Information on EC 1.1.1.37 - malate dehydrogenase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY hide
1.1.1.37
-
RECOMMENDED NAME
GeneOntology No.
malate dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-malate + NAD+ = oxaloacetate + NADH + H+
show the reaction diagram
also oxidizes some other 2-hydroxydicarboxylic acids
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
anaerobic energy metabolism (invertebrates, cytosol)
-
-
aspartate and asparagine metabolism
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-
Biosynthesis of antibiotics
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Biosynthesis of secondary metabolites
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C4 and CAM-carbon fixation
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-
C4 photosynthetic carbon assimilation cycle, NAD-ME type
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Carbon fixation in photosynthetic organisms
-
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Carbon fixation pathways in prokaryotes
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-
Citrate cycle (TCA cycle)
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citric acid cycle
-
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Cysteine and methionine metabolism
-
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formaldehyde assimilation I (serine pathway)
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gluconeogenesis I
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gluconeogenesis III
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Glyoxylate and dicarboxylate metabolism
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-
glyoxylate cycle
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incomplete reductive TCA cycle
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L-aspartate degradation II
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Metabolic pathways
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Methane metabolism
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methylaspartate cycle
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Microbial metabolism in diverse environments
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-
mixed acid fermentation
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partial TCA cycle (obligate autotrophs)
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pyruvate fermentation to propanoate I
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Pyruvate metabolism
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reductive TCA cycle I
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reductive TCA cycle II
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superpathway of glyoxylate cycle and fatty acid degradation
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TCA cycle I (prokaryotic)
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TCA cycle II (plants and fungi)
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TCA cycle III (animals)
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TCA cycle IV (2-oxoglutarate decarboxylase)
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-
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)
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-
SYSTEMATIC NAME
IUBMB Comments
(S)-malate:NAD+ oxidoreductase
Also oxidizes some other 2-hydroxydicarboxylic acids.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-64-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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-
Uniprot
Manually annotated by BRENDA team
pineapple, cv. Havaiano
-
-
Manually annotated by BRENDA team
sea urchin
-
-
Manually annotated by BRENDA team
Aptenia cordifolia
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain B60
-
-
Manually annotated by BRENDA team
strain B60
-
-
Manually annotated by BRENDA team
strain D-402
-
-
Manually annotated by BRENDA team
strain D-402
-
-
Manually annotated by BRENDA team
3I1B-143 bacteroids
-
-
Manually annotated by BRENDA team
two isozymes
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Bryophyllum calycinum
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
watermelon
-
-
Manually annotated by BRENDA team
Citrus sp.
lemon fruit
-
-
Manually annotated by BRENDA team
Coccochloris peniocystis
no. 1548
-
-
Manually annotated by BRENDA team
Coccochloris peniocystis 1548
no. 1548
-
-
Manually annotated by BRENDA team
ATCC 14067
SwissProt
Manually annotated by BRENDA team
strain NC4 (ATCC 24697)
-
-
Manually annotated by BRENDA team
strain NC4 (ATCC 24697)
-
-
Manually annotated by BRENDA team
Oregon K
-
-
Manually annotated by BRENDA team
Drosophila melanogaster Oregon K
Oregon K
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-
Manually annotated by BRENDA team
Drosophila virilis Texmelucan
Texmelucan
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-
Manually annotated by BRENDA team
strain MG1655, gene mdh
UniProt
Manually annotated by BRENDA team
SM-ZK
-
-
Manually annotated by BRENDA team
brown shrimp
-
-
Manually annotated by BRENDA team
Duch. cv. Elsanta
-
-
Manually annotated by BRENDA team
teleost
-
-
Manually annotated by BRENDA team
soybean, Williams 79 cultivar
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
isoforms A1, A2 and B
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-
Manually annotated by BRENDA team
marine snail
-
-
Manually annotated by BRENDA team
Laceyella sacchari NCIB 10486
N.C.I.B. 10486
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
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Uniprot
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
strain D-405
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-
Manually annotated by BRENDA team
strain D-405
-
-
Manually annotated by BRENDA team
strain GPI
-
-
Manually annotated by BRENDA team
Methanothermobacter thermautotrophicum
-
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
strain 2D2
SwissProt
Manually annotated by BRENDA team
strain 5710
-
-
Manually annotated by BRENDA team
strain INMI
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-
Manually annotated by BRENDA team
mouse
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
H37Rv, H37Ra, BCG
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-
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
marine diatom
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-
Manually annotated by BRENDA team
no activity in Chromatium sp.
