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EC Tree
IUBMB Comments There are several forms of malate dehydrogenases that differ by their use of substrate and cofactors. This NAD+-dependent enzyme forms oxaloacetate and unlike EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), is unable to convert it to pyruvate. Also oxidizes some other 2-hydroxydicarboxylic acids. cf. EC 1.1.1.82, malate dehydrogenase (NADP+); EC 1.1.1.299, malate dehydrogenase [NAD(P)+]; and EC 1.1.5.4, malate dehydrogenase (quinone).
The taxonomic range for the selected organisms is: Dictyostelium discoideum The enzyme appears in selected viruses and cellular organisms
Synonyms
malate dehydrogenase, mdh, mitochondrial malate dehydrogenase, malic dehydrogenase, cytosolic malate dehydrogenase, maldh, nad-dependent malate dehydrogenase, mitochondrial mdh, s-mdh, l-malate dehydrogenase,
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(R)-2-hydroxyacid dehydrogenase
-
-
-
-
L-malate dehydrogenase
-
-
-
-
malate (NAD) dehydrogenase
-
-
-
-
malate dehydrogenase (NAD)
-
-
-
-
malic acid dehydrogenase
-
-
-
-
malic dehydrogenase
-
-
-
-
NAD-dependent malate dehydrogenase
-
-
-
-
NAD-dependent malic dehydrogenase
-
-
-
-
NAD-L-malate dehydrogenase
-
-
-
-
NAD-linked malate dehydrogenase
-
-
-
-
NAD-malate dehydrogenase
-
-
-
-
NAD-malic dehydrogenase
-
-
-
-
NAD-specific malate dehydrogenase
-
-
-
-
Vegetative protein 69
-
-
-
-
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-
-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
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(S)-malate:NAD+ oxidoreductase
There are several forms of malate dehydrogenases that differ by their use of substrate and cofactors. This NAD+-dependent enzyme forms oxaloacetate and unlike EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), is unable to convert it to pyruvate. Also oxidizes some other 2-hydroxydicarboxylic acids. cf. EC 1.1.1.82, malate dehydrogenase (NADP+); EC 1.1.1.299, malate dehydrogenase [NAD(P)+]; and EC 1.1.5.4, malate dehydrogenase (quinone).
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(S)-malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
oxaloacetate + NADH
L-malate + NAD+
-
-
-
-
r
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malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
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1.33
L-malate
-
mitochondrial MDH
0.1
NAD+
-
mitochondrial MDH
0.03
NADH
-
whole cell MDH
0.04
NADH
-
mitochondrial MDH
0.17
oxaloacetate
-
-
0.27
oxaloacetate
-
mitochondrial MDH
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9.3 - 9.5
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both isoenzymes
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-
-
-
brenda
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-
brenda
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brenda
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MDHA_DICDI
391
0
42265
Swiss-Prot
other Location (Reliability: 1 )
MDHB_DICDI
348
0
37648
Swiss-Prot
Mitochondrion (Reliability: 2 )
MDHC_DICDI
333
0
35986
Swiss-Prot
other Location (Reliability: 4 )
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Emyanitoff, R.G.; Kelly, P.J.
Kinetic characterization of Mitochondrial malate dehydrogenase from Dictyostelium discoideum
J. Gen. Microbiol.
128
1767-1771
1982
Bos taurus, Saccharomyces cerevisiae, Dictyostelium discoideum, Gallus sp., Physarum polycephalum, Schizosaccharomyces pombe, Sus scrofa, Dictyostelium discoideum NC-4 / ATCC 24697
brenda