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Information on EC 1.13.11.24 - quercetin 2,3-dioxygenase and Organism(s) Homo sapiens

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IUBMB Comments
The enzyme from Aspergillus sp. is a copper protein whereas that from Bacillus subtilis contains iron. Quercetin is a flavonol (5,7,3',4'-tetrahydroxyflavonol).
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
pirin, quercetinase, quercetin 2,3-dioxygenase, 2,3qd, 2,3-qd, flavonol 2,4-dioxygenase, mn-qdo, vdqase, quercetin dioxygenase, quercetin 2,4-dioxygenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
flavonol 2,4-oxygenase
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pirin
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quercetinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
quercetin:oxygen 2,3-oxidoreductase (decyclizing)
The enzyme from Aspergillus sp. is a copper protein whereas that from Bacillus subtilis contains iron. Quercetin is a flavonol (5,7,3',4'-tetrahydroxyflavonol).
CAS REGISTRY NUMBER
COMMENTARY hide
9075-67-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
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high level of pirin leads to the resistance of poliovirus replication to quercetin by inactivating this flavonoid
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
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high level of pirin leads to the resistance of poliovirus replication to quercetin by inactivating this flavonoid
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?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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HeLa cells contain higher content of pirin protein than normal kidney human epithelial or HEK-293 cells
Manually annotated by BRENDA team
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HeLa cells contain higher content of pirin protein than normal kidney human epithelial or HEK-293 cells
Manually annotated by BRENDA team
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HeLa cells contain higher content of pirin protein than normal kidney epithelial or HEK-293 cells
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PIR_HUMAN
290
0
32113
Swiss-Prot
other Location (Reliability: 5)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Neznanov, N.; Kondratova, A.; Chumakov, K.M.; Neznanova, L.; Kondratov, R.; Banerjee, A.K.; Gudkov, A.V.
Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin
DNA Cell Biol.
27
191-198
2008
Homo sapiens
Manually annotated by BRENDA team