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(1R)-1-hydroxy-1-phenylpropan-2-one + NADPH + H+
(1R)-1-phenylpropane-1,2-diol + NADP+
-
-
-
-
?
(2R)-2-hydroxy-1-(4-methoxyphenyl)propan-1-one + NADPH + H+
(2R)-1-(4-methoxyphenyl)propane-1,2-diol + NADP+
-
-
-
-
?
(2S)-2-hydroxy-1-(4-methoxyphenyl)propan-1-one + NADPH + H+
(2S)-1-(4-methoxyphenyl)propane-1,2-diol + NADP+
-
-
-
-
?
(2S,5S)-2,5-hexanediol + NADP+
? + NADPH + H+
(4R,6R)-6-butyloxane-2,4-diol + NAD+
(4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADH + H+
(4R,6R)-6-butyloxane-2,4-diol + NADP+
(4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADPH + H+
(4R,6R)-6-pentyloxane-2,4-diol + NAD+
(4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADH + H+
(4R,6R)-6-pentyloxane-2,4-diol + NADP+
(4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADPH + H+
(4R,6S)-6-(chloromethyl)oxane-2,4-diol + NAD+
(4R,6S)-6-(chloromethyl)-4-hydroxyoxan-2-one + NADH + H+
-
-
-
-
?
(4R,6S)-6-(chloromethyl)oxane-2,4-diol + NADP+
(4R,6S)-6-(chloromethyl)-4-hydroxyoxan-2-one + NADPH + H+
-
-
-
-
?
(R)-2-hydroxypropiophenone + NADPH + H+
?
-
-
-
-
r
(RS)-1-phenylethanol + NAD+
1-phenylethanone + NADH + H+
-
100% activity
-
-
?
(RS)-1-phenylethanol + NADP+
1-phenylethanone + NADPH + H+
-
100% activity
-
-
?
(S)-2-butanol + NADP+
butanone + NADPH
196% relative activity as compared to 2-propanol
-
-
?
(S)-2-butanol + NADP+
butanone + NADPH + H+
196% of the activity with 2-propanol, 2fold preference for (S)-2-butanol over (RS)-2-butanol
-
-
?
(S)-2-hydroxypropiophenone + NADPH + H+
?
-
-
-
-
r
1,2-propanediol + NAD+
? + NADH + H+
-
-
-
r
1,3-butanediol + NADP+
? + NADPH + H+
91% relative activity as compared to 2-propanol
-
-
?
1,3-propanediol + NAD+
? + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
? + NADH + H+
-
-
-
r
1-(2-bromophenyl)ethanol + NAD(P)+
1-(2-bromophenyl)ethanone + NAD(P)H + H+
-
11.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-(2-chlorophenyl)ethanol + NAD(P)+
1-(2-chlorophenyl)ethanone + NAD(P)H + H+
-
16.4% activity compared to (RS)-1-phenylethanol
-
-
?
1-(3-bromophenyl)ethanol + NAD(P)+
1-(3-bromophenyl)ethanone + NAD(P)H + H+
-
315% activity compared to (RS)-1-phenylethanol
-
-
?
1-(3-chlorophenyl)ethanol + NAD(P)+
1-(3-chlorophenyl)ethanone + NAD(P)H + H+
-
205% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-bromophenyl)ethanol + NAD(P)+
1-(4-bromophenyl)ethanone + NAD(P)H + H+
-
167% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-chlorophenyl)ethanone + NAD(P)+
1-(4-chlorophenyl)ethanone + NAD(P)H + H+
-
151% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-fluorophenyl)ethanol + NAD(P)+
1-(4-fluorophenyl)ethanol + NAD(P)H + H+
-
119% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-methylphenyl)ethanone + NAD(P)+
1-(4-methylphenyl)ethanol + NAD(P)H + H+
-
189% activity compared to (RS)-1-phenylethanol
-
-
?
1-butanol + NAD(P)+
butanal + NAD(P)H + H+
-
2.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-butanol + NAD+
butanal + NADH + H+
1-butanol + NADP+
1-butanal + NADPH + H+
-
-
-
?
1-butanol + NADP+
butanal + NADPH
80% relative activity as compared to 2-propanol
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
1-heptanol + NAD(P)+
heptanal + NAD(P)H + H+
-
3.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-heptanol + NAD+
heptanal + NADH + H+
1-hexanol + NAD(P)+
hexanal + NAD(P)H + H+
-
2.8% activity compared to (RS)-1-phenylethanol
-
-
?
1-hexanol + NAD+
hexanal + NADH + H+
1-octanol + NAD(P)+
octanal + NAD(P)H + H+
-
2.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-octanol + NAD+
octanal + NADH + H+
-
-
-
r
1-pentanol + NAD(P)+
pentanal + NAD(P)H + H+
-
2.8% activity compared to (RS)-1-phenylethanol
-
-
?
1-pentanol + NAD+
pentanal + NADH + H+
-
-
-
r
1-pentanol + NADP+
pentanal + NADPH + H+
1-phenyl-1,2-ethanediol + NAD(P)+
?
-
3.4% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-1-propanol + NAD(P)+
1-phenylpropionaldehyde + NAD(P)H + H+
-
13.1% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-2-propanol + NAD(P)+
1-phenylpropan-2-one + NAD(P)H + H+
-
39.1% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenylethanol + NADP+
1-phenylethanone + NADPH + H+
35% of the activtiy with 1-propanol
-
-
?
1-phenylethanol + NADP+
acetophenone + NADPH + H+
35% compared to activity with 1-propanol
-
-
?
1-phenylmethanol + NADP+
benzaldehyde + NADPH + H+
180% relative activity as compared to 2-propanol
-
-
?
1-propanol + NAD(P)+
propionaldehyde + NAD(P)H + H+
-
1.2% activity compared to (RS)-1-phenylethanol
-
-
?
1-propanol + NAD+
propanal + NADH + H+
1-propanol + NADP+
propanal + NADPH + H+
2,2,2-trifluoroacetophenone + NAD(P)H + H+
2,2,2-trifluoro-1-phenylethan-1-ol + NAD(P)+
-
180% activity compared to acetoin
-
-
?
2,3-pentanedione + NADPH + H+
? + NADP+
2,5-hexandione + NADH + H+
?
-
-
-
-
r
2-bromoacetophenone + NAD(P)H + H+
1-(2-bromophenyl)ethanone + NAD(P)+
-
8.7% activity compared to acetoin
-
-
?
2-bromobenzaldehyde + NADPH
2-bromobenzyl alcohol + NADP+
-
-
-
-
r
2-bromobenzaldehyde + NADPH + H+
2-bromobenzyl alcohol + NADP+
-
-
-
-
?
2-butanol + NAD(P)+
butan-2-one + NAD(P)H + H+
-
22.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-butanol + NADP+
2-butanone + NADPH + H+
43% of the activity compared to ethanol
-
-
?
2-butanol + NADP+
butanone + NADPH + H+
2-chloro-1-phenylethanol + NAD(P)+
2-chloro-1-phenylethan-1-one + NAD(P)H + H+
-
0.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-cyclohexenol + NADP+
2-cyclohexenone + NADH + H+
-
-
-
-
r
2-cyclohexenone + NADH + H+
2-cyclohexenol + NADP+
-
-
-
-
r
2-fluorobenzaldehyde + NADPH + H+
2-fluorobenzyl alcohol + NADP+
-
-
-
-
?
2-heptanol + NAD(P)+
heptan-2-one + NAD(P)H + H+
-
61.6% activity compared to (RS)-1-phenylethanol
-
-
?