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-
Manually annotated by BRENDA team
no activity in Mycobacterium fortuitum
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-
Manually annotated by BRENDA team
no activity in Mycobacterium smegmatis
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-
Manually annotated by BRENDA team
no activity in Mycobacterium smegmatis 607
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-
Manually annotated by BRENDA team
cactus
-
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Manually annotated by BRENDA team
lamb
-
-
Manually annotated by BRENDA team
strain E
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Manually annotated by BRENDA team
pea
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Manually annotated by BRENDA team
Pontonia pinnophylax
inhabiting the mantle cavity of host Pinna nobilis
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-
Manually annotated by BRENDA team
; a hyperthermophilic archaeon, strain DSM 4184
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Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
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Manually annotated by BRENDA team
strain 37b4
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Manually annotated by BRENDA team
B100
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-
Manually annotated by BRENDA team
strain 2R
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-
Manually annotated by BRENDA team
strain 6770
-
-
Manually annotated by BRENDA team
strain 6770
-
-
Manually annotated by BRENDA team
strain EY33
-
-
Manually annotated by BRENDA team
strain EY33
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-
Manually annotated by BRENDA team
strain f8pt
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-
Manually annotated by BRENDA team
strain 1.1.1
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-
Manually annotated by BRENDA team
strain 1.1.1
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-
Manually annotated by BRENDA team
castor bean
-
-
Manually annotated by BRENDA team
DSM 13855
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-
Manually annotated by BRENDA team
potato
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
gene mdh
Uniprot
Manually annotated by BRENDA team
gene mdh
Uniprot
Manually annotated by BRENDA team
strain 6803 CF
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-
Manually annotated by BRENDA team
strain 6803 CF
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Manually annotated by BRENDA team
DSM 10017
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-
Manually annotated by BRENDA team
N.C.I.B. 11185
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-
Manually annotated by BRENDA team
Thermobifida fusca NCIB 11185
N.C.I.B. 11185
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Manually annotated by BRENDA team
strain B
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Manually annotated by BRENDA team
strain YT-1
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-
Manually annotated by BRENDA team
AT-62
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Manually annotated by BRENDA team
strain TV 10-02, strain Tv-1961, strain Tv-1973
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Manually annotated by BRENDA team
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Uniprot
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
black gram, mung bean
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-
Manually annotated by BRENDA team
Viola sp.
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
Zea mays Goldener Badischer Landmais
-
-
-
Manually annotated by BRENDA team
Zea mays VA35
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2S,3S)-tartrate + NAD+
? + NADH
show the reaction diagram
(S)-2-hydroxyglutarate + NAD+
2-oxoglutarate + NADH + H+
show the reaction diagram
-
oxidized at an extremely slow rate, less than 0.001% of the rate of L-malate oxidation
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r
(S)-malate + 3-acetylpyridine-adenine dinucleotide
oxaloacetate + reduced 3-acetylpyridine-adenine dinucleotide + H+
show the reaction diagram
-
can also use 3-acetylpyridine-adenine as cofactor
-
-
r
(S)-malate + acetylpyridine adenine dinucleotide
oxaloacetate + reduced acetylpyridine adenine dinucleotide
show the reaction diagram
-
-
-
?
(S)-malate + NAD(P)+
oxaloacetate + NAD(P)H
show the reaction diagram
-
-
-
-
r
(S)-malate + NAD+
acetate + CO2 + H2 + NADH
show the reaction diagram
-
-
-
?
(S)-malate + NAD+
oxaloacetate + NADH + H+
show the reaction diagram
(S)-malate + NADP+
oxaloacetate + NADPH + H+
show the reaction diagram
1,4,5,6-tetrahydronicotinamide + L-malate
?
show the reaction diagram
-
-
-
-
?
2-oxobutyrate + NADH
2-hydroxybutyrate + NAD+
show the reaction diagram
-
-
-
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?
3-acetylpyridine adenine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
3-bromopyruvate + NADH
3-bromo-2-hydroxypropanoate + NAD+
show the reaction diagram
about 10% of the activity with oxaloacetate at pH 6.8
-
-
?
alpha-keto-malonate + NADH
? + NAD+
show the reaction diagram
alpha-ketoglutarate + NADH
2-hydroxyglutarate + NAD+
show the reaction diagram
about 10% of the activity with oxaloacetate at pH 6.8 and at pH 8.2
-
-
?
alpha-ketoisovalerate + NADH
2-hydroxyisovalerate + NAD+
show the reaction diagram
about 10% of the activity with oxaloacetate at pH 8.2
-
-
?
alpha-ketomalonate + NADH
?
show the reaction diagram
-
-
-
?
citrate + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
hydroxymalonate + NAD+
? + NADH
show the reaction diagram
L-lactate + NAD+
? + NADH
show the reaction diagram
-
cMDH less catalytically efficient than against its natural substrate malate
-
-
?
malate + NAD+
oxaloacetate + NADH
show the reaction diagram
meso-tartrate + NAD+
? + NADH
show the reaction diagram
nicotinamide 1-N6-ethenoadenine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
nicotinamide hypoxanthine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
oxaloacetate + NADH
(S)-malate + NAD+
show the reaction diagram
oxaloacetate + NADH
L-malate + NAD+
show the reaction diagram
oxaloacetate + NADH + H+
(S)-malate + NAD
show the reaction diagram
oxaloacetate + NADH + H+
(S)-malate + NAD+
show the reaction diagram
oxaloglycolate + NAD+
? + NADH
show the reaction diagram
-
-
-
-
r
p-hydroxyphenylpyruvate + NADH + H+
2-hydroxy-3-(4-hydroxyphenyl)propanoate
show the reaction diagram
-
-
-
?
phenylpyruvate + NADH
2-hydroxy-3-phenylpropanoate + NAD+
show the reaction diagram
about 30% of the activity with oxaloacetate at pH 8.2
-
-
?
phenylpyruvate + NADH + H+
2-hydroxy-3-phenylpropanoate + NAD+
show the reaction diagram
-
-
-
?
pyridine 3-aldehyde adenine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
pyruvate + NAD+
? + NADH
show the reaction diagram
-
cMDH less catalytically efficient than against its natural substrate malate
-
-
?
pyruvate + NADH
2-hydroxypropanoate + NAD+
show the reaction diagram
about 25% of the activity with oxaloacetate at pH 8.2
-
-
?
pyruvate + NADH + H+
(S)-lactate + NAD+
show the reaction diagram
thionicotinamide adenine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
additional information
?
-