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EC Tree
IUBMB Comments The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).
The taxonomic range for the selected organisms is: Bos taurus The enzyme appears in selected viruses and cellular organisms
Synonyms
g6pd, glucose-6-phosphate dehydrogenase, g6pdh, g-6-pd, glucose 6-phosphate dehydrogenase, g-6-pdh, g-6pd, zwf-1, glucose-6-phosphate 1-dehydrogenase, glc6pdh,
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6-phosphoglucose dehydrogenase
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D-glucose 6-phosphate dehydrogenase
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Entner-Doudoroff enzyme
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glucose 6-phosphate dehydrogenase (NADP)
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glucose-6-phosphate 1-dehydrogenase
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glucose-6-phosphate dehydrogenase
NADP-dependent glucose 6-phophate dehydrogenase
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NADP-glucose-6-phosphate dehydrogenase
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Vegetative protein 11
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G6PD
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G6PD1
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G6PD2
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glucose-6-phosphate dehydrogenase
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glucose-6-phosphate dehydrogenase
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D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+
physiological regulating function is discussed
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D-glucose-6-phosphate:NADP+ 1-oxidoreductase
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).
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D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
D-glucose 6-phosphate + NAD+
D-glucono-1,5-lactone 6-phosphate + NADH + H+
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D-glucose 6-phosphate + NADP+
6-phospho-D-glucono-1,5-lactone + NADPH + H+
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D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
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r
D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
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6-phosphoglucono-delta-lactone
r
D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
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6-phosphoglucono-delta-lactone
r
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D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
D-glucose 6-phosphate + NADP+
6-phospho-D-glucono-1,5-lactone + NADPH + H+
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D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
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r
D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
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6-phosphoglucono-delta-lactone
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D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
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6-phosphoglucono-delta-lactone
r
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Co2+
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about 110% activity at 5 mM (isoform G6PD1)
Mn2+
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about 112% activity at 2 mM (isoform G6PD1)
Ni2+
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about 110% activity at 5 mM (isoform G6PD2), about 115% activity at 2 mM (isoform G6PD1)
additional information
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not influenced by Ca2+
Mg2+
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activation
Mg2+
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about 130% activity at 5 mM (isoform G6PD2), about 150% activity at 5 mM (isoform G6PD1)
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Cu2+
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potent inhibitor, about 65% residual activity at 2 mM (isoform G6PD2), about 50% residual activity at 2 mM (isoform G6PD1)
Fe2+
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potent inhibitor, about 10% residual activity at 5 mM (isoform G6PD2), about 30% residual activity at 5 mM (isoform G6PD1)
glucose
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at concentration above 10 mM
Mn2+
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about 10% residual activity at 5 mM (isoform G6PD2)
NADPH
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competitive inhibition
p-chloromercuribenzoate
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Zn2+
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potent inhibitor, about 58% residual activity at 5 mM (isoform G6PD2), about 35% residual activity at 2 mM (isoform G6PD1)
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0.042
D-glucose 6-phosphate
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cosubstrate NADP+
0.0056
NADP+
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0.059
NADP+
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isoform G6PD1, at pH 8.0, temperature not specified in the publication
0.06
NADP+
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isoform G6PD1, at pH 8.0, temperature not specified in the publication
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0.012
NADPH
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isoform G6PD1, at pH 8.0, temperature not specified in the publication
0.03
NADPH
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isoform G6PD2, at pH 8.0, temperature not specified in the publication
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0.0374
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crude extract, at pH 8.0, temperature not specified in the publication
0.916
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isoform G6PD1, after 24.49fold purification, at pH 8.0, temperature not specified in the publication
2.221
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isoform G6PD2, after 59.38fold purification, at pH 8.0, temperature not specified in the publication
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5.7 - 5.9
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isoform G6PD2, isoelectric focusing
7.7 - 7.9
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isoform G6PD1, isoelectric focusing
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brenda
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brenda
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G6PD is more than 2fold higher in pulmonary arteries compared with coronary arteries
brenda
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brenda
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brenda
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A0A3Q1MM55_BOVIN
555
0
63252
TrEMBL
other Location (Reliability: 3 )
F1MMK2_BOVIN
545
0
62414
TrEMBL
other Location (Reliability: 4 )
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238700
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ultracentrifugation
28000
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isoform G6PD1, gel filtration
66000
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isoform G6PD2, gel filtration
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monomer
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1 * 28000, isoform G6PD1, SDS-PAGE
monomer
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1 * 66000, isoform G6PD2, SDS-PAGE
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thioglycolate stabilizes
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ammonium sulfate precipitation, DEAE-cellulose column chromatography, and Sephacryl S-300 gel filtration, and 2',5'-ADP Sepharose 4B column chromatography
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Julian, G.R.; Reithel, F.J.
Glucose-6-phosphate dehydrogenase from bovine mammary gland
Methods Enzymol.
41
183-188
1975
Bos taurus
brenda
McKerns, K.W.
Glucose-6-phosphate dehydrogenase from cow adrenal cortex-1
Methods Enzymol.
41
188-196
1975
Bos taurus
brenda
Zhang, Z.; Apse, K.; Pang, J.; Stanton, R.C.
High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells
J. Biol. Chem.
275
40042-40047
2000
Bos taurus
brenda
Gupte, S.A.
Glucose-6-phosphate dehydrogenase: a novel therapeutic target in cardiovascular diseases
Curr. Opin. Investig. Drugs
9
993-1000
2008
Bos taurus, Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Ibrahim, M.A.; Ghazy, A.H.; Salem, A.M.; Ghazy, M.A.; Abdel-Monsef, M.M.
Biochemical characterization of buffalo liver glucose-6-phosphate dehydrogenase isoforms
Protein J.
34
193-204
2015
Bos taurus
brenda