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IUBMB Comments4-Hydroxybutanoate and (R)-2-hydroxyglutarate can also act as donors; 4-oxobutanoate can also act as acceptor.
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
adhfe1, hydroxyacid-oxoacid transhydrogenase, alcohol dehydrogenase iron containing 1,
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transhydrogenase, hydroxy acid-oxo acid
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(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase
4-Hydroxybutanoate and (R)-2-hydroxyglutarate can also act as donors; 4-oxobutanoate can also act as acceptor.
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4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
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4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
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recombinant enzyme in HEK-293 cells
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4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
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recombinant enzyme in HEK-293 cells
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0.077
2-oxoglutarate
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pH 7.1, 30°C, recombinant enzyme
0.067
4-hydroxybutyrate
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pH 7.1, 30°C, recombinant enzyme
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0.0013
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recombinant soluble enzyme in HEK-293 cells
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brenda
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HOT_MOUSE
465
0
49937
Swiss-Prot
Mitochondrion (Reliability: 2)
A0A087WRE7_MOUSE
457
0
49150
TrEMBL
Mitochondrion (Reliability: 5)
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DNA and amino acid sequence determination and analysis, expression in HEK-293 cells as soluble protein
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Kardon, T.; Noel, G.; Vertommen, D.; Van Schaftingen, E.
Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate
FEBS Lett.
580
2347-2350
2006
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
1.1.99.24 hydroxyacid-oxoacid transhydrogenase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
