenchymal transition and enhances clear cell renal cell carcinoma metastasis through the activation of SLUG.
Neoplasm Metastasis
KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBP? transcription.
Neoplasm Metastasis
KDM6B promotes ovarian cancer cell migration and invasion by induced transforming growth factor-?1 expression.
Neoplasm Metastasis
KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma.
Neoplasm Metastasis
Long noncoding RNA HOTAIR promotes metastasis of renal cell carcinoma by up-regulating histone H3K27 demethylase JMJD3.
Neoplasm Metastasis
Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBP?
Neoplasm Metastasis
The diagnostic performance of lysine(K)-specific demethylase 6B (KDM6B) in non-small cell lung cancer.
Neoplasm Metastasis
The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1.
Neoplasm Metastasis
The histone methyltransferase EZH2 promotes mammary stem and luminal progenitor cell expansion, metastasis and inhibits estrogen receptor-positive cellular differentiation in a model of basal breast cancer.
Neoplasm Metastasis
[Association of JMJD3, MMP-2 and VEGF expressions with clinicopathological features of invasive ductal breast carcinoma].
Neoplasms
Aberrant JMJD3 Expression Upregulates Slug to Promote Migration, Invasion, and Stem Cell-Like Behaviors in Hepatocellular Carcinoma.
Neoplasms
An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFR? Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma.
Neoplasms
Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B.
Neoplasms
Comprehensive profiling of JMJD3 in gastric cancer and its influence on patient survival.
Neoplasms
Different expression patterns of histone H3K27 demethylases in renal cell carcinoma and bladder cancer.
Neoplasms
Endothelial progenitor cells-secreted extracellular vesicles containing microRNA-93-5p confer protection against sepsis-induced acute kidney injury via the KDM6B/H3K27me3/TNF-? axis.
Neoplasms
Epigenetic regulation of TGF-?-induced EMT by JMJD3/KDM6B histone H3K27 demethylase.
Neoplasms
Expression and significance of histone H3K27 demethylases in renal cell carcinoma.
Neoplasms
EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells.
Neoplasms
Gene networking and inflammatory pathway analysis in a JMJD3 knockdown human monocytic cell line.
Neoplasms
GSKJ4 Protects Mice Against Early Sepsis via Reducing Proinflammatory Factors and Up-Regulating MiR-146a.
Neoplasms
H3K27 Demethylase JMJD3 Employs the NF-?B and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis.
Neoplasms
Histone demethylase JMJD3 at the intersection of cellular senescence and cancer.
Neoplasms
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS.
Neoplasms
Histone demethylase Jmjd3 modulates osteoblast apoptosis induced by tumor necrosis factor-alpha through directly targeting RASSF5.
Neoplasms
Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation.
Neoplasms
Histone demethylase KDM6B inhibits breast cancer metastasis by regulating Wnt/?-catenin signaling.
Neoplasms
Histone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX.
Neoplasms
Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer.
Neoplasms
Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL.
Neoplasms
Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin.
Neoplasms
Inhibition of the histone H3K27 demethylase UTX enhances tumor cell radiosensitivity.
Neoplasms
JMJD3 as an epigenetic regulator in development and disease.
Neoplasms
JMJD3 enhances invasiveness and migratory capacity of non-small cell lung cancer cell via activating EMT signaling pathway.
Neoplasms
JMJD3 facilitates C/EBP?-centered transcriptional program to exert oncorepressor activity in AML.
Neoplasms
JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms.
Neoplasms
JMJD3 promotes the epithelial-mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis.
Neoplasms
JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity.
Neoplasms
JMJD3: a critical epigenetic regulator in stem cell fate.
Neoplasms
KDM6B (JMJD3) and its dual role in cancer.
Neoplasms
Kdm6b and Pmepa1 as Targets of Bioelectrically and Behaviorally Induced Activin A Signaling.
Neoplasms
KDM6B histone demethylase is an epigenetic regulator of estrogen receptor ? expression in human pleural mesothelioma.
Neoplasms
KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival.
Neoplasms
KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBP? transcription.
Neoplasms
KDM6B promotes ovarian cancer cell migration and invasion by induced transforming growth factor-?1 expression.
Neoplasms
Kdm6b Regulates the Generation of Effector CD8+ T Cells by Inducing Chromatin Accessibility in Effector-Associated Genes.
Neoplasms
KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma.
Neoplasms
KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells.
Neoplasms
Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBP?
Neoplasms
Loss of TET1 facilitates DLD1 colon cancer cell migration via H3K27me3-mediated down-regulation of E-cadherin.
Neoplasms
Lysine Demethylase KDM6A in Differentiation, Development, and Cancer.
Neoplasms
Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination.
Neoplasms
Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma.
Neoplasms
New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.
