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Disease on EC 1.1.1.270 - 3beta-hydroxysteroid 3-dehydrogenase

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DISEASE
TITLE OF PUBLICATION
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11beta-hydroxysteroid dehydrogenase deficiency
Epidemiologic study of adrenal gland disorders in Japan.
3(or 17)beta-hydroxysteroid dehydrogenase deficiency
Characterization of two novel homozygous missense mutations involving codon 6 and 259 of type II 3beta-hydroxysteroid dehydrogenase (3betaHSD) gene causing, respectively, nonsalt-wasting and salt-wasting 3betaHSD deficiency disorder.
Male pseudohermaphroditism consistent with 17,20-desmolase deficiency.
Masculinizing genitoplasty in intersex patients.
New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency: identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzymes.
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor) deficiency
Masculinizing genitoplasty in intersex patients.
3beta-hydroxy-delta5-steroid dehydrogenase deficiency
Carriers for type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) deficiency can only be identified by HSD3B2 genotype study and not by hormone test.
3beta-hydroxysteroid 3-dehydrogenase deficiency
A new insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency.
A novel A10E homozygous mutation in the HSD3B2 gene causing severe salt-wasting 3beta-hydroxysteroid dehydrogenase deficiency in 46,XX and 46,XY French-Canadians: evaluation of gonadal function after puberty.
An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency.
An inborn error of bile acid synthesis (3beta-hydroxy-delta5-C27-steroid dehydrogenase deficiency) presenting as malabsorption leading to rickets.
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
Definitive diagnosis of enzymatic deficiencies of steroidogenesis in at-risk newborns and infants by urinary marker analysis using GC/MS-SIM.
Delayed diagnosis of congenital adrenal hyperplasia with salt wasting due to type II 3beta-hydroxysteroid dehydrogenase deficiency.
Determination of 17alpha-hydroxypregnenolone in human plasma by routine isotope dilution mass spectrometry using benchtop gas chromatography-mass selective detection.
Evaluation of the tubular and interstitial functions of the testis in 46,XY patients with ambiguous genitalia.
Human 3beta-hydroxysteroid dehydrogenase deficiency associated with normal spermatic numeration despite a severe enzyme deficit.
Hydrops of placental stem villi complicated with fetal congenital adrenal hyperplasia.
Masculinizing genitoplasty in intersex patients.
Mutations in the type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) gene can cause premature pubarche in girls.
New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency: identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzymes.
Newly proposed hormonal criteria via genotypic proof for type II 3beta-hydroxysteroid dehydrogenase deficiency.
Plasma 17-OH pregnenolone: comparison of a time-resolved fluoroimmunoassay using a new tracer 17-OH pregnenolone-3-oxyacetyl-biotine with a radioimmunoassay using 125I 17-OH pregnenolone-3-hemisuccinate-histamine.
Prevalence of 3beta-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia in hyperandrogenic women with adrenal androgen excess.
Rapid second-tier molecular genetic analysis for congenital adrenal hyperplasia attributable to steroid 21-hydroxylase deficiency.
Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping.
Testicular endocrine function in a pubertal boy with 3beta-hydroxysteroid dehydrogenase deficiency.
The Molecular and Clinical Spectrum of 3beta-hydroxysteroid Dehydrogenase Deficiency Disorder.
Variable clinical spectrum of the most common inborn error of bile acid metabolism--3beta-hydroxy-Delta 5-C27-steroid dehydrogenase deficiency.
[3Beta-hydroxysteroid dehydrogenase deficiency]
[Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase deficiency]
Abortion, Spontaneous
Genetic variation in the HSD3B1 gene and recurrent spontaneous abortions.
Metabolism of cholesterol and progesterone is differentially regulated in primary trophoblastic subtypes and might be disturbed in recurrent miscarriages.
Acne Vulgaris
Association of HSD17B3 and HSD3B1 polymorphisms with acne vulgaris in Southwestern Han Chinese.
Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone.
Acquired Immunodeficiency Syndrome
Cisplatin resistance by induction of aldo-keto reductase family 1 member C2 in human bladder cancer cells.
