1.1.3.39: nucleoside oxidase (H2O2-forming)

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For detailed information about nucleoside oxidase (H2O2-forming), go to the full flat file.

Reaction

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.3 With oxygen as acceptor

                1.1.3.39 nucleoside oxidase (H2O2-forming)

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Results	in table
1	CAS Registry Number
1	Cofactor
15	Inhibitors
12	KM Value [mM]
5	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
4	Organism
1	pH Optimum
1	pH Stability
2	Posttranslational Modification
1	Purification (Commentary)
3	Reaction
3	Reaction Type
3	Reference
3	Source Tissue
1	Specific Activity [micromol/min/mg]
33	Substrates and Products (Substrate)
2	Subunits
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 1.1.3.39 - nucleoside oxidase (H2O2-forming)

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SYSTEMATIC NAME

IUBMB Comments

nucleoside:oxygen 5'-oxidoreductase (H2O2-forming)

A heme-containing flavoprotein (FAD). Other purine and pyrimidine nucleosides (as well as 2'-deoxyribonucleosides and arabinosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.28, nucleoside oxidase, as it produces hydrogen peroxide rather than water.