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Information on EC 1.1.1.112 - indanol dehydrogenase and Organism(s) Homo sapiens

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EC Tree
     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.112 indanol dehydrogenase
IUBMB Comments
3(20)alpha-Hydroxysteroids are also oxidized, more slowly.
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This record set is specific for:
Homo sapiens
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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
hide
indan-1-ol
+
NAD(P)+
=
indanone
+
NAD(P)H
+
H+
+
=
+
+
Synonyms
indanol dehydrogenase, more
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
indan-1-ol:NAD(P)+ 1-oxidoreductase
3(20)alpha-Hydroxysteroids are also oxidized, more slowly.
CAS REGISTRY NUMBER
COMMENTARY hide
37250-43-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
indan-(S)-1-ol + NAD(P)+
indan-1-one + NAD(P)H
show the reaction diagram
-
-
-
ir
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
-
-
NADP+
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0008
-
cytosolic fraction, cofactor NADP+
0.001
-
cytosolic fraction, cofactor NAD+
0.0079
-
mitochondrial fraction, cofactor NADP+
0.0126
-
microsomal fraction, cofactor NADP+
0.0181
-
microsomal fraction, cofactor NAD+
0.118
-
mitochondria fraction, cofactor NAD+
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9.8
-
second maximum at pH 8.6
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
AK1C1_HUMAN
323
0
36788
Swiss-Prot
other Location (Reliability: 2)
AK1C2_HUMAN
323
0
36735
Swiss-Prot
other Location (Reliability: 2)
AK1C3_HUMAN
323
0
36853
Swiss-Prot
other Location (Reliability: 5)
PDB
SCOP
CATH
UNIPROT
ORGANISM
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kulkarni, A.P.; Strohm, B.H.; Houser, W.H.
Human placental indanol dehydrogenase: some properties of the microsomal enzyme
Xenobiotica
15
513-519
1985
Homo sapiens
Manually annotated by BRENDA team