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Information on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+) and Organism(s) Sus scrofa

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IUBMB Comments
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).
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This record set is specific for:
Sus scrofa
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Word Map
The taxonomic range for the selected organisms is: Sus scrofa
The enzyme appears in selected viruses and cellular organisms
Synonyms
g6pd, glucose-6-phosphate dehydrogenase, g6pdh, g-6-pd, glucose 6-phosphate dehydrogenase, g-6-pdh, g-6pd, zwf-1, glucose-6-phosphate 1-dehydrogenase, glc6pdh, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6-phosphoglucose dehydrogenase
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-
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D-glucose 6-phosphate dehydrogenase
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-
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Entner-Doudoroff enzyme
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-
-
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G6PD
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-
-
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G6PD1
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-
-
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G6PD2
-
-
-
-
G6PD3
-
-
-
-
G6PD4
-
-
-
-
G6PD5
-
-
-
-
G6PD6
-
-
-
-
G6PDH1
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-
-
-
G6PDH2
-
-
-
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G6PDH3
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-
-
-
G6PDH4
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-
-
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G6PDH5
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-
-
-
G6PDH6
-
-
-
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glucose 6-phosphate dehydrogenase (NADP)
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-
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glucose-6-phosphate 1-dehydrogenase
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-
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glucose-6-phosphate dehydrogenase
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-
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NADP-dependent glucose 6-phophate dehydrogenase
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-
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NADP-glucose-6-phosphate dehydrogenase
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VEG11
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-
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Vegetative protein 11
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-
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Zwischenferment
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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-
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reduction
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SYSTEMATIC NAME
IUBMB Comments
D-glucose-6-phosphate:NADP+ 1-oxidoreductase
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).
CAS REGISTRY NUMBER
COMMENTARY hide
9001-40-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
6-phosphonogluconate + NADPH
?
show the reaction diagram
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isoenzyme II
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-
?
D-galactose 6-phosphate + NAD(P)+
D-galactonate 6-phosphate + NADH
show the reaction diagram
-
-
-
-
?
D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
show the reaction diagram
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-
-
?
additional information
?
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both isoenzymes show no activity with glucose and NAD+, isoenzyme I shows no activity with 6-phosphonogluconate
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
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absolute specificity
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
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activation
Mg2+
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activation
additional information
-
no metal ions necessary
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATP
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EDTA
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slightly
NADPH
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palmitoyl-CoA
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leads to dissociation of active tetramers to inactive dimers
Zn2+
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.279
6-phosphonogluconate
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isoenzyme II
0.046 - 0.051
D-galactose 6-phosphate
0.056 - 0.167
D-glucose 6-phosphate
0.006 - 0.008
NADP+
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isoenzymes I and II, with glucose 6-phosphate
0.023
NADPH
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isoenzyme II, with 6-phosphonogluconate 0.1 mM
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
201
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purified isoenzyme II
50
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purified isoenzyme I
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
2 isoenzymes
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-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A8D1JCM6_PIG
555
0
63216
TrEMBL
other Location (Reliability: 4)
A0A4X1T5A0_PIG
554
0
63250
TrEMBL
other Location (Reliability: 4)
A0A8D1XGC9_PIG
560
0
63715
TrEMBL
other Location (Reliability: 4)
A0A8D1SQ30_PIG
499
0
57212
TrEMBL
other Location (Reliability: 2)
A0A8D0TZN4_PIG
485
0
55018
TrEMBL
other Location (Reliability: 4)
A0A8D1XHE5_PIG
555
0
63361
TrEMBL
other Location (Reliability: 4)
A0A8D1UI59_PIG
556
0
63593
TrEMBL
other Location (Reliability: 3)
A0A8D1T524_PIG
502
0
57728
TrEMBL
other Location (Reliability: 5)
A0A481CYD6_PIG
504
0
57824
TrEMBL
other Location (Reliability: 2)
A0A8D1T533_PIG
515
0
59252
TrEMBL
Secretory Pathway (Reliability: 5)
A0A8D0N6R5_PIG
515
0
57390
TrEMBL
other Location (Reliability: 4)
A0A8D1TXA7_PIG
528
0
58882
TrEMBL
other Location (Reliability: 4)
A0A8D1PSQ8_PIG
564
0
63690
TrEMBL
other Location (Reliability: 4)
A0A8D1JB36_PIG
515
0
59102
TrEMBL
other Location (Reliability: 2)
A0A8D0QUS3_PIG
597
0
65624
TrEMBL
other Location (Reliability: 4)
A0A287BSL9_PIG
649
0
72425
TrEMBL
other Location (Reliability: 4)
A0A8D1XCN2_PIG
515
0
59248
TrEMBL
other Location (Reliability: 2)
A0A8D0QUQ2_PIG
572
0
64595
TrEMBL
other Location (Reliability: 2)
A0A8D1SXM4_PIG
475
0
54799
TrEMBL
other Location (Reliability: 3)
A0A8D0NA16_PIG
547
0
60569
TrEMBL
other Location (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
220000
-
isoenzymes I and II, gel filtration
57000
-
4 * 57000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
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4 * 57000, SDS-PAGE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
isoenzymes I and II
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cho, S.W.; Joshi, J.G.
Characterization of glucose-6-phosphate dehydrogenase isozymes from human and pig brain
Neuroscience
38
819-828
1990
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team