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Information on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase and Organism(s) Pseudomonas aeruginosa

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EC Tree
IUBMB Comments
The product decarboxylates spontaneously to yield 4-methyl-2-oxopentanoate.
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Select one or more organisms in this record: ?
This record set is specific for:
Pseudomonas aeruginosa
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The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms
Synonyms
3-isopropylmalate dehydrogenase, ipmdh, beta-isopropylmalate dehydrogenase, isopropylmalate dehydrogenase, ipmdh2, ipmdh3, sbipmdh, ipmdh1, beta-ipm dehydrogenase, soipmdh, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-hydroxy-4-methyl-3-carboxyvalerate:NAD+ oxidoreductase
-
-
-
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2R,3S-isopropylmalate:NAD+ oxidoreductase (decaboxylating)
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-
-
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3-IPM dehydrogenase
-
-
-
-
3-IPM-DH
-
-
-
-
beta-IPM dehydrogenase
-
-
-
-
beta-IPMDH
-
-
-
-
beta-isopropylmalate dehydrogenase
-
-
-
-
beta-isopropylmalic enzyme
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-
-
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dehydrogenase, 3-isopropylmalate
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-
-
-
IMDH
-
-
-
-
IPMDH
-
-
-
-
isopropylmalate dehydrogenase
-
-
-
-
threo-Ds-3-isopropylmalate dehydrogenase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
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reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
The product decarboxylates spontaneously to yield 4-methyl-2-oxopentanoate.
CAS REGISTRY NUMBER
COMMENTARY hide
9030-97-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2R,3S)-3-isopropylmalate + NAD+
2-oxoisocaproate + NADH + H+ + CO2
show the reaction diagram
-
erythro-Lg-beta-isopropylmalate
-
-
?
(2R,3S)-3-isopropylmalate + thionicotinamide NAD+
2-oxoisohexanoate + thionicotinamideNADH + CO2
show the reaction diagram
-
-
-
-
?
3-ethylmalate + NAD+
3-ethylpyruvate + NADH + CO2
show the reaction diagram
-
DL-erythro-beta-ethylmalate
-
-
?
D-3-ethylmalate + NAD+
D-3-ethyl-2-oxosuccinate + NADH + H+
show the reaction diagram
-
-
-
-
?
erythro-Lg-beta-isopropylmalate + NAD+
?
show the reaction diagram
-
-
-
-
r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.019
dl-erythro-beta-ethylmalate
-
pH 9.0, 22°C
0.0092
erythro-Lg-beta-isopropylmalate
-
pH 9.0, 22°C
0.28
NAD+
-
pH 9.0, 22°C
0.051
thionicotinamide-NAD+
-
pH 9.0, 22°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.54
-
slow electrophoretic form
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A7M3B5Z4_PSEAI
360
0
39094
TrEMBL
-
A0A2R3IVC7_PSEAI
360
0
38994
TrEMBL
-
A0A8G4D9I0_PSEAI
360
0
39135
TrEMBL
-
A0A8G3ZEU1_PSEAI
360
0
39063
TrEMBL
-
A0A3M5EFN0_PSEAI
368
0
39966
TrEMBL
-
A0A8G4JF47_PSEAI
360
0
39068
TrEMBL
-
A0A8B5A5I5_PSEAI
360
0
39095
TrEMBL
-
A0A367LZK2_PSEAI
183
0
19970
TrEMBL
-
A0A8G4LBL7_PSEAI
360
0
39149
TrEMBL
-
A0A8A4EPP4_PSEAI
360
0
39160
TrEMBL
-
A0A3S0J248_PSEAI
360
0
38923
TrEMBL
-
A0A8G7AVR1_PSEAI
360
0
39052
TrEMBL
-
A0A8G4A5N8_PSEAI
360
0
39040
TrEMBL
-
A0A8G2VRA2_PSEAI
360
0
39036
TrEMBL
-
A0A0A8RCH0_PSEAI
360
0
39108
TrEMBL
-
A0A8G3WE56_PSEAI
361
0
39178
TrEMBL
-
A0A8G4L1R4_PSEAI
360
0
39149
TrEMBL
-
A0A071KZ07_PSEAI
360
0
39121
TrEMBL
-
A0A8G4G7D3_PSEAI
360
0
39036
TrEMBL
-
A0A5E9K2Y0_PSEAI
360
0
39094
TrEMBL
-
A0A643IZI4_PSEAI
360
0
39135
TrEMBL
-
A0A8G4SMY0_PSEAI
360
0
39068
TrEMBL
-
A0A6A9JW62_PSEAI
360
0
39118
TrEMBL
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50000
-
gel filtration
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rabin, R.; Urbano, C.; Ajl, S.J.
Isoenzymes of beta-isopropylmalate dehydrogenase from Pseudomonas aeruginosa
Arch. Biochem. Biophys.
134
259-261
1969
Pseudomonas aeruginosa
Manually annotated by BRENDA team