Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Acute Kidney Injury
Development of an Immunoassay for the Kidney-Specific Protein myo-Inositol Oxygenase, a Potential Biomarker of Acute Kidney Injury.
Acute Kidney Injury
Effectiveness of myo-inositol oxygenase in the early diagnosis of experimental acute kidney injury.
Acute Kidney Injury
Myo-inositol Oxygenase as a Novel Marker in the Diagnosis of Acute Kidney Injury.
Acute Kidney Injury
Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule.
Diabetes Complications
Expression of myo-inositol oxygenase in tissues susceptible to diabetic complications.
Diabetes Mellitus
Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus.
Diabetes, Gestational
Myo-inositol oxygenese activity in second trimester of pregnancy: altered myoinositol catabolism in gestational diabetes mellitus.
Diabetic Nephropathies
CONTRIBUTION OF MYO-INOSITOL OXYGENASE IN AGE: RAGE MEDIATED RENAL TUBULO-INTERSTITIAL INJURY IN THE CONTEXT OF DIABETIC NEPHROPATHY.
Diabetic Nephropathies
Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney disease.
Diabetic Nephropathies
Increased Expression of Myo-inositol Oxygenase is Involved in the Tubulointerstitial Injury of Diabetic Nephropathy.
Diabetic Nephropathies
myo-Inositol Oxygenase Overexpression Accentuates Generation of Reactive Oxygen Species and Exacerbates Cellular Injury following High Glucose Ambience: A NEW MECHANISM RELEVANT TO THE PATHOGENESIS OF DIABETIC NEPHROPATHY.
Diabetic Nephropathies
PATHOBIOLOGY OF RENAL SPECIFIC OXIDOREDUCTASE/MYO-INOSITOL OXYGENASE IN DIABETIC NEPHROPATHY: ITS IMPLICATIONS IN TUBULO-INTERSTITIAL FIBROSIS.
Diabetic Nephropathies
Relevance of renal-specific oxidoreductase in tubulogenesis during mammalian nephron development.
Diabetic Nephropathies
The Kidney Specific Protein myo-Inositol Oxygenase, a Potential Biomarker for Diabetic Nephropathy.
Diabetic Nephropathies
Transcriptional and Post-translational Modulation of myo-Inositol Oxygenase by High Glucose and Related Pathobiological Stresses.
Diabetic Nephropathies
Withdrawal: myo-Inositol oxygenase overexpression accentuates generation of reactive oxygen species and exacerbates cellular injury following high glucose ambience: A new mechanism relevant to the pathogenesis of diabetic nephropathy.
Obesity
Modulation of Renal Injury by Variable Expression of Myo-Inositol Oxygenase (MIOX) via Perturbation in Metabolic Sensors.
Obesity
Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
malfunction
upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and altered expression of mitochondrial dynamic and mitophagic proteins under high-glucose ambience. Additionally, dysfunctional mitochondria accumulate in the cytoplasm. Decreasing the expression of MIOX under high-glucose ambience increases PTEN-induced putative kinase 1 expression and the dependent mitofusin-2-Parkin interaction. Overexpression of MIOX in the cells enhances the effects of high-glucose, whereas MIOX siRNA or D-glucarate, an inhibitor of MIOX, partially reverse these perturbations
additional information
-
increase in MIOX enzyme activity is in proportion to serum glucose concentrations and may be responsible for the myo-inositol depletion found in the type I diabetes mellitus complications, detailed phenotype analysis of 130 Caucasian patients, overview
metabolism
-
MIOX is the first and rate-limiting enzyme in myo-inositol metabolism pathway
metabolism
a mechanism links MIOX to impaired mitochondrial quality control during tubular injury in the pathogenesis of diabetic kidney disease
physiological function
MIOX is a renal specific, proximal tubule protein that is increased in plasma ofanimals and critically ill patients with acute kidney injury, AKI. MIOX preceds the elevation in SCr by approximately two days in human patients
physiological function
myo-inositol oxygenase (MIOX) is a tubular-specific enzyme, that modulates redox imbalance and apoptosis in tubular cells in diabetes, role of MIOX in perturbation of mitochondrial quality control, including mitochondrial dynamics and autophagy/mitophagy, under high-glucose ambience or a diabetic state, overview
physiological function
-
enzyme overexpression accentuates the cellular injury related to endoplasmic reticulum stress and accentuates tunicamycin-induced generation of reactive oxygen species
physiological function
-
ferroptosis, an integral process in the pathogenesis of cisplatin-induced acute kidney injury, is modulated by the expression profile of the enzyme. Overexpression of the enzyme promotes cisplatin-induced cell death and RSL3-induced ferroptosis in HK-2 cells
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Arner, R.J.; Prabhu, K.S.; Reddy, C.C.
Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney
Biochem. Biophys. Res. Commun.
324
1386-1392
2004
Homo sapiens (Q9UGB7), Homo sapiens, Mus musculus (Q9QXN5), Mus musculus, Rattus norvegicus (Q9QXN4)
brenda
Prabhu, K.S.; Arner, R.J.; Vunta, H.; Reddy, C.C.
Up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells
J. Biol. Chem.
280
19895-19901
2005
Homo sapiens (Q9UGB7), Homo sapiens
brenda
Arner, R.J.; Prabhu, K.S.; Krishnan, V.; Johnson, M.C.; Reddy, C.C.
Expression of myo-inositol oxygenase in tissues susceptible to diabetic complications
Biochem. Biophys. Res. Commun.
339
816-820
2006
Homo sapiens, Mus musculus, Sus scrofa
brenda
Thorsell, A.G.; Persson, C.; Voevodskaya, N.; Busam, R.D.; Hammarstroem, M.; Graeslund, S.; Graeslund, A.; Hallberg, B.M.
Structural and biophysical characterization of human myo-inositol oxygenase
J. Biol. Chem.
283
15209-15216
2008
Homo sapiens
brenda
Yang, B.; Hodgkinson, A.; Millward, B.; Demaine, A.
Polymorphisms of myo-inositol oxygenase gene are associated with type 1 diabetes mellitus
J. Diabetes Complicat.
24
404-408
2010
Homo sapiens
brenda
Senthilraja, P.; Paul Aime, N.; Manikandaprabhu, S.; Prakash, M.
Computational screening and docking analysis of natural compounds derived from mangrove plant against type-2 diabetes, myo-inositol oxygenase enzyme (MIOX)
Int. J. Pharm. Sci. Rev. Res.
20
158-161
2013
Homo sapiens
-
brenda
Gaut, J.P.; Crimmins, D.L.; Ohlendorf, M.F.; Lockwood, C.M.; Griest, T.A.; Brada, N.A.; Hoshi, M.; Sato, B.; Hotchkiss, R.S.; Jain, S.; Ladenson, J.H.
Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury
Clin. Chem.
60
747-757
2014
Homo sapiens (Q9UGB7), Homo sapiens, Mus musculus (Q9QXN5), Mus musculus, Mus musculus C57BL/6 (Q9QXN5)
brenda
Zhan, M.; Usman, I.M.; Sun, L.; Kanwar, Y.S.
Disruption of renal tubular mitochondrial quality control by myo-inositol oxygenase in diabetic kidney disease
J. Am. Soc. Nephrol.
26
1304-1321
2015
Mus musculus (Q9QXN5), Homo sapiens (Q9UGB7)
brenda
Tominaga, T.; Dutta, R.K.; Joladarashi, D.; Doi, T.; Reddy, J.K.; Kanwar, Y.S.
Transcriptional and translational modulation of myo-inositol oxygenase (Miox) by fatty acids implications in renal tubular injury induced in obesity and diabetes
J. Biol. Chem.
291
1348-1367
2016
Homo sapiens (Q9UGB7), Mus musculus (Q9QXN5), Mus musculus CD1 (Q9QXN5), Rattus norvegicus (Q9QXN4), Sus scrofa (Q8WN98)
brenda
Sharma, I.; Dutta, R.K.; Singh, N.K.; Kanwar, Y.S.
High glucose-induced hypomethylation promotes binding of Sp-1 to myo-inositol oxygenase implication in the pathobiology of diabetic tubulopathy
Am. J. Pathol.
187
724-739
2017
Homo sapiens, Mus musculus (Q9QXN5), Mus musculus
brenda
Tominaga, T.; Sharma, I.; Fujita, Y.; Doi, T.; Wallner, A.K.; Kanwar, Y.S.
Myo-inositol oxygenase accentuates renal tubular injury initiated by endoplasmic reticulum stress
Am. J. Physiol. Renal Physiol.
316
F301-F315
2019
Homo sapiens, Mus musculus (Q9QXN5), Sus scrofa
brenda
Deng, F.; Sharma, I.; Dai, Y.; Yang, M.; Kanwar, Y.S.
Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule
J. Clin. Invest.
129
5033-5049
2019
Homo sapiens
brenda
Mertoglu, C.; Gunay, M.; Gurel, A.; Gungor, M.
Myo-inositol oxygenase as a novel marker in the diagnosis of acute kidney injury
J. Med. Biochem.
37
1-6.
2018
Homo sapiens
brenda