2-hexanol + NAD(P)+
hexan-2-one + NAD(P)H + H+
-
38.7% activity compared to (RS)-1-phenylethanol
-
-
?
2-hexanone + NAD(P)H + H+
hexan-2-ol + NAD(P)+
-
3.6% activity compared to acetoin
-
-
?
2-hydroxy-2-methyl-1-phenylpropan-1-one + NADPH + H+
2-methyl-1-phenylpropan-1,2-diol + NADP+
-
-
-
-
?
2-hydroxy-3-methoxybenzaldehyde + NADPH + H+
2-hydroxy-3-methoxybenzyl alcohol + NADP+
-
-
-
?
2-methoxybenzaldehyde + NADPH + H+
2-methoxybenzyl alcohol + NADP+
2-methylbenzaldehyde + NADPH + H+
2-methylbenzyl alcohol + NADP+
-
-
-
-
?
2-octanol + NAD(P)+
octan-2-one + NAD(P)H + H+
-
45.8% activity compared to (RS)-1-phenylethanol
-
-
?
2-pentanol + NAD(P)+
pentan-2-one + NAD(P)H + H+
-
30.2% activity compared to (RS)-1-phenylethanol
-
-
?
2-pentanol + NADP+
2-pentanone + NADPH + H+
67% relative activity as compared to 2-propanol
-
-
?
2-pentanol + NADP+
pentan-2-one + NADPH + H+
67% of the activity with 2-propanol
-
-
?
2-phenylethanol + NAD(P)+
phenylacetaldehyde + NAD(P)H + H+
-
0.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-propanol + NAD(P)+
propan-2-one + NAD(P)H + H+
-
5.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-propanol + NADP+
acetone + NADPH
2-propanol + NADP+
acetone + NADPH + H+
3,4-dimethoxybenzaldehyde + NADPH + H+
3,4-dimethoxybenzyl alcohol + NADP+
-
-
-
?
3-fluorobenzaldehyde + NADPH
3-fluorobenzyl alcohol + NADP+
-
-
-
-
r
3-hydroxypropionaldehyde + NADPH + H+
propan-1,3-diol + NADP+
3-methoxybenzaldehyde + NADPH + H+
3-methoxybenzyl alcohol + NADP+
-
-
-
-
?
3-methyl-2-pentanone + NADPH + H+
? + NADP+
13% relative activity as compared to pyruvaldehyde
-
-
?
3-methylbenzaldehyde + NADPH + H+
3-methylbenzyl alcohol + NADP+
-
-
-
-
?
3-methylbutanal + NADP+
? + NADPH + H+
about% of the activity with 1-butanol
-
-
?
3-methylcyclohexanol + NADP+
?
-
-
-
-
r
3-methylcyclohexanone + NADH + H+
3-methylcyclohexanol + NAD+
-
-
-
-
r
4-androstene-3,17-dione + NADPH + H+
?
-
-
-
-
?
4-bromobenzaldehyde + NADPH + H+
4-bromobenzyl alcohol + NADP+
-
-
-
-
?
4-fluorobenzaldehyde + NADPH + H+
4-fluorobenzyl alcohol + NADP+
-
-
-
-
?
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
4-methylbenzaldehyde + NADPH + H+
4-methylbenzyl alcohol + NADP+
-
-
-
-
?
4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH + H+
?
-
-
-
-
?
4-methylpentan-2-one + NADPH + H+
4-methylpentan-2-ol + NADP+
-
-
-
-
?
4-nitroacetophenone + NADPH + H+
?
-
-
-
-
?
4-phenyl-2-butanone + NADH + H+
4-phenyl-2-butanol + NAD+
-
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
acetaldehyde + NADPH
ethanol + NADP+
-
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
acetohexamide + NADPH + H+
?
-
-
-
-
?
acetoin + NAD(P)+
butan-2,3-dione + NAD(P)H + H+
-
100% activity
-
-
?
acetoin + NAD(P)H + H+
2,3-butanediol + NAD(P)+
-
4.5% activity compared to (RS)-1-phenylethanol
-
-
?
acetoin + NADPH + H+
?
-
1.9% activity compared to 3-hydroxypropionaldehyde
-
-
?
acetone + NAD(P)H + H+
propan-2-ol + NAD(P)+
-
4.1% activity compared to acetoin
-
-
?
acetone + NADH + H+
propan-2-ol + NAD+
-
-
-
-
r
acetophenone + NADH + H+
1-phenylethan-1-ol + NAD+
-
-
-
-
r
acrolein + NADPH + H+
prop-2-en-1-ol + NADP+
-
41.8% activity compared to 3-hydroxypropionaldehyde
-
-
?
all-trans-retinal + NADPH + H+
all-trans-retinol + NADP+
-
-
-
-
?
all-trans-retinol + NADP+
all-trans-retinal + NADPH + H+
-
-
-
r
allyl alcohol + NADP+
acrylaldehyde + NADPH
benzaldehyde + NAD(P)H
benzyl alcohol + NAD(P)+
-
-
-
?
benzaldehyde + NADPH
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
-
-
-
?
benzyl alcohol + NADP+
benzaldehyde + NADPH
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
benzylalcohol + NAD+
benzaldehyde + NADH + H+
-
-
-
r
butan-1,4-diol + NADP+
butandialdehyde + NADPH
-
29% of activity with hexan-1-ol
-
r
butan-1-ol + NADP+
butanal + NADPH
butan-1-ol + NADP+
butanal + NADPH + H+
butan-2-ol + NADP+
butan-2-one + NADPH + H+
-
-
-
-
?
butan-2-one + NADPH + H+
butan-2-ol + NADP+
-
-
-
-
?
butanal + NAD(P)H + H+
butan-1-ol + NAD(P)+
-
-
-
?
butanal + NADPH + H+
1-butanol + NAD(P)+
44% activity compared to pentanal
-
-
?
butanal + NADPH + H+
butan-1-ol + NADP+
butyraldehyde + NADPH + H+
butanol + NADP+
cellobiose + NADP+
? + NADPH + H+
cinnamaldehyde + NADPH + H+
cinnamyl alcohol + NADP+
-
-
-
?
cis-2-butenol + NAD(P)H
trans-2-butenal + NAD(P)+
cis-4-cyclopentene-1,3-diol + NADP+
(R)-4-hydroxy-2-cyclopentenone + NADPH + H+
-
-
-
-
?
cis-4-heptenal + NAD(P)+
cis-4-heptenol + NAD(P)H
-
-
-
?
cis-hex-3-en-1-ol + NADP+
cis-hex-3-en-1-al + NADPH
-
18.7% of activity with hexan-1ol
-
r
citral + NAD(P)H
citrol + NAD(P)+
-
-
-
?
cyclohexanol + NAD(P)+
cyclohexanone + NAD(P)H + H+
-
52.3% activity compared to (RS)-1-phenylethanol
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH + H+
-
-
-
r
cyclohexanol + NADP+
cyclohexanone + NADH + H+
-
-
-
-
r
cyclohexanone + NAD(P)H + H+
cyclohexanol + NAD(P)+
-
19.1% activity compared to acetoin
-
-
?
cyclohexanone + NADH + H+
cyclohexanol + NAD+
-
-
-
-
r
cyclohexanone + NADH + H+
cyclohexanol + NADP+
-
-
-
-
r
D-arabinose + NAD(P)+
?
-
21.4% activity compared to (RS)-1-phenylethanol
-
-
?
