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Information on EC 1.14.14.26 - 24-hydroxycholesterol 7alpha-hydroxylase

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IUBMB Comments
A P-450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium . The enzyme is specific for (24S)-cholest-5-ene-3beta,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
cyp39a1, cyp39a1 oxysterol 7alpha-hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(24S)-cholest-5-ene-3beta,24-diol + [reduced NADPH-hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3beta,7alpha,24-triol + [oxidized NADPH-hemoprotein reductase] + H2O
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PATHWAY SOURCE
PATHWAYS
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