Addison Disease
Epidemiologic study of adrenal gland disorders in Japan.
Adenocarcinoma
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma.
Adenoma
Cushing's syndrome due to bilateral adrenocortical adenomas with unique histological features.
Ectopic cortisol-producing adrenocortical adenoma in the renal hilum: histopathological features and steroidogenic enzyme profile.
Immunohistochemical study of cytochrome b5 in human adrenal gland and in adrenocortical adenomas from patients with Cushing's syndrome.
Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis.
Adrenal Hyperplasia, Congenital
A novel A10E homozygous mutation in the HSD3B2 gene causing severe salt-wasting 3beta-hydroxysteroid dehydrogenase deficiency in 46,XX and 46,XY French-Canadians: evaluation of gonadal function after puberty.
A novel homozygous nonsense mutations E135* in the type II 3beta-hydroxysteroid dehydrogenase gene in a girl with salt-losing congenital adrenal hyperplasia. Mutations in brief no. 168. Online.
A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene causing, respectively, nonclassic and classic 3beta-HSD deficiency congenital adrenal hyperplasia.
An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency.
Carboxyl-Terminal Mutations in 3{beta}-Hydroxysteroid Dehydrogenase Type II Cause Severe Salt-Wasting Congenital Adrenal Hyperplasia.
Carriers for type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) deficiency can only be identified by HSD3B2 genotype study and not by hormone test.
Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase deficiency.
Delayed diagnosis of congenital adrenal hyperplasia with salt wasting due to type II 3beta-hydroxysteroid dehydrogenase deficiency.
Sonography of congenital adrenal hyperplasia due to partial deficiency of 3beta-hydroxysteroid dehydrogenase: a case report.
The Molecular and Clinical Spectrum of 3beta-hydroxysteroid Dehydrogenase Deficiency Disorder.
[Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase deficiency]
Adrenal Rest Tumor
An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency.
Adrenocortical Carcinoma
Decrease in the expression of the 3beta-hydroxysteroid dehydrogenase gene in human adrenal tissue during prepuberty and early puberty: implications for the mechanism of adrenarche.
Adrenocortical Hyperfunction
Changes in ultrasonographic appearance of adrenal glands in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane.
Results of clinical examinations, laboratory tests, and ultrasonography in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane.
Study of the effects of once daily doses of trilostane on cortisol concentrations and responsiveness to adrenocorticotrophic hormone in hyperadrenocorticoid dogs.
Alopecia
Higher levels of steroidogenic acute regulatory protein and type I 3beta-hydroxysteroid dehydrogenase in the scalp of men with androgenetic alopecia.
HSD3B1 gene polymorphism and female pattern hair loss in women with polycystic ovary syndrome.
Treatment of canine Alopecia X with trilostane.
Androgen-Insensitivity Syndrome
Evaluation of the tubular and interstitial functions of the testis in 46,XY patients with ambiguous genitalia.
Masculinizing genitoplasty in intersex patients.
Asthma
HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma.
Barrett Esophagus
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma.
Breast Neoplasms
Adrenal-permissive HSD3B1 genetic inheritance and risk of estrogen-driven postmenopausal breast cancer.
Analysis of 17beta-hydroxysteroid dehydrogenase types 5, 7, and 12 genetic sequence variants in breast cancer cases from French Canadian Families with high risk of breast and ovarian cancer.
Expression of 3?-Hydroxysteroid Dehydrogenase Type 1 in Breast Cancer is Associated with Poor Prognosis Independent of Estrogen Receptor Status.
Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.
Genetic Variation in the Progesterone Receptor and Metabolism Pathways and Hormone Therapy in Relation to Breast Cancer Risk.
Identification of miR-193b targets in breast cancer cells and systems biological analysis of their functional impact.
Induction of 1C aldoketoreductases and other drug dose-dependent genes upon acquisition of anthracycline resistance.
Induction of 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13.
Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.
Inhibition of 3?-Hydroxysteroid Dehydrogenase Type 1 Suppresses Interleukin-6 in Breast Cancer.
Intratumoral estrogen disposition in breast cancer.
In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis.
Non-competitive steroid inhibition of oestrogen receptor functions.
Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.
Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.
Stromal markers AKR1C1 and AKR1C2 are prognostic factors in primary human breast cancer.
Structural basis for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase 1 in human breast tumor MCF-7 cells.
Structure/function of the inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane.
The functions of key residues in the inhibitor, substrate and cofactor sites of human 3beta-hydroxysteroid dehydrogenase type 1 are validated by mutagenesis.
The higher affinity of human type 1 3beta-hydroxysteroid dehydrogenase (3beta-HSD1) for substrate and inhibitor steroids relative to human 3beta-HSD2 is validated in MCF-7 tumor cells and related to subunit interactions.
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
The Stimulation of HSD17B7 Expression by Estradiol Provides a Powerful Feed-Forward Mechanism for Estradiol Biosynthesis in Breast Cancer Cells.
Trilostane, a 3?-hydroxysteroid dehydrogenase inhibitor, suppresses growth of hepatocellular carcinoma and enhances anti-cancer effects of sorafenib.
Carcinogenesis
AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway.
AKR1C2 small interfering RNA (siRNA) inhibited beta-catenin expression and transcriptional activation in human liver cancer cell line QGY7701.
Differential proteomic analysis of hepatocellular carcinoma.
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma.
Small interfering RNA (siRNA) inhibited human liver cancer cell line SMMC7721 proliferation and tumorigenesis.
Up-Regulated AKR1C2 is correlated with favorable prognosis in thyroid carcinoma.
Carcinoma
AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway.
Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal, akr1c2, and rab11a expression.
Expression of MEL-CAM and HSD3B1 in cervical carcinoma.
HSD3B1 as a novel trophoblast-associated marker that assists in the differential diagnosis of trophoblastic tumors and tumorlike lesions.
HSD3B1 is a specific trophoblast-associated marker not expressed in a wide spectrum of tumors.
Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.
Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis.
Steroid-converting enzymes in human ovarian carcinomas.
Stromal markers AKR1C1 and AKR1C2 are prognostic factors in primary human breast cancer.
The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoateinduced esophageal squamous cell carcinoma cell death.
Carcinoma, Ductal
The Stimulation of HSD17B7 Expression by Estradiol Provides a Powerful Feed-Forward Mechanism for Estradiol Biosynthesis in Breast Cancer Cells.
Carcinoma, Ovarian Epithelial
Steroid-converting enzymes in human ovarian carcinomas.
Carcinoma, Squamous Cell
Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal, akr1c2, and rab11a expression.
Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.
Chondrodysplasia Punctata
Genetic disorders of cholesterol biosynthesis in mice and humans.
Choriocarcinoma
HSD3B1 as a novel trophoblast-associated marker that assists in the differential diagnosis of trophoblastic tumors and tumorlike lesions.
Oestrogen formation from C19 precursors in human choriocarcinoma in culture.
Cryptorchidism
Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice.
Cystitis, Interstitial
Differentiation associated changes in gene expression profiles of interstitial cystitis and control urothelial cells.
Diabetes Mellitus, Type 1
3beta-hydroxysteroid dehydrogenase autoantibodies are rare in premature ovarian failure.
Diabetes Mellitus, Type 2
[Ginkgo biloba extract enhances testosterone synthesis of Leydig cells in type 2 diabetic rats]
Disorder of Sex Development, 46,XY
Masculinizing genitoplasty in intersex patients.
The Molecular and Clinical Spectrum of 3beta-hydroxysteroid Dehydrogenase Deficiency Disorder.
Disorders of Sex Development
[Rare forms of female pseudohermaphroditism: when to investigate?]
Distemper
Distribution of 3beta-hydroxysteroid dehydrogenase in the cerebellum in canine distemper virus infection.
Endometrial Neoplasms
Expression of enzyme associated with steroid hormone synthesis and local production of steroid hormone in endometrial carcinoma cells.
Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines.
Endometriosis
Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.
Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: Potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins.
Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis.
Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions.
Esophageal Squamous Cell Carcinoma
AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway.
The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoateinduced esophageal squamous cell carcinoma cell death.
Essential Hypertension
Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension.
Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure.