D-arabinose + NADP+
? + NADPH + H+
200% relative activity as compared to 2-propanol
-
-
?
D-arabinose + NADP+
D-arabitol + NADPH + H+
200% of the activity with 2-propanol. D-arabinose is preferred over L-arabinose
-
-
?
D-glucose + NADP+
? + NADPH + H+
D-mannose + NADP+
? + NADPH + H+
48% relative activity as compared to 2-propanol
-
-
?
D-ribose + NADP+
? + NADPH + H+
35% relative activity as compared to 2-propanol
-
-
?
D-xylose + NADP+
? + NADPH + H+
decan-1-ol + NADP+
decanal + NADPH
-
decrease in enzyme activity with increase in chain length
-
r
decanal + NAD(P)H
decan-1-ol + NAD(P)+
-
-
-
?
dihydroxyacetone + NAD(P)H + H+
?
-
34.8% activity compared to acetoin
-
-
?
dimethylglyoxal + NADPH + H+
? + NADP+
DL-glyceraldehyde + NADPH + H+
?
-
-
-
-
?
dodecan-1-ol + NADP+
dodecanal + NADPH
-
decrease in enzyme activity with increase in chain length
-
r
dodecanal + NAD(P)H
dodecan-1-ol + NAD(P)+
-
-
-
?
estrone + NADPH + H+
?
-
-
-
-
?
ethanal + NAD(P)H
ethanol + NAD(P)+
-
-
-
?
ethanediol + NADP+
glyoxal + NADPH
ethanol + NAD(P)+
acetaldehyde + NAD(P)H + H+
-
0.5% activity compared to (RS)-1-phenylethanol
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
ethanol + NADP+
acetaldehyde + NADPH + H+
ethanol + NADP+
ethanal + NADPH + H+
ethyl acetoacetate + NADPH + H+
? + NADP+
-
-
-
-
r
ethyl pyruvate + NAD(P)H + H+
?
-
294% activity compared to acetoin
-
-
?
farnesyl aldehyde + NAD(P)H
farnesol + NAD(P)+
-
-
-
?
formaldehyde + NADPH + H+
methanol + NADP+
-
-
-
-
?
furan-2-carbaldehyde + NADPH + H+
(furan-2-yl)methanol + NADP+
-
-
-
-
?
furfural + NADPH + H+
(furan-2-yl)methanol + NAD(P)+
5% activity compared to pentanal
-
-
?
glycerol + NADP+
glyceraldehyde + NADPH + H+
16% relative activity as compared to 2-propanol
-
-
?
glycoaldehyde + NADPH + H+
?
5% activity compared to pentanal
-
-
?
glyoxylic acid + NADPH + H+
? + NADP+
36% relative activity as compared to pyruvaldehyde
-
-
?
heptan-1-ol + NADP+
heptanal + NADPH
-
-
-
r
heptan-4-one + NADPH + H+
heptan-4-ol + NADP+
-
-
-
-
?
heptanal + NAD(P)H
heptan-1-ol + NAD(P)+
-
-
-
?
heptanal + NADPH + H+
1-heptanol + NAD(P)+
56% activity compared to pentanal
-
-
?
hexan-1-ol + NADP+
hexaldehyde + NADPH + H+
-
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
hexan-2-one + NADPH + H+
hexan-2-ol + NADP+
-
-
-
-
?
hexanal + NAD(P)H + H+
hexan-1-ol + NAD(P)+
-
12.9% activity compared to acetoin
-
-
?
hexanal + NADPH + H+
1-hexanol + NAD(P)+
62% activity compared to pentanal
-
-
?
hexanal + NADPH + H+
hexan-1-ol + NADP+
-
-
-
-
?
hexanal + NADPH + H+
hexanol + NADP+
-
-
-
?
hydrocinnamaldehyde + NADPH + H+
hydrocinnamyl alcohol + NADP+
-
-
-
?
isoamyl alcohol + NADP+
? + NADPH + H+
about 80% of the activity with 1-butanol
-
-
?
L-arabinose + NAD(P)+
?
-
5.2% activity compared to (RS)-1-phenylethanol
-
-
?
L-arabinose + NADP+
? + NADPH + H+
17% relative activity as compared to 2-propanol
-
-
?
linolenyl aldehyde + NAD(P)H
linolenol + NAD(P)+
-
-
-
?
linoleyl aldehyde + NAD(P)H
linoleol + NAD(P)+
-
-
-
?
mannitol + NADP+
D-mannose + NADPH
-
6.5% of activity with hexan-1-ol
-
r
meso-2,3-butanediol + NAD+
?
-
272% activity compared to (RS)-1-phenylethanol
-
-
?
meso-2,3-butanediol + NADP+
?
-
272% activity compared to (RS)-1-phenylethanol
-
-
?
methanol + NAD(P)+
formaldehyde + NAD(P)H + H+
-
0.2% activity compared to (RS)-1-phenylethanol
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
methyl benzoylformate + NAD(P)H + H+
?
-
67% activity compared to acetoin
-
-
?
methylglyoxal + NADPH + H+
2-hydroxy-propanal + NADP+
-
-
-
?
methylglyoxal + NADPH + H+
?
29% activity compared to pentanal
-
-
?
octan-1-ol + NADP+
octaldehyde + NADPH + H+
-
-
-
-
?
octan-1-ol + NADP+
octanal + NADPH
-
decrease in enzyme activity with increase in chain length
-
r
octan-1-ol + NADP+
octanal + NADPH + H+
-
-
-
-
r
octan-2-one + NADPH + H+
octan-2-ol + NADP+
-
-
-
-
?
octanal + NAD(P)H + H+
octan-1-ol + NAD(P)+
-
-
-
?
octanal + NADPH + H+
1-octanol + NAD(P)+
55% activity compared to pentanal
-
-
?
octanal + NADPH + H+
octanol + NADP+
-
-
-
?
oleyl aldehyde + NAD(P)H
oleol + NAD(P)+
-
-
-
?
pentan-1-ol + NADP+
pentaldehyde + NADPH + H+
-
-
-
-
?
pentan-1-ol + NADP+
pentanal + NADPH
pentanal + NADPH + H+
1-pentanol + NAD(P)+
100% activity
-
-
?
phenylacetaldehyde + NAD(P)H + H+
2-phenylethan-1-ol + NAD(P)+
-
18.6% activity compared to acetoin
-
-
?
propan-1-ol + NADP+
propanal + NADPH
propan-1-ol + NADP+
propionaldehyde + NADPH + H+
-
-
-
-
?
propan-2-ol + NADP+
propan-2-one + NADPH + H+
-
-
-
-
?
propanal + NADPH + H+
1-propanol + NAD(P)+
14% activity compared to pentanal
-
-
?
propionaldehyde + NADPH + H+
propanol + NADP+
pyridine-2-carbaldehyde + NADPH + H+
(pyridin-2-yl)methanol + NADP+
-
-
-
-
?
pyruvaldehyde + NADPH + H+
? + NADP+
-
-
-
?
pyruvaldehyde + NADPH + H+
lactaldehyde + NADP+
pyruvic aldehyde + NAD(P)H + H+
?
