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Information on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+) and Organism(s) Bos taurus

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IUBMB Comments
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).
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Bos taurus
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Synonyms
g6pd, glucose-6-phosphate dehydrogenase, g6pdh, g-6-pd, glucose 6-phosphate dehydrogenase, g-6-pdh, g-6pd, zwf-1, glucose-6-phosphate 1-dehydrogenase, glc6pdh, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6-phosphoglucose dehydrogenase
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D-glucose 6-phosphate dehydrogenase
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Entner-Doudoroff enzyme
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G6PD1
G6PD2
G6PD3
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G6PD4
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G6PD5
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G6PD6
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G6PDH1
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G6PDH2
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G6PDH3
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G6PDH4
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G6PDH5
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G6PDH6
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glucose 6-phosphate dehydrogenase (NADP)
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glucose-6-phosphate 1-dehydrogenase
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glucose-6-phosphate dehydrogenase
NADP-dependent glucose 6-phophate dehydrogenase
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NADP-glucose-6-phosphate dehydrogenase
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VEG11
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Vegetative protein 11
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Zwischenferment
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
physiological regulating function is discussed
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
D-glucose-6-phosphate:NADP+ 1-oxidoreductase
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).
CAS REGISTRY NUMBER
COMMENTARY hide
9001-40-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
show the reaction diagram
D-glucose 6-phosphate + NAD+
D-glucono-1,5-lactone 6-phosphate + NADH + H+
show the reaction diagram
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?
D-glucose 6-phosphate + NADP+
6-phospho-D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
show the reaction diagram
D-glucose 6-phosphate + NADP+
6-phospho-D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
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NADPH
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
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about 110% activity at 5 mM (isoform G6PD1)
Mn2+
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about 112% activity at 2 mM (isoform G6PD1)
Ni2+
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about 110% activity at 5 mM (isoform G6PD2), about 115% activity at 2 mM (isoform G6PD1)
additional information
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not influenced by Ca2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cu2+
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potent inhibitor, about 65% residual activity at 2 mM (isoform G6PD2), about 50% residual activity at 2 mM (isoform G6PD1)
estrogen
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Fe2+
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potent inhibitor, about 10% residual activity at 5 mM (isoform G6PD2), about 30% residual activity at 5 mM (isoform G6PD1)
glucose
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at concentration above 10 mM
Mn2+
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about 10% residual activity at 5 mM (isoform G6PD2)
NADPH
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competitive inhibition
p-chloromercuribenzoate
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progesterone
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Zn2+
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potent inhibitor, about 58% residual activity at 5 mM (isoform G6PD2), about 35% residual activity at 2 mM (isoform G6PD1)
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.042
D-glucose 6-phosphate
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cosubstrate NADP+
0.047
NAD+
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0.0056 - 0.06
NADP+
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.012 - 0.03
NADPH
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0374
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crude extract, at pH 8.0, temperature not specified in the publication
0.916
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isoform G6PD1, after 24.49fold purification, at pH 8.0, temperature not specified in the publication
2.221
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isoform G6PD2, after 59.38fold purification, at pH 8.0, temperature not specified in the publication
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8
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isoform G6PD1
8 - 9
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8.2
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isoform G6PD2
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
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assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.7 - 5.9
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isoform G6PD2, isoelectric focusing
7.7 - 7.9
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isoform G6PD1, isoelectric focusing
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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G6PD is more than 2fold higher in pulmonary arteries compared with coronary arteries
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A3Q1MM55_BOVIN
555
0
63252
TrEMBL
other Location (Reliability: 3)
F1MMK2_BOVIN
545
0
62414
TrEMBL
other Location (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
238700
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ultracentrifugation
28000
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isoform G6PD1, gel filtration
66000
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isoform G6PD2, gel filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
EDTA stabilizes
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thioglycolate stabilizes
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate precipitation, DEAE-cellulose column chromatography, and Sephacryl S-300 gel filtration, and 2',5'-ADP Sepharose 4B column chromatography
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Julian, G.R.; Reithel, F.J.
Glucose-6-phosphate dehydrogenase from bovine mammary gland
Methods Enzymol.
41
183-188
1975
Bos taurus
Manually annotated by BRENDA team
McKerns, K.W.
Glucose-6-phosphate dehydrogenase from cow adrenal cortex-1
Methods Enzymol.
41
188-196
1975
Bos taurus
Manually annotated by BRENDA team
Zhang, Z.; Apse, K.; Pang, J.; Stanton, R.C.
High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells
J. Biol. Chem.
275
40042-40047
2000
Bos taurus
Manually annotated by BRENDA team
Gupte, S.A.
Glucose-6-phosphate dehydrogenase: a novel therapeutic target in cardiovascular diseases
Curr. Opin. Investig. Drugs
9
993-1000
2008
Bos taurus, Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Ibrahim, M.A.; Ghazy, A.H.; Salem, A.M.; Ghazy, M.A.; Abdel-Monsef, M.M.
Biochemical characterization of buffalo liver glucose-6-phosphate dehydrogenase isoforms
Protein J.
34
193-204
2015
Bos taurus
Manually annotated by BRENDA team