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Information on EC 1.1.1.225 - chlordecone reductase and Organism(s) Homo sapiens

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EC Tree
     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.225 chlordecone reductase
IUBMB Comments
Chlordecone is an organochlorine pesticide.
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
chlordecone reductase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CDR
-
-
-
-
reductase, chlordecone
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
chlordecone-alcohol:NADP+ 2-oxidoreductase
Chlordecone is an organochlorine pesticide.
CAS REGISTRY NUMBER
COMMENTARY hide
102484-73-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH
chlordecone alcohol + NADP+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
no activity with NADH
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cu2+
-
slight inhibition
Ethacrynic acid
-
-
Hg2+
-
slight inhibition
indomethacin
-
-
p-chloromercuribenzoate
-
-
quercetin
-
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.003
Chlordecone
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.008
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
-
2 optima: pH 7.5 and 9.0
9
-
2 optima: pH 7.5 and 9.0
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
AK1C4_HUMAN
323
0
37067
Swiss-Prot
other Location (Reliability: 2)
PDB
SCOP
CATH
UNIPROT
ORGANISM
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-70°C, 50% glycerol
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
-
gene is located on chromosome 10 at 10p14-p15
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Molowa, D.T.; Wrighton, S.A.; Blanke, R.V.; Guzelian, P.S.
Characterization of a unique aldo-keto reductase responsible for the reduction of chlordecone in the liver of the gerbil and man
J. Toxicol. Environ. Health
17
375-384
1986
Homo sapiens, Meriones unguiculatus, no activity in Cavia porcellus, no activity in Mesocricetus auratus, no activity in Mus musculus, no activity in Rattus norvegicus, Oryctolagus cuniculus
Manually annotated by BRENDA team
Winters, C.J.; Molowa, D.T.; Guzelian, P.S.
Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase
Biochemistry
29
1080-1087
1990
Homo sapiens
Manually annotated by BRENDA team
Molowa, D.T.; Shayne, A.G.; Guzelian, P.S.
Purification and characterization of chlordecone reductase from human liver
J. Biol. Chem.
261
12624-12627
1986
Homo sapiens, Meriones unguiculatus, no activity in Mesocricetus auratus, no activity in Mus musculus, no activity in Rattus norvegicus, Oryctolagus cuniculus
Manually annotated by BRENDA team
Khanna, M.; Qin, I.; Belkin, S.; Sparkes, R.S.; Cheng, K.C.
Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization
Genomics
25
588-590
1995
Homo sapiens
Manually annotated by BRENDA team