1.1.1.B40: 11beta-hydroxysteroid dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about 11beta-hydroxysteroid dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

11 beta-hydroxysteroid dehydrogenase, 11 beta-hydroxysteroid dehydrogenase type 2, 11-beta hydroxysteroid dehydrogenase type 1, 11-beta hydroxysteroid dehydrogenase type 2, 11-beta-HSD2, 11beta hydroxysteroid dehydrogenase type 2, 11beta-HSD, 11beta-HSD 2, 11beta-HSD type 2, 11beta-HSD1, 11beta-HSD2, 11beta-HSD2 (oxidase) NAD+, 11beta-HSD2/HSD11B2, 11beta-hydroxysteroid dehydrogenase 2, 11beta-hydroxysteroid dehydrogenase isoforms 2, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type-2, 11beta-hydroxysteroid dehydrogenases type 2, 11beta-OHSD, 11betaHSD2, 11HSD1, 7-alpha-HCD, 7-alpha-hydroxycholesterol dehydrogenase, corticosteroid 11-beta-dehydrogenase isozyme 1, HSD 2, HSD11B type 1, HSD11B type 2, Hsd11B2, isozyme 11beta-HSD2, More, NAD(+)-dependent 11beta-dehydrogenase, NAD+-dependent 11beta-hydroxysteroid dehydrogenase 2, type 2 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.B40 11beta-hydroxysteroid dehydrogenase (NAD+)

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Results	in table
8	Activating Compound
9	AA Sequence
9	Application
27	Cloned(Commentary)
68	Cofactor
1	Crystallization (Commentary)
448	Disease/ Diagnostics
4	Expression
11	General Information
127	IC50 Value
251	Inhibitors
57	Ki Value [mM]
37	KM Value [mM]
20	Localization
15	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
258	Organism
20	pH Optimum
1	pH Range
2	Purification (Commentary)
8	Reaction
3	Reaction Type
91	Reference
149	Source Tissue
12	Specific Activity [micromol/min/mg]
2	Storage Stability
118	Substrates and Products (Substrate)
17	Subunits
119	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
1	Temperature Stability [°C]

Sequence

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Sequence on EC 1.1.1.B40 - 11beta-hydroxysteroid dehydrogenase (NAD+)

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTIONThe reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

P16232 pBLAST

DHI1_RAT

Rattus norvegicus

288

0

31883

Swiss-Prot

Show Sequence

Secretory Pathway (Reliability: 2)

P28845 pBLAST

DHI1_HUMAN

Homo sapiens

292

1

32401

Swiss-Prot

Show Sequence

other Location (Reliability: 3)

P51661 pBLAST

DHI2_MOUSE

Mus musculus

386

0

42187

Swiss-Prot

Show Sequence

-

P51976 pBLAST

DHI2_RABIT

Oryctolagus cuniculus

406

0

44182

Swiss-Prot

Show Sequence

-

P80365 pBLAST

DHI2_HUMAN

Homo sapiens

405

0

44127

Swiss-Prot

Show Sequence

-

Q05KC1 pBLAST

Q05KC1_ANGJA

Anguilla japonica

417

0

45764

TrEMBL

Show Sequence

-

Q6QLL4 pBLAST

DHI1_CAVPO

Cavia porcellus

300

1

33226

Swiss-Prot

Show Sequence

-

Q6R0J2 pBLAST

DHI1_MESAU

Mesocricetus auratus

292

1

32305

Swiss-Prot

Show Sequence

-

Q8MKG1 pBLAST

Q8MKG1_PIG

Sus scrofa

400

0

43583

TrEMBL

Show Sequence

-

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