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Information on EC 1.1.1.30 - 3-hydroxybutyrate dehydrogenase and Organism(s) Homo sapiens

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IUBMB Comments
Also oxidizes other 3-hydroxymonocarboxylic acids.
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This record set is specific for:
Homo sapiens
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
beta-hydroxybutyrate dehydrogenase, 3-hydroxybutyrate dehydrogenase, d-beta-hydroxybutyrate dehydrogenase, d-3-hydroxybutyrate dehydrogenase, beta-hydroxybutyric dehydrogenase, dhrs6, 3-hbdh, 3-hydroxybutyrate dehydrogenase-2, beta-hydroxybutyric acid dehydrogenase, 3hbdh, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-D-hydroxybutyrate dehydrogenase
-
-
-
-
3-HBDH
-
-
-
-
3-hydroxybutyrate dehydrogenase
-
-
-
-
BDH
-
-
-
-
beta-hydroxybutyrate dehydrogenase
beta-hydroxybutyric acid dehydrogenase
-
-
-
-
beta-hydroxybutyric dehydrogenase
-
-
-
-
D-(-)-3-hydroxybutyrate dehydrogenase
-
-
-
-
D-3-hydroxybutyrate dehydrogenase
-
-
-
-
D-beta-hydroxybutyrate dehydrogenase
-
-
-
-
DHRS6
-
-
hydroxybutyrate oxidoreductase
-
-
-
-
NAD-beta-hydroxybutyrate dehydrogenase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
(R)-3-hydroxybutanoate:NAD+ oxidoreductase
Also oxidizes other 3-hydroxymonocarboxylic acids.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-38-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH
show the reaction diagram
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH + H+
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
phosphatidylcholine
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.71 - 12.6
(R)-3-hydroxybutanoate
0.0598 - 0.8
NAD+
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.22
-
apo-3-hydroxybutyrate dehydrogenase, reconstituted with phosphatidylcholine/phosphatidylethanolamine/diphosphatidylglycerol, 5/4/1
0.5
-
enzyme expressed in SF9 cells, S24T mutatant
0.6
-
enzyme expressed in SF9 cells, M92V mutatant
0.63
-
enzyme expressed in SF9 cells, membrane bound
0.8
-
enzyme expressed in SF9 cells, C242S mutatant
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
BDH2_HUMAN
245
0
26724
Swiss-Prot
other Location (Reliability: 5)
BDH_HUMAN
343
0
38157
Swiss-Prot
Mitochondrion (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
33117
-
alpha4, 4 * 33117, mature protein, calculated from deduced amino acid sequence
38000
-
alpha4, 4 * 38000, preprotein, calculated from deduced amino acid sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
sitting drop vapor diffusion method at 20°C, structure determined at a resolution of 1.8 A in complex with NAD(H)
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C242S
-
PCR derived cDNA clone
M92V
-
PCR derived cDNA clone
S24T
-
PCR derived cDNA clone
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
His-tagged 3-hydroxybutyrate dehydrogenase, expressed in Escherichia coli
-
mature form, expressed in Spodoptera frugiperda, SF9 cells
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Loeb-Hennard, C.; McIntyre, J.O.
(R)-3-Hydroxybutyrate dehydrogenase: selective phosphatidylcholine binding by the C-terminal domain
Biochemistry
39
11929-11938
2000
Homo sapiens
-
Manually annotated by BRENDA team
Green, D.; Marks, a.R.; Fleischer, S.; McIntyre, J.O.
Wild type and mutant human heart (R)-3-hydroxybutyrate dehydrogenase expressed in insect cells
Biochemistry
35
8158-8165
1996
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Marks, A.R.; McIntyre, J.O.; Duncan, T.M.; Erdjument-Bromage, H.; Tempst, P.; Fleischer, S.
Molecular cloning and characterization of (R)3-hydroxybutyrate dehydrogenase from human heart
J. Biol. Chem.
267
15459-15463
1992
Homo sapiens
Manually annotated by BRENDA team
Guo, K.; Lukacik, P.; Papagrigoriou, E.; Meier, M.; Lee, W.H.; Adamski, J.; Oppermann, U.
Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase
J. Biol. Chem.
281
10291-10297
2006
Homo sapiens
Manually annotated by BRENDA team