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EC Tree
IUBMB Comments There are several forms of malate dehydrogenases that differ by their use of substrate and cofactors. This NAD+-dependent enzyme forms oxaloacetate and unlike EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), is unable to convert it to pyruvate. Also oxidizes some other 2-hydroxydicarboxylic acids. cf. EC 1.1.1.82, malate dehydrogenase (NADP+); EC 1.1.1.299, malate dehydrogenase [NAD(P)+]; and EC 1.1.5.4, malate dehydrogenase (quinone).
The taxonomic range for the selected organisms is: Drosophila melanogaster The enzyme appears in selected viruses and cellular organisms
Synonyms
malate dehydrogenase, mdh, mitochondrial malate dehydrogenase, malic dehydrogenase, cytosolic malate dehydrogenase, maldh, nad-dependent malate dehydrogenase, mitochondrial mdh, s-mdh, l-malate dehydrogenase,
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(R)-2-hydroxyacid dehydrogenase
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-
-
-
L-malate dehydrogenase
-
-
-
-
malate (NAD) dehydrogenase
-
-
-
-
malate dehydrogenase (NAD)
-
-
-
-
malic acid dehydrogenase
-
-
-
-
malic dehydrogenase
-
-
-
-
NAD-dependent malate dehydrogenase
-
-
-
-
NAD-dependent malic dehydrogenase
-
-
-
-
NAD-L-malate dehydrogenase
-
-
-
-
NAD-linked malate dehydrogenase
-
-
-
-
NAD-malate dehydrogenase
-
-
-
-
NAD-malic dehydrogenase
-
-
-
-
NAD-specific malate dehydrogenase
-
-
-
-
Vegetative protein 69
-
-
-
-
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-
-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
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(S)-malate:NAD+ oxidoreductase
There are several forms of malate dehydrogenases that differ by their use of substrate and cofactors. This NAD+-dependent enzyme forms oxaloacetate and unlike EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), is unable to convert it to pyruvate. Also oxidizes some other 2-hydroxydicarboxylic acids. cf. EC 1.1.1.82, malate dehydrogenase (NADP+); EC 1.1.1.299, malate dehydrogenase [NAD(P)+]; and EC 1.1.5.4, malate dehydrogenase (quinone).
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(S)-malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
oxaloacetate + NADH
L-malate + NAD+
-
-
-
-
r
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malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
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8.5
-
oxaloacetate reduction
9
-
malate oxidation, cytoplasmic isoenzymes
9.5
-
mitochondrial isoenzyme
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Oregon K
-
-
brenda
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-
-
brenda
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Q9VU29_DROME
347
0
36737
TrEMBL
Mitochondrion (Reliability: 4 )
Q8T8X0_DROME
349
0
36798
TrEMBL
Secretory Pathway (Reliability: 5 )
Q8T412_DROME
347
0
36737
TrEMBL
Mitochondrion (Reliability: 3 )
Q9VEB1_DROME
336
0
35318
TrEMBL
Mitochondrion (Reliability: 5 )
B5RJP8_DROME
358
0
37866
TrEMBL
Secretory Pathway (Reliability: 1 )
Q8MQS7_DROME
337
0
36073
TrEMBL
other Location (Reliability: 5 )
Q9VKX2_DROME
337
0
36059
TrEMBL
other Location (Reliability: 5 )
Q9VU28_DROME
349
0
36784
TrEMBL
Secretory Pathway (Reliability: 5 )
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68000
-
both isoenzymes, gel filtration
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McReynolds, M.S.; Barrie Kitto, G.
Purification and properties of Drosophila malate dehydrogenase
Biochim. Biophys. Acta
198
165-175
1970
Bos taurus, Drosophila melanogaster, Drosophila virilis, Equus sp., Gallus sp., Locusta migratoria, Sus scrofa, Thunnus albacares, Drosophila melanogaster Oregon K, Drosophila virilis Texmelucan
brenda