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Information on EC 1.1.1.42 - isocitrate dehydrogenase (NADP+) and Organism(s) Danio rerio

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EC Tree
IUBMB Comments
Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+), oxalosuccinate can be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm . The enzyme from some species can also use NAD+ but much more slowly [6,7].
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Danio rerio
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Word Map
The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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Synonyms
isocitrate dehydrogenase 1, nadp-isocitrate dehydrogenase, nadp-dependent isocitrate dehydrogenase, isocitrate dehydrogenase-1, nadp-icdh, nadp-idh, nadp+-dependent isocitrate dehydrogenase, nadp-linked isocitrate dehydrogenase, nadp-specific isocitrate dehydrogenase, nadp+-specific isocitrate dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CtIDP1
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CtIDP2
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IDH
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IDP
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isocitrate dehydrogenase (NADP)
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isocitrate dehydrogenase (NADP-dependent)
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isocitrate dehydrogenase (nicotinamide adenine dinucleotide phosphate)
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NADP isocitric dehydrogenase
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NADP+-linked isocitrate dehydrogenase
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NADP+-specific ICDH
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NADP-dependent isocitrate dehydrogenase
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NADP-dependent isocitric dehydrogenase
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NADP-linked isocitrate dehydrogenase
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NADP-specific isocitrate dehydrogenase
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oxalosuccinate decarboxylase
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oxalsuccinic decarboxylase
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PS-NADP-IDH
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidative decarboxylation
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redox reaction
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reductive carboxylation
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SYSTEMATIC NAME
IUBMB Comments
isocitrate:NADP+ oxidoreductase (decarboxylating)
Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+), oxalosuccinate can be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm [6]. The enzyme from some species can also use NAD+ but much more slowly [6,7].
CAS REGISTRY NUMBER
COMMENTARY hide
9028-48-2
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A8E575_DANRE
302
0
33896
TrEMBL
other Location (Reliability: 5)
Q7ZUP6_DANRE
449
0
50397
TrEMBL
Mitochondrion (Reliability: 3)
A8KB14_DANRE
414
0
46889
TrEMBL
Mitochondrion (Reliability: 5)
E7F4R9_DANRE
225
0
25331
TrEMBL
other Location (Reliability: 3)
A0A2R8RLN3_DANRE
416
0
47022
TrEMBL
other Location (Reliability: 4)
F6NIA7_DANRE
291
0
32597
TrEMBL
other Location (Reliability: 2)
A0A2R8Q9X5_DANRE
420
0
47767
TrEMBL
Mitochondrion (Reliability: 5)
Q802Y2_DANRE
429
0
48491
TrEMBL
Mitochondrion (Reliability: 5)
A0A2R8QMB7_DANRE
422
0
47640
TrEMBL
other Location (Reliability: 4)
A0A2R8QIZ6_DANRE
426
0
48385
TrEMBL
Mitochondrion (Reliability: 5)
B0UXL2_DANRE
429
0
48505
TrEMBL
Mitochondrion (Reliability: 5)