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Information on EC 1.1.1.71 - alcohol dehydrogenase [NAD(P)+] and Organism(s) Homo sapiens

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EC Tree
IUBMB Comments
Reduces aliphatic aldehydes of carbon chain length from 2 to 14, with greatest activity on C4, C6 and C8 aldehydes; also reduces retinal to retinol.
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This record set is specific for:
Homo sapiens
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
dhrs3, retinaldehyde reductase, tesadh, retsdr1, nadph-dependent alcohol dehydrogenase, adh12, tsib_0319, phadh, nad(p)h-dependent adh, retinol-active alcohol dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aldehyde reductase (NADPH/NADH)
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-
-
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DHRS3
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retinal reductase
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-
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retinal short-chain dehydrogenase/reductase member 3
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retSDR1
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-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
show the reaction diagram
the human pancreas protein 2 has a retinal reductase activity
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
alcohol:NAD(P)+ oxidoreductase
Reduces aliphatic aldehydes of carbon chain length from 2 to 14, with greatest activity on C4, C6 and C8 aldehydes; also reduces retinal to retinol.
CAS REGISTRY NUMBER
COMMENTARY hide
37250-10-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-androstene-3,17-dione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
4-nitroacetophenone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
acetohexamide + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
all-trans-retinal + NADPH + H+
all-trans-retinol + NADP+
show the reaction diagram
-
-
-
-
?
all-trans-retinol + NADP+
all-trans-retinal + NADPH + H+
show the reaction diagram
-
-
-
r
DL-glyceraldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
estrone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
retinaldehyde + NADH
retinol + NAD+
show the reaction diagram
-
-
-
?
additional information
?
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4-nitroacetophenone, benzyl, cortisone and progesterone are no substrates
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
all-trans-retinal + NADPH + H+
all-trans-retinol + NADP+
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
-
the enzyme prefers NADPH as a cofactor
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.08
all-trans-retinal
pH 7.4, 37°C
0.4
all-trans-retinol
pH 7.4, 37°C
1060
NAD+
pH 7.4, 37°C
1200
NADH
pH 7.4, 37°C
0.65
NADP+
pH 7.4, 37°C
0.32
NADPH
pH 7.4, 37°C
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CBR1_HUMAN
277
0
30375
Swiss-Prot
other Location (Reliability: 4)
RDH14_HUMAN
336
1
36865
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
36000
-
x * 36000, SDS-PAGE
37000
SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 36000, SDS-PAGE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
HisTrap column chromatography, and Superdex 200 gel filtration
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Sf9 insect cells
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expression in insect SF9 cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Belyaeva, O.V.; Kedishvili, N.Y.
Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues
FEBS Lett.
531
489-493
2002
Homo sapiens (Q9HBH5)
Manually annotated by BRENDA team
Lundova, T.; Zemanova, L.; Malcekova, B.; Skarka, A.; Stambergova, H.; Havrankova, J.; Safr, M.; Wsol, V.
Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3)
Chem. Biol. Interact.
234
178-187
2015
Homo sapiens
Manually annotated by BRENDA team