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Information on EC 1.1.1.267 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC1.1.1.267
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IUBMB Comments
The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with the first being most effective. The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, {terp/nonMVA}). The mechanism has been shown to be a retroaldol/aldol reaction .
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This record set is specific for:
Pseudomonas aeruginosa
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Word Map
The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms
Synonyms
1-deoxy-d-xylulose 5-phosphate reductoisomerase, 1-deoxy-d-xylulose-5-phosphate reductoisomerase, 1-deoxy-d-xylulose-5-phosphate, pfdxr, dxp reductoisomerase, mep synthase, cadxr, doxp reductoisomerase, deoxyxylulose 5-phosphate reductoisomerase, mtdxr, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-deoxy-D-xylulose 5-phosphate isomeroreductase
-
-
-
-
2-C-methyl-D-erythritol 4-phosphate synthase
-
-
-
-
deoxyxylulose 5-phosphate reductoisomerase
-
-
-
-
DXP reductoisomerase
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-
-
-
DXP-reductoisomerase
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
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redox reaction
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-
-
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reduction
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)
The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with the first being most effective. The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, {terp/nonMVA}). The mechanism has been shown to be a retroaldol/aldol reaction [2].
CAS REGISTRY NUMBER
COMMENTARY hide
210756-42-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-deoxy-D-xylulose 5-phosphate + NADPH + H+
2-C-methyl-D-erythritol 4-phosphate + NADP+
show the reaction diagram
-
-
-
ir
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1-deoxy-D-xylulose 5-phosphate + NADPH + H+
2-C-methyl-D-erythritol 4-phosphate + NADP+
show the reaction diagram
-
-
-
ir
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-hydroxy-5-phenylpyridin-2(1H)-one
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minimal inhibitory concentration for growth 0.05 mM
4-benzylbenzene-1,2-diol
-
minimal inhibitory concentration for growth 0.2 mM
biphenyl-3,4-diol
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minimal inhibitory concentration for growth 0.2 mM
fosmidomycin
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A8F9JJJ2_PSEAI
396
0
42508
TrEMBL
-
A0A8G1K942_PSEAI
396
0
42499
TrEMBL
-
A0A8G2Z4S4_PSEAI
396
0
42442
TrEMBL
-
A0A0Q3M0H2_PSEAI
396
0
42495
TrEMBL
-
A0A8G3GK88_PSEAI
396
0
42509
TrEMBL
-
A0A8G4DYB2_PSEAI
396
0
42528
TrEMBL
-
A0A509JIM5_PSEAI
396
0
42518
TrEMBL
-
A0A8G3UYS6_PSEAI
396
0
42493
TrEMBL
-
A0A8G3MRZ7_PSEAI
396
0
42479
TrEMBL
-
A0A3S3TXW8_PSEAI
396
0
42542
TrEMBL
-
A0A8G7HI70_PSEAI
396
0
42499
TrEMBL
-
A0A0C7D1T5_PSEAI
396
0
42509
TrEMBL
-
A0A8G6YR25_PSEAI
396
0
42558
TrEMBL
-
A0A8G5CU26_PSEAI
396
0
42521
TrEMBL
-
A0A0A8REZ1_PSEAI
396
0
42486
TrEMBL
-
A0A8G6FFH5_PSEAI
396
0
42535
TrEMBL
-
A0A8G3ZP14_PSEAI
396
0
42475
TrEMBL
-
A0A8G2VWI3_PSEAI
396
0
42551
TrEMBL
-
A0A2R3IYV5_PSEAI
396
0
42602
TrEMBL
-
A0A8B4ZJB8_PSEAI
396
0
42537
TrEMBL
-
A0A485EIU2_PSEAI
536
5
57595
TrEMBL
-
A0A7M3AXH8_PSEAI
396
0
42509
TrEMBL
-
A0A8F9K191_PSEAI
396
0
42537
TrEMBL
-
A0A485EG63_PSEAI
132
0
14419
TrEMBL
-
A0A3M5EX05_PSEAI
316
0
33986
TrEMBL
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
of recombinant protein
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
overexpression in Escherichia coli
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Altincicek, B.; Hintz, M.; Sanderbrand, S.; Wiesner, J.; Beck, E.; Jomaa, H.
Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa
FEMS Microbiol. Lett.
190
329-333
2000
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Deng, L.; Sundriyal, S.; Rubio, V.; Shi, Z.Z.; Song, Y.
Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase
J. Med. Chem.
52
6539-6542
2009
Bacillus anthracis, Escherichia coli, Micrococcus luteus, Pseudomonas aeruginosa
Manually annotated by BRENDA team