-
328% activity compared to acetoin
-
-
?
rac-1-nonen-4-ol + NADP+
(S)-1-nonen-4-ol + 1-nonen-4-one + NADPH + H+
-
-
-
-
?
rac-1-phenylethanol + NAD(P)+
acetophenone + (R)-1-phenylethanol + NAD(P)H + H+
-
-
-
-
?
rac-1-phenylethanol + NADP+
(R)-1-phenylethanol + (S)-1-phenylethanol + NADPH + H+
-
-
-
-
?
retinal + NAD(P)H
retinol + NAD(P)+
-
-
-
?
retinaldehyde + NADH
retinol + NAD+
ribitol + NADP+
D-ribose + NADPH
-
4% of activity with hexan-1-ol
-
r
salicylaldehye + NADPH + H+
salicylalcohol + NADP+
-
-
-
?
tetradecanal + NAD(P)H
tetradecan-1-ol + NAD(P)+
-
-
-
?
trans-2,cis-6-nonadienal + NAD(P)+
trans-2,cis-6-nonadienol + NAD(P)H
-
-
-
?
trans-2,cis-6-nonadienal + NADPH + H+
trans-2,cis-6-nonadienol + NADP+
-
-
-
?
trans-2-hexenal + NADPH + H+
trans-2-hexenol + NADP+
-
-
-
?
trans-2-nonenal + NADPH + H+
trans-2-nonen-1-ol + NADP+
-
-
-
?
trans-2-nonenal + NADPH + H+
trans-2-nonenol + NADP+
-
-
-
?
trans-2-octenal + NADPH + H+
trans-2-octen-1-ol + NADP+
-
-
-
?
trans-2-pentenol + NAD(P)+
trans-2-pentenal + NAD(P)H
-
-
-
?
trans-trans-2,4-decadienal + NADPH + H+
trans-trans-2,4-decadienol + NADP+
-
-
-
?
vanillyl alcohol + NAD+
vanillin + NADH + H+
-
-
-
-
?
additional information
?
-
(2S,5S)-2,5-hexanediol + NADP+
? + NADPH + H+
-
-
-
?
(2S,5S)-2,5-hexanediol + NADP+
? + NADPH + H+
-
-
-
?
(4R,6R)-6-butyloxane-2,4-diol + NAD+
(4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADH + H+
-
-
-
-
?
(4R,6R)-6-butyloxane-2,4-diol + NAD+
(4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADH + H+
-
-
-
-
?
(4R,6R)-6-butyloxane-2,4-diol + NADP+
(4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADPH + H+
-
-
-
-
?
(4R,6R)-6-butyloxane-2,4-diol + NADP+
(4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADPH + H+
-
-
-
-
?
(4R,6R)-6-pentyloxane-2,4-diol + NAD+
(4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADH + H+
-
-
-
-
?
(4R,6R)-6-pentyloxane-2,4-diol + NAD+
(4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADH + H+
-
-
-
-
?
(4R,6R)-6-pentyloxane-2,4-diol + NADP+
(4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADPH + H+
-
-
-
-
?
(4R,6R)-6-pentyloxane-2,4-diol + NADP+
(4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADPH + H+
-
-
-
-
?
1-butanol + NAD+
butanal + NADH + H+
-
-
-
r
1-butanol + NAD+
butanal + NADH + H+
-
-
-
r
1-butanol + NAD+
butanal + NADH + H+
-
-
-
r
1-butanol + NAD+
butanal + NADH + H+
-
-
-
r
1-butanol + NAD+
butanal + NADH + H+
-
-
-
r
1-butanol + NAD+
butanal + NADH + H+
-
-
-
r
1-butanol + NADP+
butanal + NADPH + H+
117% of the activity compared to ethanol
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
80% compared to activity with 1-propanol
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
80% compared to activity with 1-propanol
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
80% of the activtiy with 1-propanol
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
80% of the activtiy with 1-propanol
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
-
-
-
r
1-heptanol + NAD+
heptanal + NADH + H+
-
-
-
r
1-heptanol + NAD+
heptanal + NADH + H+
-
-
-
r
1-heptanol + NAD+
heptanal + NADH + H+
-
-
-
r
1-heptanol + NAD+
heptanal + NADH + H+
-
-
-
r
1-heptanol + NAD+
heptanal + NADH + H+
-
-
-
r
1-heptanol + NAD+
heptanal + NADH + H+
-
-
-
r
1-hexanol + NAD+
hexanal + NADH + H+
-
-
-
r
1-hexanol + NAD+
hexanal + NADH + H+
-
-
-
r
1-hexanol + NAD+
hexanal + NADH + H+
-
-
-
r
1-hexanol + NAD+
hexanal + NADH + H+
-
-
-
r
1-hexanol + NAD+
hexanal + NADH + H+
-
-
-
r
1-hexanol + NAD+
hexanal + NADH + H+
-
-
-
r
1-pentanol + NADP+
pentanal + NADPH + H+
74% of the activity compared to ethanol
-
-
?
1-pentanol + NADP+
pentanal + NADPH + H+
about 75% of the activity with 1-butanol
-
-
?
1-pentanol + NADP+
pentanal + NADPH + H+
about 75% of the activity with 1-butanol
-
-
?
1-propanol + NAD+
propanal + NADH + H+
dual cofactor dependency, NAD+ shows 60% of the activity with NADP+
-
-
?
1-propanol + NAD+
propanal + NADH + H+
dual cofactor dependency, NAD+ shows 60% of the activity with NADP+
-
-
?
1-propanol + NAD+
propanal + NADH + H+
-
-
-
r
1-propanol + NADP+
propanal + NADPH + H+
137% of the activity compared to ethanol
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
dual cofactor dependency, NAD+ shows 60% of the activity with NADP+
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
-
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
-
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
about 60% of the activity with 1-butanol
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
about 60% of the activity with 1-butanol
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
-
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
-
-
-
?
2,3-pentanedione + NADPH + H+
? + NADP+
-
-
-
?
2,3-pentanedione + NADPH + H+
? + NADP+
-
-
-
?
2-butanol + NADP+
butanone + NADPH + H+
30% compared to activity with 1-propanol
-
-
?
2-butanol + NADP+
butanone + NADPH + H+
30% of the activtiy with 1-propanol
-
-
?
2-butanol + NADP+
butanone + NADPH + H+
about 25% of the activity with 1-butanol
-
-
?
2-methoxybenzaldehyde + NADPH + H+
2-methoxybenzyl alcohol + NADP+
-
-
-
-
?
2-methoxybenzaldehyde + NADPH + H+
2-methoxybenzyl alcohol + NADP+
-
-
-
-
?
2-methoxybenzaldehyde + NADPH + H+
2-methoxybenzyl alcohol + NADP+
highest activity
-
-
?
2-propanol + NADP+
acetone + NADPH
-
-
-
?
2-propanol + NADP+
acetone + NADPH
-
-
-
-
?
2-propanol + NADP+
acetone + NADPH
-
-
-
?
2-propanol + NADP+
acetone + NADPH + H+
25% compared to activity with 1-propanol
-
-
?
2-propanol + NADP+
acetone + NADPH + H+
25% compared to activity with 1-propanol
-
-
?
2-propanol + NADP+
acetone + NADPH + H+
-
-
-
?
2-propanol + NADP+
acetone + NADPH + H+
-
-
-
-
?
2-propanol + NADP+
acetone + NADPH + H+
-
-
-
?
3-hydroxypropionaldehyde + NADPH + H+
propan-1,3-diol + NADP+
-
100% activity
-
-
?
3-hydroxypropionaldehyde + NADPH + H+
propan-1,3-diol + NADP+
-
100% activity
-
-
?
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
-
-
-
-
?
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
-
-
-
-
?
