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Information on EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+) and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC1.1.1.197
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IUBMB Comments
Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
prostaglandin e 9-ketoreductase, 9-ketoprostaglandin reductase, nadp-dependent 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostaglandin dehydrogenase (nadp+), more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9-ketoprostaglandin reductase
-
-
carbonyl reductase
-
-
NADP-dependent 15-hydroxyprostaglandin dehydrogenase
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-
-
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NADP-linked 15-hydroxyprostglandin dehydrogenase
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-
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NADP-specific 15-hydroxyprostaglandin dehydrogenase
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-
-
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prostaglandin 9-ketoreductase
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type II 15-hydroxyprostaglandin dehydrogenase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
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reduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
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-
SYSTEMATIC NAME
IUBMB Comments
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase
Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.
CAS REGISTRY NUMBER
COMMENTARY hide
54989-39-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-methyl-3-glutathionyl-1,4-benzoquinone + NADPH
? + NADP+
show the reaction diagram
-
toluquinone thioether
-
-
?
2-methyl-3-glutathionyl-1,4-naphthoquinone + NADPH
? + NADP+
show the reaction diagram
-
menadione thioether
-
-
?
4,5-benzo[a]pyrenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
5,6-chrysenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
7,8-benzo[a]pyrenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
glutathione-9-hydroxy-prostaglandin A1 thioether + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
?
glutathione-prostaglandin A1 thioether + NADP+
? + NADPH
show the reaction diagram
-
PGA1-SG, excellent substrate for the placental enzyme
-
-
?
menadione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
prostaglandin A1 + NADP+
15-oxoprostaglandin A1 + NADPH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin B1 + NADP+
15-oxoprostaglandin B1 + NADPH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin E2 + NADPH + H+
prostaglandin F2alpha + NADP+
show the reaction diagram
-
biological inactivation of prostaglandins is mediated by the enzyme
-
r
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
show the reaction diagram
-
-
-
-
r
prostaglandin I2 + NADP+
? + NADPH
show the reaction diagram
-
poor substrate for the enzyme
-
-
?
thromboxane B2 + NADP+
? + NADPH
show the reaction diagram
-
slowly oxidized
-
-
?
toluquinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
additional information
?
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the trans-dihydrodiols trans-dihydroxy-4,5-dihydrobenzo[alpha]pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo[alpha]pyrene, trans-3,4-dihydroxy-3,4-dihydrobenz[alpha]anthracene and its 7-methyl, 12-methyl, and 7,12-dimethyl derivatives are not substrates for the enzyme
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-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-glutathionyl-2-hydroxy-3(allyloxy)propane
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competitive inhibition of prostaglandin B1 oxidation
beta-mercaptoacetate
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beta-mercaptolactate
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beta-Mercaptopyruvate
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glutathione-9-hydroxy-prostaglandin A1 thioether
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inhibition of polycyclic aromatic hydrocarbon quinone reduction
GSSG
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-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0024
2-methyl-3-glutathionyl-1,4-benzoquinone
-
-
0.0034
2-methyl-3-glutathionyl-1,4-naphthoquinone
-
-
0.00018
4,5-benzo[a]pyrenequinone
-
-
0.00051
5,6-chrysenequinone
-
-
0.00087
7,8-benzo[a]pyrenequinone
-
-
0.00036
9,10-phenanthrenequinone
-
-
0.00033
glutathione-prostaglandin A1 thioether
-
-
0.0076
menadione
-
-
0.09
prostaglandin A1
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-
0.03
toluquinone
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.09
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CBR1_HUMAN
277
0
30375
Swiss-Prot
other Location (Reliability: 4)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
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-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partial
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Westbrook, C.; Lin, Y.M.; Jarabak, J.
NADP-linked 15-hydroxyprostaglandin dehydrogenase from human placenta: partial purification and characterization of the enzyme and identification of an inhibitor in placental tissue
Biochem. Biophys. Res. Commun.
76
943-949
1977
Homo sapiens
Manually annotated by BRENDA team
Jarabak, J.; Fried, J.
Comparison of substrate specificities of the human placental NAD-and NADP-linked 15-hydroxyprostaglandin dehydrogenases
Prostaglandins
18
241-246
1979
Homo sapiens
Manually annotated by BRENDA team
Levasseur, S.; Friedman, Y.; Burke, G.
Prostaglandin metabolism in the rat adrenal cortex: Characterization of prostaglandin-9-ketoreductase and 15-hydroxyprostaglandin dehydrogenase
Biochem. Biophys. Res. Commun.
95
236-242
1980
Homo sapiens, Platyrrhini, Rattus norvegicus
Manually annotated by BRENDA team
Chang, D.B.G; Sun, M.; Tai, H.H.
Prostaglandin-9-ketoreductase and type II 15-hydroxyprostaglandin dehydrogenase from swine kidney are alternate activities of a single enzyme protein
Biochem. Biophys. Res. Commun.
99
745-751
1981
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Chung, H.; Fried, J.; Williams-Ashman, E.; Jarabak, J.
Glutathione mixed disulfide inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase
Prostaglandins
33
383-390
1987
Homo sapiens
Manually annotated by BRENDA team
Chung, H.; Harvey, R.G.; Armstrong, R.N.; Jarabak, J.
Polycyclic aromatic hydrocarbon quinones and glutathione thioethers as substrates and inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase
J. Biol. Chem.
262
12448-12451
1987
Homo sapiens
Manually annotated by BRENDA team
Wermuth, B.
NADP-dependent 15-hydroxyprostaglandin dehydrogenase is homologous to NAD-dependent 15-hydroxyprostaglandin dehydrogenase and other short-chain alcohol dehydrogenases
Prostaglandins
44
5-9
1992
Homo sapiens
Manually annotated by BRENDA team
Krook, M.; Ghosh, D.; Duax, W.; Jrnvall, H.
Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase)
FEBS Lett.
322
139-142
1993
Homo sapiens
Manually annotated by BRENDA team
Krook, M.; Ghosh, D.; Stromberg, R.; Carlquist, M.; Jornvall, H.
Carboxyethyllysine in a protein: Native carbonyl reductase/NADP+-dependent prostaglandin dehydrogenase
Proc. Natl. Acad. Sci. USA
90
502-506
1993
Homo sapiens
Manually annotated by BRENDA team