Neoplasms
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma.
Neoplasms
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.
Neoplasms
Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.
Neoplasms
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.
Neoplasms
Synergistic triad epistasis of epigenetic H3K27me modifier genes, EZH2, KDM6A, and KDM6B, in gastric cancer susceptibility.
Neoplasms
Targeting P16INK4A in uterine serous carcinoma through inhibition of histone demethylation.
Neoplasms
The Functions of the Demethylase JMJD3 in Cancer.
Neoplasms
The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma.
Neoplasms
The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1.
Neoplasms
The histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner.
Neoplasms
The Prognostic Significance Of JMJD3 In Primary Sarcomatoid Carcinoma Of The Lung, A Rare Subtype Of Lung Cancer.
Neoplasms
The role and prospect of JMJD3 in stem cells and cancer.
Neoplasms
The Roles of Histone Demethylase UTX and JMJD3 (KDM6B) In Cancers: Current Progress and Future Perspectives.
Neoplasms
Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines.
Neoplasms
UTX condensation underlies its tumour-suppressive activity.
Neoplasms
UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1.
Neoplasms
UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.
Neoplasms
[Association of JMJD3, MMP-2 and VEGF expressions with clinicopathological features of invasive ductal breast carcinoma].
Neuralgia
KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats.
Neuroblastoma
Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation.
Neurodegenerative Diseases
EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells.
Neurodegenerative Diseases
JMJD3 as an epigenetic regulator in development and disease.
Neurofibroma
Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge.
Neuroinflammatory Diseases
Effects of chronic stress on depressive-like behaviors and JMJD3 expression in the prefrontal cortex and hippocampus of C57BL/6 and ob/ob mice.
Neuroinflammatory Diseases
H3K27 demethylase KDM6B aggravates ischemic brain injury through demethylation of IRF4 and Notch2-dependent SOX9 activation.
Neuroinflammatory Diseases
Jmjd3 is involved in the susceptibility to depression induced by maternal separation via enhancing the neuroinflammation in the prefrontal cortex and hippocampus of male rats.
Neuroinflammatory Diseases
Upregulation of KDM6B contributes to lipopolysaccharide-induced anxiety-like behavior via modulation of VGLL4 in mice.
Non-alcoholic Fatty Liver Disease
Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase.
Obesity
Effects of chronic stress on depressive-like behaviors and JMJD3 expression in the prefrontal cortex and hippocampus of C57BL/6 and ob/ob mice.
Obesity
Epigenetic Modulation in Periodontitis: Interaction of Adiponectin and JMJD3-IRF4 Axis in Macrophages.
Obesity
Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid ?-oxidation.
Osteoarthritis
Disruption of Jmjd3/p16Ink4a Signaling Pathway Causes Bizarre Parosteal Osteochondromatous Proliferation (BPOP)-like Lesion in Mice.
Osteoarthritis, Knee
Jumonji domain containing-3 (JMJD3) inhibition attenuates IL-1?-induced chondrocytes damage in vitro and protects osteoarthritis cartilage in vivo.
Osteoporosis
Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.
Osteoporosis
The miRNA-15b/USP7/KDM6B axis engages in the initiation of osteoporosis by modulating osteoblast differentiation and autophagy.
Osteosarcoma
Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma.
Ovarian Neoplasms
GSKJ4, A Selective Jumonji H3K27 Demethylase Inhibitor, Effectively Targets Ovarian Cancer Stem Cells.
Ovarian Neoplasms
KDM6B promotes ovarian cancer cell migration and invasion by induced transforming growth factor-?1 expression.
Ovarian Neoplasms
Targeting estrogen receptor beta (ER?) for treatment of ovarian cancer: importance of KDM6B and SIRT1 for ER? expression and functionality.
Pancreatic Neoplasms
Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBP?
Parkinson Disease
Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease.
Periodontitis
Disruption of Monocyte and Macrophage Homeostasis in Periodontitis.
Periodontitis
Epigenetic Modulation in Periodontitis: Interaction of Adiponectin and JMJD3-IRF4 Axis in Macrophages.
Periodontitis
Porphyromonas gingivalis LPS stimulation downregulates DNMT1, DNMT3a, and JMJD3 gene expression levels in human HaCaT keratinocytes.
Peripheral Nerve Injuries
KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats.
Peritonitis
Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages.
Pre-Eclampsia
[Function and mechanism of histone demethytransferase Jmjd3 mediated regulation of Th1/Th2 balance through epigenetic modification in pre-eclampsia].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
H3K27 Demethylase JMJD3 Employs the NF-?B and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis.
Preleukemia
JMJD3 facilitates C/EBP?-centered transcriptional program to exert oncorepressor activity in AML.
Prostatic Neoplasms
A new metabolic gene signature in prostate cancer regulated by JMJD3 and EZH2.