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
-
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
-
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
-
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
2.2% activity compared to 3-hydroxypropionaldehyde
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
2.2% activity compared to 3-hydroxypropionaldehyde
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
?
allyl alcohol + NADP+
acrylaldehyde + NADPH
-
28% of activity with hexan-1-ol
-
r
allyl alcohol + NADP+
acrylaldehyde + NADPH
-
-
-
r
allyl alcohol + NADP+
acrylaldehyde + NADPH
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH
-
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH
-
-
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH
-
-
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
20% compared to activity with 1-propanol
-
-
?
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
about% of the activity with 1-butanol
-
-
?
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
about% of the activity with 1-butanol
-
-
?
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
180% of the activity with 2-propanol
-
-
?
butan-1-ol + NADP+
butanal + NADPH
-
36.3% of activity with hexan-1-ol
-
r
butan-1-ol + NADP+
butanal + NADPH
-
-
-
r
butan-1-ol + NADP+
butanal + NADPH
-
-
-
r
butan-1-ol + NADP+
butanal + NADPH + H+
-
-
-
-
r
butan-1-ol + NADP+
butanal + NADPH + H+
-
-
-
-
r
butanal + NADPH + H+
butan-1-ol + NADP+
-
-
-
-
r
butanal + NADPH + H+
butan-1-ol + NADP+
-
-
-
-
r
butanal + NADPH + H+
butan-1-ol + NADP+
-
-
-
-
r
butyraldehyde + NADPH + H+
butanol + NADP+
-
118.4% activity compared to 3-hydroxypropionaldehyde
-
-
?
butyraldehyde + NADPH + H+
butanol + NADP+
-
118.4% activity compared to 3-hydroxypropionaldehyde
-
-
?
cellobiose + NADP+
? + NADPH + H+
71% relative activity as compared to 2-propanol
-
-
?
cellobiose + NADP+
? + NADPH + H+
71% of the activity with 2-propanol
-
-
?
cis-2-butenol + NAD(P)H
trans-2-butenal + NAD(P)+
-
-
-
?
cis-2-butenol + NAD(P)H
trans-2-butenal + NAD(P)+
-
-
-
?
D-glucose + NADP+
? + NADPH + H+
146% relative activity as compared to 2-propanol
-
-
?
D-glucose + NADP+
? + NADPH + H+
146% of the activity with 2-propanol
-
-
?
D-xylose + NADP+
? + NADPH + H+
246% relative activity as compared to 2-propanol
-
-
?
D-xylose + NADP+
? + NADPH + H+
246% of the activity with 2-propanol
-
-
?
dimethylglyoxal + NADPH + H+
? + NADP+
270% relative activity as compared to pyruvaldehyde
-
-
?
dimethylglyoxal + NADPH + H+
? + NADP+
270% of the activity with pyruvaldehyde
-
-
?
ethanediol + NADP+
glyoxal + NADPH
-
8.5% of activity with hexan-1-ol
-
r
ethanediol + NADP+
glyoxal + NADPH
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
enzyme appears to preferentially catalyze the reductive reaction. Activity with NAD+ is 75% less than that detected with NADP+
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
enzyme appears to preferentially catalyze the reductive reaction. Activity with NAD+ is 75% less than that detected with NADP+
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
85% compared to activity with 1-propanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
85% compared to activity with 1-propanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
84% of the activtiy with 1-propanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
84% of the activtiy with 1-propanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
about 50% of the activity with 1-butanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
about 50% of the activity with 1-butanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
36% relative activity as compared to 2-propanol
-
-
?
ethanol + NADP+
ethanal + NADPH + H+
-
8.5% of activity with hexan-1-ol
-
r
ethanol + NADP+
ethanal + NADPH + H+
-
-
-
r
ethanol + NADP+
ethanal + NADPH + H+
-
-
-
r
ethanol + NADP+
ethanal + NADPH + H+
-
oxidation rate at 5% of reduction rate
-
r
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?, r
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
r
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
r
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
-
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
-
-
-
r
methanol + NAD+
formaldehyde + NADH + H+
-
-
-
r
methanol + NAD+
formaldehyde + NADH + H+
-
-
-
r
methanol + NAD+
formaldehyde + NADH + H+
-
-
-
r
methanol + NAD+
formaldehyde + NADH + H+
-
-
-
r
methanol + NAD+
formaldehyde + NADH + H+
-
-
-
r
pentan-1-ol + NADP+
pentanal + NADPH
-
4% of activity with hexan-1-ol
-
r
pentan-1-ol + NADP+
pentanal + NADPH
-
-
-
r
pentan-1-ol + NADP+
pentanal + NADPH
-
-
-
r
pentan-1-ol + NADP+
pentanal + NADPH
-
-
-
-
?
pentan-1-ol + NADP+
pentanal + NADPH
-
-
-
-
?
propan-1-ol + NADP+
propanal + NADPH
-
28% of activity with hexan-1-ol
-
r
propan-1-ol + NADP+
propanal + NADPH
-
oxidation rate at 5% of reduction rate
-
r
propionaldehyde + NADPH + H+
propanol + NADP+
-
37.1% activity compared to 3-hydroxypropionaldehyde
-
-
?
propionaldehyde + NADPH + H+
propanol + NADP+
-
37.1% activity compared to 3-hydroxypropionaldehyde
-
-
?
pyruvaldehyde + NADPH + H+
lactaldehyde + NADP+
-
-
-
?
pyruvaldehyde + NADPH + H+
lactaldehyde + NADP+
-
-
-
-
?
pyruvaldehyde + NADPH + H+
lactaldehyde + NADP+
-
-
-
?
retinaldehyde + NADH
retinol + NAD+
-
-
-
-
?
retinaldehyde + NADH
retinol + NAD+
-
-
-
?
retinaldehyde + NADH
retinol + NAD+
-
-
-
-
?
retinaldehyde + NADH
retinol + NAD+
-
-
-
-
r
retinaldehyde + NADH
retinol + NAD+
-
the enzyme is involved in retinol and vitamin A metabolism, retinoic acid is important in intestinal epithelial cell proliferation and differentiation, the enzyme also plays a role in dietary conversion of beta-carotene to retinol via retinaldehyde
-
-
r
additional information
?
-
in wild-type strains, NADH is the preferred cofactor for both aldehyde dehydrogenase ALDH and alcohol dehydrogenase ADH activities. The AdhE protein of the ethanologenic strain of Clostridium thermocellum has acquired high NADPH-linked ADH activity while maintaining NADH-linked ALDH and ADH activities at wild-type levels
-
-
?
additional information
?
-
the enzyme does not accept methanol, 2-propanol, glycerol or glucose as substrates
-
-
?
additional information
?
-
-
the enzyme does not accept methanol, 2-propanol, glycerol or glucose as substrates
-
-
?
additional information
?
-
preference for short-chain alcohol substrates, particularly for 1-propanol (100%) and ethanol (84%), no activity with glycerol or methanol
-
-
?
additional information
?
-
preference for short-chain alcohol substrates, particularly for 1-propanol (100%) and ethanol (84%), no activity with glycerol or methanol
-
-
?
additional information
?
-
no substrates: methanol, glycerol
-
-
?
additional information
?
-
no substrates: methanol, glycerol
-
-
?
additional information
?
-
HvADH2 accepts a broad range of substrates, no activity with methanol
-
-
?
additional information
?
-
HvADH2 accepts a broad range of substrates, no activity with methanol
-
-
?
additional information
?
-
-
4-nitroacetophenone, benzyl, cortisone and progesterone are no substrates
-
-
?
additional information
?
-
-
no activity with dihydroxyacetone, hydroxyacetone, and acetone
-
-
?
additional information
?
