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EC Tree
The taxonomic range for the selected organisms is: Homo sapiens The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
beta-hydroxybutyrate dehydrogenase, 3-hydroxybutyrate dehydrogenase, d-beta-hydroxybutyrate dehydrogenase, d-3-hydroxybutyrate dehydrogenase, beta-hydroxybutyric dehydrogenase, dhrs6, 3-hbdh, 3-hydroxybutyrate dehydrogenase-2, beta-hydroxybutyric acid dehydrogenase, 3hbdh,
more
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3-D-hydroxybutyrate dehydrogenase
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3-hydroxybutyrate dehydrogenase
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beta-hydroxybutyrate dehydrogenase
beta-hydroxybutyric acid dehydrogenase
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beta-hydroxybutyric dehydrogenase
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D-(-)-3-hydroxybutyrate dehydrogenase
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D-3-hydroxybutyrate dehydrogenase
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D-beta-hydroxybutyrate dehydrogenase
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hydroxybutyrate oxidoreductase
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NAD-beta-hydroxybutyrate dehydrogenase
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beta-hydroxybutyrate dehydrogenase
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beta-hydroxybutyrate dehydrogenase
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(R)-3-hydroxybutanoate:NAD+ oxidoreductase
Also oxidizes other 3-hydroxymonocarboxylic acids.
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(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH + H+
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?
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH
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r
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH
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r
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH
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r
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(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH
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r
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH
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r
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH
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r
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Brain Neoplasms
The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer.
Carcinoma
Monitoring by alpha-hydroxybutyrate dehydrogenase of human ovarian carcinoma grown in nude mice.
Carcinoma, Hepatocellular
Immunochemical analysis of the membrane proteins of rat liver and Zajdela hepatoma mitochondria.
Carcinoma, Hepatocellular
Regulation of D-beta-hydroxybutyrate dehydrogenase in rat hepatoma cell lines.
Carcinoma, Hepatocellular
[Activity of the beta-hydroxybutyric dehydrogenase of mitochondria of ascitic hepatoma and of the normal rat liver.]
Cardiomegaly
Cardiac hypertrophy in spontaneously hypertensive rats. Ultrastructural cytochemistry of beta-hydroxybutyrate dehydrogenase [proceedings]
Cardiomegaly
Proceedings: Cardiac hypertrophy in spontaneously hypertensive rats. I. Chronological changes in the mitochondrial beta-hydroxybutyrate dehydrogenase activity in the myocardium.
Diabetes Mellitus
Metabolic control of the expression of mitochondrial D-beta-hydroxybutyrate dehydrogenase, a ketone body converting enzyme.
Diabetes Mellitus
The effect of spontaneous diabetes mellitus on fatty acid oxidation, beta-hydroxybutyrate dehydrogenase activity and respiratory coupling of hepatic mitochondria in the guinea-pig (Cavia porcellus).
Diabetes Mellitus
The structures of Alcaligenes faecalis D-3-hydroxybutyrate dehydrogenase before and after NAD+ and acetate binding suggest a dynamical reaction mechanism as a member of the SDR family.
Diabetes Mellitus, Experimental
Variations of specific mRNA and polypeptide contents of rat liver D-beta-hydroxybutyrate dehydrogenase during an experimental diabetes mellitus.
Fatty Liver
Deficiency of 3-hydroxybutyrate dehydrogenase (BDH1) in mice causes low ketone body levels and fatty liver during fasting.
Glioma
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.
Heart Failure
[Histochemical study of the enzyme activity of the myocardium of sudden death victims with postinfarct cardiosclerosis]
Hutchinson's Melanotic Freckle
Histochemical findings in different types of malignant melanoma: biological and clinical significance.
Hyperthyroidism
Accelerated postnatal development of D(-)- -hydroxybutyrate dehydrogenase (EC 1.1.1.30) activity in the brain in hyperthyroidism.
Hyperthyroidism
Concerning the decreased D-3-hydroxybutyrate dehydrogenase activity in the liver and heart of hyperthyroid rats.
Hyperthyroidism
Differential action of thyroid hormones on the activity of certain enzymes in rat kidney and brain.
Hyperthyroidism
Ketone-body metabolism in hyperthyroid rats: reduced activity of D-3-hydroxybutyrate dehydrogenase in both liver and heart and of succinyl-coenzyme A: 3-oxoacid coenzyme A-transferase in heart.
Hypothyroidism
Mitochondrial oxidative enzyme activity in individual fibre types in hypo- and hyperthyroid rat skeletal muscles.
Hypothyroidism
[Enzymatic and immunologic study of the role of the thyroid hormone in the formation of the internal mitochondrial membrane during postnatal development of the rat]
Infections
Neisseria gonorrhoeae modulates iron-limiting innate immune defenses in macrophages.
Iron Deficiencies
3-Hydroxybutyrate dehydrogenase-2 and ferritin-H synergistically regulate intracellular iron.
Ketosis
Effect of prenatally-induced and postnatally-maintained ketosis on beta-hydroxybutyrate dehydrogenase and hexokinase levels in the developing rat brain.