Glaucoma
HSD18B7 Enzyme Assay Technique Using a Triple Quadrupole Mass Spectrometer.
Gonadal Dysgenesis
Evaluation of the tubular and interstitial functions of the testis in 46,XY patients with ambiguous genitalia.
Gonadal Dysgenesis, Mixed
Masculinizing genitoplasty in intersex patients.
Herpes Zoster
A case of aldosterone-producing adenoma with severe postoperative hyperkalemia.
A case with primary aldosteronism due to unilateral multiple adrenocortical micronodules.
Androgen synthesis in adrenarche.
Angiotensin II triggers expression of the adrenal gland zona glomerulosa-specific 3?-hydroxysteroid dehydrogenase isoenzyme through de novo protein synthesis of the orphan nuclear receptors NGFIB and NURR1.
Changes in the glomerulosa cell phenotype during adrenal regeneration in rats.
Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging.
Development of monoclonal antibodies against the human 3?-hydroxysteroid dehydrogenase/isomerase isozymes.
Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF-2 deficient mice.
Morphometric and statistical analysis of macro- and microscopic characteristics of the brain and their relationships with adrenocortical histophysiology in newborn rats.
Properties of rat adrenal zona reticularis cells: preparation by gravitational sedimentation.
Role of Cryptochrome-1 and Cryptochrome-2 in Aldosterone-Producing Adenomas and Adrenocortical Cells.
Unique cases of unilateral hyperaldosteronemia due to multiple adrenocortical micronodules, which can only be detected by selective adrenal venous sampling.
Hirsutism
3{alpha}-Hydroxysteroid Dehydrogenase Type III Deficiency: A Novel Mechanism for Hirsutism.
Genotyping of the type II 3beta-hydroxysteroid dehydrogenase gene (HSD3B2) in women with hirsutism and elevated ACTH-stimulated delta(5)-steroids.
Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping.
Hydatidiform Mole
HSD3B1 as a novel trophoblast-associated marker that assists in the differential diagnosis of trophoblastic tumors and tumorlike lesions.
Hyperaldosteronism
A case with primary aldosteronism due to unilateral multiple adrenocortical micronodules.
Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II.
Development of monoclonal antibodies against the human 3?-hydroxysteroid dehydrogenase/isomerase isozymes.
Hypertension
Genetic associations with hypertension: meta-analyses of six candidate genetic variants.
Hypertension, Pregnancy-Induced
Estrogen synthesis genes CYP19A1, HSD3B1, and HSD3B2 in hypertensive disorders of pregnancy.
Hypospadias
Characterization of two novel homozygous missense mutations involving codon 6 and 259 of type II 3beta-hydroxysteroid dehydrogenase (3betaHSD) gene causing, respectively, nonsalt-wasting and salt-wasting 3betaHSD deficiency disorder.
Defects of the testosterone biosynthetic pathway in boys with hypospadias.
Dysregulated expression of androgen metabolism genes and genetic analysis in hypospadias.
Fine mapping analysis confirms and strengthens linkage of four chromosomal regions in familial hypospadias.
Lack of defects in androgen production in children with hypospadias.
Infections
HIV-1 clade C infection and progressive disruption in the relationship between cortisol, DHEAS and CD4 cell numbers: a two-year follow-up study.
Liver receptor homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone-induced granulosa cell differentiation.
Insulin Resistance
An analysis of the relationship between insulin resistance and the activity of steroid C17,20-lyase and 3beta-hydroxysteroid dehydrogenase in ovaries and adrenals in women with polycystic ovary syndrome.
Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity.
The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency.
Klinefelter Syndrome
Masculinizing genitoplasty in intersex patients.
Liver Diseases
An inborn error of bile acid synthesis (3beta-hydroxy-delta5-C27-steroid dehydrogenase deficiency) presenting as malabsorption leading to rickets.
Liver Neoplasms
AEG-1 Promotes Metastasis Through Downstream AKR1C2 and NF1 in Liver Cancer.
AKR1C1-3, notably AKR1C3, are distinct biomarkers for liver cancer diagnosis and prognosis: Database mining in malignancies.
AKR1C2 small interfering RNA (siRNA) inhibited beta-catenin expression and transcriptional activation in human liver cancer cell line QGY7701.