-
-
no activity with dihydroxyacetone, hydroxyacetone, and acetone
-
-
?
additional information
?
-
no activity with glyoxal, methanal, and ethanal
-
-
?
additional information
?
-
the enzyme shows no oxidative activities towards alcoholic compounds
-
-
?
additional information
?
-
-
no activity with glyoxal, methanal, and ethanal
-
-
?
additional information
?
-
-
the enzyme shows no oxidative activities towards alcoholic compounds
-
-
?
additional information
?
-
no activity with glyoxal, methanal, and ethanal
-
-
?
additional information
?
-
the enzyme shows no oxidative activities towards alcoholic compounds
-
-
?
additional information
?
-
substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol
-
-
-
additional information
?
-
substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol
-
-
-
additional information
?
-
substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol
-
-
-
additional information
?
-
substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol
-
-
-
additional information
?
-
substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol
-
-
-
additional information
?
-
substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol
-
-
-
additional information
?
-
-
no activity with methanol and ethanol
-
-
?
additional information
?
-
-
no activity with methanol and ethanol
-
-
?
additional information
?
-
the enzyme plays an important role in potato defence response to Erwinia carotovora
-
-
?
additional information
?
-
not: conferyl aldehyde and sinapaldehyde, the enzyme exhibits an absolute requirement for NADPH as cofactor and can not be substituted by NADH
-
-
?
additional information
?
-
-
lactol substrates (4R,6S)-6-(chloromethyl)oxane-2,4-diol and (4R,6R)-6-butyloxane-2,4-diol for the biocatalytic oxidations are obtained from 2-deoxy-D-ribose 5-phosphate aldolase (DERA) catalyzed reactions of the corresponding acceptor aldehydes chloroacetaldehyde and pentanal, respectively and at least two equivalents of acetaldehyde as described previously. Development of an efficient biocatalytic process on pilot plant scale to oxidize the aliphatic hydroxylactol substrate (4R,6R)-6-butyloxane-2,4-diol to the corresponding lactone product (4R,6R)-6-butyl-4-hydroxyoxan-2-one employing the wild-type alcohol dehydrogenase ADHA
-
-
-
additional information
?
-
-
lactol substrates (4R,6S)-6-(chloromethyl)oxane-2,4-diol and (4R,6R)-6-butyloxane-2,4-diol for the biocatalytic oxidations are obtained from 2-deoxy-D-ribose 5-phosphate aldolase (DERA) catalyzed reactions of the corresponding acceptor aldehydes chloroacetaldehyde and pentanal, respectively and at least two equivalents of acetaldehyde as described previously. Development of an efficient biocatalytic process on pilot plant scale to oxidize the aliphatic hydroxylactol substrate (4R,6R)-6-butyloxane-2,4-diol to the corresponding lactone product (4R,6R)-6-butyl-4-hydroxyoxan-2-one employing the wild-type alcohol dehydrogenase ADHA
-
-
-
additional information
?
-
in wild-type strains, NADH is the preferred cofactor for both aldehyde dehydrogenase ALDH and alcohol dehydrogenase ADH activities. In high-ethanol-producing (ethanologen) strains of Thermoanaerobacterium saccharolyticum, both ALDH and ADH activities show increased NADPH-linked activity
-
-
?
additional information
?
-
-
no activity with D-arabinose, L-arabinose, acetophenone, and 4-chloroacetophenone
-
-
?
additional information
?
-
no oxidation of methanol, methoxyethanol, ethylene glycol, or D-galactose. No reduction of acetone, cyclopentanone, D-arabinose, D-xylose, D-glucose or cellobiose
-
-
?
additional information
?
-
-
no oxidation of methanol, methoxyethanol, ethylene glycol, or D-galactose. No reduction of acetone, cyclopentanone, D-arabinose, D-xylose, D-glucose or cellobiose
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(RS)-1-phenylethanol + NAD+
1-phenylethanone + NADH + H+
-
100% activity
-
-
?
(RS)-1-phenylethanol + NADP+
1-phenylethanone + NADPH + H+
-
100% activity
-
-
?
1-(2-bromophenyl)ethanol + NAD(P)+
1-(2-bromophenyl)ethanone + NAD(P)H + H+
-
11.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-(2-chlorophenyl)ethanol + NAD(P)+
1-(2-chlorophenyl)ethanone + NAD(P)H + H+
-
16.4% activity compared to (RS)-1-phenylethanol
-
-
?
1-(3-bromophenyl)ethanol + NAD(P)+
1-(3-bromophenyl)ethanone + NAD(P)H + H+
-
315% activity compared to (RS)-1-phenylethanol
-
-
?
1-(3-chlorophenyl)ethanol + NAD(P)+
1-(3-chlorophenyl)ethanone + NAD(P)H + H+
-
205% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-bromophenyl)ethanol + NAD(P)+
1-(4-bromophenyl)ethanone + NAD(P)H + H+
-
167% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-chlorophenyl)ethanone + NAD(P)+
1-(4-chlorophenyl)ethanone + NAD(P)H + H+
-
151% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-fluorophenyl)ethanol + NAD(P)+
1-(4-fluorophenyl)ethanol + NAD(P)H + H+
-
119% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-methylphenyl)ethanone + NAD(P)+
1-(4-methylphenyl)ethanol + NAD(P)H + H+
-
189% activity compared to (RS)-1-phenylethanol
-
-
?
1-butanol + NAD(P)+
butanal + NAD(P)H + H+
-
2.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-heptanol + NAD(P)+
heptanal + NAD(P)H + H+
-
3.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-hexanol + NAD(P)+
hexanal + NAD(P)H + H+
-
2.8% activity compared to (RS)-1-phenylethanol
-
-
?
1-octanol + NAD(P)+
octanal + NAD(P)H + H+
-
2.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-pentanol + NAD(P)+
pentanal + NAD(P)H + H+
-
2.8% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-1,2-ethanediol + NAD(P)+
?
-
3.4% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-1-propanol + NAD(P)+
1-phenylpropionaldehyde + NAD(P)H + H+
-
13.1% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-2-propanol + NAD(P)+
1-phenylpropan-2-one + NAD(P)H + H+
-
39.1% activity compared to (RS)-1-phenylethanol
-
-
?
1-propanol + NAD(P)+
propionaldehyde + NAD(P)H + H+
-
1.2% activity compared to (RS)-1-phenylethanol
-
-
?
2,2,2-trifluoroacetophenone + NAD(P)H + H+
2,2,2-trifluoro-1-phenylethan-1-ol + NAD(P)+
-
180% activity compared to acetoin
-
-
?
2-bromoacetophenone + NAD(P)H + H+
1-(2-bromophenyl)ethanone + NAD(P)+
-
8.7% activity compared to acetoin
-
-
?
2-butanol + NAD(P)+
butan-2-one + NAD(P)H + H+
-
22.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-chloro-1-phenylethanol + NAD(P)+
2-chloro-1-phenylethan-1-one + NAD(P)H + H+
-
0.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-heptanol + NAD(P)+
heptan-2-one + NAD(P)H + H+
-
61.6% activity compared to (RS)-1-phenylethanol
-
-
?
2-hexanol + NAD(P)+
hexan-2-one + NAD(P)H + H+
-
38.7% activity compared to (RS)-1-phenylethanol
-
-
?
2-hexanone + NAD(P)H + H+
hexan-2-ol + NAD(P)+
-
3.6% activity compared to acetoin
-
-
?
2-octanol + NAD(P)+
octan-2-one + NAD(P)H + H+
-
45.8% activity compared to (RS)-1-phenylethanol
-
-
?
