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Information on EC 1.1.1.37 - malate dehydrogenase and Organism(s) Mus musculus

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EC Tree
     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.37 malate dehydrogenase
IUBMB Comments
There are several forms of malate dehydrogenases that differ by their use of substrate and cofactors. This NAD+-dependent enzyme forms oxaloacetate and unlike EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), is unable to convert it to pyruvate. Also oxidizes some other 2-hydroxydicarboxylic acids. cf. EC 1.1.1.82, malate dehydrogenase (NADP+); EC 1.1.1.299, malate dehydrogenase [NAD(P)+]; and EC 1.1.5.4, malate dehydrogenase (quinone).
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Mus musculus
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
malate dehydrogenase, mdh, mitochondrial malate dehydrogenase, malic dehydrogenase, cytosolic malate dehydrogenase, maldh, nad-dependent malate dehydrogenase, mitochondrial mdh, s-mdh, l-malate dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
(R)-2-hydroxyacid dehydrogenase
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L-malate dehydrogenase
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malate (NAD) dehydrogenase
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malate dehydrogenase (NAD)
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malic acid dehydrogenase
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malic dehydrogenase
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mbNAD-MDH
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mNAD-MDH
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NAD-dependent malate dehydrogenase
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NAD-dependent malic dehydrogenase
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NAD-L-malate dehydrogenase
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NAD-linked malate dehydrogenase
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NAD-malate dehydrogenase
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NAD-malic dehydrogenase
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NAD-specific malate dehydrogenase
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VEG69
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Vegetative protein 69
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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-
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reduction
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SYSTEMATIC NAME
IUBMB Comments
(S)-malate:NAD+ oxidoreductase
There are several forms of malate dehydrogenases that differ by their use of substrate and cofactors. This NAD+-dependent enzyme forms oxaloacetate and unlike EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), is unable to convert it to pyruvate. Also oxidizes some other 2-hydroxydicarboxylic acids. cf. EC 1.1.1.82, malate dehydrogenase (NADP+); EC 1.1.1.299, malate dehydrogenase [NAD(P)+]; and EC 1.1.5.4, malate dehydrogenase (quinone).
CAS REGISTRY NUMBER
COMMENTARY hide
9001-64-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-malate + NAD+
oxaloacetate + NADH + H+
show the reaction diagram
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-
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r
malate + NAD+
oxaloacetate + NADH + H+
show the reaction diagram
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-
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r
oxaloacetate + NADH
L-malate + NAD+
show the reaction diagram
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r
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
malate + NAD+
oxaloacetate + NADH + H+
show the reaction diagram
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r
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
mouse
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Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MDHM_MOUSE
338
0
35611
Swiss-Prot
Mitochondrion (Reliability: 2)
MDHC_MOUSE
334
0
36511
Swiss-Prot
Secretory Pathway (Reliability: 5)
A0A0G2JGY4_MOUSE
153
0
16055
TrEMBL
Mitochondrion (Reliability: 2)
A0A0G2JF23_MOUSE
199
0
21047
TrEMBL
Mitochondrion (Reliability: 1)
A0A5F8MPN8_MOUSE
355
0
38997
TrEMBL
Secretory Pathway (Reliability: 5)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Van Kuijk, B.L.M.; Stams, A.J.M.
Purification and characterization of malate dehydrogenase from the syntrophic propionate-oxidizing bacterium strain MPOB
FEMS Microbiol. Lett.
144
141-144
1996
Geobacillus stearothermophilus, Bacillus subtilis, Syntrophobacter fumaroxidans, Chlorobaculum tepidum, Prosthecochloris vibrioformis, Citrullus lanatus, Escherichia coli, Thermus thermophilus, Heliomicrobium gestii, Methanothermus fervidus, Mus musculus, Phenylobacterium immobile, Planomonospora venezuelensis, Streptomyces atratus, Streptosporangium roseum, Syntrophobacter fumaroxidans MPOB
Manually annotated by BRENDA team
Musrati, R.A.; Kollarova, M.; Mernik, N.; Mikulasova, D.
Malate dehydrogenase: Distribution, function and properties
Gen. Physiol. Biophys.
17
193-210
1998
Saccharomyces cerevisiae, Citrullus lanatus, Escherichia coli, Eucalyptus globulus, Euglena gracilis, Thermus thermophilus, Haloarcula marismortui, Methanothermus fervidus, Mus musculus, Nitzschia alba, Rattus norvegicus, Kitasatospora aureofaciens, Sulfolobus acidocaldarius, Sus scrofa, Zea mays
Manually annotated by BRENDA team