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Information on EC 1.1.1.27 - L-lactate dehydrogenase and Organism(s) Danio rerio

for references in articles please use BRENDA:EC1.1.1.27
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IUBMB Comments
Also oxidizes other (S)-2-hydroxymonocarboxylic acids. NADP+ also acts, more slowly, with the animal, but not the bacterial, enzyme.
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This record set is specific for:
Danio rerio
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The taxonomic range for the selected organisms is: Danio rerio
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
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(S)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+
+
=
+
+
Synonyms
lactate dehydrogenase, lactic dehydrogenase, ldh-a, lactate dehydrogenase a, l-lactate dehydrogenase, ldh-5, lactic acid dehydrogenase, ldh-1, pfldh, alpha-hydroxybutyrate dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dehydrogenase, lactate
-
-
-
-
Epsilon crystallin
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-
-
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epsilon-crystallin
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-
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Immunogenic protein p36
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-
-
-
L(+)-nLDH
-
-
-
-
L-(+)-lactate dehydrogenase
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-
-
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L-lactic acid dehydrogenase
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-
-
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L-lactic dehydrogenase
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-
-
-
L-LDH
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-
-
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lactate dehydrogenase
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-
-
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lactate dehydrogenase NAD-dependent
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-
-
-
lactic acid dehydrogenase
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-
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lactic dehydrogenase
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-
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LDH
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-
-
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NAD-lactate dehydrogenase
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-
-
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proteins, specific or class, anoxic stress response, p34
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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-
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-
SYSTEMATIC NAME
IUBMB Comments
(S)-lactate:NAD+ oxidoreductase
Also oxidizes other (S)-2-hydroxymonocarboxylic acids. NADP+ also acts, more slowly, with the animal, but not the bacterial, enzyme.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-60-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
pyruvate + NADH + H+
(S)-lactate + NAD+
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADH
-
coenzyme
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
-
KM-values at position of temperatur minimum
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
LDHBA_DANRE
334
0
36247
Swiss-Prot
other Location (Reliability: 4)
LDHBB_DANRE
334
0
36710
Swiss-Prot
other Location (Reliability: 4)
LDHA_DANRE
333
0
36246
Swiss-Prot
other Location (Reliability: 2)
E9QH54_DANRE
134
0
14727
TrEMBL
other Location (Reliability: 2)
E9QGA6_DANRE
300
0
32829
TrEMBL
other Location (Reliability: 4)
Q7ZVJ4_DANRE
333
0
36274
TrEMBL
other Location (Reliability: 2)
B2GRW6_DANRE
334
0
36710
TrEMBL
other Location (Reliability: 4)
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
73.5
-
30 min, 50% loss of activity
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Klyachko, O.S.; Ozernyuk, N.D.
Functional and structural properties of lactate dehydrogenase from embryos of different fishes
Comp. Biochem. Physiol. B
119
77-80
1998
Acipenser baerii, Acipenser ruthenus, Danio rerio, Carassius auratus, Cyprinus carpio, Coregonus autumnalis, Coregonus sardinella, Misgurnus fossilis, Oncorhynchus mykiss, Salmo salar
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Manually annotated by BRENDA team