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Information on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+) and Organism(s) Mus musculus

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IUBMB Comments
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).
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This record set is specific for:
Mus musculus
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
g6pd, glucose-6-phosphate dehydrogenase, g6pdh, g-6-pd, glucose 6-phosphate dehydrogenase, g-6-pdh, g-6pd, zwf-1, glucose-6-phosphate 1-dehydrogenase, glc6pdh, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6-phosphoglucose dehydrogenase
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D-glucose 6-phosphate dehydrogenase
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Entner-Doudoroff enzyme
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G6PD1
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G6PD2
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G6PD3
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G6PD4
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G6PD5
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G6PD6
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G6PDH1
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G6PDH2
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G6PDH3
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G6PDH4
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G6PDH5
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G6PDH6
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glucose 6-phosphate dehydrogenase
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glucose 6-phosphate dehydrogenase (NADP)
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glucose-6-phosphate 1-dehydrogenase
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glucose-6-phosphate dehydrogenase
NADP-dependent glucose 6-phophate dehydrogenase
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NADP-glucose-6-phosphate dehydrogenase
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VEG11
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Vegetative protein 11
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Zwischenferment
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
reaction mechanism is important for regulation
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
D-glucose-6-phosphate:NADP+ 1-oxidoreductase
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).
CAS REGISTRY NUMBER
COMMENTARY hide
9001-40-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
show the reaction diagram
D-glucose 6-phosphate + NADP+
6-phospho-D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
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D-glucose 6-phosphate + NADP+
D-glucono-1,5-lactone 6-phosphate + NADPH + H+
show the reaction diagram
additional information
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G6PD overexpressed in adipocytes in obese (including db/db, ob/ob and diet-induced obesity) mice, in adipocytes and stromal-vascular cells in diabetic db/db mice, and in adipocytes cultured under high-glucose conditions in vitro induces the expression of NADPH oxidase and leads to an increase in oxidative stress
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
show the reaction diagram
D-glucose 6-phosphate + NADP+
6-phospho-D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
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?
D-glucose 6-phosphate + NADP+
D-glucono-1,5-lactone 6-phosphate + NADPH + H+
show the reaction diagram
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G6PDH is the rate-limiting step in the formation of NADPH via the triphosphate, and is responsible for the major supply of NADPH in the cell
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
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inhibition patterns of substrates and product
quartz
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24 h incubation with quartz particles (80 microg/cm(2)) inhibits G6PD activity by 70%. Inhibition is fully prevented by glutathione. Silica exerts on G6PD an oxidative damage
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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moderate overexpression of the enzyme (G6PD) can protect beta-cells from age-associated oxidative stress thus reducing the risk of developing type 2 diabetes. The animal show an improved glucose tolerance and insulin sensitivity when compared to old age-matched wild type ones
Manually annotated by BRENDA team
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murine thymic lymphoma cells
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
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moderate overexpression of the enzyme (G6PD) can protect beta-cells from age-associated oxidative stress thus reducing the risk of developing type 2 diabetes
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
G6PD1_MOUSE
515
0
59263
Swiss-Prot
other Location (Reliability: 2)
G6PD2_MOUSE
513
0
59126
Swiss-Prot
other Location (Reliability: 2)
A0FF38_MOUSE
513
0
59095
TrEMBL
other Location (Reliability: 2)
G3UWD6_MOUSE
513
0
59151
TrEMBL
other Location (Reliability: 2)
Q3TNL1_MOUSE
515
0
59264
TrEMBL
other Location (Reliability: 2)
Q790Y8_MOUSE
515
0
59263
TrEMBL
other Location (Reliability: 2)
A3KG36_MOUSE
396
0
45202
TrEMBL
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
117000
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gel filtration
240000
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31000
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4 * 31000, SDS-PAGE
60000
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4 * 60000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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stable overexpression in WEHI7.2 murine thymic lymphoma cells models glucose deprivation and sensitizes lymphoma cells to dexamethasone-induced apoptosis, overview, G6PDH-overexpressing WEHI7.2 cells are more sensitive to oxidative stress and glucocorticoids
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
overexpression in WEHI7.2 cells
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
high glucose level inhibits G6PD expression
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lee, C.Y.
Glucose-6-phosphate dehydrogenase from mouse
Methods Enzymol.
89
252-257
1982
Mus musculus
Manually annotated by BRENDA team
Schraven, E.; Gruber, C.
Organ- und speziesspezifische Eigenschaften von Glucose-6-phosphatdehydrogenase und deren Beeinflussung durch Molsidomin
Arzneimittelforschung
38
36-39
1988
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Velasco, P.; Barcia, R.; Ibarguren, I.; Sieiro, A.M.; Ramos-Martinez, J.I.
Purification, characterization and kinetic mechanism of glucose-6-phosphate dehydrogenase from mouse liver
Int. J. Biochem.
26
195-200
1994
Mus musculus
Manually annotated by BRENDA team
Tome, M.E.; Johnson, D.B.; Samulitis, B.K.; Dorr, R.T.; Briehl, M.M.
Glucose 6-phosphate dehydrogenase overexpression models glucose deprivation and sensitizes lymphoma cells to apoptosis
Antioxid. Redox Signal.
8
1315-1327
2006
Mus musculus
Manually annotated by BRENDA team
Polimeni, M.; Gazzano, E.; Ghiazza, M.; Fenoglio, I.; Bosia, A.; Fubini, B.; Ghigo, D.
Quartz inhibits glucose 6-phosphate dehydrogenase in murine alveolar macrophages
Chem. Res. Toxicol.
21
888-894
2008
Mus musculus
Manually annotated by BRENDA team
Gupte, S.A.
Glucose-6-phosphate dehydrogenase: a novel therapeutic target in cardiovascular diseases
Curr. Opin. Investig. Drugs
9
993-1000
2008
Bos taurus, Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Zhang, Z.; Liew, C.W.; Handy, D.E.; Zhang, Y.; Leopold, J.A.; Hu, J.; Guo, L.; Kulkarni, R.N.; Loscalzo, J.; Stanton, R.C.
High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis
FASEB J.
24
1497-1505
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
De la Rosa, A.; Gomez-Cabrera, M.; Vinue, A.; Gonzalez-Navarro, H.; Sanchez-Andres, J.; Vina, J.
Overexpression of glucose 6 phosphate dehydrogenase preserves mouse pancreatic beta cells function until late in life
Free Radic. Biol. Med.
164
149-153
2021
Mus musculus
Manually annotated by BRENDA team