Ketosis
The structures of Alcaligenes faecalis D-3-hydroxybutyrate dehydrogenase before and after NAD+ and acetate binding suggest a dynamical reaction mechanism as a member of the SDR family.
Melanoma
Histochemical findings in different types of malignant melanoma: biological and clinical significance.
Nasopharyngeal Carcinoma
Inactivation of 3-hydroxybutyrate dehydrogenase type 2 promotes proliferation and metastasis of nasopharyngeal carcinoma by iron retention.
Neoplasm Metastasis
Inactivation of 3-hydroxybutyrate dehydrogenase type 2 promotes proliferation and metastasis of nasopharyngeal carcinoma by iron retention.
Neoplasms
Beta-hydroxybutyrate dehydrogenase activity in liver and liver tumors.
Neoplasms
Fatty acid oxidation, substrate shuttles, and activity of the citric acid cycle in hepatocellular carcinomas of varying differentiation.
Neoplasms
Loss of acetoacetate coenzyme A transferase activity in tumours of peripheral tissues.
Neoplasms
Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo.
Neoplasms
Monitoring by alpha-hydroxybutyrate dehydrogenase of human ovarian carcinoma grown in nude mice.
Neoplasms
The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer.
Obesity
Treatment with the 5-HT3 antagonist tropisetron modulates glucose-induced obesity in mice.
Reperfusion Injury
[Transmural differences between damaged cardiomyocytes due to post-ischemic reperfusion and calcium paradox]
Starvation
Activities of some key enzymes of carbohydrate, ketone body, adenosine and glutamine metabolism in liver, and brown and white adipose tissues of the rat.
Starvation
Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase.
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0.71 - 12.6
(R)-3-hydroxybutanoate
0.71
(R)-3-hydroxybutanoate
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enzyme expressed in SF9 cells
9.1
(R)-3-hydroxybutanoate
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30°C, pH 9.0
10
(R)-3-hydroxybutanoate
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enzyme expressed in SF9 cells, C242S mutant, C242 important for substrate binding
10.5
(R)-3-hydroxybutanoate
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25°C, pH 9.0
12.6
(R)-3-hydroxybutanoate
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25°C, pH 7.5
0.0598
NAD+
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25°C, pH 9.0
0.53
NAD+
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enzyme expressed in SF9 cells
0.8
NAD+
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enzyme expressed in SF9 cells, C242S mutant
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0.22
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apo-3-hydroxybutyrate dehydrogenase, reconstituted with phosphatidylcholine/phosphatidylethanolamine/diphosphatidylglycerol, 5/4/1
0.5
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enzyme expressed in SF9 cells, S24T mutatant
0.6
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enzyme expressed in SF9 cells, M92V mutatant
0.63
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enzyme expressed in SF9 cells, membrane bound
0.8
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enzyme expressed in SF9 cells, C242S mutatant
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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located on the matrix face of the inner membrane
brenda
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BDH2_HUMAN
245
0
26724
Swiss-Prot
other Location (Reliability: 5 )
BDH_HUMAN
343
0
38157
Swiss-Prot
Mitochondrion (Reliability: 1 )
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33117
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alpha4, 4 * 33117, mature protein, calculated from deduced amino acid sequence
38000
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alpha4, 4 * 38000, preprotein, calculated from deduced amino acid sequence
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tetramer
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alpha4, 4 * 38000, preprotein, calculated from deduced amino acid sequence
tetramer
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alpha4, 4 * 33117, mature protein, calculated from deduced amino acid sequence
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sitting drop vapor diffusion method at 20°C, structure determined at a resolution of 1.8 A in complex with NAD(H)
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C242S
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PCR derived cDNA clone
M92V
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PCR derived cDNA clone
S24T
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PCR derived cDNA clone
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His-tagged 3-hydroxybutyrate dehydrogenase, expressed in Escherichia coli
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mature form, expressed in Spodoptera frugiperda, SF9 cells
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Loeb-Hennard, C.; McIntyre, J.O.
(R)-3-Hydroxybutyrate dehydrogenase: selective phosphatidylcholine binding by the C-terminal domain
Biochemistry
39
11929-11938
2000
Homo sapiens
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brenda
Green, D.; Marks, a.R.; Fleischer, S.; McIntyre, J.O.
Wild type and mutant human heart (R)-3-hydroxybutyrate dehydrogenase expressed in insect cells
Biochemistry
35
8158-8165
1996
Bos taurus, Homo sapiens
brenda
Marks, A.R.; McIntyre, J.O.; Duncan, T.M.; Erdjument-Bromage, H.; Tempst, P.; Fleischer, S.
Molecular cloning and characterization of (R)3-hydroxybutyrate dehydrogenase from human heart
J. Biol. Chem.
267
15459-15463
1992
Homo sapiens
brenda
Guo, K.; Lukacik, P.; Papagrigoriou, E.; Meier, M.; Lee, W.H.; Adamski, J.; Oppermann, U.
Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase
J. Biol. Chem.
281
10291-10297
2006
Homo sapiens
brenda