Prostatic Neoplasms
EZH2 Histone Methyltransferase and JMJD3 Histone Demethylase Implications in Prostate Cancer.
Prostatic Neoplasms
Inhibitor of H3K27 demethylase JMJD3/UTX GSK-J4 is a potential therapeutic option for castration resistant prostate cancer.
Prostatic Neoplasms
JMJD3 is a histone H3K27 demethylase.
Prostatic Neoplasms
KDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer.
Prostatic Neoplasms
Role of JMJD3 Demethylase and Its Inhibitor GSK-J4 in Regulation of MGMT, TRA2A, RPS6KA2, and U2AF1 Genes in Prostate Cancer Cell Lines.
Prostatic Neoplasms
The JMJD3 Histone Demethylase and the EZH2 Histone Methyltransferase in Prostate Cancer.
Proteinuria
[Role of histone demethylase KDM6B in HBx-mediated podocyte-macrophage transdifferentiation].
Pulmonary Fibrosis
Cu,Zn-SOD-mediated Redox Regulation of Jmjd3 Modulates Macrophage Polarization and Pulmonary Fibrosis.
Pulpitis
Epigenetic Control of Autophagy Related Genes Transcription in Pulpitis via JMJD3.
Renal Insufficiency, Chronic
Histone demethylase JMJD3 protects against renal fibrosis by suppressing TGF? and Notch signaling and preserving PTEN expression.
Respiratory Syncytial Virus Infections
Upregulation of H3K27 Demethylase KDM6 During Respiratory Syncytial Virus Infection Enhances Proinflammatory Responses and Immunopathology.
Sarcoma, Ewing
Pharmaceutical Interference of the EWS-FLI1-driven Transcriptome By Cotargeting H3K27ac and RNA Polymerase Activity in Ewing Sarcoma.
Scleroderma, Systemic
Overexpression of JMJD3 may contribute to demethylation of H3K27me3 in CD4+ T cells from patients with systemic sclerosis.
Scleroderma, Systemic
The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis.
Seizures
Acute and Chronic Electroconvulsive Seizures (ECS) Differentially Regulate the Expression of Epigenetic Machinery in the Adult Rat Hippocampus.
Sepsis
GSKJ4 Protects Mice Against Early Sepsis via Reducing Proinflammatory Factors and Up-Regulating MiR-146a.
Sepsis
JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis.
Sepsis
microRNA-27b shuttled by mesenchymal stem cell-derived exosomes prevents sepsis by targeting JMJD3 and downregulating NF-?B signaling pathway.
Shock, Septic
Bioinformatic analysis of pivotal genes associated with septic shock.
Spinal Cord Injuries
Gallic acid attenuates blood-spinal cord barrier disruption by inhibiting Jmjd3 expression and activation after spinal cord injury.
Spinal Cord Injuries
Jmjd3 mediates blood-spinal cord barrier disruption after spinal cord injury by regulating MMP-3 and MMP-9 expressions.
Spinal Cord Injuries
Unlocking the Recovery Potential: JMJD3 Inhibition-Mediated SAPK/JNK Signaling Inactivation Supports Endogenous Oligodendrocyte-Lineage Commitment Post Mammalian Spinal Cord Injury.
Squamous Cell Carcinoma of Head and Neck
Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1.
Stomach Neoplasms
Comprehensive profiling of JMJD3 in gastric cancer and its influence on patient survival.
Stomach Neoplasms
Synergistic triad epistasis of epigenetic H3K27me modifier genes, EZH2, KDM6A, and KDM6B, in gastric cancer susceptibility.
Tuberculosis, Pulmonary
Histone H3K14 hypoacetylation and H3K27 hypermethylation along with HDAC1 up-regulation and KDM6B down-regulation are associated with active pulmonary tuberculosis disease.
Urinary Bladder Neoplasms
Different expression patterns of histone H3K27 demethylases in renal cell carcinoma and bladder cancer.
Uterine Cervical Neoplasms
Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming.
Vascular Diseases
Critical role of histone demethylase JMJD3 in the regulation of neointima formation following vascular injury.
Vascular System Injuries
Critical role of histone demethylase JMJD3 in the regulation of neointima formation following vascular injury.
Vascular System Injuries
JMJD3 and vascular injury: The Emperor's new clothes.
Virus Diseases
Kdm6b Regulates the Generation of Effector CD8+ T Cells by Inducing Chromatin Accessibility in Effector-Associated Genes.
Virus Diseases
Upregulation of H3K27 Demethylase KDM6 During Respiratory Syncytial Virus Infection Enhances Proinflammatory Responses and Immunopathology.
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1.14.18.B1 5,6-dihydroxyindole-2-carboxylic acid oxidase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