2-pentanol + NAD(P)+
pentan-2-one + NAD(P)H + H+
-
30.2% activity compared to (RS)-1-phenylethanol
-
-
?
2-phenylethanol + NAD(P)+
phenylacetaldehyde + NAD(P)H + H+
-
0.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-propanol + NAD(P)+
propan-2-one + NAD(P)H + H+
-
5.3% activity compared to (RS)-1-phenylethanol
-
-
?
acetoin + NAD(P)+
butan-2,3-dione + NAD(P)H + H+
-
100% activity
-
-
?
acetoin + NAD(P)H + H+
2,3-butanediol + NAD(P)+
-
4.5% activity compared to (RS)-1-phenylethanol
-
-
?
acetone + NAD(P)H + H+
propan-2-ol + NAD(P)+
-
4.1% activity compared to acetoin
-
-
?
all-trans-retinal + NADPH + H+
all-trans-retinol + NADP+
-
-
-
-
?
cyclohexanol + NAD(P)+
cyclohexanone + NAD(P)H + H+
-
52.3% activity compared to (RS)-1-phenylethanol
-
-
?
cyclohexanone + NAD(P)H + H+
cyclohexanol + NAD(P)+
-
19.1% activity compared to acetoin
-
-
?
D-arabinose + NAD(P)+
?
-
21.4% activity compared to (RS)-1-phenylethanol
-
-
?
dihydroxyacetone + NAD(P)H + H+
?
-
34.8% activity compared to acetoin
-
-
?
ethanol + NAD(P)+
acetaldehyde + NAD(P)H + H+
-
0.5% activity compared to (RS)-1-phenylethanol
-
-
?
ethyl pyruvate + NAD(P)H + H+
?
-
294% activity compared to acetoin
-
-
?
hexanal + NAD(P)H + H+
hexan-1-ol + NAD(P)+
-
12.9% activity compared to acetoin
-
-
?
L-arabinose + NAD(P)+
?
-
5.2% activity compared to (RS)-1-phenylethanol
-
-
?
meso-2,3-butanediol + NAD+
?
-
272% activity compared to (RS)-1-phenylethanol
-
-
?
meso-2,3-butanediol + NADP+
?
-
272% activity compared to (RS)-1-phenylethanol
-
-
?
methanol + NAD(P)+
formaldehyde + NAD(P)H + H+
-
0.2% activity compared to (RS)-1-phenylethanol
-
-
?
methyl benzoylformate + NAD(P)H + H+
?
-
67% activity compared to acetoin
-
-
?
phenylacetaldehyde + NAD(P)H + H+
2-phenylethan-1-ol + NAD(P)+
-
18.6% activity compared to acetoin
-
-
?
pyruvic aldehyde + NAD(P)H + H+
?
-
328% activity compared to acetoin
-
-
?
retinaldehyde + NADH
retinol + NAD+
-
the enzyme is involved in retinol and vitamin A metabolism, retinoic acid is important in intestinal epithelial cell proliferation and differentiation, the enzyme also plays a role in dietary conversion of beta-carotene to retinol via retinaldehyde
-
-
r
additional information
?
-
additional information
?
-
the enzyme plays an important role in potato defence response to Erwinia carotovora
-
-
?
additional information
?
-
-
no activity with D-arabinose, L-arabinose, acetophenone, and 4-chloroacetophenone
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Hirschberg, D.; Cederlund, E.; Crosas, B.; Jonsson, A.; Tryggvason, S.; Farres, J.; Pares, X.; Bergmann, T.; Jrnvall, H.
N-terminal acetylation in a third protein family of vertebrate alcohol dehydrogenase/retinal reductase found through a proteomics approach in enzyme characterization
Cell. Mol. Life Sci.
58
1323-1326
2001
Gallus gallus
brenda
Korkhin, Y.; Kalb(Giloa), A.J.; Peretz, M.; Bogin, O.; Burstein, Y.; Frolow, F.
NADP-dependent bacterial alcohol dehydrogenases: crystal structure, cofactor-binding and cofactor specificity of the ADHs of Clostridium beijerinckii and Thermoanaerobacter brockii
J. Mol. Biol.
278
967-981
1998
Clostridium beijerinckii, Thermoanaerobacter brockii
brenda
Wales, M.R.; Fewson, C.A.
NADP-dependent alcohol dehydrogenases in bacteria and yeast: purification and partial characterization of the enzymes from Acinetobacter calcoaceticus and Saccharomyces cerevisiae
Microbiology
140
173-183
1994
Acinetobacter calcoaceticus, Bacillus subtilis, Saccharomyces cerevisiae, Escherichia coli, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Pseudomonas putida, Rhodococcus rhodochrous, Rhodotorula graminis, Streptomyces rimosus, Streptomyces rimosus 4018, Rhodococcus rhodochrous NCIMB 13259, Pseudomonas putida NCIMB 9494, Rhodotorula graminis KGX 39, Saccharomyces cerevisiae D273-10B, Bacillus subtilis NCIMB 3610, Escherichia coli ML30
brenda
Brophy, P.M.; Crowley, P.; Barrett, J.
A novel NADPH/NADH-dependent aldehyde reduction enzyme isolated from the tapeworm Moniezia expansa
FEBS Lett.
263
305-307
1990
Moniezia expansa
brenda
Hiu, S.F.; Zhu, C.X.; Yan R.T.; Chen, J.S.
Butanol-ethanol dehydrogenase and butanol-ethanol-isopropanol dehydrogenase: different alcohol dehydrogenases in two strains of Clostridium beijerinckii (Clostridium butylicium)
Appl. Environ. Microbiol.
53
697-703
1987
Clostridium beijerinckii
brenda
Hatanaka, A.; Kajiwara, T.; Tomohiro, S.
Purification and properties of alcohol dehydrogenase from Leuconostoc mesenteroides
Agric. Biol. Chem.
38
1819-1833
1974
Leuconostoc mesenteroides, Leuconostoc mesenteroides IFO 3426
-
brenda
Rhodes, M.J.C.
Co-factor specificity of plant alcohol dehydrogenase
Phytochemistry
12
307-314
1973
Cucumis melo
-
brenda
Fidge, N.H.; Goodman, D.S.
The enzymatic reduction of retinal to retinol in rat intestine
J. Biol. Chem.
243
4372-4379
1968
Rattus norvegicus
brenda
Belyaeva, O.V.; Kedishvili, N.Y.
Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues
FEBS Lett.
531
489-493
2002
Homo sapiens (Q9HBH5)
brenda
Montesano, M.; Hyytiainen, H.; Wettstein, R.; Palva, E.T.
A novel potato defence-related alcohol:NADP+ oxidoreductase induced in response to Erwinia carotovora
Plant Mol. Biol.
52
177-189
2003
Solanum tuberosum (Q8H0L8)
brenda
Thomas, S.; Prabhu, R.; Balasubramanian, K.A.
Retinoid metabolism in the rat small intestine
Br. J. Nutr.
93
59-63
2005
Rattus norvegicus
brenda
Timpson, L.M.; Alsafadi, D.; Mac Donnchadha, C.; Liddell, S.; Sharkey, M.A.; Paradisi, F.