Growth factor NUN increased AKR1C2 expression by activated CDK2 related RB signal transduction pathway in human liver cancer cell line.
High-Content Functional Screening of AEG-1 and AKR1C2 for the Promotion of Metastasis in Liver Cancer.
Small interfering RNA (siRNA) inhibited human liver cancer cell line SMMC7721 proliferation and tumorigenesis.
Lung Neoplasms
NNK reduction pathway gene polymorphisms and risk of lung cancer.
Lymphatic Metastasis
AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway.
Metabolism, Inborn Errors
Genetic disorders of cholesterol biosynthesis in mice and humans.
Mevalonate Kinase Deficiency
Genetic disorders of cholesterol biosynthesis in mice and humans.
Molluscum Contagiosum
Similarity in genome organization between Molluscum contagiosum virus (MCV) and vaccinia virus (VV): identification of MCV homologues of the VV genes for protein kinase 2, structural protein VP8, RNA polymerase 35 kDa subunit and 3beta-hydroxysteroid dehydrogenase.
Neoplasm Metastasis
AEG-1 Promotes Metastasis Through Downstream AKR1C2 and NF1 in Liver Cancer.
AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway.
Association of HSD3B1 Genotype With Response to Androgen-Deprivation Therapy for Biochemical Recurrence After Radiotherapy for Localized Prostate Cancer.
EGFR-PKM2 signaling promotes the metastatic potential of nasopharyngeal carcinoma through induction of FOSL1 and ANTXR2.
High-Content Functional Screening of AEG-1 and AKR1C2 for the Promotion of Metastasis in Liver Cancer.
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth.
Neoplasms
A case of aldosterone-producing adenoma with severe postoperative hyperkalemia.
Adrenocortical carcinoma manifesting pure primary aldosteronism: a case report and analysis of steroidogenic enzymes.
An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency.
Bilateral aldosteronoma associated with secondary aldosteronism in a chronic hemodialysis subject.
Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen.
Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal, akr1c2, and rab11a expression.
Enzyme histochemical and electron microscopic study of a virilizing adrenocortical adenoma.
Expression of 3?-Hydroxysteroid Dehydrogenase Type 1 in Breast Cancer is Associated with Poor Prognosis Independent of Estrogen Receptor Status.
Gene expression of androgen metabolising enzymes in benign prostatic hyperplasia.
Germline polymorphisms associated with impaired survival outcomes and somatic tumor alterations in advanced prostate cancer.
HSD3B1 as a novel trophoblast-associated marker that assists in the differential diagnosis of trophoblastic tumors and tumorlike lesions.
HSD3B1 is a specific trophoblast-associated marker not expressed in a wide spectrum of tumors.
Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2.
Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling.
Incidentally detected giant oncocytoma arising in retroperitoneal heterotopic adrenal tissue.
Intratumoral estrogen disposition in breast cancer.
Localization and altered expression of AKR1C family members in human ovarian tissues.
Long-term in vitro treatment of human glioblastoma cells with temozolomide increases resistance in vivo through up-regulation of GLUT transporter and aldo-keto reductase enzyme AKR1C expression.
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth.
Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.
Modulated expression of genes encoding estrogen metabolizing enzymes by G1-phase cyclin-dependent kinases 6 and 4 in human breast cancer cells.
Origin and evolution of somatic cell testicular tumours in transgenic mice.
Overexpression of aldo-keto reductase 1C2 as a high-risk factor in bladder cancer.
Preclinical Evaluation of the Supercritical Extract of Azadirachta Indica (Neem) Leaves In Vitro and In Vivo on Inhibition of Prostate Cancer Tumor Growth.
Prevalence and Prognostic Value of the Polymorphic Variant 1245A>C of HSD3B1 in Castration-resistant Prostate Cancer.
Quantitative analysis of the human AKR family members in cancer cell lines using the mTRAQ/MRM approach.
Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.
Small interfering RNA (siRNA) inhibited human liver cancer cell line SMMC7721 proliferation and tumorigenesis.
Sprouty2 loss-induced IL6 drives castration-resistant prostate cancer through scavenger receptor B1.
