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1.1.2.4: D-lactate dehydrogenase (cytochrome)

This is an abbreviated version!
For detailed information about D-lactate dehydrogenase (cytochrome), go to the full flat file.

Word Map on EC 1.1.2.4

Reaction

(R)-lactate
+
2 ferricytochrome c
=
pyruvate
+ 2 ferrocytochrome c + 2 H+

Synonyms

AtD-LDH, cytochrome-dependent D-(-)-lactate dehydrogenase, cytochromec-dependent D-LDH, D(-)-lactic cytochrome c reductase, D-iLDH, D-lactate cytochrome c oxidoreductase, D-lactate dehydrogenase (cytochrome), D-lactate dehydrogenase [cytochrome], mitochondrial, D-lactate ferricytochrome c oxidoreductase, D-lactate-cytochrome c reductase, D-lactate: cytochrome c oxidoreductase, D-LCR, D-LDH, DLD, DLD1, DLDH, glycolate deshydrogenase, iLDH, L-lactate-cytochrome c oxidoreductase, lactic acid dehydrogenase, NAD+-independent LDH, Os07g06890

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.2 With a cytochrome as acceptor
                1.1.2.4 D-lactate dehydrogenase (cytochrome)

Substrates Products

Substrates Products on EC 1.1.2.4 - D-lactate dehydrogenase (cytochrome)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-lactate + 2 ferricytochrome c
pyruvate + 2 ferrocytochrome c
show the reaction diagram
(R)-lactate + 2 ferricytochrome c
pyruvate + 2 ferrocytochrome c + 2 H+
show the reaction diagram
(R)-lactate + 2 ferricytochrome c
pyruvate + ferrocytochrome c
show the reaction diagram
(R)-lactate + ferricyanide
pyruvate + ferrocyanide
show the reaction diagram
(R)-lactate + ferricytochrome c
pyruvate + ferrocytochrome c
show the reaction diagram
(R)-lactate + PMS-DCIP
pyruvate + reduced PMS-DCIP
show the reaction diagram
D-2-hydroxybutyrate + cytochrome c
2-oxobutanoate + ferrocytochrome c
show the reaction diagram
D-2-hydroxybutyrate + ferricytochrome c
?
show the reaction diagram
135% relative activity compared to (R)lactate, highest catalytic efficiency, prefered substrate
-
-
?
D-2-hydroxybutyrate + PMS-DCIP
2-oxobutanoate + reduced PMS-DCIP
show the reaction diagram
D-2-hydroxyglutarate + ferricytochrome c
?
show the reaction diagram
0.15% relative activity compared to (R)lactate
-
-
?
D-2-hydroxyvalerate + cytochrome c
2-oxovalerate + ferrocytochrome c
show the reaction diagram
-
very poor substrate
-
-
?
D-glycerate + ferricytochrome c
?
show the reaction diagram
9.2% relative activity compared to (R)lactate
-
-
?
D-lactate + 2 ferricytochrome
pyruvate + 2 ferrocytochrome
show the reaction diagram
-
-
-
-
?
D-lactate + 2 ferricytochrome c
pyruvate + 2 ferrocytochrome c
show the reaction diagram
D-lactate + 2,6-dichlorophenolindophenol
pyruvate + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
D-lactate + cytochrome c2ox
pyruvate + cytochrome c2red
show the reaction diagram
-
-
-
-
?
D-lactate + ferricyanide
pyruvate + ferrocyanide + H+
show the reaction diagram
-
-
-
-
r
D-lactate + ferricytochrome c
pyruvate + ferrocytochrome c
show the reaction diagram
-
-
-
-
?
D-lactate + oxidized phenazine methosulfate
pyruvate + reduced phenazine methosulfate + H+
show the reaction diagram
-
-
-
-
r
DL-2-hydroxybutyrate + ferricytochrome c
2-oxobutanoate + ferrocytochrome c
show the reaction diagram
-
40% of the activity with (R)-lactate
-
-
?
DL-glycerate + ferricyanide
?
show the reaction diagram
-
10% of the rate of D-lactate oxidation
-
-
?
DL-glycerate + ferricytochrome c
?
show the reaction diagram
10.3% relative activity compared to (R)lactate
-
-
?
glycolate + ferricytochrome c
?
show the reaction diagram
0.15% relative activity compared to (R)lactate, O2 does not function as the acceptor for glycolate electrons
-
-
?
L-lactate + ferricytochrome c
?
show the reaction diagram
10.8% relative activity compared to (R)lactate
-
-
?
additional information
?
-