Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 1.1.1.145 - 3beta-hydroxy-DELTA5-steroid dehydrogenase and Organism(s) Drosophila melanogaster

for references in articles please use BRENDA:EC1.1.1.145
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This activity is found in several bifunctional enzymes that catalyse the oxidative conversion of Delta5-3-hydroxy steroids to a Delta4-3-oxo configuration. This conversion is carried out in two separate, sequential reactions; in the first reaction, which requires NAD+, the enzyme catalyses the dehydrogenation of the 3beta-hydroxy steroid to a 3-oxo intermediate. In the second reaction the reduced coenzyme, which remains attached to the enzyme, activates the isomerization of the Delta5 form to a Delta4 form (cf. EC 5.3.3.1, steroid Delta-isomerase). Substrates include dehydroepiandrosterone (which is converted into androst-5-ene-3,17-dione), pregnenolone (converted to progesterone) and cholest-5-en-3-one, an intermediate of cholesterol degradation.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Drosophila melanogaster
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The enzyme appears in selected viruses and cellular organisms
Synonyms
hsd3b2, hsd3b, dhrs4, 3-beta-hydroxysteroid dehydrogenase, hsd3b6, 3betahsd2, 3beta hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase type ii, 3beta-hydroxysteroid dehydrogenase type 2, 3beta-hsd type ii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-beta-hydroxy-5-ene steroid dehydrogenase
-
-
-
-
3-beta-hydroxy-delta(5)-steroid dehydrogenase
-
-
-
-
3beta-HSDH
-
-
-
-
3beta-hydroxy steroid dehydrogenase/5-ene-4-ene isomerase
-
-
-
-
3beta-hydroxy steroid dehydrogenase/isomerase
-
-
-
-
3beta-hydroxy-5-ene steroid dehydrogenase
-
-
-
-
3beta-hydroxy-5-ene-steroid dehydrogenase
-
-
-
-
3beta-hydroxy-5-ene-steroid oxidoreductase
-
-
-
-
3beta-hydroxy-DELTA5-C27-steroid dehydrogenase/isomerase
-
-
-
-
3beta-hydroxy-DELTA5-C27-steroid oxidoreductase
-
-
-
-
5-ene-3-beta-hydroxysteroid dehydrogenase
-
-
-
-
5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase
-
-
-
-
dehydrogenase, 3beta-hydroxy-DELTA5-steroid
-
-
-
-
DELTA5-3beta-hydroxysteroid dehydrogenase
-
-
-
-
progesterone reductase
-
-
-
-
steroid-DELTA5-3beta-ol dehydrogenase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
3beta-hydroxy-DELTA5-steroid:NAD+ 3-oxidoreductase
This activity is found in several bifunctional enzymes that catalyse the oxidative conversion of Delta5-3-hydroxy steroids to a Delta4-3-oxo configuration. This conversion is carried out in two separate, sequential reactions; in the first reaction, which requires NAD+, the enzyme catalyses the dehydrogenation of the 3beta-hydroxy steroid to a 3-oxo intermediate. In the second reaction the reduced coenzyme, which remains attached to the enzyme, activates the isomerization of the Delta5 form to a Delta4 form (cf. EC 5.3.3.1, steroid Delta-isomerase). Substrates include dehydroepiandrosterone (which is converted into androst-5-ene-3,17-dione), pregnenolone (converted to progesterone) and cholest-5-en-3-one, an intermediate of cholesterol degradation.
CAS REGISTRY NUMBER
COMMENTARY hide
9044-85-3
-