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Information on EC 1.14.18.5 - sphingolipid C4-monooxygenase and Organism(s) Homo sapiens

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IUBMB Comments
The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes. Some enzymes are bifunctional and also catalyse EC 1.14.19.17, sphingolipid 4-desaturase .
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This record set is specific for:
Homo sapiens
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
sur2p, sphingolipid c4-hydroxylase, syr2p, sphinganine c4-hydroxylase, sphingolipid hydroxylase, sphingolipid delta(4)-desaturase/c4-monooxygenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dihydroceramide hydroxylase
-
SBH1
-
-
-
-
SBH2
-
-
-
-
sphinganine C4-monooxygenase
-
-
-
-
sphingolipid C4-hydroxylase
SUR2
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes. Some enzymes are bifunctional and also catalyse EC 1.14.19.17, sphingolipid 4-desaturase [4].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dihydroceramide + reduced acceptor + H+ + O2
phytoceramide + acceptor + H2O
show the reaction diagram
-
-
-
?
N-octanoyl-D-erythro-dihydrosphingosine + reduced acceptor + H+ + O2
?
show the reaction diagram
-
-
-
?
sphingosine + reduced acceptor + H+ + O2
phytosphingosine + acceptor + H2O
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
highest expression in skin
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme plays an essential role in phytosphingolipid synthesis in human skin and other phytosphingolipid-containing tissues
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DEGS2_HUMAN
323
1
37197
Swiss-Prot
other Location (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35000
x * 35000, FLAG3-tagged enzyme, SDS-PAGE
41200
x * 41200, estimated from amino acid sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in HEK-293 cells
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the enzyme is up-regulated during keratinocyte differentiation
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mizutani, Y.; Kihara, A.; Igarashi, Y.
Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation
FEBS Lett.
563
93-97
2004
Homo sapiens (Q6QHC5), Homo sapiens
Manually annotated by BRENDA team