Stromal markers AKR1C1 and AKR1C2 are prognostic factors in primary human breast cancer.
The higher affinity of human type 1 3beta-hydroxysteroid dehydrogenase (3beta-HSD1) for substrate and inhibitor steroids relative to human 3beta-HSD2 is validated in MCF-7 tumor cells and related to subunit interactions.
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
The Stimulation of HSD17B7 Expression by Estradiol Provides a Powerful Feed-Forward Mechanism for Estradiol Biosynthesis in Breast Cancer Cells.
TMPRSS2-ERG fusions confer efficacy of enzalutamide in an in vivo bone tumor growth model.
Trilostane, a 3?-hydroxysteroid dehydrogenase inhibitor, suppresses growth of hepatocellular carcinoma and enhances anti-cancer effects of sorafenib.
Up-Regulated AKR1C2 is correlated with favorable prognosis in thyroid carcinoma.
Nevus
Mutations in the NSDHL gene, encoding a 3beta-hydroxysteroid dehydrogenase, cause CHILD syndrome.
Obesity, Abdominal
Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity.
Obstetric Labor, Premature
Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2.
Overweight
HSD3B1 gene polymorphism and female pattern hair loss in women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
An analysis of the relationship between insulin resistance and the activity of steroid C17,20-lyase and 3beta-hydroxysteroid dehydrogenase in ovaries and adrenals in women with polycystic ovary syndrome.
Concentration of unconjugated adrenogenic hormones and their precursors in normal and polycystic ovaries.
HSD3B1 gene polymorphism and female pattern hair loss in women with polycystic ovary syndrome.
The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency.
Pre-Eclampsia
Estrogen synthesis genes CYP19A1, HSD3B1, and HSD3B2 in hypertensive disorders of pregnancy.
Primary Ovarian Insufficiency
3beta-hydroxysteroid dehydrogenase autoantibodies are rare in premature ovarian failure.
Human leukocyte antigen-DQB1* genotypes encoding aspartate at position 57 are associated with 3beta-hydroxysteroid dehydrogenase autoimmunity in premature ovarian failure.
Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity.
Prostatic Hyperplasia
Pre-receptor regulation of the androgen receptor.
Prostatic Neoplasms
3beta-hydroxysteroid dehydrogenase is a possible pharmacological target in the treatment of castration-resistant prostate cancer.
AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells.
Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol.
AR Signaling in Prostate Cancer Regulates a Feed-Forward Mechanism of Androgen Synthesis by Way of HSD3B1 Upregulation.
Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk.
Association of HSD3B1 Genotype With Response to Androgen-Deprivation Therapy for Biochemical Recurrence After Radiotherapy for Localized Prostate Cancer.
Association of Missense Polymorphism in HSD3B1 With Outcomes Among Men With Prostate Cancer Treated With Androgen-Deprivation Therapy or Abiraterone.
Examining HSD3B1 as a possible biomarker to detect prostate cancer patients who are likely to progress on ADT.
Germline HSD3B1 Genetics and Prostate Cancer Outcomes.
Germline Variant in HSD3B1 (1245 A > C) and Response to Abiraterone Acetate Plus Prednisone in Men With New-Onset Metastatic Castration-Resistant Prostate Cancer.
HSD3B1 (1245A>C) germline variant and clinical outcomes in metastatic castration-resistant prostate cancer patients treated with abiraterone and enzalutamide: results from two prospective studies.
HSD3B1 and resistance to androgen-deprivation therapy in prostate cancer: a retrospective, multicohort study.
HSD3B1 and Response to a Nonsteroidal CYP17A1 Inhibitor in Castration-Resistant Prostate Cancer.
HSD3B1 Genotype and Clinical Outcomes in Metastatic Castration-Sensitive Prostate Cancer.
HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond.
HSD3B1 status as a biomarker of androgen deprivation resistance and implications for prostate cancer.
HSD3B1 variant and androgen-deprivation therapy outcome in prostate cancer.
Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.
Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling.
Independent Validation of Effect of HSD3B1 Genotype on Response to Androgen-Deprivation Therapy in Prostate Cancer.
