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Information on EC 1.1.1.284 - S-(hydroxymethyl)glutathione dehydrogenase and Organism(s) Danio rerio

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EC Tree
IUBMB Comments
The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22, S-(hydroxymethyl)glutathione synthase. This enzyme forms part of the pathway that detoxifies formaldehyde, since the product is hydrolysed by EC 3.1.2.12, S-formylglutathione hydrolase. The human enzyme belongs to the family of zinc-dependent alcohol dehydrogenases. Also specifically reduces S-nitrosylglutathione.
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This record set is specific for:
Danio rerio
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Word Map
The taxonomic range for the selected organisms is: Danio rerio
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
nitroreductase, gsnor, s-nitrosoglutathione reductase, gsno reductase, gsnor1, adh iii, gsno-r, alcohol dehydrogenase class iii, slgsnor, formic dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Alcohol dehydrogenase SFA
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-
-
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dehydrogenase, formaldehyde
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-
-
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FALDH
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-
-
-
FDH
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-
-
-
FLD
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-
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-
formaldehyde dehydrogenase
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-
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formic dehydrogenase
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-
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GD-FAlDH
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NAD-linked formaldehyde dehydrogenase
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
S-(hydroxymethyl)glutathione:NAD+ oxidoreductase
The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22, S-(hydroxymethyl)glutathione synthase. This enzyme forms part of the pathway that detoxifies formaldehyde, since the product is hydrolysed by EC 3.1.2.12, S-formylglutathione hydrolase. The human enzyme belongs to the family of zinc-dependent alcohol dehydrogenases. Also specifically reduces S-nitrosylglutathione.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-84-6
-
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q6NXA6_DANRE
376
0
40032
TrEMBL
other Location (Reliability: 2)
A0A8M1P9C8_DANRE
376
0
40032
TrEMBL
other Location (Reliability: 2)
Q90XD4_DANRE
376
0
40046
TrEMBL
other Location (Reliability: 2)