Information on EC 1.1.1.22 - UDP-glucose 6-dehydrogenase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY
1.1.1.22
-
RECOMMENDED NAME
GeneOntology No.
UDP-glucose 6-dehydrogenase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Amino sugar and nucleotide sugar metabolism
-
Ascorbate and aldarate metabolism
-
Biosynthesis of secondary metabolites
-
Metabolic pathways
-
Pentose and glucuronate interconversions
-
Starch and sucrose metabolism
-
UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)
-
SYSTEMATIC NAME
IUBMB Comments
UDP-alpha-D-glucose:NAD+ 6-oxidoreductase
Also acts on UDP-alpha-D-2-deoxyglucose.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
ADH-like UDP-glucose dehydrogenase
Q6IVK8
-
BceC
Burkholderia cepacia IST408
-
-
-
dehydrogenase, uridine diphosphoglucose
-
-
-
-
dual specificity UDP-glucose dehydrogenase
Q6IVK8
-
HasB
Streptococcus pyogenes 5448
P0C0F5
-
-
HasB2
Streptococcus pyogenes 5448
Q490A1
-
-
PA2022
O86422
-
PA3559
Q9HY58
-
Sugarless protein
-
-
-
-
UDP-alpha-D-glucose:NAD oxidoreductase
-
-
-
-
UDP-D-glucose dehydrogenase
-
-
-
-
UDP-GDH
A1RUM9
-
UDP-Glc dehydrogenase
-
-
-
-
UDP-Glc DH
-
-
-
-
UDP-GlcDH
-
-
-
-
UDP-GlcDH
Streptococcus equi subsp. zooepidemicus FHA0
-
-
-
UDP-GlcDHase
B5L017
-
UDP-GlcDHase
Phoma herbarum YS4108
B5L017
-
-
UDP-glucose dehydrogenase
Q9FM01, Q9LF33, Q9LIA8, Q9MAB5
-
UDP-glucose dehydrogenase
B4EB36, B4EMQ8, B4EN77
-
UDP-glucose dehydrogenase
-
-
UDP-glucose dehydrogenase
Burkholderia cepacia IST408
-
-
-
UDP-glucose dehydrogenase
-
-
UDP-glucose dehydrogenase
C3VI43
-
UDP-glucose dehydrogenase
A1RUM9
-
UDP-glucose dehydrogenase
A4UTT2
-
UDP-glucose dehydrogenase
A4UTT2
-
-
UDP-glucose dehydrogenase
-
-
UDP-glucose dehydrogenase
Streptococcus equi subsp. zooepidemicus FHA0
-
-
-
UDPG dehydrogenase
-
-
-
-
UDPG:NAD oxidoreductase
-
-
-
-
UDPGDH
-
-
-
-
UDPGDH
Q6IVK8
-
UDPGDH
-
-
UDPGDH-A
-
-
UDPGDH-B
-
-
UDPGlc dehydrogenase
-
-
-
-
UDPglucose dehydrogenase
-
-
-
-
UDPglucose:NAD+ oxidoreductase
-
-
-
-
Ugd
B4EB36, B4EMQ8, B4EN77
-
Ugd
C3VI43
-
UGD1
L0N5L6
-
UgdG
A4UTT2
-
UGDH
O60701
-
UGDH
Q56R95
-
uridine diphosphate D-glucose dehydrogenase
-
-
-
-
uridine diphosphate glucose dehydrogenase
-
-
-
-
uridine diphosphate glucose-6-dehydrogenase
-
-
uridine diphosphate-glucose dehydrogenase
-
-
uridine diphosphoglucose dehydrogenase
-
-
-
-
uridine-5'-diphosphoglucose dehydrogenase
-
-
uridine-5'-diphosphoglucose dehydrogenase
Burkholderia cepacia IST408
-
-
-
uridyl phosphate dehydrogenase
-
-
CAS REGISTRY NUMBER
COMMENTARY
9028-26-6
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
syncytia induced by nematode Heterodera schachtii
UniProt
Manually annotated by BRENDA team
Burkholderia cepacia IST408
gene bceC
-
-
Manually annotated by BRENDA team
overexpression of enzyme plus transformation of gene cluster for K5 polysaccharide production
-
-
Manually annotated by BRENDA team
recombinant enzyme
-
-
Manually annotated by BRENDA team
chemically synthesized gene expressed in Escherichia coli
UniProt
Manually annotated by BRENDA team
recombinant His-tagged enzyme
UniProt
Manually annotated by BRENDA team
cultivar NVS or K326
SwissProt
Manually annotated by BRENDA team
two-dimensional IEF SDS-PAGE showed several isoforms of the purified enzyme
-
-
Manually annotated by BRENDA team
Phoma herbarum YS4108
-
UniProt
Manually annotated by BRENDA team
induction by short-term feeding with sucrose, sorbitol, ethylene glycol or light exposure
SwissProt
Manually annotated by BRENDA team
gene ugd
UniProt
Manually annotated by BRENDA team
strain PAO1, isoform PA2022, constitutively expressed
SwissProt
Manually annotated by BRENDA team
strain PAO1, isoform PA3559, expressed primarily in low concentrations of Mg2+
SwissProt
Manually annotated by BRENDA team
Saccharum spp.
hybrid
-
-
Manually annotated by BRENDA team
gene ugdG
UniProt
Manually annotated by BRENDA team
strain ATCC 31461
-
-
Manually annotated by BRENDA team
Streptococcus equi subsp. zooepidemicus FHA0
FHA0
-
-
Manually annotated by BRENDA team
isoform HasB
UniProt
Manually annotated by BRENDA team
isoform HasB2
UniProt
Manually annotated by BRENDA team
Streptococcus pyogenes 5448
isoform HasB
UniProt
Manually annotated by BRENDA team
Streptococcus pyogenes 5448
isoform HasB2
UniProt
Manually annotated by BRENDA team
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5.5
11
B5L017
no enzymic activity beyond
6.3
8.6
-
at pH 6.3 and 8.6 about 50% of activity maximum
7
9.5
-
-
7
-
-
46% of maximum acitivity
7
-
-, C9E261
37% of maximum activity
7.5
9.4
-
at pH 7.5 and 9.4 about 50% of activity maximum
7.8
9.4
-
at pH 7.8 and 9.4 about 50% of activity maximum
8.8
-
-
80-83% of maximum activity
9.5
11
-
pH 9.5: about 40% of maximal activity, pH 11.0: about 10% of maximal activity
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
25
45
-
-
30
-
-
assay at
30
-
-
-
30
-
-, C9E261
-
35
-
B5L017
-
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
25
-
-, C9E261
significant decrease in activity below
30
-
-
90% of maximum activity
40
-
-, C9E261
70% of maximum activity
50
-
B5L017
no enzymic activity above
PDB
SCOP
CATH
ORGANISM
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189)
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5
10
-
80°C, 10 min, enzyme retains full activity
5.4
6.5
-
enzyme retains 93-97% of initial activity