In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis.
Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility.
Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer.
Overexpression of aldo-keto reductase 1C2 is associated with disease progression in patients with prostatic cancer.
Prevalence and Prognostic Value of the Polymorphic Variant 1245A>C of HSD3B1 in Castration-resistant Prostate Cancer.
Prostate cancer: HSD3B1 variant confers inferior ADT outcomes.
Prostate cancer: Response prediction with HSD3B1.
Re: HSD3B1 and Resistance to Androgen-Deprivation Therapy in Prostate Cancer: A Retrospective, Multicohort Study.
Role of human type 3 3alpha-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells.
Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism.
Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer.
The association between missense polymorphisms in SRD5A2 and HSD3B1 and treatment failure with abiraterone for castration-resistant prostate cancer.
Treatment with abiraterone and enzalutamide does not overcome poor outcome from metastatic castration-resistant prostate cancer in men with the germline homozygous HSD3B1 c.1245C genotype.
Variant allele of HSD3B1 increases progression to castration-resistant prostate cancer.
Prostatic Neoplasms, Castration-Resistant
Overexpression of aldo-keto reductase 1C2 is associated with disease progression in patients with prostatic cancer.
Pseudohypoaldosteronism
Epidemiologic study of adrenal gland disorders in Japan.
Rickets
An inborn error of bile acid synthesis (3beta-hydroxy-delta5-C27-steroid dehydrogenase deficiency) presenting as malabsorption leading to rickets.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia and P450 oxidoreductase deficiency.
steroid 17alpha-monooxygenase deficiency
Defects of the testosterone biosynthetic pathway in boys with hypospadias.
steroid 21-monooxygenase deficiency
A case of 3beta-hydroxysteroid dehydrogenase type II (HSD3B2) deficiency picked up by neonatal screening for 21-hydroxylase deficiency: difficulties and delay in etiologic diagnosis.
Definitive diagnosis of enzymatic deficiencies of steroidogenesis in at-risk newborns and infants by urinary marker analysis using GC/MS-SIM.
steroid delta-isomerase deficiency
A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene causing, respectively, nonclassic and classic 3beta-HSD deficiency congenital adrenal hyperplasia.
Stomach Neoplasms
Cholesterol import and steroidogenesis are biosignatures for gastric cancer patient survival.
Testicular Neoplasms
Immunohistochemical detection of inhibin-alpha, -betaB, and -betaA chains and 3beta-hydroxysteroid dehydrogenase in canine testicular tumors and normal testes.
Use of antibodies against LH receptor, 3beta-hydroxysteroid dehydrogenase and vimentin to characterize different types of testicular tumour in dogs.
Thyroid Cancer, Papillary
Up-Regulated AKR1C2 is correlated with favorable prognosis in thyroid carcinoma.
Thyroid Neoplasms
Up-Regulated AKR1C2 is correlated with favorable prognosis in thyroid carcinoma.
Trophoblastic Neoplasms
HSD3B1 as a novel trophoblast-associated marker that assists in the differential diagnosis of trophoblastic tumors and tumorlike lesions.
Tuberculosis
Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.
Urinary Bladder Neoplasms
Cisplatin resistance by induction of aldo-keto reductase family 1 member C2 in human bladder cancer cells.
Overexpression of aldo-keto reductase 1C2 as a high-risk factor in bladder cancer.
Uterine Diseases
Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases.
Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: Potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins.
In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis.
Vaccinia
Similarity in genome organization between Molluscum contagiosum virus (MCV) and vaccinia virus (VV): identification of MCV homologues of the VV genes for protein kinase 2, structural protein VP8, RNA polymerase 35 kDa subunit and 3beta-hydroxysteroid dehydrogenase.
Virus Diseases
Distribution of 3beta-hydroxysteroid dehydrogenase in the cerebellum in canine distemper virus infection.
Vitamin A Deficiency
Effect of vitamin A deficiency on 3beta-hydroxysteroid dehydrogenase activity and corticosterone in the rat adrenal.
Xanthomatosis
A novel somatic mutation of the 3beta-hydroxysteroid dehydrogenase gene in sporadic cutaneous verruciform xanthoma.