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Information on EC 1.14.14.16 - steroid 21-monooxygenase

for references in articles please use BRENDA:EC1.14.14.16
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IUBMB Comments
A P-450 heme-thiolate protein responsible for the conversion of progesterone and 17alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol. The electron donor is EC 1.6.2.4, NADPH---hemoprotein reductase.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
21-hydroxylase, cyp21a2, cyp21, cyp2d, steroid 21-hydroxylase, p450c21, progesterone 21-hydroxylase, cytochrome p450c21, p-450(c21), 21-hydroxylase cytochrome p-450, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a C21 steroid + [reduced NADPH-hemoprotein reductase] + O2 = a 21-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O
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