Characterization of alcohol dehydrogenase (ADH12) from Haloarcula marismortui, an extreme halophile from the Dead Sea
Extremophiles
16
57-66
2012
Haloarcula marismortui (Q5V676), Haloarcula marismortui
brenda
Lyashenko, A.V.; Bezsudnova, E.Y.; Gumerov, V.M.; Lashkov, A.A.; Mardanov, A.V.; Mikhailov, A.M.; Polyakov, K.M.; Popov, V.O.; Ravin, N.V.; Skryabin, K.G.; Zabolotniy, V.K.; Stekhanova, T.N.; Kovalchuk, M.V.
Expression, purification and crystallization of a thermostable short-chain alcohol dehydrogenase from the archaeon Thermococcus sibiricus
Acta Crystallogr. Sect. F
66
655-657
2010
Thermococcus sibiricus (C6A190), Thermococcus sibiricus DSM 12597 (C6A190)
brenda
Stekhanova, T.N.; Bezsudnova, E.Y.; Mardanov, A.V.; Gumerov, V.M.; Artemova, N.; Kleymenov, S.Y.; Popov, V.O.
Sodium chloride-induced modulation of the activity and thermal stability of short-chain oxidoreductase from the archaeon Thermococcus sibiricus
Appl. Biochem. Biotechnol.
171
1877-1889
2013
Thermococcus sibiricus (C6A190), Thermococcus sibiricus DSM 12597 (C6A190)
brenda
Stekhanova, T.N.; Mardanov, A.V.; Bezsudnova, E.Y.; Gumerov, V.M.; Ravin, N.V.; Skryabin, K.G.; Popov, V.O.
Characterization of a thermostable short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Thermococcus sibiricus
Appl. Environ. Microbiol.
76
4096-4098
2010
Thermococcus sibiricus (C6A190), Thermococcus sibiricus, Thermococcus sibiricus DSM 12597 (C6A190)
brenda
Timpson, L.M.; Liliensiek, A.K.; Alsafadi, D.; Cassidy, J.; Sharkeym M.A.; Liddell, S.; Allers, T.; Paradisi, F.
A comparison of two novel alcohol dehydrogenase enzymes (ADH1 and ADH2) from the extreme halophile Haloferax volcanii
Appl. Microbiol. Biotechnol.
97
195-203
2012
Haloferax volcanii (D4GP73), Haloferax volcanii DSM 3757 (D4GP73)
brenda
Liliensiek, A.K.; Cassidy, J.; Gucciardo, G.; Whitely, C.; Paradisi, F.
Heterologous overexpression, purification and characterisation of an alcohol dehydrogenase (ADH2) from Halobacterium sp. NRC-1
Mol. Biotechnol.
55
143-149
2013
Halobacterium salinarum (Q9HMB6), Halobacterium sp. (Q9HMB6), Halobacterium salinarum NRC 1 (Q9HMB6), Halobacterium sp. NRC-1 (Q9HMB6)
brenda
Wu, X.; Zhang, C.; Orita, I.; Imanaka, T.; Fukui, T.; Xing, X.H.
Thermostable alcohol dehydrogenase from Thermococcus kodakarensis KOD1 for enantioselective bioconversion of aromatic secondary alcohols
Appl. Environ. Microbiol.
79
2209-2217
2013
Thermococcus kodakarensis
brenda
Elleuche, S.; Fodor, K.; von der Heyde, A.; Klippel, B.; Wilmanns, M.; Antranikian, G.
Group III alcohol dehydrogenase from Pectobacterium atrosepticum: insights into enzymatic activity and organization of the metal ion-containing region
Appl. Microbiol. Biotechnol.
98
4041-4051
2014
Pectobacterium atrosepticum (U6CL97), Pectobacterium atrosepticum DSM18077 (U6CL97)
brenda
Zheng, T.; Olson, D.G.; Tian, L.; Bomble, Y.J.; Himmel, M.E.; Lo, J.; Hon, S.; Shaw, A.J.; van Dijken, J.P.; Lynd, L.R.
Cofactor specificity of the bifunctional alcohol and aldehyde dehydrogenase (AdhE) in wild-type and mutant Clostridium thermocellum and Thermoanaerobacterium saccharolyticum
J. Bacteriol.
197
2610-2619
2015
Acetivibrio thermocellus (A0A0H3W5U9), Thermoanaerobacterium saccharolyticum (A0A0H3W5V0)
brenda
Brown, S.D.; Guss, A.M.; Karpinets, T.V.; Parks, J.M.; Smolin, N.; Yang, S.; Land, M.L.; Klingeman, D.M.; Bhandiwad, A.; Rodriguez, M. Jr.; Raman, B.; Shao, X.; Mielenz, J.R.; Smith, J.C.; Keller, M.; Lynd, L.R.
Mutant alcohol dehydrogenase leads to improved ethanol tolerance in Clostridium thermocellum
Proc. Natl. Acad. Sci. USA
108
13752-71375
2011
Acetivibrio thermocellus (A0A0H3W5U9)
brenda
Holec, C.; Neufeld, K.; Pietruszka, J.
P450 BM3 monooxygenase as an efficient NAD(P)H-oxidase for regeneration of nicotinamide cofactors in ADH-catalysed preparative scale biotransformations
Adv. Synth. Catal.
358
1810-1819
2016
Thermoanaerobacter brockii, Equus caballus, Ralstonia sp.
-
brenda
Kulig, J.; Frese, A.; Kroutil, W.; Pohl, M.; Rother, D.
Biochemical characterization of an alcohol dehydrogenase from Ralstonia sp.
Biotechnol. Bioeng.
110
1838-1848
2013
Ralstonia sp., Ralstonia sp. DSM 6428
brenda
Lundova, T.; Zemanova, L.; Malcekova, B.; Skarka, A.; Stambergova, H.; Havrankova, J.; Safr, M.; Wsol, V.
Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3)
Chem. Biol. Interact.
234
178-187
2015
Homo sapiens
brenda
Ma, C.W.; Zhang, L.; Dai, J.Y;, Xiu, Z.L.
Characterization and cofactor binding mechanism of a novel NAD(P)H-dependent aldehyde reductase from Klebsiella pneumoniae DSM2026
J. Microbiol. Biotechnol.
23
1699-1707
2013
Klebsiella pneumoniae, Klebsiella pneumoniae DSM2026
brenda
Brummund, J.; Sonke, T.; Mueller, M.
Process Development for biocatalytic oxidations applying alcohol dehydrogenases
Org. Process Res. Dev.
19
1590-1595
2015
Rhodococcus ruber
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brenda
Bartsch, S.; Brummund, J.; Koepke, S.; Straatman, H.; Vogel, A.; Schuermann, M.
Optimization of alcohol dehydrogenase for industrial scale oxidation of lactols
Biotechnol. J.
15
e2000171
2020
Starmerella magnoliae, Starmerella magnoliae DSMZ 70638
brenda
An, J.; Nie, Y.; Xu, Y.
Structural insights into alcohol dehydrogenases catalyzing asymmetric reductions
Crit. Rev. Biotechnol.
39
366-379
2019
Thermoanaerobacter ethanolicus
brenda
Sugimoto, C.; Takeda, K.; Kariya, Y.; Matsumura, H.; Yohda, M.; Ohno, H.; Nakamura, N.
A method of expression for an oxygen-tolerant group III alcohol dehydrogenase from Pyrococcus horikoshii OT3
J. Biol. Inorg. Chem.
22
527-534
2017
Pyrococcus horikoshii (O58517), Pyrococcus horikoshii DSM 12428 (O58517), Pyrococcus horikoshii NBRC 100139 (O58517), Pyrococcus horikoshii JCM 9974 (O58517), Pyrococcus horikoshii ATCC 700860 (O58517), Pyrococcus horikoshii OT-3 (O58517)
brenda